The invention provides a composite purification packaging bag which is prepared from the following components in parts by weight: 50-60 parts of HDPE (High-Density Polyethylene), 35-45 parts of LLDPE(Linear low density polyethylene), 10 parts of a thermoplastic elastomer and 10 parts of composite calcium carbonate. Composite calcium carbonate is prepared by the following steps: putting calcium carbonate superfine powder into ultrapure water, performing ultrasonic dispersion for 30 minutes, adding isopropanol zirconium, tetraethoxysilane, water and ethanol, heating to 75 DEG C, performing magnetic stirring for 10 hours, performing centrifugation for 20 minutes to obtain a mixture, washing the mixture with deionized water twice, putting into a muffle furnace, performing pyrolysis for 1 hourat 450 DEG C, cooling to the room temperature, and grinding, thereby obtaining composite calcium carbonate. The invention further provides a preparation method of the composite purification packagingbag. The composite purification packaging bag provided by the invention is not only good in puncture resistance, but also very good in toughness, tearing resistance and scraping resistance.