64results about How to "Improve thymus index" patented technology

The present invention relates to the field of feed formula design, specifically to a novel green broiler chickens complete feed and technique of preparing the same. A safe, pollution-free novel green broiler chickens complete feed of the invention is composed of the following components by weight parts: 55 -60 parts of corn, 10 -20 parts of dehulled bean pulp, 2 -3 parts of corn protein powder, 2 -3 parts of corn alcohol dreg, 2 -5 parts of cottonseed meal, 2 -8 parts of Chinese herbal compound preparation, 0.3-0.4 parts of multi-vitamin, 0.2 parts of composite trace elements. Thebroiler chickens complete feed develops a novel pollution-free non-drug residue green broiler chickens complete feed by adding Chinese herbal compound preparation. The broiler chickens fed by the feed greatly enhances immune function, greatly enhances the immunity against the disease and substantially improves the survival rate.

The invention discloses a preparation method and application of cycloastragenol. The preparation method of the cycloastragenol comprises the following steps: by using astragaloside or astrasieversianin as a raw material, oxidizing, reducing, hydrolyzing, extracting and purifying to obtain high-purity cycloastragenol. The method is simple to operate, gentle in condition, good in product quality and high in yield. The cycloastragenol can be applied to preparation of anticancer adjuvant therapeutic medicine. An anticancer adjuvane therapeutic medicine prepared by using the cycloastragenol as a pharmaceutical active ingredient has the anticancer adjuvant therapeutic effect of enhancing the anticancer therapeutic effect, reducing the toxicity of the anticancer medicine, preventing and treating the neutropenia caused by the anticancer medicine therapy.

The invention discloses a method for preparing functional extracellular polysaccharide of lactic acid bacteria, which is characterized by comprising the following steps of: inoculating a Lactococcus lactis subsp. lactis strain fermentation agent for culture, performing ultrafiltration concentration, precipitation and ethanol extraction on fermentation liquor, centrifuging a precipitate, and performing freeze drying to obtain powdery crude extracellular polysaccharide; performing separation and purification by using a diethylaminoethanol (DEAE) cellulose ion exchange column and SepharoseCL-6B gel column chromatography in turn, desalting, performing ultrafiltration concentration, precipitating by using an ethanol solution, and performing freeze drying on a precipitate to obtain pure extracellular polysaccharide; and performing phosphorylation and selenide formation on the pure extracellular polysaccharide. The method has the advantages that: the extracellular polysaccharide produced by the Lactococcus lactis subsp. lactis strain is subjected to selenide formation and phosphorylation modification by a dry heating method, and the functional extracellular polysaccharide of lactic acid bacteria with obvious antioxidant and immunity enhancing effects is obtained.

Disclosed is a method for extracting dihydro quercetin from larch. The invention is an improved production method. Due to different production materials and extraction processes, the dihydro quercetin products in U.S. and European markets are very expensive, at a price of 200-1000 euros per gram. Such a high market price economically limits the wide range of practicability of dihydro quercetin products. During the pretreatment of raw materials, 50 kilograms of larch wood chips and 500-800 liters of 50% ethanol solution are added into a reactor to get fully stirred and mixed; then the mixture is extracted and filtered for the second extraction; the filtrates are combined and adsorbed; the organic solvents are collected and dried by a vacuum evaporator through organic phase vacuum distillation; according to a weight proportion of 10:1, the residues are dissolved with hot water, decolorized with activated carbon and then crystallized at a temperature of 3-5 DEG C to precipitate the dihydro quercetin product which is then crushed after vacuum drying to finished product. The invention is used to extract dihydro quercetin from larch.

Disclosed is a preparation method for extracting dihydro quercetin from larch. The invention is an improved production method. Due to different production materials and extraction processes, the dihydro quercetin products in U.S. and European markets are very expensive, at a price of 200-1000 euros per gram. Such a high market price economically limits the wide range of practicability of dihydro quercetin products. During the pretreatment of raw materials, 50 kilograms of larch wood chips and 500-800 liters of 50% ethanol solution are added into an extractor to get fully stirred and mixed; then the mixture is extracted and filtered for the second extraction; the filtrates are combined and adsorbed; the organic solvents are collected and dried by a vacuum evaporator through organic phase vacuum distillation; according to a weight proportion of 10:1, the residues are dissolved with hot water, decolorized with activated carbon and then crystallized at a temperature of 3-5 DEG C to precipitate the dihydro quercetin product which is then crushed after vacuum drying to finished product. The invention is used to extract dihydro quercetin from larch.

The invention discloses an environmentally-friendly compound Chinese herbal medicinal feed additive for enhancing the immunities of broilers, and an application thereof, and belongs to the technical field of animal feed additives. The bulk drugs of the additive comprise Radix Astragali, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae, Poria cocos, hyacinth bean, medicated leaven, hawthorn fruit and malt. The additive is prepared through drying the bulk drugs at 50-60DEG C, crushing, sieving, and mixing 29-31g of Radix Astragali, 29-31g of Radix Codonopsis, 29-31g of Rhizoma Atractylodis Macrocephalae, 29-31g of Poria cocos, 29-31g of hyacinth bean, 14-16g of medicated leaven, 14-16g of hawthorn fruit and 14-16g of malt The prepared additive is added to a mixed broiler feed according to a mass percentage of 0.5-1.5% to obtain a mixture for use in order to substantially reduce the feed conversion ratio and increase the spleen index, the thymus index and the index of bursa of Fabricius.

The present invention relates the application of nano copper powder in preparation of immunity-enhancing medicine. It adopts the commercial nano copper powder whose grain size is 0.1-1000 nm as raw material, the weight ratio of raw material nano copper powder required for preparing medicine and preparation is 0.002-0.04:1. Said nano copper powder has the enhancement for specific immunity and non-specific immunity of body, and said medicine can be used for curing various diseases due to infective microbe and its toxin, tumor, dead cell or mutant cell.

The invention discloses an anti-radiation traditional Chinese medicine composition which comprises the following components in parts by weight: 160-200 parts of membranous milkvetch root, 110-130 parts of scurfy pea, 80-100 parts of Chinese angelica, 160-200 parts of epimedium, 135-165 parts of madder root, 110-130 parts of glossy privet fruit, 110-130 parts of white paeony root, 110-130 parts ofradix rehmanniae preparata, 80-100 parts of Szechuan lovage rhizome, 215-265 parts of Chinese yam and 35-45 parts of prepared liquoric root. The traditional Chinese medicine composition can increase thymus index and spleen index of a 60Co gamma-radiated mouse and protect immune organs; improve the activity of superoxide dismutase in blood serum and the liver of the 60Co gamma-radiated mouse, reduce the content of malonaldehyde and improve the anti-oxidation capability of an organism; increase peripheral white blood cells of the 60Co gamma-radiated mouse and improve the hematogenesis function;and reduce the micronuclear rate of marrow cells of the 60Co gamma-radiated mouse and inhibit the action of causing chromosomal aberration of 60Co gamma rays. In addition, the traditional Chinese medicine composition is low in toxicity and side effects, and medicinal materials in the formula are low in price and easy to obtain, thereby having great development and application prospects in the aspects of preventing and treating radiation injuries.

The invention relates to an animal feed additive, and in particular relates to a composite feed additive preparation technology based on gynostemma pentaphylla. According to the composite feed additive preparation technology, ACCC10634 bacillus subtilis and ACCC11016 Lactobacillus plantarun are respectively used as strains and are inoculated to an inorganic salt culture solution containing gynostemma pentaphylla micro powder to be cultured grade by grade; a tissue structure of the gynostemma pentaphylla is digested in a way that an intestinal environment of an animal body is simulated in vitro, so that effective components are released, and the extraction rate of the effective components of the gynostemma pentaphylla is improved; the efficacy of the gynostemma pentaphylla is enhanced; the composite feed additive preparation technology has a function of promoting the growth of pigs and livestock and can improve the disease resistance of the pigs and the livestock and increase the feed reward.

The invention relates to a medicine and food dual-purpose traditional Chinese medicine composition with anti-tumor activity and immunoregulation effect and application thereof. The composition comprises ganoderma lucidum extract and radix astragali extract in mass ratio of 1:0.5-3, wherein the ganoderma lucidum extract comprises the following effective medicinal ingredients in percentage by weight: 50-70% of ganoderma lucidum polysaccharides and 6-10% of ganoderma lucidum total triterpene; and the radix astragali extract comprises the effective medicinal ingredient in percentage by weight: 20-45% of radix astragali polysaccharide. Based on traditional Chinese medicine pharmacological animal experiments, the composition of the invention is found having anti-tumor effect, improves the immunocompetence of a body, and has a medicine and food dual-purpose property. In addition, compared with single ganoderma lucidum, the use of the radix astragali as raw material reduces the cost of the traditional Chinese medicine composition, the anti-tumor and immunoregulation curative effects are close to the curative effects of the same amount of the single ganoderma lucidum, and the invention has certain economic value.

The invention relates to a periplaneta americana immunomodulating peptide and a preparation method and medical application thereof. Specifically, the invention relates to an immunomodulating peptide which is extracted from periplaneta americana and has the effects of preventing and treating tumor diseases and improving the immunity function of an organism. The polypeptide substance is a single chain polypeptide of which the amino acid sequence is arginine-arginine-asparagine-leucine-leucine-alanine-alanine-serine-leucine-leucine-asparagine- aspartate, and is prepared by extracting fresh or dry periplaneta americana in water or an organic solvent and a buffer solution and refining through a membrane separation method and an HPLC (High Performance Liquid Chromatography) technology. The immunomodulating peptide has remarkable antitumor activity and immunomodulating effect, and can be used to make medicaments for preventing and treating tumor diseases and / or modulating immunity, daily chemical products or medical devices.

The invention discloses a composition for strengthening the immunity function of an organism and a preparation method thereof. The composition is mainly prepared from the following raw materials in parts by weight: 67-201 parts of glossy ganoderma spore powder, 33.5-100.5 parts of astragalus membranaceus extracts, 25-75 parts of glossy privet fruit extracts, and 17.5-52.5 parts of turmeric extracts. A modern preparation technology is used, and an advanced quality control method is used, so that products are safe, stable and controllable. Animal experiments prove that compared with a preparation made of single glossy ganoderma spore powder and a preparation made of single astragalus membranaceus extracts, the composition disclosed by the invention has more excellent effects of strengthening the immunity of the organisms under the condition of the same dosage, and in addition, the composition does not have any toxic or side effects, so that the composition has higher development and utilization values and market application prospects.

The invention relates to the field of a preparation method and application of a traditional Chinese medicine effective component and in particular relates to a preparation method of rhizoma polygonatipolysaccharide and application of the rhizoma polygonati polysaccharide to the preparation of an immunological enhancement medicine. The rhizoma polygonati polysaccharide is obtained by processing raw rhizoma polygonati, extracting and separating; when an extraction method provided by the invention is adopted, the extraction rate of the rhizoma polygonati polysaccharide is high and the content oftotal polysaccharide is high; the proliferation activity of the rhizoma polygonati polysaccharide on normal mouse spleen cells is improved; cyclophosphamide induced spleen and thymus gland index of mice with low immunity also can be improved; the in-vitro proliferation capability of spleen and thymus gland cells under the stimulation of concanavalin A is enhanced; the phagocytic function of macrophage of the mice with the low immunity and the capability of secreting IL-6 and TNF-alpha are enhanced; the rhizoma polygonati polysaccharide has actual application value in the aspect of treatment of diseases including immunodeficiency diseases, tumors and the like.

The invention relates to the field of medicines, and particularly relates to a ginsenoside composition, a preparing method thereof and applications of the ginsenoside composition. The ginsenoside composition comprises rare ginsenosides Rh4, Rk3, Rk1 and Rg5. Changes of active components in a ginseng steaming process are researched systematically, response surface design tests are utilized to optimize a ginseng processing process, and the inventor unexpectedly found a processing method in which ginsenoside component changes of a raw medicine material are most obvious, and especially unexpectedly found a processing method for efficiently preparing the rare ginsenosides. Through later pharmacological activity screening, the inventor also unexpectedly found that a ginseng processing product rich in the rare ginsenosides has significant kidney and yang tonifying effects.

The invention provides a medicine for treating pulmonary tuberculosis. The medicine is mixture of glucoprotein or polysaccharide and protein or is polypeptide or protein. The medicine provided by the invention has a favorable curative effect on pulmonary tuberculosis, is capable of obviously improving the sputum negative conversion rate, the focal absorption rate and the cavity closing rate, reducing the number of colonies of the lung and spleen, increasing the quantity of T lymphocytes CD4<+>T, increasing the thymus index and increasing the IFN-gamma content after being used for treating pulmonary tuberculosis for three months, is safe, efficient and free of side effect, and has obvious effects on preventing and treating pulmonary tuberculosis.

The invention belongs to the technical field of preparation of health wine and particularly relates to deer blood health wine and a preparation method thereof. The deer blood health wine is prepared by taking deer blood, rhizoma curculiginis, cacumen platycladi, fructus lycii, dendrobium officinale, cortex acanthopanacis, obscured homalomena rhizome, radix polygoni multiflori and liquorice root as raw materials, soaking with Baijiu and then extracting. By utilizing the characteristics of promoting blood circulation, being divergent and easy to absorb and promoting drug property of the Baijiu and combining with regulation and control of process parameters, the utilization rate of traditional Chinese medicines is improved; in addition, by use of reasonable proportion design, the medicines are synergized under the action of the Baijiu, and further the health effects of medicinal wine is enhanced. The deer blood wine disclosed by the invention has the advantages of proper wine aroma, strong and mellow wine taste and clear wine body; besides, the deer blood wine has the efficacy of promoting blood circulation and eliminating stasis, beautifying and nourishing skin, invigorating stomach and promoting digestion, enhancing immunity and the like.

The invention discloses an active polypeptide with an antagonistic chemotactic factor receptor CCR5, which has an amino acid sequence in SEQ ID NO:1 or an amino acid sequence obtained by carrying out deletion, addition, insertion and substitution of one or more amino acid residues on the amino acid sequence in SEQ ID NO:1. The invention also discloses a preparation method of the polypeptide, which comprises the following steps of: searching related protein sequences in a database; carrying out multiple alignment comparative analysis to screen out a highly conservative region for combination of a vMIP-II receptor; eliminating interference of unrelated residues through analysis simulation means; determining a target peptide sequence; synthetizing the active polypeptide by a solid-phase synthesis method; and finally testing the bioactivity of the polypeptide. The polypeptide can be used as a CCR5 receptor antagonist for the development of an anti-inflammatory drug, can be used as a lead drug for treating AIDS (Acquired Immune Deficiency Syndrome) and can also be used as a medicament with the immune regulation effect or a medicament for improving the functions of an immune system of an organism.

The invention discloses a preparation method of papaya seed benzyl glucosinolate extract and its function of enhancing body immunity. With papaya seed benzyl glucosinolate extract as an object, the influence of the papaya seed benzyl glucosinolate extract upon mice humoral immunity, nonspecific immunity and immune organ index is studied according to the pharmacological methods provided in Technical Standards for Testing and Assessment of Immune-Health Foods by the Ministry of Health of the PRC. The results indicate that the papaya seed benzyl glucosinolate extract can significantly increase thymus index in mice, promote the generation of serum hemolysin and enhance the phagocytosis of peritoneal macrophage. It is indicated that the papaya seed benzyl glucosinolate extract can enhance body immunity.

The invention belongs to the technical field of food, and discloses a black garlic extract and application thereof in preventing and curing breast cancer. It is proved by the cell test that the black garlic extract inhibits growth of breast cancer MD231 cells and T47D cells in a concentration-dependent and time-dependent manner, so that the adhesiveness among cancer cells is enhanced, and the vigor of the cancer cells is reduced; besides, it is proved by the animal test that the black garlic extract can inhibit growth of nude mouse MCF-7 transplanted tumor remarkably, the gross tumor volume is reduced, the thymus index and the spleen index are increased, tumor immunosuppression is avoided, and the black garlic extract has the immunological enhancement effect. Therefore, the black garlic extract can be used for preventing and curing breast cancer, is rich in source and pure-natural, and has important development and application prospects.

The invention provides a medicated diet composition for enhancing immunity. The medicated diet composition comprises, by weight, 60-75 parts of selenium-rich grifola frondosa, 35-45 parts of selenium-rich agaricus blazei murill, 30-40 parts of selenium-rich radix astragali, 2-10 parts of gypenoside and 2-10 parts of glutathione, wherein the selenium contents of the selenium-rich grifola frondosa,the selenium-rich agaricus blazei murill and the selenium-rich radix astragali are greater than 400 ppm. The invention further provides a preparation method of the medicated diet composition. The method is based on water extraction and repeated low-temperature extraction. The medicated diet composition has the advantages that components are reasonably compounded, the formulation is ingenious, andthe composition has the effect of regulating the balance of qi, blood, yin and yang of the human body and enhancing the body immunity. The preparation method has the advantages that through repeated low-temperature extraction, active ingredients can be extracted as many as possible on the premise of ensuring the activity of the active ingredients.

The invention relates to the technical field of deep processing of lycium barbarum and provides lycium barbarum polysaccharide soft sweets. The lycium barbarum polysaccharide soft sweets comprise thefollowing raw materials in parts by weight: 40-60 parts of lycium barbarum polysaccharide extract, 6-12 parts of kappa-carrageenan, 7-10 parts of iota-carrageenan, 280-330 parts of xylitol, 550-650 parts of maltitol, 2-4 parts of sodium citrate and 8-15 parts of citric acid solution, wherein the total sugar content of the lycium barbarum polysaccharide extract is 37-45 wt%. Animal experiments showthat the lycium barbarum polysaccharide soft sweets provided by the invention are capable of obviously improving white blood cell count and thymus indexes of model mice with low immunity, and have obvious immunity improvement effects. The market vacancy of the products is filled.

The invention discloses a Chinese medicine composite capable of improving immunity. The composite comprises the following components: 30-60% of barbary wolfberry fruit, 10-50% of white atractylodes rhizome, 10-50% of Chinese yam, 10-40% of liquorice and 10-40% of medicated leaven. The composite can be prepared into medicines in the forms of powder, liquid, paste, particles or capsules or a pharmaceutically acceptable physical form. According to the Chinese medicine composite disclosed by the invention, the survive rate can reach 70%, the immunity is effectively improved, and specific to the immune organ indexes, the spleen index is improved by 23.2 percent, the thymus index is improved by 32.4%, and the index of bursa of Fabricius is improved by 41.2%; and especially, in terms of the contents of serum globulins, the content of IgA (immunoglobulin A) is improved by 20.7%, and the content of IgY (immunoglobulin Y) is improved by 23.4%, so that the composite disclosed by the invention can obviously promote specific immunity.

The invention discloses a preparation method and application of cycloastragenol. The preparation method of the cycloastragenol comprises the following steps: by using astragaloside or astrasieversianin as a raw material, oxidizing, reducing, hydrolyzing, extracting and purifying to obtain high-purity cycloastragenol. The method is simple to operate, gentle in condition, good in product quality and high in yield. The cycloastragenol can be applied to preparation of anticancer adjuvant therapeutic medicine. An anticancer adjuvane therapeutic medicine prepared by using the cycloastragenol as a pharmaceutical active ingredient has the anticancer adjuvant therapeutic effect of enhancing the anticancer therapeutic effect, reducing the toxicity of the anticancer medicine, preventing and treating the neutropenia caused by the anticancer medicine therapy.

The invention relates to the technical field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition for treating a porcine reproductive and respiratory syndrome andan application of the traditional Chinese medicine composition. The traditional Chinese medicine composition comprises saffron crocus, fructus amomi, folium perillae, radix rehmanniae recen, gastrodia elata, ganoderma lucidum polysaccharide, folium artemisiae argyi, a glossy privet fruit, acanthopanax and dandelion. According to the composition, different traditional Chinese medicine ingredientsare matched for use; the traditional Chinese medicine composition is based on enhancement and repairing of a porcine immune system, and has functions of enhancing phagocytosis of mononuclear macrophages, activating lymphocytes, promoting immune response of a body, and enhancing and regulating humoral immunity; based on a combined effect of traditional Chinese medicine active ingredients, the composition directly eliminates reproductive and respiratory syndrome viruses, controls development of viremia, can effectively rise an antibody level of the porcine reproductive at the same time, and respiratory syndrome and enhances porcine immunologic functions and disease resistance.

The invention discloses an application of codonopsis pilosula, rhizoma atractylodis macrocephalae, poria and liquorice powder in preparing medicament for improving immunity of rabbits. According to the application, the codonopsis pilosula, rhizoma atractylodis macrocephalae, poria and liquorice powder accounting for 1-5 percent of the weight of basic ration is added into the basic ration, the basic ration is fed to rabbits, and the rabbit sacculus rotundus index, thymus index, spleen index or dendritic index of a rabbit can be increased, the immunity of the rabbit can be improved, the expression quantity of an antifungal protein gene can be increased, and theoretical direction is provided to the codonopsis pilosula, rhizoma atractylodis macrocephalae, poria and liquorice powder in improving rabbit immunity.

The invention discloses application of a lung-heat-clearing stonecrop medicine composition to preparation of anti-influenza A virus medicine. The lung-heat-clearing stonecrop medicine composition is prepared from the following raw materials in weight part: 300 parts of rhodiola rosea, 300 parts of travertine, 200 parts of platycodon grandiflorum and 200 parts of liquorice. The lung-heat-clearing stonecrop medicine composition is a lung-heat-clearing stonecrop capsule or a pharmaceutical preparation which is prepared after the medicinal materials in a prescription are prepared into active ingredients, and the pharmaceutical preparation can be a sugarcoated tablet, a thin membrane coated tablet or a capsule preparation. The pharmacological experiments show that the lung-heat-clearing stonecrop medicine composition has a certain inhibition effect on influenza A in vitro and in vivo, can remarkably inhibit the influenza A virus-induced pulmonary index increase in miceinhibit the influenza A virus-induced pulmonary index increase in mice, remarkably inhibit the influenza A viruses to reduce immune organs in mice, remarkably prevent the influenza viruses from killing the mice, and has a significant regulating effect on hypoimmunity caused by virus infection. Moreover, the protective effect of the lung-heat-clearing stonecrop medicine composition prepared by a novel process is commensurate with that of virazole.

The invention belongs to the technical field of traditional Chinese medicines, and in particular provides a medicament composition for treating cognitive dysfunction. The medicament composition is prepared from the following components in parts by weight by virtue of combination: 10-100 parts of manyinflorescaned sweetvetch root, 8-80 parts of baikal skullcap root, 5-60 parts of root of kirilow rhodiola, 5-60 parts of rhizoma acori graminei and 3-50 parts of earth worm. The invention also provides a preparation method and specific application of the medicament composition. Experiments prove that the medicament composition provided by the invention can significantly improve the learning and memorizing abilities of a vascular dementia rat model and reduce activity of MDA and MAO in hippocampus tissues and serums, and can improve mouse pia mater local microcirculation disorders caused by norepinephrine in different degrees to ensure that micro arteries are expanded, and the blood stream is accelerated; and experimental results show that the medicament composition provided by the invention has an obvious treatment effect on vascular dementia.

The invention provides composition having an immunoregulatory activity, as well as a preparation and an application thereof. The composition comprises an active ingredient and optional auxiliary materials, and is characterized in that the active ingredient comprises seaweed or defatted seaweed and oyster shells or comprises an extract from extraction of the seaweed or defatted seaweed and the oyster shells. The seaweed and oyster shell composition has the technical effect of synergistic interaction on the effect of improving immunocompetence.

The invention relates to the technical field of biological medicine. In particular, the invention relates to a fomes fomentarius compound extract, a preparation method and an application thereof. The fomes fomentarius compound extract is prepared from the following components according to a weight ratio of 1-10 parts of fomes fomentarius:1-9 parts of phellinus pini:1 part of ganoderma lucidum; the extraction method of the compound extract comprises: preparing a fomes fomentarius compound, mixing, crushing, adding pure water, performing water extraction and alcohol precipitation to obtain a supernatant, performing reduced pressure concentration, and performing vacuum drying of the concentrate to obtain the product. The content of triterpene and triterpene saponin in the fomes fomentarius compound extract of the invention is not less than 5.5%. The extract not only has significant in-vivo and in-vitro antineoplastic efficacy, but also has no obvious acute toxicity; the maximum tolerance dose for mice is 0.2 g (equivalent to 4.58 g of crude drugs), which is 327 times of human oral dosage. The extract can be prepared into compound preparation when mixed with pharmaceutically acceptable carriers, and the compound preparation can be oral liquid, injection, suspension, pills, tablets, capsules, powder, granules, or drop pills.