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Method for extracting dihydroquercetin form larch

A technology for extracting dihydroquercetin and larch, which is applied in the direction of organic chemistry and medical raw materials derived from gymnosperms, can solve the problems of limited practicality and high price of dihydroquercetin, and achieve an increase in content Inhibition, improvement of coronary blood flow, and the effect of reducing consumption

Inactive Publication Date: 2008-12-31
黑龙江花旗科技发展有限公司 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Dihydroquercetin is widely used, but due to different production raw materials and extraction processes, the price of dihydroquercetin products in the European and American markets is very expensive, 200-1000 euros per gram
Such a market price, economically limits its wide applicability

Method used

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  • Method for extracting dihydroquercetin form larch

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029]The preparation process for extracting dihydroquercetin from larch is as follows: select larch rhizomes, saw sections of raw materials, peel them, process them into sawdust, weigh 50 grams of larch sawdust, and place them in a constant-temperature ultrasonic extraction machine. Measure 500-800ml of 50% ethanol solution with a measuring cylinder and add it to the extractor and fully stir and mix it with the larch sawdust. Turn on the ultrasonic reactor, and use the turmoil effect and cavitation effect generated by the ultrasonic radiation pressure to accelerate the diffusion and dissolution of the substance. After 35 minutes, turn off the ultrasonic device, and the mixture will appear as a yellowish-brown slightly oily turbid liquid. Filter, extract twice, and combine filtrate. The filtrate was extracted twice at a ratio of 1:10 with methyl tert-butyl ether at a temperature of 30° C. to 50° C., and the organic solution was collected. The organic phase was distilled to dr...

Embodiment 2

[0031] In the process of extracting dihydroquercetin, it is affected by many factors. Among them, the ratio of larch sawdust mass to ethanol solution, ultrasonic time, filtrate extraction dosage ratio, extraction time, extraction times and pH value are the main influencing factors. After several experiments and the quality of the obtained products, the optimal process route for extracting dihydroquercetin from larch was determined. The reaction kettle is kept at a constant temperature of 30-50°C.

[0032] 1. Change the solid-liquid ratio and compare the experimental results with other conditions unchanged:

[0033] solid to liquid ratio

Ultrasound time

Extractant dosage

extraction time

Number of extractions

PH value

Extraction %

[0034] 1 / 8

35 minutes

1 / 10

1 hour

2

5

2.80

1 / 10

35 minutes

1 / 10

1 hour

2

5

3.50

1 / 12

35 minutes

1 / 10

...

Embodiment 3

[0053] 1. Physical and chemical indicators of the product:

[0054] Appearance Powder

[0055] Color white-yellow

[0056] Odor No smell

[0057] Taste No special taste

[0058] Solubility 0.001mg / kg water

[0059] Moisture ≤8

[0060] Purity ≥90%

[0061] Melting point 230°C

[0062] Mineral ≤0.3

[0063] 2. Comparison of melting points:

[0064] Compare with a melting point analyzer.

[0065] 3. Infrared spectrum detection:

[0066] The product dihydroquercetin was tested by an infrared spectrometer.

[0067] 4. Liquid chromatographic detection of products:

[0068] Put 0.1 g of the reference standard dihydroquercetin into a drying oven at 120° C. to dry. Then dissolve in 10 ml of acetone solution.

[0069] Add 700 ml of 2% acetic acid solution into 300 ml of acetone solution, and stir well.

[0070] Fill 19 milliliters of 2% acetic acid solution into a measuring beaker with a capacity of one liter, add distilled water to one liter, and stir well.

[0071] Dis...

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Abstract

Disclosed is a preparation method for extracting dihydro quercetin from larch. The invention is an improved production method. Due to different production materials and extraction processes, the dihydro quercetin products in U.S. and European markets are very expensive, at a price of 200-1000 euros per gram. Such a high market price economically limits the wide range of practicability of dihydro quercetin products. During the pretreatment of raw materials, 50 kilograms of larch wood chips and 500-800 liters of 50% ethanol solution are added into an extractor to get fully stirred and mixed; then the mixture is extracted and filtered for the second extraction; the filtrates are combined and adsorbed; the organic solvents are collected and dried by a vacuum evaporator through organic phase vacuum distillation; according to a weight proportion of 10:1, the residues are dissolved with hot water, decolorized with activated carbon and then crystallized at a temperature of 3-5 DEG C to precipitate the dihydro quercetin product which is then crushed after vacuum drying to finished product. The invention is used to extract dihydro quercetin from larch.

Description

Technical field: [0001] The invention relates to an improvement of a process for extracting dihydroquercetin from larch. Background technique: [0002] Dihydroquercetin (taxifolin) is a bioflavonoid (bioflavonoids) pseudovitamin P. Also known as Taxifolin, Taxifolin, Taxifolin. [dihydroquercetin; 2-(3,4-dihydroxyphenyl1)-2,3-dihydro-3,5,7-trihydroxy-4H-denzopyran-4-one], molecular formula: C 15 h 12 o 7 , Molecular mass: 304.3. [0003] Quercetin Dihydroquercetin was discovered by the Nobel Prize winner and biologist St. Gergier. Dihydroquercetin from larch extract, fine crystalline or amorphous powder, is white, light yellow, and has no peculiar smell. No special taste, it is a natural antioxidant with various biological activities. With the continuous development of new varieties, dihydroquercetin has been used in medicine, food, cosmetics, industry, agricultural plant growth regulation and other fields. [0004] Dihydroquercetin is widely used, but due to different...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/30A61K36/15
Inventor 才健辉战凤军
Owner 黑龙江花旗科技发展有限公司
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