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Anti-radiation traditional Chinese medicine composition

A technology of anti-radiation and composition, which is applied in the field of medicine, can solve the problems of high toxic and side effects, unfavorable preventive medication, and high cost, and achieve the effects of low toxic and side effects, good development and application prospects, and reduced content

Inactive Publication Date: 2012-03-21
THE SECOND AFFILIATED HOSPITAL ARMY MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, cytokine therapy has a good prospect but is expensive; sulfur-containing compounds and hormones have relatively large toxic and side effects, which is not conducive to preventive medication

Method used

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  • Anti-radiation traditional Chinese medicine composition
  • Anti-radiation traditional Chinese medicine composition
  • Anti-radiation traditional Chinese medicine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment 1, preparation of anti-radiation Chinese medicine composition and its extract and preparation

[0014]

[0015] Preparation method: Take 11 medicinal materials such as Astragalus membranaceus according to the prescription, grind them into fine powder, add 8 times the amount of ethanol solution with a volume fraction of 70%, reflux extraction for 2 hours, extract twice in total, combine the extracts, filter, and recover the filtrate solvent to a thick paste, and then dried under reduced pressure into powder to obtain the extract powder of the Chinese medicine composition; the extract powder of the obtained Chinese medicine composition and microcrystalline cellulose are mixed in a weight ratio of 2:1, and the volume fraction The soft material is made of 95% ethanol solution, granulated with No. 2 sieve, dried at 60°C, granulated with No. 2 sieve, filled into empty capsules, and made into 1500 capsules to obtain capsules.

Embodiment 2

[0016] Embodiment 2, pharmacodynamic research of anti-radiation Chinese medicine composition

[0017] Get 8-10 weeks old, Kunming mice with a body weight of 18-20g, and randomly divide them into normal control group, radiation model group, high, medium and low dose groups of anti-radiation Chinese medicine composition and positive drug group (Diyu Shengbai Tablets) group or Yixuesheng capsule group), 10 per group. The normal control group and the radiation model group were intragastrically administered normal saline, the anti-radiation traditional Chinese medicine composition high, medium and low dose groups were intragastrically administered the capsule content solution prepared according to prescription 3 in Example 1, and the positive drug group were intragastrically administered the corresponding drug solution. After 7 days, except for the mice in the normal control group, the mice in the other groups were 60 Coγ irradiation, the dose is 5Gy. After irradiation, each gr...

Embodiment 3

[0057] Example 3, Toxicological Research of Anti-radiation Chinese Medicine Composition

[0058] According to the "Technical Guidelines for Acute Toxicity Research of Traditional Chinese Medicines and Natural Medicines", the acute toxicity study of anti-radiation traditional Chinese medicine compositions was carried out. Kunming mice were used, half male and half male. Before the experiment, they were fasted for 12 hours, and the mice in the test group were gavaged with the maximum dosage of the solution of the contents of the anti-radiation Chinese medicine composition capsules prepared according to the prescription 3 of Example 1, once in the morning and evening; brine. The body weight, diet, appearance, behavior, secretion, excretion, poisoning and death of mice in each group were observed for 14 consecutive days. The results showed that the maximum dose of the anti-radiation traditional Chinese medicine composition administered to mice twice a day was 293.6g / Kg, equiva...

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Abstract

The invention discloses an anti-radiation traditional Chinese medicine composition which comprises the following components in parts by weight: 160-200 parts of membranous milkvetch root, 110-130 parts of scurfy pea, 80-100 parts of Chinese angelica, 160-200 parts of epimedium, 135-165 parts of madder root, 110-130 parts of glossy privet fruit, 110-130 parts of white paeony root, 110-130 parts ofradix rehmanniae preparata, 80-100 parts of Szechuan lovage rhizome, 215-265 parts of Chinese yam and 35-45 parts of prepared liquoric root. The traditional Chinese medicine composition can increase thymus index and spleen index of a 60Co gamma-radiated mouse and protect immune organs; improve the activity of superoxide dismutase in blood serum and the liver of the 60Co gamma-radiated mouse, reduce the content of malonaldehyde and improve the anti-oxidation capability of an organism; increase peripheral white blood cells of the 60Co gamma-radiated mouse and improve the hematogenesis function;and reduce the micronuclear rate of marrow cells of the 60Co gamma-radiated mouse and inhibit the action of causing chromosomal aberration of 60Co gamma rays. In addition, the traditional Chinese medicine composition is low in toxicity and side effects, and medicinal materials in the formula are low in price and easy to obtain, thereby having great development and application prospects in the aspects of preventing and treating radiation injuries.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a traditional Chinese medicine composition. Background technique [0002] With the development of modern nuclear military technology, soldiers are increasingly threatened by nuclear radiation, and the possibility that terrorists use nuclear loads, nuclear materials or radioactive substances to carry out terrorist sabotage activities is also increasing. In the face of the increasing energy crisis and the greenhouse effect and environmental pollution caused by the use of fossil energy, nuclear energy is a clean and efficient energy source, and the peaceful development and use of nuclear energy is also the development direction of the energy industry for a long period of time in the future. In addition, the use of medical equipment such as nuclear magnetic resonance, isotopes, and medical X-rays has also increased the possibility of medical staff and patients being exposed to radiation hazards....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8945A61P39/00A61P17/16
Inventor 晋献春张恩娟孔佩艳胡雪莲
Owner THE SECOND AFFILIATED HOSPITAL ARMY MEDICAL UNIV
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