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Black garlic extract and application thereof in preventing and curing breast cancer

An extract and technology of black garlic, applied in the field of prevention and treatment of breast cancer, black garlic extract, can solve the problems of drug resistance of tumor cells, shortening of treatment remission period, and treatment failure, so as to avoid tumor immunosuppression and increase thymus index and spleen index, the effect of reducing tumor volume

Inactive Publication Date: 2016-05-25
广东益生康生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Chinese patent application 201510423938.9 discloses a black garlic ganoderma composition, which is composed of black garlic extract, ganoderma lucidum extract, and fermented cordyceps fungus powder. And other precious raw materials lead to the problem of higher cost
[0007] Although comprehensive treatment has significantly improved the curative effect of breast cancer, and drug therapy has become more and more important in the comprehensive treatment of breast cancer, the tumor cells of patients with distant metastasis of breast cancer have developed resistance due to repeated chemotherapy. Drug properties, often leading to treatment failure or shortened remission period

Method used

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  • Black garlic extract and application thereof in preventing and curing breast cancer
  • Black garlic extract and application thereof in preventing and curing breast cancer
  • Black garlic extract and application thereof in preventing and curing breast cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The preparation of embodiment 1 black garlic extract

[0036] Weigh 1000kg of black garlic, slice it, add 4000kg of water, extract at 100°C for 4 hours, filter, squeeze the residue, collect the first filtrate, and keep the filter residue; add 3000kg of water to the filter residue, add 8kg of compound plant hydrolase, and enzymatically hydrolyze at 40°C for 4 hours , then add 3000kg75% ethanol solution, heat and reflux for extraction for 4h, filter the filtrate, concentrate under reduced pressure, and obtain the second filtrate after removing ethanol; combine the first filtrate and the second filtrate, mix well, and obtain black garlic extract. The soluble solid content of black garlic extract was 19.6%.

Embodiment 2

[0037] The preparation of embodiment 2 black garlic extract

[0038] Weigh 1000kg of black garlic, slice it, add 4000kg of water, extract at 100°C for 4 hours, filter, squeeze the residue, collect the first filtrate, and keep the filter residue; add 3000kg of water to the filter residue, add 5kg of compound plant hydrolase, and enzymatically hydrolyze at 40°C for 4 hours , then add 3000kg75% ethanol solution, heat and reflux for extraction for 4h, filter the filtrate, concentrate under reduced pressure, and obtain the second filtrate after removing ethanol; combine the first filtrate and the second filtrate, mix well, and obtain black garlic extract. The soluble solid content of black garlic extract was 18.4%.

Embodiment 3

[0039] The preparation of embodiment 3 black garlic extract

[0040] Weigh 1000kg of black garlic, slice it, add 4000kg of water, extract at 100°C for 4 hours, filter, squeeze the residue, collect the first filtrate, and keep the filter residue; add 3000kg of water to the filter residue, add 10kg of compound plant hydrolytic enzyme, and enzymatically hydrolyze at 40°C for 4 hours , then add 3000kg75% ethanol solution, heat and reflux for extraction for 4h, filter the filtrate, concentrate under reduced pressure, and obtain the second filtrate after removing ethanol; combine the first filtrate and the second filtrate, mix well, and obtain black garlic extract. The soluble solid content of black garlic extract was 18.6%.

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Abstract

The invention belongs to the technical field of food, and discloses a black garlic extract and application thereof in preventing and curing breast cancer. It is proved by the cell test that the black garlic extract inhibits growth of breast cancer MD231 cells and T47D cells in a concentration-dependent and time-dependent manner, so that the adhesiveness among cancer cells is enhanced, and the vigor of the cancer cells is reduced; besides, it is proved by the animal test that the black garlic extract can inhibit growth of nude mouse MCF-7 transplanted tumor remarkably, the gross tumor volume is reduced, the thymus index and the spleen index are increased, tumor immunosuppression is avoided, and the black garlic extract has the immunological enhancement effect. Therefore, the black garlic extract can be used for preventing and curing breast cancer, is rich in source and pure-natural, and has important development and application prospects.

Description

technical field [0001] The invention belongs to the technical field of food and discloses black garlic extract and its application in preventing and treating breast cancer. Background technique [0002] Black Garlic Extract (BlackGgarlicExtract, BGE) is a mixed component obtained after various treatments of plant garlic. Compared with fresh raw garlic, black garlic has obvious advantages in terms of sensory, smell and nutritional value, and the content of protein, amino acid and polyphenols in black garlic is significantly increased. Allicin in black garlic can disinfect, sterilize and resist oxidation, enhance immune function and regulate blood sugar level, and has broad market prospects. [0003] Chinese patent application 201310390623.X discloses the use of black garlic extract in regulating the intestinal flora of animals. The black garlic extract is obtained by peeling black garlic, removing the film, crushing, squeezing and filtering. [0004] Chinese patent applicat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8962A61P35/00A61P15/14A23L33/105
CPCA61K36/8962A23V2002/00A61K2236/19A61K2236/333A23V2200/308A23V2250/21
Inventor 樊曙明
Owner 广东益生康生物科技有限公司
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