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92results about How to "Good inhibition rate" patented technology

High molecule adriamycin bonding medicine nano capsule with targeting function and preparation thereof

The invention provides a nanometer capsule of a macromolecule adriamycin bonding medicine with a targeting function and a preparation method thereof. The nanometer capsule is mixed assembled with two block copolymers of poly ethylene glycol-polylactic acid, wherein the polylactic acid chain end of one block copolymer is connected with adriamycin, with a molar ratio of 98-70 percent in the nanometer capsule, while the poly ethylene glycol chain end of the other block copolymer is connected with lactose, with a molar ratio of 2-30 percent in the nanometer capsule. The adriamycin connected with the polylactic acid chain end is located in the capsule inner core, which is double protected by polylactic acid and poly ethylene glycol and has sustained release function; while the lactose connected with the poly ethylene glycol chain end is located in the outer layer of the capsule, which has targeting function and leads the nanometer capsule preferentially enter the cells carrying the lactose receptors.
Owner:CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI

Mung bean fermentation broth capable of repairing damaged skin surface lipid films and soothing skin allergy, and preparation method thereof

The invention discloses a mung bean fermentation broth capable of repairing damaged skin surface lipid films and soothing skin allergy. The mung bean fermentation broth comprises a wall-broken filtrate obtained after fermentation of mung bean sprouts via lactic acid bacteria, wherein the solid content of the filtrate is 1 to 20%. The invention also discloses a preparation method for the mung beanfermentation broth capable of repairing damaged skin surface lipid films and soothing skin allergy. The preparation method comprises the following steps: 1) germination of mung beans; 2) breeding of lactic acid bacteria; 3) liquid homogenization of mung bean sprouts, addition of milk and trace elements, steam sterilization and cooling; 4) inoculation of the lactic acid bacteria for fermentation; 5) high-pressure homogenization and wall breaking; 6) freeze concentration and coarse filtration; and 7) membrane filtration and degerming. According to the invention, mung bean seeds are subjected topreliminary germination at first and then to fermentation via lactic acid bacteria, and the obtained wall-broken filtrate is safe and free of any irritation during external application, and can substantially inhibit hyaluronidase, rapidly eliminate Bacillus acnes, reduce hyperpigmentation and inhibit the formation of acne scars.
Owner:重庆雅素生物科技有限公司

Substituted acetophenone oxime derivative and preparation process and use thereof

The present invention relates to a kind of hypnone oxime derivative, its preparation and application. The tests show that said derivative has the good bactericidal activity and control effect for common diseases of vegetable, melon and fruit crops, such as powdery mildew, anthracnose and sclerotium disease, specially, for powdery mildew it can obtain better control effect.
Owner:SHANGHAI PESTICIDE RES INST

Application of dihydromyricetin (DHM) in preparation of anti-hepatoma medicines

The invention relates to the biological medicine field, and concretely relates to an application of DHM in the preparation of anti-hepatoma medicines. The DHM has a strong anticancer characteristic as a flavonoid compound. Tests prove that the DHM plays a positive role in hepatoma carcinoma cell propagation inhibition, hepatoma carcinoma cell apoptosis induction, hepatoma carcinoma cell adhesion capability reduction and hepatoma carcinoma cell invasion and transfer prevention, and can substantially reduce the contents of peroxides, glutathione and ATP in the hepatoma carcinoma cells.
Owner:HOSPITAL AFFILIATED TO GUANDONG MEDICAL COLLEGE

Novel antibacterial application of NPS-2143

The invention discloses novel antibacterial application of NPS-2143. The systematic name of NPS-2143 is 2-chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile. Theinvention provides application of NPS-2143 in inhibition of Gram-positive bacteria and persistent bacteria thereof. According to the results of determination of inhibitory activity against the growthof a plurality of Gram-positive bacteria, NPS-2143 has good inhibitory activity against common Gram-positive bacteria such as MSSA strains (ATCC 25923), MSSA strains (ATCC 6538) and MRSA strains (ATCC33591). NPS-2143 has superiority in inhibition of sensitive Gram-positive bacteria and drug-resistant Gram-positive bacteria and in resistance of persistent bacteria compared with ciprofloxacin (CPFX), and shows good application prospects in the development of novel antibacterial drugs.
Owner:SICHUAN UNIV

Marsdenia tenacissima saponins H and preparation method and application thereof

The invention provides a Marsdenia tenacissima saponins H and a preparation method thereof. According to the preparation method, traditional Chinese medicine Marsdenia tenacissima is used as raw material, Marsdenia tenacissima saponins H with good antineoplastic activity and high content is obtained through a series of steps such as extraction, separating, crystallization, recrystallization and the like, and a high efficiency liquid phase chromatography is adopted to determine that the content of the marsdenia tenacissima saponins H is in a range of 60-99.8%. Proper pharmaceutically acceptable carriers can be added to the Marsdenia tenacissima saponins H to prepare certain dosage form, so as to be used for clinic treatment of tumour. The Marsdenia tenacissima saponins H and the preparation method thereof of the invention employ traditional Chinese medicine modernization separating and purifying technology, the technology is innovative, is suitable for industrialization production, and has strong practicality.
Owner:JIANGSU TIANSHENG PHARMA

Acylated derivative of genistein and preparation process of acylated derivative

The invention discloses a preparation process of an acylated derivative of genistein. The preparation process comprises the following process steps: (1) taking genistein, dissolving the genistein in an organic solvent, dripping a catalyst, controlling the pH value to be 2-7, and controlling the temperature of the solution to be 0-5 DEG C; (2) dissolving chloroacetyl chloride into the organic solvent, adding into a constant pressure funnel, dripping into the solution in (1), and producing solids after dripping; monitoring the reaction process by TLC (Thin-Layer Chromatography), raising the temperature to be 10 DEG C, continuously reacting, and stopping the reaction within 17 hours; (3) standing the reaction solution for an hour, performing suction filtration, performing vacuum drying on thefilter cake at the temperature of 40 DEG C, thereby obtaining the acylated derivative of genistein. The preparation process has the advantages that the compound has excellent solubility in water, thein-vivo oavailability of the compound can be greatly improved, the compound has excellent inhibition rate on hepatoma carcinoma cell HepG2, and a novel drug with excellent water solubility and an anti-tumor effect is expected to be developed.
Owner:荆门医药工业技术研究院

Small interfering ribonucleic acid-containing pharmaceutical composition and application thereof

ActiveCN108210510AExcellent inhibition efficiencyDecreased surface antigen expressionOrganic active ingredientsAntiviralsDrugSmall interfering RNA
The invention provides a small interfering ribonucleic acid-containing pharmaceutical composition and application thereof in preparation of medicines for preventing and / or treating hepatitis B. The small interfering ribonucleic acid-containing pharmaceutical composition contains two small interfering ribonucleic acids specified at different genotypes of the hepatitis B virus and serving as activeingredients, can achieve an effect of extensively covering multiple genotypes of HBV, has a synergistic effect in the aspect of inhibiting the multiple genotypes of the HBV, can simultaneously lower the level of HBsAg, and has the clinical application potential.
Owner:SUZHOU RIBO LIFE SCIENCE CO LTD

Annonaceous acetogenins nanoparticles taking cyclodextrin and lecithin as vectors as well as preparation method and application of annonaceous acetogenins nanoparticles

The invention relates to annonaceous acetogenins nanoparticles, which are prepared by taking cyclodextrin and lecithin as vectors, as well as a preparation method and an application of annonaceous acetogenins nanoparticles. The annonaceous acetogenins (annonaceous acetogenins total lactone or monomer ingredients thereof) nanoparticles are prepared by virtue of a solvent precipitation method; the mass ratio of the annonaceous acetogenins to the cyclodextrin to the lecithin is at 1 to (0.02-20) to (0.02-20); and in accordance with an optimal prescription, the combining proportion of the annonaceous acetogenins to the cyclodextrin to the lecithin is at 4 to 2 to 1 (in percentage by mass). The average grain size of the annonaceous acetogenins nanoparticles is 20-1000nm, and the annonaceous acetogenins nanoparticles are good in dispersity; the annonaceous acetogenins nanoparticles are stable in both gastrointestinal fluid and plasmid, and the annonaceous acetogenins nanoparticles are suitable for both oral administration and intravenous injection; with the application of the nanoparticles, the inhibitory effect of the annonaceous acetogenins on tumor cells can be significantly improved, and meanwhile, in vivo anti-tumor efficacy can be enhanced; and the annonaceous acetogenins nanoparticles have a broad development prospect.
Owner:INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI

Extracting method and application of traditional Chinese medicine extracts in whitening cosmetics

The invention belongs to the technical field of cosmetics, and particularly relates to an extracting method and application of traditional Chinese medicine extracts in whitening cosmetics. A traditional Chinese medicine classic famous formula, namely a Simiaoyong'an decoction formula, is regarded as the research object for the first time, mixed liquid of acetone, ethyl acetate and water serves asan extraction agent for extracting a high-tyrosinase-inhibition-rate extract traditional Chinese medicine source whitening agent from a mixture of flos lonicerae, radix scrophulariae, radix angelicaesinensis and licorice root, and the traditional Chinese medicine source whitening agent can be used for preparing whitening lotions, whitening creams, whitening toners and other forms of cosmetics. The traditional Chinese medicine source whitening agent is provided for overcoming the defect that a chemical whitening agent has cytotoxicity and is harmful to human bodies.
Owner:陈思

Novel heterogeneous moisture evaporation inhibitor preparation method

InactiveCN104772094AGood inhibition rateWater time extension decayProductsReagentsAlcoholEvaporation
The present invention belongs to the technical field of research on moisture evaporation inhibitor preparation processes, and more particularly relates to a novel heterogeneous moisture evaporation inhibitor preparation method. The inhibitor comprises 0.8-1.4% of even carbon fatty alcohol or 0.6-1% of odd carbon fatty alcohol, 4-10% of short-chain alcohol, 40-65% of petroleum ether, 0.7-1.1% of a fatty alcohol polyoxyethylene ether series emulsifier AEO-3 and/or AEO-5 and/or AEO-7, and the balance of distilled water. The preparation method comprises: (1) according to the ratio, weighing even carbon fatty alcohol or odd carbon fatty alcohol and short-chain alcohol, completely dissolving in petroleum ether at a room temperature, adding a fatty alcohol polyoxyethylene ether series emulsifier, and completely and uniformly mixing so as to be used as a moisture evaporation inhibitor oil phase system; and (2) weighing distilled water, adding to the obtained oil phase system, placing the oil phase system into an ultrasonic wave treatment apparatus, and carrying out intermittent shaking so as to prepare the stable water-in-oil type heterogeneous moisture evaporation inhibitor. The moisture evaporation inhibitor of the present invention has the significant technical effect in the water resource protection field.
Owner:TARIM UNIV
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