40results about How to "Excellent anti-protein adsorption performance" patented technology

The invention provides a glucan-based transparent hydrogel dressing and a preparation method thereof. The preparation method of the glucan-based transparent hydrogel dressing comprises the following steps: conducting a reaction between a glucan quaternary ammonium salt derivative and succinic anhydride; then promoting an obtained product to react with small molecules of amination, so that a macromonomer which contains illuminated cross-linking double bonds is obtained; mixing the macromonomer which contains illuminated cross-linking double bonds with an antibacterial agent and an initiating agent; conducting photo initiation so as to prepare a glucan-based transparent hydrogel; and combining the glucan-based transparent hydrogel with a polyurethane film by virtue of a bonding agent, so that the glucan-based transparent hydrogel dressing is prepared. The finished product (the glucan-based transparent hydrogel dressing) prepared by the invention not only can absorb a great amount of wound exudates so as to keep a wound surface wet, but also can avoid wound adhesion, so that the probability of wound infection is reduced and wound surface healing is promoted.

The invention discloses a split type blood vessel coating support which comprises a main support and a trouser leg support connected with the main support. Water-absorbing self-expansion material layers are attached to the outer walls of one or all of a connecting part between the main support and the trouser leg support, other ends of the main support and other ends of the trouser leg support. Water-absorbent resin materials covering ports of the support have good biological compatibility and excellent protein-adsorption-resistance performance. The covering materials can quickly expand by absorbing water in a blood environment, are stable in structure after expansion and have a controllable water absorbing rate. The materials used for the support have no damage and side effect on human body blood vessels, the success rate of aortic aneurysm endovascular graft exclusion is increased, and the safety and curing effect of the aortic aneurysm endovascular graft exclusion are further improved.

The invention relates to a blood purification adsorbent with an embedding material and a preparation method of the blood purification adsorbent. The embedding material comprises zwitterionic monomer, a cross-linking agent, an initiator and a solvent, and the zwitterionic monomer comprises one or two types of zwitterionic molecules of carboxyl betaine, sulfobetaine and phosphorylcholine. The method includes: mixing the zwitterionic monomer, the cross-linking agent, the initiator and the solvent; adding activated carbon or resin to form mixed solution, wherein the mass of added activated carbon or resin is 6%-50% of that of the zwitterionic monomer; subjecting the mixed solution with activated carbon or resin to ultraviolet radiation or heating or normal-temperature standing to enable curing of the monomer on the surface of the adsorbent through cross-linking polymerization to form the adsorbent with the zwitterionic embedding material. The embedding material is excellent in protein adsorption resistance and biocompatibility and is extremely high in toxin diffusion efficiency in application to blood adsorption. The blood purification adsorbent is easy to store, and the preparation method is simple and feasible.

The invention provides a functional waterborne polyurethane leather finishing agent and a preparation method thereof. The method includes the steps that firstly, doping type surface-PEGlated nanometer titanium dioxide is prepared through a solvent-thermal method and then dissolved in polymer polyhydric alcohol, and modified nanometer titanium dioxide with visible-light responses is introduced to polyurethane through in-situ polymerization. The waterborne polyurethane leather finishing agent prepared through the method contains the nanometer titanium dioxide with the visible-light responses and is high in sterilization and mould-proof capacity due to the fact that visible light in sunlight can be completely utilized; PEG is grafted to the surface of the nanometer titanium dioxide, and in combination with photocatalytic activity of the nanometer titanium dioxide and the excellent protein adsorption resistance of the PEG, the self-cleaning function of a polyurethane coating is remarkably improved. Good dispersion of the nanometer titanium dioxide in polyurethane can be effectively promoted, the heat-resisting stability and mechanical strength of the coating are improved, and meanwhile the transparency of finishing materials is kept.

The invention relates to a blood-compatible polymer layer and a preparation method thereof. Under the condition of ultraviolet light irradiation, a copolymerization reaction of 6-acrylamidocaproic acid and N-vinylpyrrolidone is initiated on the surface of a silanized substrate to obtain the preparation method. The blood-compatible polymer layer; the water contact angle of the prepared blood-compatible polymer layer is 40 to 45°; after the blood-compatible polymer layer is grafted on the surface of the silanized substrate, the BSA and Fib proteins are adsorbed The amount was reduced by 75-80% and 60-68% respectively. Using laser confocal microscope test, no obvious adhesion phenomenon was observed on the red blood cell adhesion test picture and the platelet adhesion test picture. The invention utilizes ultraviolet light to initiate the copolymerization of AACA and NVP monomers, and introduces a blood-compatible polymer layer with hydrophilic-hydrophobic balance ability on the surface of the substrate, the operation is simple, the reaction process is controllable, clean and pollution-free, and large-scale production is possible; The blood-compatible polymer layer has excellent anti-protein adsorption properties, anti-erythrocyte adhesion properties and anti-platelet adhesion properties.

The invention relates to a polyethylene glycol diazonium polymer. The polyethylene glycol diazonium polymer is of a structure which is shown in a first image and is obtained through modified polyethylene glycol. After the polyethylene glycol diazonium polymer is illuminated by ultraviolet light, and photocuring and cross-linking reactions are carried on the polyethylene glycol diazonium polymer and silanol groups on the inner wall of a capillary tube to form a coating. The preparation of the coating can be conducted in an aqueous phase through a self-assembly mode, and the preparation process is simple and rapid. Chemical bonding of the coating is achieved through the photocuring and cross-linking reactions of the photonasty polyethylene glycol diazonium polymer, and quality problems such as capillary tube blocking are not prone to occurring.