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Preparation method and application of zwitter-ion peptide type polymer

A zwitterionic, peptide polymer technology, used in polyester coatings, biocide-containing paints, coatings, etc., to shorten the preparation time, improve the preparation efficiency, and improve the anti-fouling ability.

Inactive Publication Date: 2019-11-26
WEST ANHUI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are few reports on the effect of ionic strength on improving the antifouling properties of zwitterionic polymers.

Method used

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  • Preparation method and application of zwitter-ion peptide type polymer
  • Preparation method and application of zwitter-ion peptide type polymer
  • Preparation method and application of zwitter-ion peptide type polymer

Examples

Experimental program
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Effect test

Embodiment 1

[0038] A method for preparing a zwitterionic peptide-like polymer, the method steps are as follows:

[0039] S1: Preparation of hydroxyl-terminated poly(2-oxazoline) by cationic ring-opening polymerization.

[0040] Such as figure 1 (a), under nitrogen, 2-methyl-2-oxazoline (13mL, 177mM), acetonitrile (10mL), 2-(3-butene)-2-oxazoline (13mL, 50mM) and MeOTf (560μL, 5mM) were sequentially added to a 50mL dry glass sealed tube equipped with small magnetic particles, and the steps of "freezing-vacuumizing-thawing" were repeated three times, the tube was sealed under vacuum, and the reaction was carried out in an oil bath at 135°C for 22 hours , after the reaction was complete, tap the sealed tube with a glass knife and add 3 mL of 1M KOH in CH 3 OH solution to terminate the reaction, stir at room temperature for 5 h, remove the solvent by rotary evaporation, and use CHCl 3 Extraction, rotary evaporation to remove most of CHCl 3 , the product was precipitated in glacial ether, ...

Embodiment 2

[0046] A method for preparing a zwitterionic peptide-like polymer, the method steps are as follows:

[0047] S1: Preparation of hydroxyl-terminated poly(2-oxazoline) by cationic ring-opening polymerization.

[0048] Such as figure 1 (a), under nitrogen, 2-methyl-2-oxazoline (15mL, 177.15mM), acetonitrile (12mL), 2-(3-butene)-2-oxazoline (15mL , 50.03mM) and MeOTf (570μL, 5.03mM) were sequentially added to a 50mL dry glass sealed tube equipped with small magnets, and the steps of "freezing-vacuumizing-thawing" were repeated three times, the tube was sealed under vacuum, and the condition was 140°C oil bath After the reaction was completed, tap the sealed tube with a glass knife and add 3mL of 1M KOH CH 3 OH solution to terminate the reaction, stir at room temperature for 6 h, remove the solvent by rotary evaporation, and use CHCl 3 Extraction, rotary evaporation to remove most of CHCl 3 , the product was precipitated in glacial ether, vacuum-dried after suction filtration t...

Embodiment 3

[0054] A method for preparing a zwitterionic peptide-like polymer, the method steps are as follows:

[0055] S1: Preparation of hydroxyl-terminated poly(2-oxazoline) by cationic ring-opening polymerization.

[0056] Such as figure 1 (a), under nitrogen, 2-methyl-2-oxazoline (17mL, 178mM), acetonitrile (14mL), 2-(3-butene)-2-oxazoline (17mL, 51mM) and MeOTf (580μL, 5.1mM) were sequentially added to a 50mL dry glass sealed tube equipped with small magnets, and the steps of "freezing-vacuumizing-thawing" were repeated three times, the tube was sealed under vacuum, and the reaction was carried out in an oil bath at 145°C 26h, after the reaction was completed, tap the sealed tube with a glass knife and add 3mL of 1M KOH CH 3 OH solution to terminate the reaction, stir at room temperature for 7 h, remove the solvent by rotary evaporation, and use CHCl 3 Extraction, rotary evaporation to remove most of CHCl 3 , the product was precipitated in glacial ether, vacuum-dried after suc...

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Abstract

The invention discloses a preparation method of a zwitter-ion peptide type polymer. The preparation method comprises the following steps: S1, performing a cation open-loop polymerization reaction so as to prepare hydroxyl-terminated poly(2-oxazoline) with double bonds on side chains; S2, performing a reaction on the side chains of poly(2-oxazoline), namely performing photocatalytic addition on sulfydryl-olefin double bonds and an open-loop addition reaction on tertiary amine and cyclic lactone so as to prepare a zwitter-ion peptide type polymer; and S3, hydrolyzing a part of the main chain ofthe zwitter-ion peptide type polymer, so as to prepare the zwitter-ion peptide type polymer with a secondary amine structure in the main chain. The zwitter-ion peptide type polymer which is partiallyhydrolyzed is synthesized, a zwitter-ion peptide type polymer anti-fouling coating is rapidly prepared in a mode of blending deposition of the zwitter-ion peptide type polymer with dopamine in an alkali solution of CuSO4 / H2O2, and by adopting the method, the preparation time of the coating can be shortened to a large extent, and the preparation efficiency and the stability of the coating can be improved.

Description

technical field [0001] The invention relates to the technical field of electrophoresis analysis, in particular to a preparation method and application of a zwitterionic peptide-like polymer. Background technique [0002] Since the 1980s, capillary electrophoresis (CE) has been applied in many fields such as biomedicine, environmental science, and food safety testing due to its advantages of fast, efficient, economical, and less sample consumption. Among them, the frontal analysis capillary electrophoresis (FACE) analysis method can be used to study the multilevel equilibrium system with medium affinity properties, for example, to study the interaction parameters between drugs and human serum albumin. After the drug enters the blood circulation, it will bind to serum albumin to a certain extent. This interaction determines the effective concentration of the drug in the blood and has an important impact on the metabolism and efficacy of the drug in the body. Therefore, the dru...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G63/08C08G63/685C08G63/78C08G73/06C09D167/04C09D5/16G01N27/447
CPCC08G63/08C08G63/6852C08G63/78C08G73/06C09D5/1662C09D167/04G01N27/447
Inventor 陈丽娟闫叶寒许莹李二梅
Owner WEST ANHUI UNIV
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