The invention discloses a secondary structure masonry construction method. The secondary structure masonry construction method specifically comprises the following steps that S1, a base layer is cleaned; S2, positioning and paying off are conducted, specifically, a foundation surface or a floor structural surface is leveled according to the elevation, wall side lines, door and window openings andcore column position lines are paid off on a floor slab, a building + 0.5m line is paid off on each layer of wall and column, and door and window opening elevation control points are marked; S3, building blocks are arranged; S4, steel bar planting operation is conducted, specifically, drilling, glue injection and steel bar planting are conducted on the core column and lintel according to the design requirements, and the planted steel bars are anchored and tied with an original structural wall and plate; S5, a filler wall is built, specifically, the filler wall is built according to an engineering design construction drawing; S6, core column concrete is poured, specifically, after the strength grade of wall masonry mortar reaches 1MPa, concrete is poured into an inner cavity of the BM interlocking building blocks to form a core column structure; and S7, a wall top is closed. According to the secondary structure masonry construction method, in the secondary structure construction process, a formwork supporting procedure in the traditional sense is omitted, surface layer construction can be conducted without plastering after masonry is completed, and the advantages of energy saving, material saving and environmental protection are achieved.