53 results about "Propranolol Hydrochloride" patented technology

The invention discloses a separation method and application of naphthol derivatives. The present invention separates 1-isopropylamino-3-(2-naphthyloxy)-2-propanol and propranolol hydrochloride through the separation method of high-efficiency liquid phase; the method is simple to operate and has good separation degree. It can also take into account the separation of other impurities in propranolol hydrochloride, and is suitable for the separation and detection of various known or unknown impurities produced under synthetic conditions.

The invention relates to a preparation method for propranolol hydrochloride tablets. The method comprises the following steps of: 1) preparing a carrier for solid dispersoid, namely weighing 200 grams of polyethylene glycol (PEG) 6000, dissolving the PEG 6000 in 95 percent (ml / ml) ethanol to obtain an auxiliary material solution, dissolving 100 grams of propranolol hydrochloride in 95 percent (ml / ml) ethanol to obtain a main medicine solution, mixing the auxiliary material solution and the main medicine solution uniformly to obtain a mixed solution, and drying the mixed solution at temperature of between 35 and 55 DEG C under the vacuum with the vacuum degree of less than 10 Pa for 12 to 24 hours; 2) preparing tablets, namely crushing the materials obtained in the step 1), and sieving to obtain solid dispersoid powder; adding a formula dose of dextrin into the solid dispersoid powder, and putting the mixture into a granulator, performing dry mixing for 5 to 10 minutes, adding 40 to 50 percent ethanol serving as an adhesive, and granulating; sieving the materials with a 20-to-30-mesh sieve, granulating in the wet state, and transferring to a fluidized drying machine for drying until the moisture is 5 to 8 percent; and sieving the dried granules with a 20-to-30-mesh sieve, granulating, and mixing the obtained granules and a lubricating agent in a formula uniformly for tabletting.

The invention relates to the technical field of medicine and provides propranolole hydrochloride gel and a preparation method thereof. The propranolole hydrochloride gel is mainly prepared from the ingredients of bulk drug propranolole hydrochloride, penetration enhancer, humectant, preservative, gel substrate and water. A propranolole hydrochloride gel preparation prepared by the invention has the characteristics of being even, fine, appropriate in viscosity, easy to smear and free of irritation to skin; when being applied to treating subcutaneous-layer infantile hemangioma, the propranolole hydrochloride gel preparation is convenient to dose and avoids a first-pass effect of the liver; furthermore, the gel preparation can form a drug storage library on the skin, so that a slow-release function is achieved; meanwhile, the gel preparation is better in child patient adaptability and has good application prospect.