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Transdermal drug administering system

A drug delivery system and drug technology, applied in the field of medicine, can solve the problem of low absolute bioavailability, and achieve the effects of reducing the number of drugs, improving the transdermal rate, and promoting constant-speed release.

Inactive Publication Date: 2005-09-07
HANGZHOU MINSHENG PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] In order to increase the delivery speed of the drug and improve the shortcoming of low absolute bioavailability of transdermal administration, the present invention provides a transdermal drug delivery system, which can increase the drug concentration in the drug storage of the transdermal drug delivery system to increase The transdermal rate of the drug can also improve the controlled release effect and absolute bioavailability of the transdermal drug delivery, enhance the efficacy of the drug, reduce the waste of the drug, and reduce the preparation cost of the transdermal drug delivery system

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0048] 1) Prescription

[0049] Drug depot 1:

[0050] Propranolol hydrochloride 1-10%; hydroxypropyl methylcellulose 1-5%; polyvinyl alcohol 1-10%; propylene glycol 2-6%; oleic acid 1-2%; %; polyethylene glycol 1-3%; water for injection as a solvent.

[0051] The prescription of the drug depot of verapamil hydrochloride and chlorpromazine hydrochloride is the same as above, but the model drug in the above prescription is changed to verapamil hydrochloride or chlorpromazine hydrochloride.

[0052] Adsorption layer 3:

[0053] Material: 5g of color-changing silica gel and 1g of C2-10 type acrylic superabsorbent resin are mixed uniformly and used as the solvent adsorption material of the drug delivery system.

[0054] Isolation layer 2:

[0055] Material: non-woven fabric with good water and air permeability.

[0056] At 37° C., the adsorption rate and adsorption amount of the solvent in the drug reservoir were detected by the adsorption layer, and the adsorption isotherm w...

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Abstract

The invention discloses a percutaneous give drug system, which comprises: a drug storeroom, the gel drug layer comprises drug, solvent, transdermal accelerating agent and gelatinizing agent; one adsorption layer comprised solvent absorption material of solvent in absorbable drug storeroom; one isolating layer between drug storeroom and adsorption layer, which is of non-woven fabrics or semipermeable membrane to make solvent of gas or liquid pass through successfully; adsorption layer can joint isolating layer of drug storeroom in opposite directions of closing up to skin of drug storeroom. The percutaneous give drug system in this invention can increase drug level in drug storeroom of the system to elevate drug transdermal speed, as well as increase controlled release effect of percutaneous give drug and absolute bioavailability, enhance drug curative effect, decrease drug waste, and depress preparation cost of the system. The invention is fit particular to percutaneous give drug system for water-soluble drug of propranolol hydrochloride, verapamil hydrochloride and chlorpromazine hydrochloride.

Description

technical field [0001] The invention relates to a preparation method in the field of medicine, in particular to a transdermal drug delivery system. Background technique [0002] The transdermal drug delivery system is a new type of drug delivery system that is applied on the skin, and the drug enters the blood circulation through the skin and reaches an effective blood concentration to achieve disease treatment or prevention. Its outstanding feature is that it can avoid the hepatic first-pass effect and gastrointestinal inactivation effect of oral administration, and can also maintain a constant blood concentration, improve curative effect, reduce toxic and side effects, increase patient compliance and safety, and reduce patient medication. inter-individual differences, etc. Because of the outstanding advantages of transdermal drug delivery, since the first transdermal patch in the United States, the scopolamine patch, was launched in 1981, dozens ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/137A61K31/138A61K31/54A61K47/16A61K47/30A61K47/38A61M37/00
Inventor 储结根
Owner HANGZHOU MINSHENG PHARM CO LTD
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