39results about How to "Prolonged dosing time" patented technology

The invention belongs to the technical field of medicine and discloses paclitaxel liposomes and a preparation method thereof, mainly including long-circulation liposomes, paclitaxel thermosensitive liposomes and paclitaxel thermosensitive long-circulation liposomes. Its composition is 1%-30% paclitaxel, 1%-95% phospholipid, 0%-30% cholesterol, 0%-50% heat-sensitive excipient D, 0%-50% excipient G, 0-80% lyoprotectant, 0-10% octadecylamine, 0.001-50% antioxidant, appropriate amount of buffer salt. These are three new paclitaxel liposome preparations, which solve the problem of paclitaxel’s water insolubility. The long circulation of long-circulation liposomes and the thermosensitivity of thermosensitive liposomes can prolong the circulation time of paclitaxel in the body, improve the targeting of tumors, and thus enhance its anti-tumor effect.

The invention discloses a nanometer silver antibiotic and antiviral compound liquid and its preparation method and products. The compound liquid is prepared by using materials of nanometer silver colloid and polyvinylpyrrolidone, wherein the weight of polyvinylpyrrolidone is 0.01-40% of the weight of the nanometer silver colloid. The invention solves problem that the silver nanometer particles have poor affinity with cells and partially coagulate in long-term preservation when the nanometer silver colloid is in antibiotic and antiviral practical application; the nanometer silver antibiotic and antiviral compound liquid has characteristics of practicability, economy, intoxicity and high efficiency.

The present invention is applicable to the technical field of pharmaceutical preparations, and provides a cabazitaxel protein nano-injection and a preparation method thereof. The cabazitaxel protein nano-injection comprises the following raw materials in parts by weight: 50-150 parts of cabazitaxel; protein carrier 400-4000 parts of materials; 50-300 parts of protein nano-modified materials; 12-100 parts of freeze-drying protective agent. In the present invention, cabazitaxel is encapsulated in a spherical or ellipsoidal nanometer composed of a protein carrier material and a protein nano-modified material or attached to the surface of the nanometer, and subjected to freeze-drying treatment with a freeze-drying protective agent to obtain the cabazitaxel protein nanometer. The injection has a good sustained-release effect and a high anti-tumor effect, which effectively avoids the hypersensitivity caused by the use of co-solvents such as surfactants, reduces the toxicity of the preparation, improves bioavailability, and reduces the dosage. Prolong the administration time.

The invention discloses a method for preparing romidepsin lipidosome. The romidepsin lipidosome is prepared by using a film dispersion method through regarding cholesterol as a stabilizer, cane sugar as a cryoprotectant and vitamin E as an antioxidant, wherein the particle size of the lipidosome is made to be smaller than 120nm and the encapsulation efficiency is made to be greater than 85% by a high pressure homogenization method at the same time. The romidepsin lipidosome prepared by the method is capable of reducing the degradation of romidepsin, prolonging the administration time, improving the adaptability of patients, improving the targeting of romidepsin, increasing the anti-tumor effect, and reducing the toxic and side effects of drugs as all ingredients in the formula are physically compatible materials with high safety. Moreover, the method for preparing romidepsin lipidosome disclosed by the invention has the advantages of simple process and low cost, and is suitable for industrial production.

The invention relates to methotrexate intralipid, a freeze-dried agent, a preparation method and an application thereof. The methotrexate intralipid consists of methotrexate active ingredient, oil for injection, emulsifying agent, stabilizing agent, isotonic adjustment agent, antioxidant, amylose, water for injection and pH modifying agent. The methotrexate intralipid of the invention is freeze-dried to obtain the freeze-dried agent of the methotrexate intralipid. The methotrexate intralipid and the freeze-dried agent of methotrexate intralipid can be applied to the medicines for treating a tumor and rheumatoid diseases.

The invention relates to a preparation for treating antifungal drugs, in particular to a long-acting slow-release preparation for treating fungal keratitis and its preparation method and application. The matrix of the long-acting sustained-release preparation for the treatment of fungal keratitis according to the present invention is composed of graphene-like materials electrostatically combined with drug-loaded chitosan substances, and the drug is loaded on the sheet-like structure of graphene-like materials, and the structure is stable. Large load. The preparation has good antibacterial activity against fungi and bacteria, and has good cell compatibility, flexibility and tensile strength. The preparation can be easily and conveniently applied to the cornea, and has no toxic effect on normal tissues while achieving excellent antibacterial activity. As an ophthalmic dosage form, it can adhere to the patient's cornea for long-term sustained release to achieve an effective drug concentration, and the preparation is simple, the drug-loaded material itself has excellent antibacterial activity, good mechanical properties, and has no irritation to eye tissues. And toxic and side effects, easy to use and so on.

The invention discloses a medicinal composition for regulating breath and nervous systems and application of the medicinal composition. The medicinal composition for regulating the breath and nervous systems comprises 100-500 parts of rhizoma atractylodis, 50-250 parts of Chinese violet, 100-500 parts of elecampane, 100-400 parts of folium artemisiae argyi and 20-80 parts of benzoin. The application refers to application of the medicinal composition for regulating the breath and nervous systems in preparing medicines for preventing / treating trachitis and rhinitis. By adopting the medicinal composition, the problems that lung discomfort can be caused as relatively large smoke can be generated because of poor sublimability of medicinal components of medicines for treating trachitis and rhinitis in the current market, and the medicines are complex in formula, high in price of formula materials and very low in cost performance, can be solved. According to the medicinal composition, a fumigant of medicines for treating trachitis and rhinitis is added into a matrix of an electric mosquito-repellent incense piece, when being used, a common electric mosquito-repellent incense box is opened, the mosquito-repellent incense piece with the fumigant of the medicines for treating trachitis and rhinitis is inserted into the common electric mosquito-repellent incense box, after the box is powered on, effective medicinal components can be volatilized into the air through electric heating, and thus the medicinal composition can be breathed in when people sleep.

The invention discloses a vestibular administration device for a nasal cavity, which comprises an air bag and a catheter communicated with the air bag; the catheter is used for filling gas or liquid into the air bag; and an administration surface is arranged on the air bag. Compared with the conventional atomizing administration mode or cotton ball administration mode, the vestibular administration device has the advantages that: 1, the administration time is long, and the administration dose is accurate; 2, the administration device is prevented from being fallen off, is convenient to operate and does not influence aeration; 3, the application range is wide in clinical medical treatment; and 4, the vestibular administration device has a structure and low manufacturing cost, and is convenient to popularize and use.