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Preparation method and application of medicament for treating insomnia and gel thereof

A gel and drug technology, applied in the field of pharmaceutical preparations, can solve problems such as drug dependence and addiction, and achieve the effects of long administration time, high brain bioavailability, and improved sleep quality

Inactive Publication Date: 2016-06-08
XIAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a medicine for treating insomnia, which solves the problem of dependence and even addiction in existing medicines for treating insomnia and the problem that the compound preparation of Chinese patent medicine is difficult to absorb into the blood through oral administration and pass through the blood-brain barrier. question

Method used

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  • Preparation method and application of medicament for treating insomnia and gel thereof
  • Preparation method and application of medicament for treating insomnia and gel thereof

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preparation example Construction

[0024] The preparation method of the above-mentioned drug gel for the treatment of insomnia is specifically implemented according to the following steps:

[0025] Step 1, weighing according to mass percentage: Jujube seed saponin extract 2%-6%, poloxamer P407 16%-22%, poloxamer P1881%-6%, PEG4006%-12%, paraben 0.01%~0.03%, the rest is phosphate buffer saline, the sum of the above mass percentages is 100%;

[0026] Step 2, take part of the phosphate buffer, add jujube seed saponin extract, dissolve it and put it in an ice-water bath, slowly add poloxamer P407, poloxamer P188, PEG400 and paraben under magnetic stirring, add the remaining Phosphate buffer solution, evenly wetted, placed in a refrigerator at 4-10°C for 12-48 hours, so that the gel is fully swollen and dispersed evenly until a clear solution is obtained.

[0027] (1) Determination experiment of gelation temperature (Tgel):

[0028] Adopt " stirring bar method ": measure the gelation temperature (Tgel) of 3 groups...

Embodiment 1

[0049] Step 1, weighed respectively according to mass percentage: jujube seed saponin extract 2%, poloxamer P40720%, poloxamer P1884%, PEG40012%, paraben 0.01%, the rest is phosphate buffer saline, the above mass The sum of the percentages is 100%;

[0050] Step 2, take part of the phosphate buffer, add jujube seed saponin extract, dissolve it and put it in an ice-water bath, slowly add poloxamer P407, poloxamer P188, PEG400 and paraben under magnetic stirring, add the remaining After wetting evenly, put it in a refrigerator at 4°C for 48 hours to make the gel fully swell and disperse evenly until a clear solution is obtained.

Embodiment 2

[0052] Step 1, weighed respectively according to mass percentage: jujube seed saponin extract 4%, poloxamer P40722%, poloxamer P1886%, PEG4006%, paraben 0.02%, the rest is phosphate buffer saline, the above mass The sum of the percentages is 100%;

[0053] Step 2, take part of the phosphate buffer, add jujube seed saponin extract, dissolve it and put it in an ice-water bath, slowly add poloxamer P407, poloxamer P188, PEG400 and paraben under magnetic stirring, add the remaining After wetting evenly, put it in a refrigerator at 8°C for 36 hours to make the gel fully swell and disperse evenly until a clear solution is obtained.

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Abstract

The invention discloses a medicament for treating insomnia and a preparation method and application thereof. The medicament for treating insomnia is composed of the following components in mass percent: 2-6% of jujuboside extract, 16-22% of poloxamer P407, 1-6% of poloxamer P188, 6-12% of PEG400, 0.01-0.03% of nipagin and balance of phosphate buffer solution, wherein the sum of the mass percents is 100%. The medicament for treating insomnia disclosed by the invention adopts a temperature-sensitive gel as a dosage form of jujuboside, thus after the medicament is dripped in liquid form into the nasal cavity, the medicament can flow onto mucous membrane in the deeper olfactory region where the brain bioavailability is verified high for administration; the medicament changes into semi-solid with a biological adhesion action in the nasal cavity, thereby continuously attaching to the mucous membrane in the olfactory region, solving the problem that the traditional dosage form is liable to lose and result in lower bioavailability and transient administration, and improving the sleeping quality of patients continuously.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a medicine for treating insomnia, and also relates to a preparation method and application of the medicine gel. Background technique [0002] At present, with the intensification of social pressure, the number and growth rate of the insomnia population has hit new highs repeatedly. Insomnia has a tendency to develop into multiple age groups and social classes. Even children and college students who traditionally believe that sleep better have a large number of insomnia problem. Among the symptoms that plague insomniacs, in addition to difficulty falling asleep, there are also problems such as shallow sleep, easy awakening, and poor sleep quality. At present, the drugs for treating insomnia mainly include benzodiazepines such as diazepam, alprazolam, lorazepam, etc., barbiturates such as phenobarbital, and other chemical drugs such as zolpidem. Th...

Claims

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Application Information

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IPC IPC(8): A61K36/725A61K9/06A61K47/34A61P25/20
CPCA61K47/10A61K9/0043A61K9/06A61K36/725
Inventor 王黎赵宁郑蕾张韫李欣冯锁民
Owner XIAN MEDICAL UNIV
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