Electric potential type chemical sensor and preparation method of full solid-state hydrochloric acid propranolol

Abstract

The invention relates to an all-solid-state propranolol hydrochloride potential chemical sensor and a preparation method thereof, and the chemical sensor can be directly applied in the field of drug (drug analysis) and analytical chemistry. The preparation method includes the following three steps: (1) the invention adopts a circulation scanning electrical polymerization method to carry out a chemical modification to a metal matrix electrode, so as to prepare a chemically modified electrode; (2) the invention takes tetrahydrofuran as a solvent, and the PVC sensitive (film) liquid is prepared by using a conventional method; (3) the PVC sensitive film is coated on the modified electrode by using a dip-coating method. Thus, the all-solid-state propranolol hydrochloride ion selective electrode is prepared. When in electrode modification, the used pyrrole solution contains sillicontungstic acid-sulfuric acid with a certain concentration; the invention effectively solves the shortcoming of the containing of the inner reference solution in the prior art, and the invention is superior to the performances of the existing ion selective electrodes.

Description

technical field [0001] The invention belongs to a medicine chemical sensor, which is directly applied to the fields of medicine (medicine analysis) and analytical chemistry. In particular, the invention relates to a potentiometric chemical sensor of all-solid-state propranolol hydrochloride and a preparation method thereof. Background technique [0002] According to bibliographical reports, the ion-selective electrode of the developed propranolol hydrochloride (medicine), as document 1.Z.R.Zhang, D.Y.Mao, Y.X.Li, and V.V.Cosofret, Talanta, 1991,37 (7), 673-676 .Document 2.H.Suzuki, H.Nakagawa, M.Mifune and Y.Saito, Chem.Bull.1993, 41(6), 1123-1126.Document 3.H.Y.Aboul-Enein and X.X.Sun (Sun Xianxiang), Analusis , 2000, 28, 855-858. Its purposes are all developed for the determination of propranolol hydrochloride drug content in pharmaceutical preparations. The structure of the device is a common ion selective electrode structure, that is, it includes an internal reference ...

AI Technical Summary

Problems solved by technology

However, the main disadvantages of the ion selective electrode containing the internal reference solution are: ①It is not conducive to the inverted use of the device; ②It is not conducive to the miniaturization of the electrode

Therefore, it is limited to use in systems such as flow injection and flow dynamic analysis

And, the response performance linear concentration response range of existing ion-selective electrode is shorter and the lower limit of detection is higher (the linear concentration response range is 10 -2 -10 -5 mol / L, the detection limit is 2.5×10 -6 -4.0×10 -6 mol / L, the slope is 53.0-57.4mV / pc, the response time is 20s, and the service life is 2 months)

The use of existing propranolol hydrochloride ion-selective electrodes under low drug concentration (activity) conditions is limited

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