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Timolol maleate potentiometric chemical sensor and preparation method thereof

A timolol maleate and chemical sensor technology, which is applied in the field of drug analysis and analytical chemistry, can solve the problems of containing and so on, and achieve the effect of low cost and good selectivity

Active Publication Date: 2012-11-28
溧阳常大技术转移中心有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The object of the present invention is to provide a kind of chemical sensor structure that has adopted all-solid state, thereby effectively solved the shortcoming that contains internal reference solution in existing timolol drug ion selective electrode (technical) structure, and more important It greatly improves the potential selectivity of timolol ion selective electrode

Method used

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  • Timolol maleate potentiometric chemical sensor and preparation method thereof
  • Timolol maleate potentiometric chemical sensor and preparation method thereof
  • Timolol maleate potentiometric chemical sensor and preparation method thereof

Examples

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example 1

[0031] 1). After the substrate electrode is pretreated, it is chemically modified by cyclic scanning electropolymerization. That is, the substrate electrode is used as the working electrode, the saturated calomel electrode is used as the reference electrode, and the platinum electrode is used as the counter electrode. The concentration of pyrrole solution for electropolymerization is 0.04mol / L, which contains 0.20mol / L KCI, the scanning rate is 60mV / s, the scanning potential range is -0.1~+0.70V, and the scanning times are 10~50 times. The instrument used is a common cyclic voltammeter.

[0032] 2). Separately prepare 10 -2 mol / L timolol maleate and phosphotungstic acid solution, let it mix under stirring to prepare its ion association. After filtering, washing the precipitate several times with deionized water, and drying to dryness at room temperature. The ionic association is used as the electroactive substance in the PVC sensitive film components; PVC, electroactive subs...

example 2

[0036] 1). After the substrate electrode is pretreated, it is chemically modified by cyclic scanning electropolymerization. That is, the substrate electrode is used as the working electrode, the saturated calomel electrode is used as the reference electrode, and the platinum electrode is used as the counter electrode. The pyrrole solution (0.20 mol / L) containing KCI0.20mol / L, the scanning rate is 60mV / s, the scanning potential range is -0.1~+0.70V, and the scanning times are 10~50 times. The instrument used is a common cyclic voltammeter.

[0037] 2). Separately prepare 10 -2 mol / L timolol maleate and phosphotungstic acid solution, let it mix under stirring to prepare its ion association. After filtering, washing the precipitate several times with deionized water, and drying to dryness at room temperature. The ionic association is used as the electroactive substance in the PVC sensitive film composition; PVC, electroactive substance, and DOP are weighed in proportion, and te...

example 3

[0041] 1). After the matrix electrode is pretreated, it is chemically modified by cyclic scanning electropolymerization. That is, the matrix electrode is used as the working electrode, the saturated calomel electrode is used as the reference electrode, and the platinum electrode is used as the counter electrode. The pyrrole solution (0.02 mol / L) containing KCI0.30mol / L, the scanning rate is 60mV / s, the scanning potential range is -0.1~+0.70V, and the scanning times are 10~50 times. The instrument used is a common cyclic voltammeter.

[0042] 2). Separately prepare 10 -2 mol / L timolol maleate and phosphotungstic acid solution, let it mix under stirring to prepare its ion association. After filtering, washing the precipitate several times with deionized water, and drying to dryness at room temperature. The ionic association is used as the electroactive substance in the PVC sensitive film composition; PVC, electroactive substance, and DOP are weighed in proportion, and tetrahyd...

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Abstract

The invention relates to and belongs to a potentiometric chemical sensor, in particular to a timolol maleate potentiometric chemical sensor and a preparation method thereof. The preparation method comprises the following steps: (1) carrying out the chemical modification by the periodic scanning electro-polymerization method after pre-processing the surface of the matrix electrode to prepare the chemically modified electrode; (2) preparing a PVC-film sensitive solution by the conventional method with the solvent being tetrahydrofuran, and coating the modified electrode with the PVC sensitive film by the dip-coating method to prepare a chemical sensor (I); (3) preparing the molecularly imprinted polymer (Polymer A) of timolol maleate, and preparing the PVC film (Film II) containing Polymer A; and (4) compounding the Film II onto the PVC sensitive film of the chemical sensor I. The invention can effectively overcome the disadvantages of the existence of internal reference solution electrodes in the prior art, furthermore, the chemical sensor of the invention is significantly superior to the existing ion-selective electrodes in term of the selectivity of the drug (such as propranolol hydrochloride and the like) ions with the molecule with the structures, such as alcohol amine, imido and the like.

Description

technical field [0001] The invention relates to a medicine chemical sensor, which is directly applied to the fields of medicine analysis and analytical chemistry. In particular, the invention relates to an all-solid-state high-selectivity timolol maleate potentiometric chemical sensor and a preparation method thereof. Background technique [0002] The drug ion selective electrode method is used to determine the content (or concentration) of drug preparations, which has the advantages of fast, accurate, low cost, good selectivity and generally does not need to do aqueous phase pretreatment to samples. According to literature reports, the developed maleic acid Timolol drug ion selective electrodes such as: [0003] Literature 1. Z.R.Zhang, D.Y.Mao, Y.X.Li and V.V.Cosofret, Talanta, 1991, 37(7), 673-676. [0004] Literature 2. S.S.M.Hassan, M.M.Abou-Sekkina, M.A.E1-Ris, A.A.Wassel, J.Pharm.Biomed.Anal.2003, 32, 175-180. [0005] Its device structure is a traditional ion-sele...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/26G01N27/333
Inventor 孙贤祥孙成俊
Owner 溧阳常大技术转移中心有限公司
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