207 results about "Amlodipine besilate" patented technology

A dispersing table of amlodipine benzosulfonate for treating hypertension is proportionally prepared from amlodipine benzosulfonate, microcrystalline cellulose, anhydrous lactose, carboxymethyl starch sodium, micropowdered silica gel, and magnesium stearate.

A preparation technology of amlodipine besylate is disclosed in the present invention, the technology is with amlodipine besylate, filler, disintegrating agent, lubricant etc. as main components. By using grinding and sieving; reasonably controlling particle water; repeatedly feeling fluidized bed granulating technology parameter, controlling spraying speed, spraying pressure and air quantity, under the situation of non-affecting tablet content and hardness, increasing the solubility of product greatly, thereby promoting the internal quality and curative effect of the product.

The invention relates to a pharmaceutical composition containing Amlodipine besilate and valsartan and a preparation method thereof. The pharmaceutical composition is prepared from the following ingredients in parts by weight: 5 parts of Amlodipine besilate, 80 parts of valsartan, 60 parts of microcrystalline cellulose, 4.7-13.2 parts of croscarmellose sodium, 4.8 parts of silicon dioxide and 1.6parts of magnesium stearate. The pharmaceutical composition is prepared by using a direct powder compression technique. The invention can reach the dissolution rate of more than 90% by using less disintegrating agent, and has advantages of good stability and faster disintegrating. The preparation method of the invention has simpler production process, reduces the investment of corresponding equipment and plants and saves the production cost; the tablet produced by using direct powder compression technique has faster disintegrating and is helpful to improve the dissolving of pharmaceutical; through detection, the tablet prepared by using the method is dissolved out by more than 90% within 15 min.

The invention discloses to dispersible tablets containing valsartan and amlodipine besylate and a preparation method thereof, and relates to medicament dispersible tablets and the preparation method thereof, solving the problem of poor stability, slow disintegration and dissolution, low oral bioavailability and high cost existing in the traditional medicine containing valsartan and amlodipine besylate. The dispersible tablets are prepared from valsartan, amlodipine besylate, disintegrant, diluent, adhesive, lubricant, fluidizer, surfactant and flavoring agent. The method comprises the following steps of: weighting and screening materials; mixing the valsartan, disintegrant and diluent to obtain mixed powder A; mixing amlodipine besylate and the mixed powder A to obtain mixed powder B; mixing the adhesive, surfactant and the mixed powder B to prepare soft material; screening, granulating and drying the soft material; mixing and screening and the dried granules with the fluidizer, lubricant, disintegrant and flavoring agent; and finally carrying out size stabilization and tabletting. The medicine prepared by the method has good stability, fast disintegration and dissolution, high oral bioavailability and low cost.

The invention provides a levamlodipine compound prepared in a novel method, which comprises the following steps: producing D-(plus)-levamlodipine camphorate through reaction of amlodipine and D-(plus)-camphanic acid, producing levamlodipine under the effect of sodium hydroxide, and producing the levamlodipine compound through salt forming reaction of the levamlodipine and benzenesulfonic acid. The method adopts a completely novel split reagent D-(plus)-camphanic acid, simplifies reaction procedures and is more suitable for industrial production. Moreover, the method has the advantage of high yield.

The invention discloses a drug composition containing amlodipine besylate and candesartan cilexetil and a drug box thereof, wherein, the weight ratio of the amlodipine besylate to the candesartan cilexetil is 1:1-6. The compound drug has a better synergistic effect in reducing blood pressure and extending blood vessels, and can be used for curing cardiovascular diseases such as hypertension and coronary heart disease.

The present invention relates to a synthesis method of high-purity amlodipine besylate. In particular, o-chlorobenzaldehyde, 4-(2-phthalyl imino radical ethoxy) acetoacetic ester and 3-amino methyl cro-tonate are used as raw materials for ring closure in an alcohol solvent, and when the amount of the 3-amino methyl cro-tonate is three times, the intermediate for ring closure can be prepared; the intermediate is refined by toluene / glacial acetic acid, dissolved in methylamine to form a salt in the aqueous solution, and the high-purity amlodipine besylate can be acquired after recrystallization with ethyl alcohol.

The invention discloses an Amlodipine Besylate oral disintegration tablet, wherein the principal drug employs Amlodipine Besylate, the auxiliary materials include lactose, mannitol, crystalline cellulose, low substituted methylcellulose propylene glycol ether, cross bonding polyvinylpyrrolidone, sodium hydrogen carbonate, citric acid, Aspartame, perfume compound, magnesium stearate, The tablet has good treatment action for hypertension and stenocardia.

The present invention relates to L-amlodipine besilate dripping pill and its preparation process and belongs to the field of medicine preparing technology. The recipe of the L-amlodipine besilate dripping pill includes L-amlodipine besilate, dripping pill substrate, antioxidant, surfactant, coating material, etc. The preparation process includes the first preparing L-amlodipine besilate into fine powder over 150 mesh, the subsequent melting the substrate, adding fine L-amlodipine besilate powder and supplementary material, mixing to form dispersed liquid, and dropping the dispersed liquid into condensating liquid to form dripping pill with or without coating. Each of the dripping pills contains L-amlodipine besilate in 1.25-15mg and weighs 10-100 mg.

The invention relates to a capsule containing valsartan and amlodipine besylate, which is prepared from high-dose valsartan and amlodipine besylate, disintegrating agent crospovidone, filling agent microcrystalline cellulose and lubricating agent silicondioxide. The problem that the compound preparation contianing a high dose of valsartan and amlodipine besylate is not easy to disintegrate and dissolve is solved by adopting the conventional process and equipment of powder mixing and direct capsule filling without using special equipment and the bilayer tablet process.

The invention provides a compound preparation of valsartan amlodipine tablet (I) and a preparation method thereof. The compound preparation comprises a tablet, a film coating layer, the tablet comprises main drug and auxiliary materials, the main drug comprises valsartan, benzenesulfonic acid amlodipine, the auxiliary material comprises filler, a disintegrating agent, a lubricant, and glidant, the tablet comprises the valsartan, benzenesulfonic acid amlodipine, the filler, the disintegrating agent, the lubricant and the glidant, and the tablet is obtained by being coated with the film coating layer. According to the method, the defect of unsafety of medicine use caused by increase of relevant material due to wet granulation is overcome, and manufacture cost can be lowered and labor intensity can be relieved due to the dry granulation technology.

The invention discloses a candesartan cilexetil and amlodipine besylate tablet composition. According to the formula, the tablet composition contains 2 to 4 weight parts of polyethylene glycol (PEG) 6000 serving as a stabilizer; and the active ingredients of the composition, namely the candesartan cilexetil and the amlodipine besylate, have high stability.

The invention relates to a medicament compound preparation formed by mixing olmesartan medoxomil with benzene sulfonic acid amlodipine and hydrochlorothiazide. Both the olmesartan medoxomil and amlodipine are unstable compounds, and are difficultly prepared into mixed medicaments with stable active ingredients. According to the invention, the adjuvant of the olmesartan medoxomil and amlodipine compound preparation is regulated, so that the amounts of degradation products and impurities of the olmesartan medoxomil are effectively reduced. The invention provides a method for preparing the fixed-dose compound preparation which takes the olmesartan medoxomil, the amlodipine and hydrochlorothiazide as the active ingredients.

The invention relates to a preparation method of a high-stability amlodipine atorvastatin calcium tablet. The preparation method of the high-stability amlodipine atorvastatin calcium tablet is characterized in that the amount of peroxide in microcrystalline cellulose is controlled. The preparation method of the high-stability amlodipine atorvastatin calcium tablet comprises the following steps: A, granulating of atorvastatin calcium, concretely comprising the steps of firstly dissolving a surfactant in water, adding a binding agent, stirring and dissolving, secondly mixing atorvastatin calcium, calcium carbonate, other diluents and a disintegrant, thirdly, granulating, and fourthly, drying wet granules obtained in the step three, so that dry atorvastatin calcium granules are prepared; and B, preparing of finished granules, concretely comprising the steps of firstly adding amlodipine besylate, a disintegrant and a flow aid into the dry atorvastatin calcium granules, secondly, uniformly mixing powder obtained in the step one in a mixing machine, thirdly, adding a lubricating agent, and uniformly mixing, and fourthly, pressing the powder into tablets.

The invention discloses an amlodipine benzenesulfonate tablet which is prepared by dissolving amlodipine benzenesulfonate and hydroxypropyl betadex into absolute ethyl alcohol so as to prepare a coating solution, coating blank pellets, subsequently uniformly mixing with pharmaceutically acceptable auxiliaries, and directly tabletting. An inclusion technique and a coating technique are combined, so that the influence of moisture to medicines in the production process of the preparation is avoided, and the tablet is coated and at the same time a hydroxypropyl betadex amlodipine benzenesulfonate clathrate compound is prepared, therefore, the stability is good; and meanwhile, as the clathrate compound is uniformly dispersed on the surface of the pellets, the contact area of dissolved mediums in dissolution measurement is increased, and the dissolution is rapid.

The invention discloses an oral tablet containing candesartan cilexetil and benzene sulfonate amlodipine. The oral tablet consists of benzene sulfonate amlodipine, candesartan cilexetil and medicinal auxiliary materials, wherein the medicinal auxiliary materials contain a stabilizing agent and other auxiliary materials such as one or more of a filling agent, a binding agent and a lubricating agent. The tablet containing candesartan cilexetil and benzene sulfonate amlodipine is attractive in surface and stable in quality. The invention also provides a preparation method for the oral tablet; and the process is simple, low in cost and suitable for commercial production.

A slowly-releasing capsule of amlodipine benzosulfonate is prepared from amlodipine benzosulfonate, auxiliaries and slow-releasing material chosen from acrylic resin, hydroxypropylmethyl cellulose, ethylcellulose, etc.

The invention discloses an oral tablet containing valsartan, hydrochlorothiazide and amlodipine besylate. The oral tablet consists of valsartan, hydrochlorothiazide, amlodipine besylate and medicinal auxiliary materials, wherein the medicinal auxiliary materials include pre-gelatinized starch. The tablet containing valsartan, hydrochlorothiazide and amlodipine besylate provided by the invention has attractive tablet surface and stable quality, and is dissolved quickly. The invention further provides a preparation method of the oral tablet. The method has a simple process and low cost, and is suitable for industrial mass production.

The invention discloses a valsartan and amlodipine tablet, which comprises a tablet core and a coating outside the tablet core. The tablet core comprises the following ingredients (by weight): 8-12 parts of valsartan, 0.8-1 part of amlodipine besylate, 8-12 parts of microcrystalline cellulose, 0.4-0.6 part of a disintegrating agent and 0.1-0.2 part of colloidal silicon dioxide. The coating comprises the following ingredients (by weight): 0.2-0.4 part of a disintegrating agent, 0.1-0.2 part of colloidal silicon dioxide and 0.4-0.6 part of magnesium stearate. The invention also correspondingly provides a preparation method of the valsartan and amlodipine tablet. The valsartan and amlodipine tablet of the invention has good disintegration and dissolution and good dispersion uniformity of active ingredients. In addition, the technology of the invention is simple and easy to operate and is suitable for industrial production.

The invention discloses a valsartan amlodipine tablet and a preparation method thereof. The valsartan amlodipine tablet comprises the following substances as raw materials in parts by weight: 80 partsof valsartan, 5 parts of amlodipine besylate (counted by amlodipine), 50-100 parts of microcrystalline cellulose PH102, 8-30 parts of crospovidone XL, 0.1-10 parts of poloxamer 188, 1-5 parts of magnesium stearate, 1- 3 parts of copovidone S630, 1-5 parts of colloidal silicon dioxide and 4-10 parts of a film coating premix (gastric). Through addition of the poloxamer 188 into a medicinal auxiliary material of the valsartan amlodipine tablet, the solubility of the valsartan is improved and the retention time thereof in the gastrointestinal tract is prolonged, so that absorption is improved, and thus the bioavailability of the valsartan amlodipine tablet is improved; through addition of the copovidone S630 into a coating solution, the solubility and the bioavailability of the valsartan canbe also improved, and thus the bioavailability of the valsartan amlodipine tablet is further improved. The preparation method of the valsartan amlodipine tablet is stable, and is suitable for large-scale preparation.

An amlodipine besylate oral preparation and a preparation method thereof. Microspheres are prepared from amlodipine besylate and acrylic resin E, and direct tabletting of the microspheres and pharmaceutically acceptable auxiliary materials is carried out to obtain the product.

The invention relates to a composition of telmisartan and benzene sulfonate amlodipine, comprising an effective dosage of telmisartan and benzene sulfonate amlodipine and selectively comprising one or a plurality of pharmaceutically acceptable additives or no; the composition is characterized in that the telmisartan and the pharmaceutically acceptable additives are used as a plain tablet, the benzene sulfonate amlodipine is dispersed in a coating material, and a coating material containing lactose, or sodium chloride, or polyethylene glycol 1500 or sorbierite is positioned between the plain tablet and the coating material. The invention has the advantages of effectively preventing the alkaline matters contained in the telmisartan plain tablet from degrading the benzene sulfonate amlodipine and quickly dissolving out the drug in an unexpected manner.

The invention relates to a valsartan amlodipine tablet composition and a preparation method, an active component of the valsartan amlodipine tablet composition is valsartan and amlodipine besylate tablet , an auxiliary material comprises microcrystalline cellulose, croscarmellose sodium , hydroxypropyl methylcellulose, magnesium stearate and silica; the valsartan amlodipine tablet composition employs a wet method for granulation and tabletting; the preparation method has the advantages of little disintegrating agent , high dissolution rate , simple production technology and low equipment requirement; through detections, the tablet prepared by the valsartan amlodipine tablet composition and the preparation method has good dissolution performance.

The invention relates to an amlodipine besylate tablet for treating hypertension and a preparation method thereof, and belongs to the technical field of western medicine preparation. The amlodipine besylate tablet comprises 10-20 parts of amlodipine besylate, 20-50 parts of microcrystalline cellulose, 30-70 parts of lactose, 10-20 parts of L-tyrosine, and 20-50 parts of pregelatinized starch. The materials are mixed with a special particle blender. The tablet is stable to release.

This invention relates to medicine chemical field, concretely relates to benzene monsulfonic acid ammonia chlorine horizon preparation method. The ammonia chlorine horizon is reacted with benzene monsulfonic acid in component organic solvent of ester and alcohol. Its preparation method and operation technique is simple, yield is high, and product quality is easy to control.

The invention discloses a tablet containing olmesartan medoxomil and amlodipine. The tablet is prepared from amlodipine besylate solid dispersion, olmesartan medoxomil and pharmaceutic adjuvants, wherein the amlodipine besylate solid dispersion consists of amlodipine besylate and hydroxypropyl methyl cellulose according to the weight rate of 1: (7-12). The amlodipine besylate in the compound tablets can be rapidly dissolved out and absorbed by organisms; and after orally taken by hypertensive, the olmesartan medoxomil and amlodipine-containing tablet plays the roles of enhancing the synergistic hypotensive effect of two active ingredients and remarkably reducing the adverse drug reaction.

The invention provides a preparation method of amlodipine besylate tablets. The preparation method comprises the following steps of: employing wet granulation and tabletting, filtering each component in a formula through an 80-mesh sieve, and then drying the filtered components at 50 DEG C for future use; evenly mixing amlodipine besylate, microcrystalline cellulose and crospovidone together, forming a soft material from the mixture by using 5% starch slurry, granulating through an 18-mesh sieve, drying at 50 DEG C, and then shaping the granules through the 18-mesh sieve, thereby obtaining granules I; next, evenly mixing starch with dextrin, forming a soft material from the mixture by using 5% starch slurry, granulating through the 18-mesh sieve and drying at 50 DEG C, and then shaping the granules through the 18-mesh sieve, thereby obtaining granules II; finally, mixing the granules I with the granules II, adding magnesium stearate and evenly mixing all the materials, and then tableting the mixture, thus obtaining the amlodipine besylate tablets. According to the invention, the major component amlodipine besylate tablets are white crystalline powder which is good in fluidity; the prepared granules are excellent in both compressibility and fluidity. The disintegration time of the tablets is appropriate, and the content of the tablets, the content uniformity and the dissolution rate all meet the requirements; therefore, the tablets have high clinical application value. The method provided by the invention is simple and suitable for industrial production.

The invention relates to a valsartan amlodipine pharmaceutical composition and a preparation method thereof. The pharmaceutical composition is composed of the following formula: 5 parts by weight of amlodipine besylate, 80 parts by weight of valsartan, 20-50 parts by weight of lactose, 10-40 parts by weight of microcrystalline cellulose, 3-6 parts by weight of low substituted hydroxypropyl cellulose, 0.3-2 parts by weight of silica and 0.5-5 parts by weight of sodium stearyl fumarate. The pharmaceutical composition is prepared from a direct powder compression process. The invention adopts a small amount of disintegrating agent to reach dissolution of more than 90%, and the composition has the advantages of good stability and fast disintegration. The preparation method provided by the invention has simple production process, reduces the corresponding investment in equipment factory, and saves the production cost. The tablet produced by the direct powder compression has faster disintegration, and helps to improve the dissolution of the drug; and through test, the tablet prepared by the method of the invention has dissolution above 90% in 15 min.

The invention belongs to the medical technicial field, and discloses an amlodipine besylate composition which comprises the following components in parts by weight: 3-6 parts by weight of amlodipine besylate, 1-1.8 parts by weight of a disintegrating agent, 65-70 parts by weight of a filler, 20-25 parts by weight of polyethylene glycol 600, and 0.05-0.1 part by weight of a lubricant. An amlodipine besylate tablet is prepared, the 5 min dissolution rate can reach up to more than 80%, the content of stability testing total impurities is less than 0.30%, the amlodipine besylate tablet having stable main drug content and high bioavailability is prepared, and besides, the preparation process has the advantages of being simple to operate, low in equipment requirement, low in production cost and suitable for industrialized production.