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Oral tablet containing valsartan, hydrochlorothiazide and amlodipine besylate

A technology for oral tablet of amlodipine besylate and hydrochlorothiazide, applied in the field of medicine, can solve the problems of easy moisture absorption of tablets, adverse effects on product production, poor product quality and the like

Active Publication Date: 2012-07-04
ZHEJIANG HUAHAI PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the disclosed tablet of patent contains a large amount of super disintegrants (as 13.5% crospovidone), and a large amount of super disintegrants can cause the tablet to be very easy to absorb moisture in the process of production and storage, which brings problems to the production of products. adverse effects; and moisture absorption during storage can lead to poor product quality

Method used

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  • Oral tablet containing valsartan, hydrochlorothiazide and amlodipine besylate
  • Oral tablet containing valsartan, hydrochlorothiazide and amlodipine besylate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Wherein 6.9g of amlodipine besylate contains 5g of amlodipine free base.

[0041] Weigh the corresponding materials according to the above prescription, mix A~F in the general blender, then granulate with a dry granulator, add G to mix, use a rotary tablet machine to compress, coat, and then use Aluminum-plastic packaging, to investigate the dissolution rate and stability under accelerated conditions.

Embodiment 2

[0044] Wherein 6.9g of amlodipine besylate contains 5g of amlodipine free base.

[0045] Weigh the corresponding materials according to the above prescription, mix A~G in the general blender, then granulate with a dry granulator, add H to mix, use a rotary tablet machine to compress, and coat. Of which hydrochlorothiazide D 90 =51 μm, valsartan D 90 =215 μm, amlodipine D90=156 μm.

Embodiment 3

100.0％

[0049] Wherein 6.9g of amlodipine besylate contains 5g of amlodipine free base.

[0050] Weigh the corresponding materials according to the above prescription, mix A~F in the general blender, then granulate with a dry granulator, mix G~I, mix with the previous A~F granules, add J After mixing, the tablets are compressed using a rotary tablet press. Of which hydrochlorothiazide D 90 =31 μm, valsartan D 90= 158 μm, amlodipine D90 = 156 μm.

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Abstract

The invention discloses an oral tablet containing valsartan, hydrochlorothiazide and amlodipine besylate. The oral tablet consists of valsartan, hydrochlorothiazide, amlodipine besylate and medicinal auxiliary materials, wherein the medicinal auxiliary materials include pre-gelatinized starch. The tablet containing valsartan, hydrochlorothiazide and amlodipine besylate provided by the invention has attractive tablet surface and stable quality, and is dissolved quickly. The invention further provides a preparation method of the oral tablet. The method has a simple process and low cost, and is suitable for industrial mass production.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular to an oral tablet containing valsartan, hydrochlorothiazide and amlodipine besylate. Background technique [0002] Valsartan is an orally effective and highly specific angiotensin (AT) II receptor antagonist, which selectively acts on the AT1 receptor subtype, chemical name: (S)-N-pentanoyl-N -{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-valine. [0003] Amlodipine is a calcium antagonist. Inhibition of calcium-induced aortic contraction is 2 times that of nifedipine. It is characterized by slow binding and dissociation with receptors, so the drug effect appears later and lasts for a long time. The selective effect on vascular smooth muscle is greater than that of nifedipine. In patients with myocardial ischemia, this product can increase cardiac output and coronary flow, increase myocardial oxygen supply and reduce oxygen consumption, and improve exercise capacity. Ch...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/36A61K31/549A61K9/20A61P9/10A61P9/12A61K31/41A61K31/4422
Inventor 葛光华黄龙梅李巧霞彭俊清胡功允
Owner ZHEJIANG HUAHAI PHARMA CO LTD
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