Propranolol hydrochloride smearing preparation and preparation method and application thereof

A technology of propranolol hydrochloride and smear, applied in the field of medicine, can solve problems such as hypotension, hypoglycemia, bradycardia, etc., and achieve the effect of promoting healing, reducing infection and no skin irritation

Inactive Publication Date: 2016-03-30
WUHAN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current oral propranolol may still cause si...

Method used

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  • Propranolol hydrochloride smearing preparation and preparation method and application thereof
  • Propranolol hydrochloride smearing preparation and preparation method and application thereof
  • Propranolol hydrochloride smearing preparation and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Weigh 1g propranolol hydrochloride and 0.05g sorbic acid, add appropriate amount of water, heat in a water bath to dissolve completely, then add 0.3g polyvinylpyrrolidone, 1.7g poloxamer 407, 0.5g chitosan, mechanically stir to make Completely swell; take another 2g of isopropyl myristate and 4g of propylene glycol, stir to completely dissolve each other, add to the matrix in which propranolol hydrochloride is dissolved, and stir evenly to obtain propranolol hydrochloride smear.

Embodiment 2

[0031] Weigh 3g of propranolol hydrochloride and 0.05g of sorbic acid, add appropriate amount of water, heat in a water bath to dissolve completely, then add 1.0g of polyvinylpyrrolidone, 5.0g of poloxamer 407, 1.0g of chitosan, and stir mechanically to make Completely swell; take another 4g of isopropyl myristate and 6g of propylene glycol, stir to completely dissolve each other, add to the matrix in which propranolol hydrochloride is dissolved, and stir evenly to obtain propranolol hydrochloride smear.

Embodiment 3

[0033] Weigh 8g of propranolol hydrochloride and 0.04g of sorbic acid, add appropriate amount of water, heat in a water bath to dissolve completely, then add 1.5g of polyvinylpyrrolidone, 8.5g of poloxamer 407, 2.0g of chitosan, and mechanically stir to make Swell completely; Take another 5g of isopropyl palmitate and 8g of glycerin, stir to completely dissolve each other, then add to the matrix in which propranolol hydrochloride is dissolved, and stir evenly to obtain propranolol hydrochloride smear.

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Abstract

The invention provides a propranolol hydrochloride smearing preparation and a preparation method and application thereof. The propranolol hydrochloride smearing preparation is prepared from, by weight, 1%-8% of propranolol hydrochloride, 2.5%-15% of substrate, 2%-10% of skin penetration enhancer, 3%-16% of moisturizing agent, 0.02%-0.2% of bacteriostatic agent and the balance water. The propranolol hydrochloride smearing preparation is small in skin irritation and capable of directly acting on infantile hemangioma ulcer parts to rapidly facilitate ulcer healing and treating hemangioma simultaneously.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular, the invention relates to a propranolol hydrochloride varnish and a preparation method and application thereof. Background technique [0002] Ulcer is the most common complication of hemangioma, with an incidence rate of 5% to 15%. During the period of rapid growth of infantile hemangioma, immersion and friction can easily cause ulcers, and then lead to bleeding, infection, etc. If not treated in time and effectively, the ulcer will leave a deformed appearance that is difficult to repair after healing, and even cause visceral function Sexual disorder brings great pain to children, so clinically it tends to actively treat ulcers in the early stage. At present, there is no special drug or treatment method for infantile hemangioma ulcer. Traditional treatment methods for hemangioma such as laser, oral medicine and local administration of hormones are mainly used for treatment, but th...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/138A61K47/36A61K47/34A61K47/32A61K47/38A61P17/02A61P35/00
Inventor 蔡育周小顺王蓉赵吉宏牟东升刘冬晓李进贺容丽
Owner WUHAN UNIV
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