34 results about "Pentadecanoic acid" patented technology

The invention relates to cyclocarya paliurus extract and the application of the cyclocarya paliurus extract. The cyclocarya paliurus extract at least comprises the following effective ingredients: 10-methoxy-nb-alpha-methyl corynantheol, n-nonyl nitrate, iso-butoxyamine, pentadecanoic acid, 4, 6, 10, 14-tetramethyl-methyl-ester, adipic acid, bis--(2-ethylhexyl) ester, 2-butyl, 1-octanol, octadecyl vinyl ether and erythro cis-4, 5-dimethyl-2-undecene. The weight percentage of the effective ingredients in the cyclocarya paliurus extract is 50% to 98%. The cyclocarya paliurus extract can significantly promote the secretion of insulin by islet beta cells so as to enhance glucose tolerance of mice and regulate blood sugar, and therefore the cyclocarya paliurus extract can be used for preparing drugs for preventing and treating diabetes, and the direction is pointed out for further developing and utilizing the medical value of cyclocarya paliurus.

The invention relates to dialkyl dimethyl quaternary ammonium salt, which has the following chemical structure as shown in the accompanying drawing. In the formula, R1 or R2 is identical or different C1 to C2 alkyls, identical or different C3 to C22 saturated or unsaturated strain chain alkyls and saturated or unsaturated branch chain alkyls, A<-> is methyl carbonate radical, bicarbonate radical, halogen ion, hydrogen sulfate radical, dihydrogen phosphate radical, nitrate radical, nitrite radical, perchlorate radical, permanganate radical, oxacid radical, acetate radical, malonate radical, lactate radical, butyrate radical, glutaconate radical, adipate radical, pimelate radical, azelate radical, quinate radical, undecandioate radical, dodecanoate radical, tridecanoic acid radical, tetradecanoic acid radical, pentadecanoic acid radical, palmitate radical, hexadecenoic acid radical, stearate radical or oleate radical. The dialkyl dimethyl quaternary ammonium salt has the advantages that no pollution is caused on the environment, the dialkyl dimethyl quaternary ammonium salt with the acid radical anions can be synthesized, and the surface activity higher than that of the traditional quaternary ammonium salt can be obtained.

Disclosed are peptides having biological and therapeutic activity. Particularly disclosed are lipidated di- or tri-peptides analogs of KPV or KdPT that exhibit antimicrobial activity. In particular, the peptides of this invention provide enhanced anti-microbial activity over the base tri-peptides, lysine-proline-valine and lysine-d-proline-tyrosine. The disclosed peptides have the general formula of C12-18 lipid-KXZ-NH2i wherein K is lysine; X is proline, d-proline, histidine or arginine; Z is optional and if present Z is valine, threonine, alanine or leucine; and the terminal COOH is NH2 amidated. The C12-18 lipid is preferably the lipid moiety of lauric acid (C12), myristic acid (C14), pentadecanoic acid (C15), palmitic acid (C16), or stearic acid (C18). The invention is further related to methods of using of these peptides to treat various insults, inflammations or bacterial infections affecting the skin and other related mucosal body surfaces such as the oral cavity.

The invention discloses a synthesis method for pentadecanoicacid. The pentadecanedioate is mixed with an organic dissolvent, and dimethylpentadecanedioate is obtained via reaction of adding a catalyst NaHSO4 and cyclohexane in a stirring condition; hydroxide is dissolved in the organic dissolvent and is dropped into the dimethylpentadecanedioate, and pentadecanedioate monoethanolamine is obtained after reaction; acid solution is used for treating the pentadecanedioate monoethanolamine to obtain pentadecanedioate monoester; the pentadecanedioate monoester is dissolved in the organic solution, adding sodium borohydride in batches to distill the organic dissolvent, and then acetic ether is utilized to extract 15-oxhydryl pentadecanoic acid; the mixture is dissolved in mixing solution of hydrobromic acid and glacial acetic acid to obtain 15-bromine pentadecanoic acid; the mixture is dissolved in organic dissolvent, carbonate and iodine are added, and the organic dissolvent is distilled to obtain a crude product of pentadecanoicacid; and the crude product of pentadecanoicacid is subjected to distillation at a reduced pressure, and fraction of 130-140 DEG C / 2mmHg is collected to obtain a product of pentadecanoicacid. The preparation method has simple process, low energy consumption, low cost, little pollution and easiness in realization of industrialization.

The invention discloses a Parkinson's disease specific serum endogenous small molecule marker and application thereof. The marker contains 2-amino-3-(4-hydroxyl-3-methoxyphenyl) propionic acid, ferulic acid and citraconic acid, altrose, pentadecanoic acid, o-phosphoserine, 4, 6 beta-hydroxymorphine, L-thyroxine, 5[epsilon], 9[epsilon], 16[epsilon]-17-hydroxy peraluminum-19-acid, 8-(1,2,dyhydroxy-3-methylbutyl-3-ene-1-yl)-7-methoxy-2H-chromine-2-2-ketone,10-hydroxydecanoic acid, perfluoro caprylic acid, and Corchorifatty acid F. The Parkinson's disease specific serum endogenous small molecule marker provided by the invention has the characteristics of high accuracy and high sensitivity. The prediction offline prediction area AUC of some markers reaches 0.95 or above, the accuracy and sensitivity of the markers are high, and the markers can be directly used for Parkinson's disease indexes.

This application discloses a method of differentiating stable angina pectoris from acute coronary syndrome, including: obtaining a blood plasma sample from a patient; measuring a relative concentration of at least one metabolic biomarker in the blood plasma sample, wherein the at least one metabolic biomarker is selected from the group consisting of malic acid, taurine, arachidonic acid, citramalic acid, methionine, and pentadecanoic acid; calculating a value according to the relative concentration of at least one metabolic biomarker; comparing the value with a predefined critical value, if the value is more than the predefined critical value, the patient has the acute coronary syndrome, otherwise, the patient has the stable angina pectoris. The method and a diagnostic kit thereof is capable of differential diagnosis of SA and ACS and it can improve the diagnostic convenience and promote the diagnostic standardization.

This invention discloses an aroma-producing compound from Cymbidium goeringii and the extraction method thereof. The compound comprises octadecatrienoic aldehyde,nerolidol,dibutylphthalate,heptacosane,pentadecanoic acid,pentadecanoic acid,hexadecanoic acid(palmic acid),oleic acid,linolic acid and cyclohexadecane. The aroma-producing compound is extracted from the flowers of Cymbidium goeringii by the following steps: leaching and filtering, reflux leaching, filtering, combined seperation, volatilized speration, concentration and drying. The main discovery is the octadecatrienoic aldehyde, a critical aroma-producing substance. Besides, the extraction rate of the aroma-producing substances is pretty high, with the content upto 30% by using octadecatrienoic aldehyde and nerolidol as the major aroma-producing product. The components of this invention has satisfied the basic requirements as natural flavoring, and can be used in flavoring agents, perfume, scent emitting objects and bath articles, allowing this natural perfume for industrial application.

A panel of metabolic biomarkers for differential diagnosis of stable angina pectoris and acute coronary syndrome is published herein. The panel comprises one or more of the metabolic biomarkers, including malic acid, taurine, arachidonic acid, citramalic acid, methionine, pentadecanoic acid. Single use of the 6 differential metabolites provided clinically diagnostic value of SA vs. ACS with AUC>0.7. When combined, the more metabolites, the larger of AUC. The highest AUC of 0.987 was obtained when all of the six metabolites were combined to distinguish SA vs. ACS with sensitivity 96.8% and specificity 97.7% using optimal cut-off value. The metabolic biomarkers provided by the invention can be used for differential diagnosis of SA vs. ACS of high accuracy, sensitivity and specificity.

The invention discloses a metabolism marker group used for diagnosing and differentiating stable angina pectoris and acute coronary syndrome. The metabolism marker group comprises one or more selected from a group consisting of malic acid, taurine, arachidonic acid, citramalic acid, methionine and pentadecanoic acid. When an individual metabolism marker is used for diagnosing and differentiating patients with stable angina pectoris and patients with acute coronary syndrome, an area under a ROC curve (AUC) is greater than 0.7, the individual metabolism marker has clinical diagnosis significance; when metabolism markers are combined and used for diagnosis, AUC further increases with increase of the number of the combined metabolism markers; and AUC reaches a highest value of 0.987 when all the six metabolism markers are combined, and sensitivity and specificity are 96.8% and 97.7% respectively under the condition of an optimal cutoff value. The metabolism marker group provided by the invention can accurately diagnose and differentiate stable angina pectoris and acute coronary syndrome and has high sensitivity and good specificity.

Disclosed are compositions and methods for producing a poultry egg that is rich in odd-chain fatty acid (OCFA), particularly pentadecanoic acid (C15:0) and heptadecanoic (C17:0) acid. Poultry feed can be mixed with a compound (e.g. biomass or oil extract) that is produced from microalgae cultured to comprise elevated levels of OCFA. The OCFA-enriched poultry feed comprises an elevated level of OCFA and it can be fed to poultry that are laying eggs. As the OCFA-enriched feed is incorporated by the poultry, the resulting eggs comprise yolks that are rich in OCFA. The OCFA rich eggs can be consumed by humans as a dietary source of OCFA, to improve health.

The invention relates to cyclocarya paliurus extract and the application of the cyclocarya paliurus extract. The cyclocarya paliurus extract at least comprises the following effective ingredients: 10-methoxy-nb-alpha-methyl corynantheol, n-nonyl nitrate, iso-butoxyamine, pentadecanoic acid, 4, 6, 10, 14-tetramethyl-methyl-ester, adipic acid, bis--(2-ethylhexyl) ester, 2-butyl, 1-octanol, octadecyl vinyl ether and erythro cis-4, 5-dimethyl-2-undecene. The weight percentage of the effective ingredients in the cyclocarya paliurus extract is 50% to 98%. The cyclocarya paliurus extract can significantly promote the secretion of insulin by islet beta cells so as to enhance glucose tolerance of mice and regulate blood sugar, and therefore the cyclocarya paliurus extract can be used for preparing drugs for preventing and treating diabetes, and the direction is pointed out for further developing and utilizing the medical value of cyclocarya paliurus.

The invention discloses a method for preparing astaxanthin monoester rich in astaxanthin odd-numbered fatty acid monoester. The method comprises the following steps: dissolving the astaxanthin monoester in dichloromethane, dropwise adding the mixture so as to form a line on an AgNO3 high-efficiency thin layer plate by using a capillary sample application tube, then putting on a glass chromatographic jar with a developing agent, and developing; after developing, taking out, airing, scraping off two strips, carrying out ultrasound treatment, centrifuging, taking a liquid supernatant, repeatedly extracting until the strips scrapped off are colorless, respectively obtaining extracting solutions to which the two strips respectively correspond, and carrying out rotary evaporation so as to remove the dichloromethane, thus obtaining two samples, wherein the first red strip is the astaxanthin monoester containing 7-9% of astaxanthin tridecylenic acid monoester and 48-51% of astaxanthin pentadecanoic acid monoester. The method has the advantages that the astaxanthin monoester rich in the odd-numbered fatty acid is obtained by using a AgNO3 high-efficiency thin layer plate separation method, the separation of the astaxanthin monoester is pushed forward greatly, and the method provides a basis for the separation of the astaxanthin odd-numbered fatty acid and lays a foundation for the future secondary separation and purification.

The invention discloses a folium artemisiae argyi extractive and relates to treatment on herpes zoster. The extractive is prepared according to the following preparation steps: using ethyl acetate as a solvent to perform dip extraction on wild dry folium artemisiae argyi, performing solid-liquid separation, concentrating the obtained liquid, and drying to obtain the extractive. The effective compositions of the extractive comprise dihydroxy, trimethoxyflavone, aliphatic acids, linolenic acid, octadecadienoic acid, pentadecanoic acid, ethyl linoleate, ethyl oleate, triterpenoids and the like. The extractive has the efficacy of warming meridian and stopping bleeding, dissipating cold and relieving pain, resolving stasis and nodules, restoring yang and relieving desertion, and is applicable to treat herpes zoster virus.

A method for preparing a corrosion-resistant hydrophobic membrane on the surface of magnesium alloy comprises the following two steps: preparing a corrosion-resistant membrane layer in a zirconium / vanadate solution; and carrying out hydrophobization treatment on the membrane layer by using low-energy surface modification liquid. The zirconium / vanadate solution is prepared by preparing basic liquid from potassium fluozirconate, sodium metavanadate and ultra-pure water, and adding one or more of sodium molybdate, ammonium molybdate, tannic acid, phytic acid or diphosphonic acid as additives. The low-energy surface modification liquid is an ethanol solution of one or more of dodecanoic acid, tridecylic acid, tetradecanoic acid, pentadecanoic acid, hexadecanoic acid, heptadecanoic acid, octadecanoic acid or a KH560 silane coupling agent. In the method, etching treatment of acid or alkali etching liquid is not required, steps are simplified, corrosion to equipment is reduced, the corrosion-resistant hydrophobic membrane can be prepared by soaking only, and complicated steps such as electrifying or lifting are not required. The process is simple, the price is low, and meanwhile, the prepared hydrophobic membrane has certain corrosion resistance and self-cleaning property, and can be produced on a large scale.

The invention relates to a lipid composition comprising fatty acids mainly in the form of triacylglycerols, in which composition at least 50% of the fatty acids are 14-methyl pentadecanoic acids, and at least 8% of the fatty acids are 12-methyl tetradecanoic acids, the percentages being expressed by weight with respect to the total fatty acids of the composition.

The invention discloses a novel cationic surface active agent and a preparing method thereof, and particularly relates to indole quaternary ammonium of monodisperse pentadecyl tribrachia polyglycol ether and a preparing method. Starting from hydroxyl pentadecanoic acid, through a primary addition reaction of the hydroxyl pentadecanoic acid and tribrachia polyethylene glycol p-toluenesulfonate under the function of alkali, pentadecanoic acid tribrachia polyethylene glycol is obtained, the pentadecanoic acid tribrachia polyethylene glycol and indole quaternary ammonium amine are subjected to anaddition reaction to obtain quaternary ammonium of pentadecyl tribrachia polyglycol ether, and acidification is conducted to obtain an indole quaternary ammonium salt of pentadecyl tribrachia polyglycol ether. The method can be used for preparation of long-chain alkyl ether and the indole quaternary ammonium salt of the monodisperse tribrachia polyethylene glycol. According to the preparing method, the tribrachia polyethylene glycol p-toluenesulfonate with a single molecular weight is taken as a raw material to achieve efficient synthesis of the pentadecanoic acid tribrachia polyethylene glycol, in the synthesis process, carboxyl protective groups are not utilized, steps are simple, and the method is suitable for industrial production; compared with PEG aliphatic-series indole quaternary ammonium salts prepared in the prior art, the obtained product has obvious advantages.

The invention is a fatty acid metabolism developer beta-methyl-15-(4-fluorophenyl [18F]) -pentadecanoic acid as well as its synthesizing method, relating to a fluorin-labeled fatty acid cardiac muscle metabolism developer. The 18F-BMFPP is reformed by beta-methyl-phenyl-pentadecanoic acid in *I-BMIPP structure as mother substance, a compound designed and synthesized by ourselves. It uses omega bromo-undecoic acid as initial raw material to synthesize BMPPA through multiple step reaction, then begins with BMPPA to make nitrification, esterification, reducing, diazotization and diazonium decomposition to obtain label precursor NO2-BMPPA and nonradiative BMFPP. It makes NO2-BMPPA through nucleophilic displacement reaction to synthesize 18F-BMFPP. And it improves the iodinating method of synthesis of intermediate phenyl-dodecyl iodine and alpha-methyl- phenyltetadecyl iodine.

Disclosed are peptides having biological and therapeutic activity. Particularly disclosed are lipidated di- or tri-peptides analogs of KPV or KdPT that exhibit antimicrobial activity. In particular, the peptides of this invention provide enhanced anti-microbial activity over the base tri-peptides, lysine-proline-valine and lysine-d-proline-tyrosine. The disclosed peptides have the general formula of C12-18 lipid-KXZ-NH2i wherein K is lysine; X is proline, d-proline, histidine or arginine; Z is optional and if present Z is valine, threonine, alanine or leucine; and the terminal COOH is NH2 amidated. The C12-18 lipid is preferably the lipid moiety of lauric acid (C12), myristic acid (C14), pentadecanoic acid (C15), palmitic acid (C16), or stearic acid (C18). The invention is further related to methods of using of these peptides to treat various insults, inflammations or bacterial infections affecting the skin and other related mucosal body surfaces such as the oral cavity.

The invention relates to dialkyl dimethyl quaternary ammonium salt, which has the following chemical structure as shown in the accompanying drawing. In the formula, R1 or R2 is identical or different C1 to C2 alkyls, identical or different C3 to C22 saturated or unsaturated strain chain alkyls and saturated or unsaturated branch chain alkyls, A<-> is methyl carbonate radical, bicarbonate radical, halogen ion, hydrogen sulfate radical, dihydrogen phosphate radical, nitrate radical, nitrite radical, perchlorate radical, permanganate radical, oxacid radical, acetate radical, malonate radical, lactate radical, butyrate radical, glutaconate radical, adipate radical, pimelate radical, azelate radical, quinate radical, undecandioate radical, dodecanoate radical, tridecanoic acid radical, tetradecanoic acid radical, pentadecanoic acid radical, palmitate radical, hexadecenoic acid radical, stearate radical or oleate radical. The dialkyl dimethyl quaternary ammonium salt has the advantages that no pollution is caused on the environment, the dialkyl dimethyl quaternary ammonium salt with the acid radical anions can be synthesized, and the surface activity higher than that of the traditional quaternary ammonium salt can be obtained.

The invention is a fatty acid metabolism developer beta-methyl-15-(4-fluorophenyl [18F]) -pentadecanoic acid as well as its synthesizing method, relating to a fluorin-labeled fatty acid cardiac muscle metabolism developer. The 18F-BMFPP is reformed by beta-methyl-phenyl-pentadecanoic acid in *I-BMIPP structure as mother substance, a compound designed and synthesized by ourselves. It uses omega bromo-undecoic acid as initial raw material to synthesize BMPPA through multiple step reaction, then begins with BMPPA to make nitrification, esterification, reducing, diazotization and diazonium decomposition to obtain label precursor NO2-BMPPA and nonradiative BMFPP. It makes NO2-BMPPA through nucleophilic displacement reaction to synthesize 18F-BMFPP. And it improves the iodinating method of synthesis of intermediate phenyl-dodecyl iodine and alpha-methyl- phenyltetadecyl iodine.

The invention discloses an aroma composition extracted from spring orchids and an extraction method thereof. The composition includes octadecatrienal, nerolidol, dibutyl phthalate, heptacosanol , Pentadecanoic acid, hexadecanoic acid (palmitic acid), oleic acid, linoleic acid and cyclohexadecane were extracted by leaching and filtering, reflux leaching, filtering, merging and separation, volatile separation, concentration and drying steps, and successfully The aroma substance has been extracted from the flowers of Chunlan, the most important thing is that the main aroma substance octadecatrienal has been found, and the extraction rate of the aroma substance of the present invention is also relatively high. Octatrienal and nerolidol are the main components of the fragrance, and their content is almost 30%. The composition of the present invention has met the basic requirements of natural fragrances, and can be used in fragrances, perfumes, fragrances, etc. according to existing methods. In fragrance body and bath products, this natural "orchid fragrance" can be applied in industry.

The invention discloses a method for synthesizing musk ketone in vitro by gene editing yeast, which comprises the following steps: malonyl-acyl carrier protein and 2-ketoisovalerate form 2-methallyl-ACP under the action of thiamine metabolic regulatory protein, and 14-methyl-pentadecanoyl-coenzyme A is synthesized by extension under the action of fatty acid synthase FAS1 / FAS2, under the action of TES1, 14-methyl-pentadecanoic acid is generated; the 14-methyl-pentadecanoic acid is subjected to omega-hydroxylation under the action of CYP54A1, CYP54A13 or CPR2, so that omega-hydroxyl-14-methyl-pentadecanoic acid is formed; and the musk ketone is formed from the omega-hydroxy-14-methyl-pentadecanoic acid under the catalysis of lactone lipase. According to the invention, a brand-new muscone biosynthesis way is constructed, the yeast obtains the muscone synthesis capability through a gene editing technology, the synthesis yield can reach 843mg / L, the cost is low, and mass production can be realized.

The invention discloses butylene glycol fatty acid ester. The butylene glycol fatty acid ester is prepared by esterifying 1,4-butylene glycol or 2,3-butylene glycol and fatty acids with the carbon atom number of 12-18 (including lauric acid, tridecanoic acid, myristic acid, pentadecanoic acid, palmitic acid, heptadecanoic acid and stearic acid); and the butylene glycol fatty acid ester provided by the invention can be used as the gel factor and can form organic gel with heat stability under low concentration (2g / L).

The invention discloses a novel cationic surfactant and a preparation method thereof, and particularly relates to indole quaternary ammonium of monodisperse pentadecyl triple-arm polyglycol ether anda preparation method thereof. The preparation method comprises the following steps: hydroxypentadecanoic acid and triple-arm polyethylene glycol p-toluenesulfonate are subjected to a primary additionreaction under the action of alkali to obtain pentadecanoic acid triple-arm polyethylene glycol; the pentadecanoic acid triple-arm polyethylene glycol and indole quaternary ammonium are subjected to an addition reaction to obtain quaternary ammonium of pentadecyl triple-arm polyglycol ether; and the quaternary ammonium of pentadecyl triple-arm polyglycol ether is acidified to obtain the indole quaternary ammonium salt of pentadecyl triple-arm polyglycol ether. The method can be used for preparing long-chain alkyl ether of monodisperse triple-arm polyethylene glycol and indole quaternary ammonium salt of the long-chain alkyl ether. According to the method, the pentadecanoic acid triple-arm polyethylene glycol is efficiently synthesized by taking the single-molecular-weight triple-arm polyethylene glycol p-toluenesulfonate as a raw material, a carboxyl protecting group is not used in the synthesis, the steps are simple and convenient, the method is suitable for industrial production, andthe obtained product has obvious advantages compared with the existing prepared PEGylated aliphatic indole quaternary ammonium salt.

The invention discloses a soil microorganism prebiotic composition for improving plant system resistance and application thereof. The soil microorganism prebiotic composition is prepared from capric acid, dodecanoic acid, tridecanoic acid, pentadecanoic acid, palmitoleic acid, hexadecanoic acid, octadecanoic acid, arachidonic acid, isoleucine, leucine, methionine, proline, tryptophan, ornithine, alanine and aspartic acid. After application, the number of pseudomonas in soil can be increased by more than two orders of magnitudes, the plant system resistance is remarkably improved, and the morbidity is reduced. The formula product is suitable for herbaceous crops such as fruits and vegetables.

The invention discloses a novel cationic surfactant and a preparation method thereof, in particular indole quaternary ammonium monodisperse pentadecyl three-arm polyethylene glycol ether and a preparation method thereof. Starting from hydroxypentadecanoic acid, pentadecanoic acid three-arm polyethylene glycol was obtained through an addition reaction with three-arm polyethylene glycol p-toluenesulfonate under the action of a base. Pentadecanoic acid three-arm polyethylene glycol Addition reaction of ethylene glycol and indole quaternary ammonium amine to obtain quaternary ammonium of pentadecyl three-arm polyethylene glycol ether, and acidification to obtain indole quaternary ammonium salt of pentadecyl three-arm polyethylene glycol ether. The method can be used in the preparation of long-chain alkyl ether of monodisperse three-arm polyethylene glycol and its indole quaternary ammonium salt. The present invention realizes the high-efficiency synthesis of pentadecanoic acid three-arm polyethylene glycol by using single-molecular-weight three-arm polyethylene glycol p-toluenesulfonate as a raw material. No carboxyl protecting group is used in the synthesis, and the steps are simple and suitable for industrial production. The obtained product has obvious advantages over the existing PEGylated aliphatic indole quaternary ammonium salts.

The invention belongs to the technical field of plant active ingredient extraction, and particularly relates to an extraction method, a detection method and application of oak bark volatile oil. A steam distillation method is adopted for extraction; the chemical components, antioxidant activity and anticoagulant activity of the oak bark volatile oil are explored, and GC-MS and FT-IR are adopted for analyzing the chemical components of the oak bark volatile oil. 28 components are identified in the oak bark volatile oil and account for 96.98% of the total mass of the oak bark volatile oil. A functional group deduced from an FT-IR curve fitting result is verified through GC-MS analysis, and the FT-IR spectrum of the oak bark volatile oil is consistent with the FT-IR spectrum of an n-pentadecanoic acid functional group. Based on the outstanding antioxidant and anticoagulant activities of the oak bark volatile oil, a soft capsule dosage form with antioxidant and anticoagulant effects is developed, and a new economic value is provided for comprehensive development and utilization of plant resources.

This application discloses a method of differentiating stable angina pectoris from acute coronary syndrome, including: obtaining a blood plasma sample from a patient; measuring a relative concentration of at least one metabolic biomarker in the blood plasma sample, wherein the at least one metabolic biomarker is selected from the group consisting of malic acid, taurine, arachidonic acid, citramalic acid, methionine, and pentadecanoic acid; calculating a value according to the relative concentration of at least one metabolic biomarker; comparing the value with a predefined critical value, if the value is more than the predefined critical value, the patient has the acute coronary syndrome, otherwise, the patient has the stable angina pectoris. The method and a diagnostic kit thereof is capable of differential diagnosis of SA and ACS and it can improve the diagnostic convenience and promote the diagnostic standardization.

The invention belongs to the field of food analysis, and relates to a method for discriminating the aftertaste of Maotai-flavor liquor based on non-volatile organic acid. The invention provides a method for judging the aftertaste of white spirit, the aftertaste of the white spirit is judged according to the composition of organic acid, and the organic acid comprises tetradecanoic acid, pentadecanoic acid, hexadecanoic acid, heptadecanoic acid and oleic acid. The inventor studies difficult-to-volatilize organic acids in Baijiu, explores the influence of the organic acids on the taste sense and taste of the Baijiu, and establishes a discrimination model based on the influence. The method has the innovation points that firstly, the content of the organic acid difficult to volatilize in the Maotai-flavor liquor can be rapidly, accurately and highly sensitively measured; the second innovation point of the invention is that a maotai-flavor liquor aftertaste discrimination model based on the content of the difficultly volatile organic acid is established; the third innovation point of the method is that only five types of difficult-to-volatilize organic acids are needed for modeling, and the method has important significance on more comprehensive understanding of Maotai-flavor liquor and control of liquor quality.