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Cyclocarya paliurus extract and application thereof

A technology of extract and green money, which is applied in the field of drug preparation, can solve the problems of scientific explanation that needs further research, and achieve the effect of enhancing blood sugar tolerance and promoting secretion

Active Publication Date: 2014-07-30
黄晓航 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These studies provide effective experimental evidence for the use of Cyclocarya paliurus leaves in folk tea drinking to prevent and treat diabetes, but its scientific explanation needs further study

Method used

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  • Cyclocarya paliurus extract and application thereof
  • Cyclocarya paliurus extract and application thereof
  • Cyclocarya paliurus extract and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] The preparation method of Cyclocarya paliurus extract, comprises the steps:

[0078] (1) Take Cyclocarya paliurus leaves, after crushing, extract with ethanol with a mass volume ratio of 85% at room temperature for 2 hours, extract the extract with chloroform at room temperature at a volume ratio of 1:1 for 5 minutes, repeat the extraction twice, and combine Organic phase to obtain extract;

[0079] (2) The extract obtained in step (1) is eluted on a silica gel column with a concentration gradient of a chloroform-methanol mixed solution, and the concentration gradient of the chloroform-methanol mixed solution is chloroform:methanol The volume ratio is 80:1, 50:1, 30:1, 20:1, 10:1, 5:1, 1:1, 0:1, the elution time of each stage is 90min, and 30 fractions are obtained after elution; the 12th-15th fraction eluate is collected , to obtain the initial extract;

[0080] (3) The primary extract obtained in step (2) is separated and purified by chromatographic chromatography, ...

Embodiment 2

[0085] The preparation method is as described in Example 1, the difference is that in step (2), in addition to collecting the 12th-15th fraction eluate, the 21st-27th fraction eluate is collected at the same time, and the embodiment is carried out at the same time In the process of step (3) and step (4) described in 1, the 12th-15th fraction Cyclocarya paliurus extract and the 21-27th fraction Cyclocarya paliurus extract are prepared. Finally, the 12th to 15th fraction of Cyclocarya paliurana extract and the 21st to 27th fraction of Cyclocarya paliurus extract were mixed to obtain Cyclocarya paliurus extract.

[0086] The chemical structure of the 21st to 27th fractions of Cyclocarya paliurus extract was confirmed by mass spectrometry as a kind of compound with strong polarity, and its main component was Cyclocarya glucoside.

Embodiment 3

[0088] The preparation method of Cyclocarya paliurus extract, comprises the steps:

[0089] (1) Take Cyclocarya paliurus leaves, after crushing, extract with ethanol with a mass volume ratio of 70% at room temperature for 1.5 hours, and extract the extract with n-hexane at room temperature at a volume ratio of 1:1 for 5 minutes to obtain an extract ;

[0090] (2) The extract obtained in step (1) is eluted on a silica gel column with a concentration gradient of a chloroform-methanol mixed solution, and the concentration gradient of the chloroform-methanol mixed solution is chloroform:methanol The volume ratio is 80:1, 50:1, 30:1, 20:1, 10:1, 5:1, 1:1, 0:1, the elution time of each stage is 70min, and 30 fractions are obtained after elution; collect the eluate of the 12th-15th fraction , to obtain the initial extract;

[0091] (3) The primary extract obtained in step (2) is separated and purified by chromatographic chromatography, and the chromatographic eluent is a mixed solu...

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Abstract

The invention relates to cyclocarya paliurus extract and the application of the cyclocarya paliurus extract. The cyclocarya paliurus extract at least comprises the following effective ingredients: 10-methoxy-nb-alpha-methyl corynantheol, n-nonyl nitrate, iso-butoxyamine, pentadecanoic acid, 4, 6, 10, 14-tetramethyl-methyl-ester, adipic acid, bis--(2-ethylhexyl) ester, 2-butyl, 1-octanol, octadecyl vinyl ether and erythro cis-4, 5-dimethyl-2-undecene. The weight percentage of the effective ingredients in the cyclocarya paliurus extract is 50% to 98%. The cyclocarya paliurus extract can significantly promote the secretion of insulin by islet beta cells so as to enhance glucose tolerance of mice and regulate blood sugar, and therefore the cyclocarya paliurus extract can be used for preparing drugs for preventing and treating diabetes, and the direction is pointed out for further developing and utilizing the medical value of cyclocarya paliurus.

Description

technical field [0001] The invention relates to an extract of Cyclocarya paliurus and its application, in particular to an extract containing non-polar compounds extracted from Cyclocarya paliurus and its application in treating diabetes, which belongs to the technical field of medicine preparation. Background technique [0002] Diabetes mellitus is a syndrome of sugar, fat, and protein metabolism disorders caused by insufficient insulin secretion or utilization. In recent years, the incidence of diabetes has increased year by year. It is one of the main causes of human death and seriously endangers human health. The number of people with prediabetes and diabetes is increasing rapidly year by year. According to the World Health Organization, there are currently more than 200 million people worldwide with diabetes (http: / / www.who.int / diabetes), and it is conservatively estimated that by 2025, the number of people with diabetes worldwide will exceed 300 million. Just taking ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K31/454A61K31/21A61K31/13A61K31/23A61K31/225A61K31/045A61K31/08A61K31/01A61P3/10
Inventor 黄晓航王庆华边际
Owner 黄晓航
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