62 results about "Morpholine hydrochloride" patented technology

The invention discloses a composite for preventing and controlling an agricultural bacterial disease, and belongs to the technical field of plant protection pesticides. The composite comprises an active component A and an active component B, wherein the active component A is benziothiazolinone; the active component B is one or two of cymoxanil, qingkuling, yekuzuo, bismerthiazol, ethylicin, thiram, dioctyl divinyltriamino glycine, active ester, metalaxyl, chlorothalonil, dithiocyano-methane, bromine chlorine hydantoin, 2-bromine-2-nitryl-1,3-propylene glycol and moroxydine hydrochloride; the weight ratio of the active component A to the active component B is 1:100 to 100:1. The composite disclosed by the invention obtains the synergetic effect through the mixing of the benziothiazolinone and other bacterial medications and is used for agricultural production.

The invention relates to a plant disease-controlling composition and disease-controlling pesticides. The composition comprises methyl thiadiazole induced amine and moroxydine hydrochloride according to the weight proportion of 1:50 to 50:1, and preferably, the compositional proportion is 1:30 to 30:1. After being blended, the two components with different mechanisms and patterns of action can produce a remarkable synergistic effect. The composition and acceptable auxiliary components in pesticides can be combined to form a variety of available disease-controlling pesticides in the common agent form, and the composition is suitable for controlling the viral diseases of crops such as tobacco, capsicum, tomato and cucumber, can effectively reduce the dosage of each single agent, helps to broaden the application range for control, delays the generation of the pesticide resistance of plants, prolongs the durability, and has a significant popularization value.

The invention provides a preparation method of a completely new gel form, namely a critical gel, wherein with carboxymethyl chitin as a raw material and natural and non-toxic amino acid, namely lysine, as a modifying substance, the critical gel is prepared under the catalytic action of a coupling reagent, namely 4-(4,6-dimethoxytriazin-2-yl)-4-methyl morpholine hydrochloride (DMTMM). The gel has the main characteristic that the gel can constantly keep viscous modulus and elasticity modulus equal, which is to say the gel possesses two properties, namely high viscosity and high elasticity. The modified gel, which is under a 'critical state', can achieve terminal sterilization, prolong an in vivo residue time and achieve single-dose injection; with the application of the non-toxic amino acid modifying substance, the intrinsic biocompatibility and bio-activity of the carboxymethyl chitin are reserved, and all potential risks are avoided; since the viscous modulus and the elasticity modulus are simultaneously increased and are constantly kept equal, the viscoelasticity of the carboxymethyl chitin is enhanced; and meanwhile, the original liquid state of the carboxymethyl chitin is kept, so that pain in injection can be relieved easily.

The invention discloses a compound isatic root injection for animals and preparation technology, which is characterized by the following: allocating main medicine, adjunct and dissolvent; choosing the main medicine from isatic root, linbevelin, moroxydine and amantadine hydrochloride; choosing the adjunct from anti-oxidant, metal chelating agent and dissolvent for injection. This invention possesses advanced productive technology and long shelf life.

The invention discloses a synthetic process of methylacrolein. The synthetic process is characterized in that the methylacrolein is synthesized by adopting paraformaldehyde and propionaldehyde under the condition of taking a morpholine hydrochloride solution as a catalyst, and controlling the reaction temperature and the proportion of all reactants. The methylacrolein synthesized by adopting the process has the yield of 97 percent or more, the purity is equal to or greater than 97 percent and the selectivity is close to 100 percent; meanwhile, the catalyst can be recycled for 20 times or more at least; the problems that the yield and the selectivity cannot be combined, the recycling of the catalyst is poor, and the methyla crolein quality is poor in a traditional method are solved.

The invention discloses a method for synthesizing an aprepitant intermediate (2R, 3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyoxyl]-3-(4-fluorophenyl)-morpholine hydrochloride I. The method comprises the following steps: performing a condensation reaction on the raw materials 4-benzyl-2-hydroxy-morpholine-3-one II and (R)-1-[3,5-bi(trifluoromethyl)phenyl]ethanol III in the presence of a catalyst to obtain a compound IV, adding a Grignard reagent to the obtained compound IV for having a Grignard reaction and converting the compound IV into a compound V under a reduction condition, and performing a hydrochlorination reaction on the obtained compound V to obtain the target compound I. The method is simple in preparation flow and suitable for industrial production, and has the advantages of high total recovery, convenient intermediate purification, high target product purity and the like.

The invention relates to a Dufulin-containing ultra low volume liquid formulation, which is prepared by using Dufulin or Dufulin and an active component II as active components and adding an auxiliary agent and a solvent. The active component II is any one selected from the group consisting of ningnanmycin, moroxydine hydrochloride, amino-oligosaccharin, chlorobromoisocyanuric acid and lentinan. The invention has advantages of simple processing, high work efficiency, water conservation, long persistent period, targets which are not easy to generate drug resistance, low environmental pollution, synergist effects and the like. Through ultra low volume spray, low volume spray or ultra low volume static electro-spray, a plurality of diseases of crops such as paddy rice, tobacco, corn, cotton, orange, capsicum, tomato, rape and the like can be prevented and cured.

The invention relates to a medicinal composition for treating fowl pox, which is characterized by comprising the following medicaments in part by weight: 2 to 5 parts of honeysuckle, 2 to 5 parts of fructus forsythiae, 2 to 5 parts of isatis root, 2 to 5 parts of red paeony root, 1 to 3 parts of periostracum cicada, 1 to 3 parts of liquoric root, 2 to 5 parts of the root of kudzu vine, 1 to 3 parts of bamboo leaf and 1 to 3 pars of Platycodon grandiflorum. The preparation method comprises: weighing the medicaments serving as raw materials in part by weight; crushing and sieving to obtain 60 to 200 mesh powder; and filling separately to obtain finished products. At present, western medicines for treating fowl pox, such as moroxydine hydrochloride and virazole are prohibited from being used by the agricultural department and the traditional Chinese medicines do not deliver a desirable effect, and thus, the fowl pox causes big economic loss to the breeding department. The medicament, which is a pure traditional Chinese medicinal preparation, avoids medicament residue and toxic and side effects on organisms.

The invention discloses a moroxydine hydrochloride purity standard substance as well as a preparation method and application thereof. The preparation method comprises the following steps: 1) samplingmoroxydine hydrochloride raw material powder, and measuring the mass percentage content of the moroxydine hydrochloride in the moroxydine hydrochloride raw material powder by a high-performance liquidchromatography area normalization method to obtain the purity definite value of the moroxydine hydrochloride raw material powder; 2) measuring the water mass percentage content, the non-volatile impurity mass percentage content and the organic volatile impurity mass percentage content of the moroxydine hydrochloride raw material powder, and performing calculation by combining the purity definitevalue of the moroxydine hydrochloride raw material powder measured in the step 1) and according the following formula I to obtain the moroxydine hydrochloride purity standard substance with the definite value, wherein the formula I is P=[100%-Xw-Xn-Xv]*100%. The moroxydine hydrochloride purity standard substance can serve as a standard substance, is applied to detection on medicine residue in livestock products, and provides technical support and substance guarantee for establishment of a national agricultural product quality safety risk evaluation, monitoring and tracing system.

The invention provides an acne removing preparation with no side effect and good curative effect. The preparation comprises the following components in percentage by weight: 28-56 percent of ketoconazole and clobetasol propionate cream, 20-28 percent of lincomycin hydrochloride gel, 8-20 percent moroxydine hydrochloride, 4-10 percent of metronidazole and 10-40 percent of traditional Chinese medicinal extract, wherein the traditional Chinese medicinal extract comprises extract of white peony root, white poria, bighead atractylodes rhizome and angelica root. The acne removing preparation is effectively combined with traditional Chinese medicines and western medicines, can be used for quickly removing pox and acne, and has the effect of whitening.

The invention discloses an efficient aprepitant preparation process. The preparation process comprises the steps that firstly, a 2R-[1R-[3,5-difluoromethyl / trifluoromethyl phenyl] ethoxy)-3S-(4-fluorophenyl)-4-(N-methoxycarbonyl group-2-aminohydrazonyl)-morpholine is prepared from a (2R,3S)-2-[(1R)-1-[3,5-difluoromethyl / trifluoromethyl phenyl] ethoxy]-3-(4-fluorophenyl)-morpholine hydrochloride; an aprepitant crude is prepared from the 2R-[1R-[3,5-difluoromethyl / trifluoromethyl phenyl] ethoxy)-3S-(4-fluorophenyl)-4-(N-methoxycarbonyl group-2-aminohydrazonyl)-morpholine; then the aprepitant crude is refined and an aprepitant finished product is obtained. According to the efficient aprepitant preparation process, the prepared aprepitant has the advantages of high recovery rate, good efficacy, low cost of the whole process, safety and no pollution.

The invention belongs to the field of pesticides, and discloses a medicament composition for preventing a maize rough dwarf disease. The effective ingredients are as follows: 10-40 parts of imidacloprid by weight, 5-15 parts of thiamethoxam by weight, 5-15 parts of moroxydine hydrochloride by weight, and 1.5-5 parts of zinc element by weight. Via the fact that the medicament composition for preventing the maize rough dwarf disease is mixed with seeds, the medicament with a strong systemic property is transmitted to each tissue of maize through the germination of seeds. The insects with a sucking mouthpart, such as plant hoppers and aphids, are prevented from invading the maize, so that a medium for spreading virus diseases is blocked. The moroxydine hydrochloride and the zinc element can play a role in preventing and treating the virus diseases. Due to the prophase seed dressing treatment, the times of spraying an insecticide by a farm worker are reduced, the labor and the cost are saved, and moreover, the pollution is decreased. Meanwhile, owing to the capability of improving the germination percentage of the maize, promoting the growth of the maize, causing the steams and the leaves of the maize to keep thickly green, enhancing the premunition of the maize, and increasing the yield, the medicament composition for preventing the maize rough dwarf disease has an abroad application prospect. The dosage form of the medicament composition for preventing the maize rough dwarf disease is low in cost and convenience in manufacture and use, as wettable powder.

The invention discloses a method for detecting an aprepitant intermediate. According to the method, a liquid chromatograph is adopted for detection, quantitative analysis is implemented by using an area normalization method, and spectrum conditions are as follows: a C18 spectrum column is adopted as a spectrum column; the feeding amount is 15-25mu l; the flowing speed is 0.8-1.2ml / minute; the column temperature is 25-35 DEG C; the detection wavelength is 210-220nm; the mobile phase includes a mobile phase 0.1-0.3% monopotassium phosphate solution of which the pH value is 7.0, and a mobile phase B acetonitrile; the volume ratio of the mobile phase A to the mobile phase B is (15-25):(75-85); acetonitrile is adopted as a dilution liquid; and a ultraviolet detector is adopted as a detector. The method disclosed by the invention is simple and rapid, accurate testing on (2R,3S)-2-[(1R)-1-[3,5-bi(trifluoromethyl) phenyl] ethyoxyl]-3-(4-fluorophenyl) morpholine hydrochloride is achieved, and very high sensitivity is achieved.

The invention discloses a detoxification drug for asexual reproduction of sugar cane and chewing cane as well as a detoxification method. The detoxification drug is prepared by mixing gibberellins, acetylsalicylic acid and moroxydine hydrochloride, and is made into liquid drug; and seeds are soaked in the liquid drug. The detoxification drug has the advantages that the detoxification effect is better; the yield of the detoxified sugar crane can be increased by more than 70%; the effect of increasing the yield and the income is remarkable; the detoxification liquid drug is not restricted by temperature when in use, and all that is needed is to soak a stalk section of sugar crane into the liquid drug and plant the stalk section; the survival rate is high; the use is convenient; and the detoxified sugar crane has excellent agronomic characters.

The invention discloses a synthetic method of moroxydine hydrochlofide. The method comprises the following steps: adding diglycol, dicyandiamide, ammonium chloride and an aqueous sulfuric acid solution with the mass concentration of 20-30% to a high pressure reaction kettle according to amass ratio of (4-6):(4-6):(2-4):(1-2), heating the obtained solution in a sealed and stirring state to 120-130DEG C, reacting under a reaction kettle pressure of 0.3-0.5MPa for 1-2h, and cooling the obtained solution to room temperature to obtain a white milk; and transferring the white milk to a reaction kettle, adding 95% ethanol according to a volume ratio of the 95% ethanol to diglycol of (7-9):1, carrying out a heating refluxing reaction for 30min to obtain a mixed solution, carrying out hot filtration on the mixed solution through a filter cylinder to a crystallization kettle, cooling the obtained filtrate in the crystallization kettle to room temperature to precipitate white crystals, centrifuging and separating the white crystals, and drying the separated white crystals in a hot wind oven at 80-85DEG C to obtain moroxydine hydrochlofide.. Moroxydine hydrochlofide is obtained through a direct reaction of dicyandiamide and morpholine hydrochloride generated through in situ reaction of diglycol and ammonium chloride under the action of sulfuric acid, so the synthetic method is simplified, side reactions are reduced, the yield is improved, and environment is protected.

The invention discloses a method for detecting the residual quantity of morpholine in a bulk drug and application of the method, and relates to the technical field of medicine analysis and detection. The bulk drug is moroxydine or moroxydine hydrochloride. The detection method detects the residual quantity of morpholine in the bulk drug through pre-column derivatization and high performance liquid chromatography. The method comprises the following steps: dissolving a bulk drug sample by use of a diluent to obtain a diluted solution, adding an acid-binding agent and a derivatization reagent into the diluted solution, carrying out a derivatization reaction to obtain the morpholine derivative, analyzing the content of the morpholine derivative by using a high performance liquid chromatograph, and carrying out simple conversion to obtain the content of morpholine in a sample. The method is high in sensitivity and accurate in detection data. The problems of serious trailing and low sensitivity when the morpholine content is detected by the existing gas chromatography are solved.

The invention provides an acne-removing medicine formula, and relates to the technical field of pharmacy. The acne-removing medicine formula comprises the following medicines in parts by mass: 2-7 parts of lincomycin hydrochloride gel, 10-20 parts of compound ketoconazole ointment, 1-1.5 parts of dexamethasone acupuncture agent, 2.7-3.8 parts of moroxydine hydrochloride, 1.5-3.2 parts of cefalexin capsules, 0.8-1.4 parts of metronidazole tablets, 0.03-0.5 part of acyclovir, 0.2-0.8 part of carbomer, sodium hydroxide, a humectant, a solubilizer, an antioxidant and a preservative. The problem that acne-removing medicines or diet conditioning time is long in the prior art is solved; mixed jelly of the lincomycin hydrochloride gel, the compound ketoconazole ointment and the dexamethasone acupuncture agent is prepared by mixing and stirring the lincomycin hydrochloride gel, the compound ketoconazole ointment and the dexamethasone acupuncture agent, and the acne-removing medicine is prepared by mixing the mixed jelly with mixed gel of the cefalexin capsules, the moroxydine hydrochloride tablets, the metronidazole tablets and the acyclovir. The acne-removing medicine can remove acnes efficiently, is obvious in effect and short in time, and is beneficial to popularization.

The invention belongs to the technical field of rhinitis treatment medicaments, and particularly relates to a rhinitis spray suitable for children and a preparation method thereof. The rhinitis spray suitable for children is prepared from chlorpheniramine maleate injection, moroxydine hydrochloride injection, a traditional Chinese medicine extracting solution and other components according to a certain proportion. The chlorpheniramine maleate contained in the chlorpheniramine maleate injection can be used for treating the allergic rhinitis and improving the symptoms of the rhinitis; the moroxydine hydrochloride injection is mainly used for sterilizing in the spray and has an inhibiting effect on each stage of a virus proliferation period; the traditional Chinese medicine extracting solution has obvious effects of dispelling wind and clearing heat, freeing lung and opening orifices and protecting nasal mucosa, and is mainly used for treating secondary symptoms such as damp-heat, nasal mucosa injury and lung function decline caused by rhinitis, so that the rhinitis spray suitable for children has the effect of treating both symptoms and root causes, does not contain components uncomfortable for children, and has a remarkable treatment effect on children rhinitis.

The invention relates to a preparation method of 1, 2-ring ding hydroxylamine and mainly solves the technical problems existing in an existing synthetic process that the path is long, the yield coefficient is low, the reaction is not easy to control, the experimental operation is inconvenient to conduct and the like. According to the preparation method of the 1, 2-ring ding hydroxylamine, N- tertiary-butoxyocarbonyl- hydroxylamine hydrochloride and 1, 4- dibromobutane are used as raw materials, potassium tert-butoxide is used as alkali, tetrahydrofuran is used as solvent, and the 1, 2-ring ding hydroxylamine is prepared under the condition of heating reflux for 12 hours. The equation is as follows: the 1, 2-ring ding hydroxylamine obtained by the preparation method of the 1, 2-ring ding hydroxylamine is a useful intermediate body or a product synthesized by a lot of drugs.

The invention provides an organic mulch. Raw materials comprise 60-80 parts of wood waste, 20-35 parts of diatomite, 7-10 parts of ginkgo leaves, 7-10 parts of locust tree leaves, 10-15 parts of soybean meal, 15-18 parts of polyacrylic acid super absorbent fibers and 0.015-0.05 part of a composite insecticidal regulator; wherein the composite insecticidal regulator comprises a chlorinated thiazoleinsecticide, celastrus angulatus, moroxydine hydrochloride and brassinolide. The organic mulch provided by the invention has significant effects on reducing the occurrence of coccids and controllingcoccids.

The invention belongs to the field of traditional Chinese medicine, and particularly relates to a cold clearing capsule and a preparation method thereof. The cold clearing capsule comprises the following components by weight: 900-980 parts of cusiae, 300-500 parts of folium isatidis, 620-700 parts of bidens biternata, 820-900 parts of holly root, 420-500 parts of screwtree root, 20-60 parts of andrographis leaf powder, 20-28 parts of acetaminophen, 20-28 parts of moroxydine hydrochloride, 5-15 parts of talc, 5-15 parts of magnesium stearate, 3-5 parts of sorbitol, 3-5 parts of ginger juice, 1-3 parts of chicory powder, 1-3 parts of honey and 0.5-1.5 parts of chlorpheniramine maleate. The cold clearing capsule adopts the combination of Chinese and western components, has the functions of dispelling wind diaphoresis and clearing away heat and toxic materials, and is stable and remarkable in effect. The preparation process is simple, low in cost and fewer in side effect.

The invention belongs to the technical field of pharmaceutical production, and relates to a preparation method of fosaprepitant dimeglumine intermediates. The technical scheme of the preparation method is particularly as follows: 3-chloromethyl-1,2,4-triazolin-5-one and a phosphine acylating reagent are subjected to a phosphine acylation reaction under the catalysis of alkali; and under the action of alkali, a product of the phosphine acylation reaction is reacted with [2R-2 alpha (R), 3 alpha]-2-[1-(3,5-di(trifluoromethyl) phenyl] ethoxy]-3-(4-fluorophenyl)-3-morpholine hydrochloride so as to generate a target compound. The phosphine acylation reaction in the technical scheme is simple in operation, mild in reaction condition, high in yield, good in product purity, and simple and efficient in post-processing; and the selected raw materials are stable in physical and chemical properties, convenient to control, low in price and easy to obtain, therefore, the method has a large implementation value, and is suitable for industrialized mass production.

The invention discloses a Brazil cherry seed treating agent for preventing and treating a drupe necrotic ring spot disease. The Brazil cherry seed treating agent comprises the following components in parts by weight: 100 parts of a 25wt% sodium carbonate solution, 23-30 parts of ferrous nitrate, 20-30 parts of cellulose, 3-10 parts of moroxydine hydrochloride, 2-5 parts of glutathione and 0.02-0.5 part of hydroxyethanediphosphonic acid sodium salt. The Brazil cherry seed treating agent for preventing and treating the drupe necrotic ring spot disease, disclosed by the invention, can be used for softening and disorganizing cell walls of a Brazil cherry seed by performing targeted cell wall tissue dissociation according to the structural tissues of the Brazil cherry seed, the activity of the seed is not affected and the sprouting rate is above 92%; meanwhile, the Brazil cherry seed treating agent also has an effect of preventing and treating the drupe necrotic ring spot disease.

The invention relates to a synthesis method of a pharmaceutical intermediate 2-hydroxymorpholine hydrochloride, using hydrochloride as a raw material, under the action of solvent acetone, first reacting with morphine at a temperature of 100°C-130°C, and then passing methyl into 2-hydroxymorpholine hydrochloride. The synthesis method of the pharmaceutical intermediate 2-hydroxymorpholine hydrochloride of the present invention is simple, efficient and safe in operation, and is very practical in specific production.

The invention relates to an amprolium hydrochloride-ethopabate-sulfaquinoxaline medicine composition powder which is added with sodium carbonate as a cosolvent of sulfaquinoxaline, and aims to solve the problem of solubility. Aerosol is added as an anti-caking agent for reducing the air-slaking and caking phenomenon in the storage process and prolonging the effective period; meanwhile with addition of a sweet wormwood extract and / or antifebrile dichroa extract with anti-coccidium active components, the relative weight increase rate of chicken is increased, the oocyst discharge rate is reduced, and the intestinal tract diseases are reduced. The invention further relates to a preparation method of the medicine composition powder. The preparation method is simple to operate, free of residue in the preparation process, and capable of effectively preparing an amprolium hydrochloride-ethopabate-sulfaquinoxaline composition which is good in solubility, free of slaking or caking in the storage process, good in treatment effect and long in expiry date. The medicine composition powder is applied to preparation of medicines for treating avian coccidiosis and is remarkable in medicine effect.

The invention discloses a zwitterionic amino polyfluorene derivative and a synthesis method and application thereof. The preparation method comprises the following steps: heating morpholine hydrochloride and potassium hydroxide for reflux reaction under the protection of an inert gas, recrystallizing a crude reaction product to obtain ethyl morpholine substituted dibromofluorene monomer; in the presence of a palladium catalyst, starting from a cyclic compound monomer with two brominated ends to obtain a cyclic compound monomer with boric acid ester; reacting the ethyl morpholine substituted dibromofluorene monomer with the cyclic compound monomer with the boric acid ester under the protection of the inert gas, cooling, taking an oil layer to drip into a non-polar solvent to obtain precipitation to obtain a neutral conjugated polymer, and processing by sulfonating and post processing to obtain the zwitterionic amino polyfluorene derivative. The zwitterionic amino polyfluorene derivative can be processed by using an environmental protection solvent such as water, alcohol and the like for dissolving, greatly reduces the pollution to the environment of solar cells, has a regular planar structure, good thermal stability and good adaptability to environment, and is easy in film processing.

The invention discloses a Brazil cherry seed treating agent for preventing and treating a little fruit disease of cherry. The Brazil cherry seed treating agent comprises the following components in parts by weight: 100 parts of acetic acid, 34-38 parts of yeast cell wall polysaccharide, 12-20 parts of citric acid, 10-15 parts of glutathione, 10-15 parts of ferrous nitrate and 0.5-2 parts of moroxydine hydrochloride. The Brazil cherry seed treating agent for preventing and treating the little fruit disease of the cherry, disclosed by the invention, can be used for softening and disorganizing cell walls of a Brazil cherry seed by performing targeted cell wall tissue dissociation according to the structural tissues of the Brazil cherry seed, the activity of the seed is not affected and the sprouting rate is above 92%; meanwhile, the Brazil cherry seed treating agent also has an effect of preventing and treating the little fruit disease of the cherry.

The invention discloses a synthetic method of moroxydine hydrochlofide. The method comprises the following steps: adding diglycol, dicyandiamide, ammonium chloride and an aqueous sulfuric acid solution with the mass concentration of 20-30% to a high pressure reaction kettle according to amass ratio of (4-6):(4-6):(2-4):(1-2), heating the obtained solution in a sealed and stirring state to 120-130DEG C, reacting under a reaction kettle pressure of 0.3-0.5MPa for 1-2h, and cooling the obtained solution to room temperature to obtain a white milk; and transferring the white milk to a reaction kettle, adding 95% ethanol according to a volume ratio of the 95% ethanol to diglycol of (7-9):1, carrying out a heating refluxing reaction for 30min to obtain a mixed solution, carrying out hot filtration on the mixed solution through a filter cylinder to a crystallization kettle, cooling the obtained filtrate in the crystallization kettle to room temperature to precipitate white crystals, centrifuging and separating the white crystals, and drying the separated white crystals in a hot wind oven at 80-85DEG C to obtain moroxydine hydrochlofide.. Moroxydine hydrochlofide is obtained through a direct reaction of dicyandiamide and morpholine hydrochloride generated through in situ reaction of diglycol and ammonium chloride under the action of sulfuric acid, so the synthetic method is simplified, side reactions are reduced, the yield is improved, and environment is protected.