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Rhinitis spray suitable for children and preparation method thereof

A technology of rhinitis and spray, which is applied in the field of rhinitis spray and its preparation, can solve the problem of single curative effect of rhinitis treatment drugs, achieve remarkable therapeutic effect, protect nasal mucosa, and improve symptoms

Pending Publication Date: 2022-01-28
栗明峰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention aims to provide a rhinitis spray suitable for children and its preparation method, which solves the technical problem of single curative effect of rhinitis treatment drugs in the prior art

Method used

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  • Rhinitis spray suitable for children and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A kind of rhinitis spray suitable for children, this rhinitis spray suitable for children is formulated by the raw material medicine of following weight ratio:

[0033] Chlorpheniramine maleate injection 1-2mL, containing 10-20mg chlorpheniramine maleate;

[0034] Morpholine hydrochloride injection 1-3mL, containing morpholine hydrochloride 50-150mg;

[0035] 3-6 mL of Chinese medicine extract, which is prepared from Bupleurum, Angelica, Magnolia, Shichangpu, Xanthium, Ephedra, Scutellaria, Asarum, and Dandelion. The preparation method of the Chinese medicine extract is as follows: take 1000g of Bupleurum radix, 500g of Angelica dahurica, 500g of Magnolia magnolia, 400g of Shichangpu, 400g of cocklebur, 50g of ephedra, 100g of scutellaria baicalensis, 100g of asarum, and 300g of dandelion, cut into 0.5-2mm fragments, add water Soak, steam distill, collect the initial distillate, and then redistill, collect the heavy distillate, add 80 3g of polysorbate, stir to dissolv...

Embodiment 2

[0038] A rhinitis spray suitable for children is different from Example 1 in that the rhinitis spray suitable for children in the present embodiment is formulated with the raw material drug in the following weight ratio:

[0039]Chlorpheniramine maleate injection 1mL, containing chlorpheniramine maleate 10mg;

[0040] Morpholine hydrochloride injection 2mL, containing morpholine hydrochloride 100mg;

[0041] Chinese medicine extract 4mL.

[0042] Wherein, the preparation method of the Chinese medicine extract in the present embodiment is as follows: get Bupleurum 800g, Angelica dahurica 400g, Magnolia magnoli 400g, Shichangpu 300g, Xanthium 300g, Ephedra 30g, Scutellaria baicalensis 80g, Asarum 80g, Dandelion 200g, cut respectively into 0.5mm fragments, soaked in water, steam distilled, collected the first distillate, and redistilled again, collected the heavy distillate, added polysorbate 80 2g, stirred to completely dissolve the liquid, then added 7g of sodium chloride, aft...

Embodiment 3

[0045] A rhinitis spray suitable for children is different from Example 1 in that the rhinitis spray suitable for children in the present embodiment is formulated with the raw material drug in the following weight ratio:

[0046] Chlorpheniramine maleate injection 1mL, containing chlorpheniramine maleate 10mg;

[0047] Morpholine hydrochloride injection 3mL, containing morpholine hydrochloride 150mg;

[0048] Chinese medicine extract 6mL.

[0049] Wherein, the preparation method of the Chinese medicine extract in the present embodiment is as follows: get Bupleurum 1200g, Angelica dahurica 600g, Magnolia magnoli 600g, Shichangpu 500g, Xanthium 500g, Ephedra 70g, Scutellaria baicalensis 120g, Asarum 120g, Dandelion 400g, cut respectively into 2mm fragments, soaked in water, steam distilled, collected the initial distillate, and redistilled again, collected the heavy distillate, added polysorbate 80 4g, stirred to completely dissolve the liquid, then added 11g of sodium chloride...

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Abstract

The invention belongs to the technical field of rhinitis treatment medicaments, and particularly relates to a rhinitis spray suitable for children and a preparation method thereof. The rhinitis spray suitable for children is prepared from chlorpheniramine maleate injection, moroxydine hydrochloride injection, a traditional Chinese medicine extracting solution and other components according to a certain proportion. The chlorpheniramine maleate contained in the chlorpheniramine maleate injection can be used for treating the allergic rhinitis and improving the symptoms of the rhinitis; the moroxydine hydrochloride injection is mainly used for sterilizing in the spray and has an inhibiting effect on each stage of a virus proliferation period; the traditional Chinese medicine extracting solution has obvious effects of dispelling wind and clearing heat, freeing lung and opening orifices and protecting nasal mucosa, and is mainly used for treating secondary symptoms such as damp-heat, nasal mucosa injury and lung function decline caused by rhinitis, so that the rhinitis spray suitable for children has the effect of treating both symptoms and root causes, does not contain components uncomfortable for children, and has a remarkable treatment effect on children rhinitis.

Description

technical field [0001] The invention belongs to the technical field of medicaments for treating rhinitis, and in particular relates to a rhinitis spray suitable for children and a preparation method thereof. Background technique [0002] Rhinitis refers to the inflammation of nasal mucosa and submucosal tissue, which is generally caused by the stimulation of viral infection, genetic factors, antigenic substances, etc. Among them, viral infection is the primary cause of rhinitis, or secondary bacterial infection on the basis of viral infection. It is known that more than 100 viruses can cause rhinitis, the most common is rhinovirus, followed by influenza and parainfluenza virus, adenovirus Viruses, coronaviruses, Coxsackie viruses, mucus and paramyxoviruses, etc., are mainly transmitted through respiratory inhalation, followed by entering the body through contaminated bodies or food. [0003] Symptoms of rhinitis usually manifest as congestion or edema. Patients often experi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/888A61K9/12A61P11/02A61P29/00A61K31/4402A61K31/5375
CPCA61K36/233A61K36/232A61K36/575A61K36/888A61K36/28A61K36/17A61K36/539A61K36/268A61K36/288A61K31/4402A61K31/5375A61K9/12A61K47/26A61P11/02A61P29/00A61K2236/15A61K2236/331A61K2236/53
Inventor 栗明峰
Owner 栗明峰
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