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Amprolium hydrochloride-ethoxyabate-sulfaquinoxaline pharmaceutical composition powder and its preparation

A technology for ethoxybenzamide and amprolium hydrochloride, applied in the field of poultry medicine, can solve the problems of solvent residue, soluble powder easy deliquescence agglomeration and the like, achieve long validity period, improve deliquescence and agglomeration phenomenon, increase relative weight gain rate effect

Active Publication Date: 2018-05-29
LUOYANG HUIZHONG ANIMAL MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In this patent, the preparation process of ethopabate solid dispersion easily leads to solvent residue, and fails to solve the problem of deliquescent agglomeration of soluble powder
[0006] The problem at present is that it is necessary to develop a kind of amprolium hydrochloride, ethopabate, sulfaquine with good solubility, no residue in the preparation process, deliquescent caking phenomenon in the storage process, good therapeutic effect and long validity period Oxaline pharmaceutical composition powder and preparation method thereof

Method used

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  • Amprolium hydrochloride-ethoxyabate-sulfaquinoxaline pharmaceutical composition powder and its preparation
  • Amprolium hydrochloride-ethoxyabate-sulfaquinoxaline pharmaceutical composition powder and its preparation
  • Amprolium hydrochloride-ethoxyabate-sulfaquinoxaline pharmaceutical composition powder and its preparation

Examples

Experimental program
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Effect test

Embodiment 1

[0037] A amprolium hydrochloride ethopabate sulfaquinoxaline soluble powder, comprising the following components in parts by weight: 20 parts of amprolium hydrochloride, 1 part of ethopabate, 12 parts of sulfaquinoxaline , 15 parts of sodium carbonate, 0.5 parts of micronized silica gel.

[0038] 1. Weigh 1g of ethopabate and 0.5g of micropowder silica gel, mix and pulverize through an 80-mesh sieve, and set aside;

[0039] 2. Mix the above crushed and sieved ethopabate and micropowder silica gel with 20g amprolium hydrochloride, 12g sulfaquinoxaline, and 15g sodium carbonate to obtain amprolium hydrochloride ethopabate sulfaquine Oxaline Soluble Powder.

Embodiment 2

[0041] A amprolium hydrochloride ethopabate sulfaquinoxaline soluble powder, comprising the following components in parts by weight: 25 parts of amprolium hydrochloride, 1.2 parts of ethopabate, 15 parts of sulfaquinoxaline , 20 parts of sodium carbonate, 10 parts of Artemisia annua extract, 1 part of micronized silica gel.

[0042]1. Weigh 1.2g of ethopabate and 1g of micropowder silica gel, mix and pulverize through an 80-mesh sieve, and 10g of Artemisia annua extract, pulverize through an 80-mesh sieve, and set aside;

[0043] 2. Mix the above pulverized and sieved ethopabate, micropowder silica gel, Artemisia annua extract, 25g amprolium hydrochloride, 15g sulfaquinoxaline, and 20g sodium carbonate to obtain amprolium hydrochloride ethoxyamide Benzyl Sulfaquinoxaline Soluble Powder.

Embodiment 3

[0045] A amprolium hydrochloride ethopabate sulfaquinoxaline soluble powder, comprising the following components in parts by weight: 25 parts of amprolium hydrochloride, 1.2 parts of ethopabate, 15 parts of sulfaquinoxaline , 20 parts of sodium carbonate, 20 parts of Artemisia annua extract, 1 part of micronized silica gel.

[0046] 1. Weigh 1.2g of ethopabate and 1g of micropowder silica gel, mix and pulverize through an 80-mesh sieve, and 20g of Artemisia annua extract pulverize through an 80-mesh sieve for later use;

[0047] 2. Mix the above pulverized and sieved ethopabate, micropowder silica gel, Artemisia annua extract, 25g amprolium hydrochloride, 15g sulfaquinoxaline, and 20g sodium carbonate to obtain amprolium hydrochloride ethoxyamide Benzyl Sulfaquinoxaline Soluble Powder.

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Abstract

The invention relates to an amprolium hydrochloride-ethopabate-sulfaquinoxaline medicine composition powder which is added with sodium carbonate as a cosolvent of sulfaquinoxaline, and aims to solve the problem of solubility. Aerosol is added as an anti-caking agent for reducing the air-slaking and caking phenomenon in the storage process and prolonging the effective period; meanwhile with addition of a sweet wormwood extract and / or antifebrile dichroa extract with anti-coccidium active components, the relative weight increase rate of chicken is increased, the oocyst discharge rate is reduced, and the intestinal tract diseases are reduced. The invention further relates to a preparation method of the medicine composition powder. The preparation method is simple to operate, free of residue in the preparation process, and capable of effectively preparing an amprolium hydrochloride-ethopabate-sulfaquinoxaline composition which is good in solubility, free of slaking or caking in the storage process, good in treatment effect and long in expiry date. The medicine composition powder is applied to preparation of medicines for treating avian coccidiosis and is remarkable in medicine effect.

Description

technical field [0001] The invention belongs to the technical field of poultry medicine, and relates to an amprolium hydrochloride-ethoxyabate-sulfaquinoxaline pharmaceutical composition powder and a preparation method thereof. Background technique [0002] The drug combination of amprolium hydrochloride, ethopabate, and sulfaquinoxaline is one of the most commonly used formulas for the prevention and treatment of poultry coccidiosis, and it has a good effect on chicken cecal coccidiosis and small intestinal coccidiosis. The three drugs have a synergistic effect on each other, can expand the scope of coccidiosis resistance, are safe and effective, can delay the occurrence of drug resistance, and play a huge role in the prevention and treatment of coccidiosis. [0003] At present, the drug combination sold on the market is made of amprolium hydrochloride, ethopabate, and sulfaquinoxaline as a premix, which is mixed in feed for administration. The formula is: amprolium hydroch...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/635A61K47/02A61K47/04A61K36/282A61K36/185A61P33/02A61K31/618A61K31/506
CPCA61K9/143A61K31/506A61K31/618A61K31/635A61K36/185A61K36/282A61K2300/00
Inventor 张许科刘兴金张晓会
Owner LUOYANG HUIZHONG ANIMAL MEDICINE
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