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107 results about "Hydroxyapatite nanoparticles" patented technology
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Preparation method of poly (lactic acid-glycolic acid)/hydroxyapatite nanofiber compound bracket for bone repair
InactiveCN101693126AMaintain crystalline structureGood biocompatibilityNanostructure manufacturePhosphorus compoundsFiberOsteoblast
The invention discloses a preparation method of a poly (lactic acid-glycolic acid) / hydroxyapatite nanofiber compound bracket for bone repair, which comprises the following steps: adding hydroxyapatite nanoparticles into a mixed solvent of tetrahydrofuran and dimethylformamide, and then, adding poly (lactic acid-glycolic acid) to obtain a mixed solution of the hydroxyapatite and the poly (lactic acid-glycolic acid); carrying out electrostatic spinning on the mixed solution; and obtaining the poly (lactic acid-glycolic acid) / hydroxyapatite nanofiber compound bracket for bone repair. The invention has simple and convenient preparation method and wide material sources, simulates the composition and the structure of natural bones of human bodies, introduces the bioactive ceramic material hydroxyapatite into a degradable poly (lactic acid-glycolic acid) substrate to form a compound nanofiber bracket, has the advantages of good biocompatibility, excellent comprehensive performance, convenient use and the like, can effectively promote the adhesion, growth and function expression of bone cells and meet the biological requirements of the bone tissue engineering.
Owner:ZHEJIANG UNIV
Magnetic composite material and application thereof in regeneration and repair of bone tissues
ActiveCN102049066AHas superparamagnetic propertiesGood biocompatibilityTissue regenerationProsthesisHydroxybutyric acidPolyamide
The invention discloses a magnetic composite material and an application thereof in regeneration and repair of bone tissues, as well as a method for preparing the magnetic composite material and a product prepared by the magnetic composite material, wherein the magnetic composite material comprises the following components: a) 10-50g of polymer material calculated by 100ml of organic solvent, wherein the polymer material is selected from polylactic acid, polyglycolic acid, lactic acid-glycolic acid copolymer, polycaprolactone, polyamide or poly-hydroxybutyric acid; b) 10g of hydroxyapatite nano-particles calculated by 100ml of the organic solvent; and c) 2.5g of gamma-Fe2O3 nano-particles calculated by 100ml of organic solvent, wherein the organic solvent is selected from tetrahydrofuran (THF), dimethylformamide (DMF), dimethylacetamide (DMAc), chloroform or dioxane.
Owner:THE INST OF BASIC MEDICAL SCI OF CHINESE ACAD OF MEDICAL SCI
Nano-hydroxyapatite/sodium alginate composite material, preparation method and application of nano-hydroxyapatite/sodium alginate composite material
ActiveCN104117341AWide variety of sourcesLow costOther chemical processesAlkali metal oxides/hydroxidesApatiteFreeze-drying
The invention relates to a preparation method of nano-hydroxyapatite / sodium alginate composite material. The obtained material can be used for sewage treatment and used for adsorbing and removing heavy metal ions. The method comprises the following steps: quickly pouring a diammonium hydrogen phosphate aqueous solution in the aqueous solution of calcium nitrate, uniformly stirring and mixing, centrifuging to obtain a precipitate, washing the precipitate by using deionized water, re-dispersing the washed precipitate to the deionized water; adding a stabilizer in the obtained suspension, ultrasonically dispersing to obtain stable hydroxyapatite suspension; controlling the mass ratio of hydroxyapatite to sodium alginate, adding sodium alginate in the hydroxyapatite suspension; continuously heating and stirring, controlling the reaction time, evaporating water, carrying out freeze-drying to obtain the product. The preparation method has the advantages that the preparation process is simple and controllable, the raw material resource is wide, the cost is low, environment is protected, the pollution does not exist, the uniform compounding of the hydroxyapatite nano-particles and sodium alginate is realized, and the uniform dispersion and the non-reunion of the hydroxyapatite nano-particles are guaranteed.
Owner:武汉华威生物材料工程有限公司
Mesoporous hydroxyapatite nonoparticles prepared by microwave-ultrasonic method, and application thereof
The invention relates to mesoporous hydroxyapatite nonoparticles prepared by a microwave-ultrasonic method, and an application thereof. Inventors of the invention are engaged in developing novel methods for synthesizing mesoporous hydroxyapatite (MHAPN), and provide technical improvements for synthesizing the MHAPN by employing the microwave-ultrasonic method. In the method provided by the invention, no emulsifying agent or structure-directing agent is needed when the MHAPN is synthesized; and the synthesized MHAPN has good dispersibility, relatively good controlled-release effect for medicine and significant antineoplastic activity.
Owner:EAST CHINA UNIV OF SCI & TECH
Magnetic composite hydroxyapatite nanoparticles as well as preparation method and application thereof
ActiveCN104549127AImprove acid resistanceEfficient removalOther chemical processesAlkali metal oxides/hydroxidesMagnetic responsePollution
The invention discloses magnetic composite hydroxyapatite nanoparticles. The magnetic composite hydroxyapatite nanoparticles are composed of Fe3O4 nanoparticles and hydroxyapatite nanoparticles, wherein the molar ratio of the Fe3O4 to the hydroxyapatite is (1-10): 1; the magnetic composite hydroxyapatite nanoparticles are spherical aggregate or agglomerate in which the Fe3O4 nanoparticles and the hydroxyapatite nanoparticles are distributed evenly and alternately. The preparation method of the magnetic composite hydroxyapatite nanoparticles is simple; the nanoparticles are capable of efficiently removing heavy metal ions in sewage, and in the later treatment period, quick magnetic separation can be realized; the nanoparticles have the adsorbing capacity of 440mg / g to lead ions, the adsorbing capacity of 238mg / g to cadmium ions, the adsorbing capacity of 139mg / g to zinc ions and the adsorbing capacity of 135mg / g to copper ions in the sewage; the magnetic composite hydroxyapatite nanoparticles have a rapid magnetic response characteristic, and are capable of realizing rapid solid-liquid separation with an external magnetic field, and the separation process is high in separation efficiency, and simple and efficient to operate; and besides, the nanoparticles are not residual in water and do not cause secondary pollution to the water and the environment.
Owner:NINGBO UNIV
Microfluidic chip based method for synthesizing needle-like hydroxyapatite nanoparticle
InactiveCN102745660AStable generationGenerate fluencyNanotechnologyPhosphorus compoundsMicroreactorHydroxyapatite nanoparticles
Owner:DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
Polyvinyl alcohol/sodium alginate/hydroxyapatite composite fiber membrane as well as preparation method and application of polyvinyl alcohol/sodium alginate/hydroxyapatite composite fiber membrane
ActiveCN106729928AEasy reunionImprove damage repairNon-adhesive dressingsAbsorbent padsFiberPolyvinyl alcohol
Owner:WUHAN UNIV OF TECH
Process for preparation of polycaprolactone-chitosan network/hydroxyapatite porous compound support frame material
The invention discloses a method for preparing polycaprolacton-chitosan / hydroxyapatite nanoparticles porous composite scaffold. The method comprises mixing polycaprolactone with glacial acetic acid to obtain a mixed solution, adding chitosan powder, pouring into NaOH solution, solidifying and oven-drying to obtain polycaprolactone-chitosan porous material; mixing hydroxyapatite nanoparticles to polyvinyl alcohol aqueous solution to obtain a slurry; placing the polycaprolactone-chitosan porous material in a centrifuge tube, and performing grout-filling with the slurry for 3-5 times. The produced composite scaffold has the advantages of good biological and mechanical properties and controllable porosity, and can be widely used as tissue-engineering scaffold for repairing various bone defects.
Owner:FUJIAN NORMAL UNIV
Artificial bone nanocomposite and method of manufacture
A composition suitable for bone replacement is provided. The composition is a nanocomposite matrix, resembling both the structure and the properties of natural bone, including morphology, composition and mechanical characteristics. The nanocomposite is preferably porous and comprises: (1) micro or nano scale cellulose crystals or fibres; (2) hydroxyapatite nanoparticles; (3) Poly L-Lactide Acid or poly glycolic acid; and (4) a coupling agent, for example a surfactant, preferably an anionic surfactant such as sodium dodecyl sulfate. The composition is useful as an artificial bone replacement or bone graft, is preferably biomimetic, and can be suitable for use, for example, in trabecular bone substitution and osteoanagenesis applications. A method of fabrication of the nanocomposite is also provided.
Owner:EFTEKHARI SAMIN
Composite biological medical materials of nano-hydroxy-apatite/silicon rubber and its preparation
A nano-class biomedical hydroxyapatite-silicon rubber material is prepared through dissolving silane coupling agent in water-alcohol solution, regulating pH value to 3.5-5.5, mixing with hydroxyapatite nanoparticles while stirring for surface modifying, washing the solid with deionized water, proportionally mixing it with raw silicon rubber, drying, and thermal sulfurizing.
Owner:SICHUAN UNIV
Method for preparing mesoporous hydroxyapatite nanometer particle with high specific surface area by virtue of template method
ActiveCN104192817ALarge specific surface areaIncrease loadMaterial nanotechnologyPhosphorus compoundsWater bathsApatite
The invention discloses a method for preparing a mesoporous hydroxyapatite nanometer particle with high specific surface area by virtue of a template method. The method comprises the following steps: firstly, mixing calcium pantothenate, F123 and a certain amount of sym-trimethylbenzene to prepare an emulsion and then dropwise adding a phosphate solution with a certain pH value into the emulsion, heating in a water bath, carrying out reflux reaction and filtering to obtain a precipitate and finally calcining the precipitate in a muffle furnace to remove a template to obtain the hydroxyapatite nanometer particle with a mesoporous structure. The mesoporous hydroxyapatite prepared by the method disclosed by the invention has the characteristics of high specific surface area, large drug loading amount and uniform pore size distribution and is distributed in a spherical nanometer state (the size is less than 100nm). The mesoporous hydroxyapatite serving as a drug carrier can well penetrate through blood vessels and cell walls to reach diseased cells. The entire preparation process is simple and the mesoporous hydroxyapatite can be produced in a large scale.
Owner:HARBIN INST OF TECH
Aggregation induced luminescence nanofluorescent probe and preparation method therefor
InactiveCN104845607ATo achieve the purpose of imagingEnhanced interactionLuminescent compositionsHigh concentrationApatite
The present invention discloses an aggregation induced luminescence nanofluorescent probe which coats a chitosan fluorescent molecule with the characteristic of aggregation induced luminescence on the surface of a hydroxyl apatite nanoparticle, and the structural formula of the chitosan fluorescent molecule is shown in a formula (1). The aggregation induced luminescence nanofluorescent probe is prepared by a chemical co-precipitation process. The size of the aggregation induced luminescence nanofluorescent probe is about 110 nm, the dispersion is stable, positive changes are formed on the surface thereof, and the aggregation induced luminescence nanofluorescent probe has the feature of the aggregation induced luminescence. Compared with a traditional fluorescent probe, the aggregation induced luminescence nanofluorescent probe has the advantages that the sensitivity is high, the light stability is good, and quenching does not exist during high concentration and a fluorescence spectrum is not drifted, so that the aggregation induced luminescence nanofluorescent probe can be applied to the fields of bioimaging, fluorescent tracing detection and the like. The aggregation induced luminescence nanofluorescent probe is shown in the figure below.
Owner:ZHEJIANG UNIV
Preparation method of magnetic and luminous bifunctional hydroxyapatite nanoparticle in core-shell structure
InactiveCN103820102AStable structureWith magnetic propertiesMaterial nanotechnologyInorganic material magnetismMaterials preparationRare earth ions
The invention discloses a magnetic and luminous bifunctional hydroxyapatite nanoparticle in a core-shell structure and belongs to the technical field of nano functional material preparation. According to the method, pure hydroxyapatite continues to grow on the surface of a magnetic hydroxyapatite nanoparticle by controlling a coprecipitation condition to realize hydroxyapatite thin layer coating of the magnetic particle, so that dissolving of magnetic ions (such as Fe<3+>) quenching luminescence of a rare earth ion is inhibited. Rare earth doped hydroxyapatite continues to grow on the surface of the magnetic hydroxyapatite nanoparticle with a hydroxyapatite coating layer, so that the magnetic and luminous hydroxyapatite nanoparticle in the core-shell structure is obtained. The core-shell type magnetic and luminous hydroxyapatite nanoparticle has good magnetic property, luminescence property and biocompatibility, further has target positioning and mark tracking functions, and has good application prospects in the field of biomedicine such as substance detection inside and outside a cell, nucleic acid hybridization and sequencing, early disease diagnosis, transport of gene drugs, and magnetic heat treatment.
Owner:NORTH CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY
Hydroxyapatite/chitosan-silk fibroin nanocomposite and preparation method thereof
The invention provides a hydroxyapatite / chitosan-silk fibroin nanocomposite and a preparation method thereof. The preparation method comprises the technological processes of coprecipitation reaction of a hydroxyapatite precursor in a wet state with chitosan and silk fibroin, separation of a generated precipitate from a liquid phase system, drying of the separated precipitate, subsequent processing and molding and the like. The preparation method has the advantages that hydroxyapatite nanoparticles can be ensured to uniformly disperse in a chitosan-silk fibroin composite organic matrix, so that the formed composite material not only has favorable biocompatibility and bioactivity, but also has sufficient mechanical strength and toughness; chitosan and silk fibroin are abundant in sources and low in prices, the preparation process is carried out under the conditions of normal temperature and normal pressure, thus, the operation is convenient and the cost is low. The hydroxyapatite / chitosan-silk fibroin nanocomposite prepared by the invention is an ideal new-generation substitute material for bone repair.
Owner:CHINA NAT ACAD NANOTECH & ENG
Application of needle nano-hydroxy apatite in tooth-paste
InactiveCN1751678AFix teeth wellGood anti-caries effectCosmetic preparationsToilet preparationsGlucose productionApatite
An application of the acicular hydroxyapatite nanoparticles in preparing toothpaste for repairing and strengthening tooth and preventing decayed tooth is disclosed.
Owner:JIAMUSI UNIVERSITY
Method for preparing injectable hydroxyapatite nano-composite supramolecular hydrogel
InactiveCN101554492AKeep basic featuresPreparation process safetyProsthesisPolyethylene oxideApatite
The invention relates to a method for preparing a hydroxyapatite nano-composite supramolecular hydrogel with biocompatibility. A method for preparing an injectable hydroxyapatite nano-composite supramolecular hydrogel is characterized in that the method comprises the following steps of 1) selecting, mixing and ultrasonic dispersing a polyethylene oxide-poly(propylene oxide)-polyethylene oxide triblock polymer, a hydroxyapatite nanoparticle and water with the ratio of 10-200mg:0.2-100mg:1mL, thus obtaining the suspension of the hydroxyapatite nanoparticle; 2) according to the polyethylene oxide-poly(propylene oxide)-polyethylene oxide triblock polymer, the hydroxyapatite nanoparticle, an Alpha-cyclodextrin and water with the ratio of 10-200mg:0.2-100mg:80-400mg:1mL and selecting Alpha-cyclodextrin and water to prepare the water solution of Alpha-cyclodextrin; and 3) mixing, ultrasonic dispersing and standing the suspension obtained in the step 1) and the Alpha-cyclodextrin water solution obtained in the step 2), thus obtaining the injectable hydroxyapatite nano-composite supramolecular hydrogel. The preparation process is safe, simple and effective.
Owner:WUHAN UNIV OF TECH
Preparation method of amphiphilic monodisperse hydroxyapatite monocrystal nanorod
ActiveCN102491300ARaw materials are cheap and easy to getLow costNanotechnologyPhosphorus compoundsApatitePhosphate
The invention relates to a preparation method of an amphiphilic monodisperse hydroxyapatite (HA) monocrystal nanorod. The method comprises: taking the mole ratio 1.67 of calcium element to phosphor element as a reference, taking a soluble calcium salt and a phosphate as the raw materials, adopting a surfactant 2-hydroxypropyl-beta-cyclodextrin (2-HP-beta-CD) for assisting, and employing ethanol and oleic acid as the auxiliary agents, subjecting the materials to reaction in an airtight system for synthesizing a nano-hydroxyapatite particle with good amphiphilic surface properties by controlling the reaction temperature, the reaction time and the raw material ratio, thus obtaining a monodisperse hydroxyapatite monocrystal nanorod with good amphipathy. The nanorod has a diameter of 8-12nm and a length of 150nm-250nm. The hydroxyapatite nanoparticle prepared in the invention can be applied in material outer coatings, degradable artificial bones, bone cement and other biomedical materials, and is an amphiphilic monodisperse hydroxyapatite monocrystal nanorod with excellent biological performance and physico-chemical performance, thus boasting good application prospects.
Owner:SHAANXI GIANT BIOTECHNOLOGY CO LTD
Method for preparing beta-calcium phosphate or hydroxyapatite nanoparticles
ActiveCN101811685AGood repeatabilityImprove stabilityPhosphorus compoundsCalcium hydroxideCalcium biphosphate
The invention provides a method for preparing beta-calcium phosphate or hydroxyapatite nanoparticles, which comprises: dispersing a phosphorous source in a calcium source which flows circularly in a vertical direction from micropores to make the phosphorous source and the calcium source flow in a crossed way; and allowing the phosphorous source to mix and react with the calcium source which flows across after the phosphorous source is sheared by the calcium source to prepare the beta-calcium phosphate or hydroxyapatite nanoparticles, wherein the phosphorous source is aqueous solution of phosphoric acid or ammonium dihydrogen phosphate and the calcium source is turbid liquid of calcium hydroxide. The method of the invention, which prepares the beta-calcium phosphate or hydroxyapatite nanoparticles by using a micropore dispersion method of shearing by liquid phase cross flows, has the advantages of high production cost, high productivity, simple and convenient operation, high repeatability and stability; and the method can prepare the beta-calcium phosphate or hydroxyapatite nanoparticles which have controllable size and uniform distribution.
Owner:TSINGHUA UNIV
Hydroxyapatite nanoparticle with antitumor activity, preparation method and application thereof
The invention relates to a hydroxyapatite nanoparticle with antitumor activity, a preparation method and application thereof. The invention discloses the near-spherical nano-hydroxyapatite with a particle size of 10-100nm, amorphous state and uniform particle distribution. The nanoparticle has very excellent antitumor activity and a tumor cell inactivation rate up to about 80%. The hydroxyapatite nanoparticle is prepared by a liquid phase precipitation method. The invention also discloses the use of the nanoparticle, and a pharmaceutical composition and a medicine box containing the nanoparticle.
Owner:EAST CHINA UNIV OF SCI & TECH
Shape memory-type bioactive nano particle/biodegradable polyester composite multi-scale pore biological scaffold and preparation method thereof
The invention belongs to the technical field of biomedical materials, and discloses a shape memory-type bioactive nano particle / biodegradable polyester composite multi-scale pore biological scaffold and a preparation method thereof. The method of the invention comprises the steps of: adding biodegradable shape memory polyester, hydroxyapatite nano particles and a rheology modifier to an organic solvent, and performing ultrasonic effect to obtain an oil phase; adding water to the oil phase, and performing emulsification to form water-in-oil high-internal phase emulsion; and taking the high-internal phase emulsion as an ink, adopting extrusion-type 3D printing to obtain a three-dimensional porous emulsion scaffold, and evaporating the solvent to obtain the biological scaffold. The scaffold contains a multi-scale pore structure, in which controllable micropores and macropores coexist. The porosity is higher than 85%, and the pore structures are connected to one another, so that the scaffold has excellent biocompatibility, biodegradability, biological activity, shape memory effect, and drug growth / factor loading and release, and can be applied in the field of drug controlled release and the field of tissue engineering scaffolds.
Owner:SOUTH CHINA AGRI UNIV
Mesenchymal stem cell cryopreservation liquid, cryopreservation method, preservation kit and thawing method
ActiveCN111011363AAvoid damageHigh activityDead animal preservationSkeletal/connective tissue cellsPolyvinyl alcoholMedicine
The invention provides a mesenchymal stem cell cryopreservation liquid, a cryopreservation method, a preservation kit and a thawing method, and relates to the technical field of cell biology. The mesenchymal stem cell cryopreservation liquid comprises the following components with the following working concentrations: 25-35 ml / 100ml of a mesenchymal stem cell culture supernatant; 4-6 ml / 100ml of glycerol, 4-6 ml / 100ml of polyvinylpyrrolidone, 0.5-1.5 g / 100ml of polyvinyl alcohol, 0.5-2.5 g / 100mL of trehalose, 1-2.5 g / 100mL of hydroxyapatite nanoparticles, 0.5-1.5 mg / 100mL of all-trans retinoicacid and 8-12 ml / 100ml of a serum substitute; the mesenchymal stem cell culture supernatant is prepared by the following method: culturing mesenchymal stem cells at the convergence degree of 78-82% for 22-26 hours, filtering, and retaining a filtrate, thereby obtaining the mesenchymal stem cell culture supernatant. The cryopreservation liquid can effectively reduce damage to cells in cryopreservation and resuscitation processes and improve the activity of the resuscitated cells.
Owner:GUANGDONG VITALIFE BIOTECHNOLOGY CO LTD
Quantitative detection tracing method of intracellular HPA (hydroxyapatite) nano particles
ActiveCN103822906AAccurate dissolutionThere is no problem of limited use conditionsFluorescence/phosphorescenceFluorescenceRare earth
The invention relates to a rare earth fluorescent signal based quantitative detection method of HPA (hydroxyapatite) nano particles, and the quantitative detection method is characterized by comprising the following steps: 1) formulating a europium ion fluorescence-concentration standard curve; 2) establishing dissolution rate of calcium ions and europium ions in the HPA (hydroxyapatite) nano particles, and determining the accuracy of a fluorescence-concentration standard curve method; 3) quantitatively detecting intracellular HAP nano particles; and 4) tracing a dissolution course of the intracellular HAP nano particles. The main advantages of the quantitative detection method are that: 1) the quantitative detection method is good in biocompatibility, safe and reliable, and is free of radioactive labeling using condition limitation problems; 2) the quantitative detection method is low in the detection limit, the detection limit concentration can reach 0.5nM, and the sample needing amount is less; and 3) the quantitative detection method can more accurately shown dissolution of the intracellular HAP nano particles, and the compatibility of the dissolving out of the europium ions and the dissolution of the HAP nano particles is high.
Owner:WUHAN UNIV OF TECH
Method for preparing surface molecular imprinting microspheres through polymerization of Pickering emulsion based on hydrophobic hydroxylapatite nanometer stable particles and application
ActiveCN106589366AIncrease profitSimple stepsOther chemical processesAlkali metal oxides/hydroxidesSpecific adsorptionApatite
The invention discloses a method for preparing surface molecular imprinting microspheres through polymerization of Pickering emulsion based on hydrophobic hydroxylapatite nanometer stable particles and application. The method for preparing the surface molecular imprinting microspheres comprises the steps that the hydrophobic hydroxylapatite nanometer particles are used as stable particles, protein is used as template molecules, polymeric microspheres are prepared through self-assembly of dopamine monomers in an aqueous phase, the template molecules are further removed through eluent, and the surface molecular imprinting microspheres can be obtained. Print sites are arranged on the surfaces of the surface molecular imprinting microspheres, the surface molecular imprinting microspheres can be in full contact with target molecules in a solution, efficient specific adsorption on the target molecules can be achieved, and the surface molecular imprinting microspheres can be widely applied to specific adsorption and separation of protein in a biosystem. According to the method, preparation is easy to grasp, preparation is easy and convenient, cost is low, and large-scale industrial production is greatly facilitated.
Owner:CENT SOUTH UNIV
Preparation method of green-fluorescence-labeled terbium/strontium codoped hydroxyapatite nano particles with high luminous intensity
InactiveCN106986319AImprove luminosityReduce usageMaterial nanotechnologyPhosphorus compoundsWater bathsLuminous intensity
The invention discloses a preparation method of green fluorescently labeled terbium / strontium co-doped hydroxyapatite nanoparticles with high luminous intensity. First, take Tb 4 o 7 Add excess concentrated nitric acid, heat in a water bath, and evaporate to form Tb(NO 3 ) 3 crystal, and then prepare terbium nitrate solution; secondly, calcium nitrate, strontium nitrate, diammonium hydrogen phosphate and sodium hydroxide are dissolved in deionized water to form a solution, and the terbium nitrate solution in (1) is mixed with calcium nitrate solution and strontium nitrate solution Evenly, add the diammonium hydrogen phosphate solution dropwise, adjust the pH value to 14 with sodium hydroxide solution after fully mixing, and fully stir to obtain solution A after the pH value is stable; finally, leave solution A to stand for aging, and then After washing, suction filtration, drying and grinding, green fluorescent-labeled Tb with high luminescence intensity can be obtained 3+ / Sr 2+ Co-doped with hydroxyapatite nanoparticles. The material prepared by the present invention compares Tb 3+ Doped with hydroxyapatite, the fluorescence intensity is higher, the color is more obvious, and the fluorescence lifetime is longer.
Owner:SHAANXI UNIV OF SCI & TECH
Preparation method of spherical nano hydroxyapatite particles
The invention discloses a preparation method of spherical nano hydroxyapatite particles. The preparation method comprises the following steps: (1) measuring a CQDs (carbon quantum dots) solution in a conical flask, regulating the pH value of the solution up to 10, and uniformly stirring at room temperature; (2) dropwisely adding a CaCl2 solution, and uniformly stirring; (3) dropwisely adding a Na2HPO4.12H2O solution, and standing at room temperature; (4) performing centrifugal separation on the prepared product, discarding the supernate, washing the underlayer product with distilled water and anhydrous ethanol respectively, then taking out the product, and drying in a drying oven to obtain khaki powder; and (5) calcining the powder in a muffle furnace, thereby removing carbon quantum dots to obtain white powder, namely HAP (hydroxyapatite) nanoparticles. According to the invention, the spherical hydroxyapatite nanoparticles are prepared at room temperature by using the carbon quantum dots as effective nucleation inducer through a chemical precipitation method. The hydroxyapatite prepared by the invention is quasi-spherical, and has the advantages of favorable dispersity, particle uniformity and high crystallinity. Besides, the preparation method has the advantages of simplicity, mild and controllable conditions and low cost.
Owner:HARBIN UNIV OF SCI & TECH
SERS detection method based on adsorption of protein by hydroxyapatite nanoparticles
ActiveCN110646401ALow cost of experimentsEasy to operateRaman scatteringSurface-enhanced Raman spectroscopyPhotochemistry
The invention discloses a surface-enhanced Raman spectroscopy (SERS) detection method based on adsorption of proteins by hydroxyapatite nanoparticles. The SERS detection method comprises the steps of:carrying out mixed incubation on hydroxyapatite nanoparticles and a biological sample and absorbing proteins in the sample, adding acid into the mixture to adjust a pH value so as to enable the proteins to fall off from the surfaces of the hydroxyapatite nanoparticles, extracting supernate containing the fallen proteins, uniformly mixing the supernate with an SERS nano active material, detectingto obtain a biological sample protein surface enhanced Raman spectrum by utilizing an SERS technology, and establishing a biological sample protein surface enhanced Raman spectrum database; and acquiring characteristic spectral peaks of surface enhanced Raman spectra corresponding to different biological sample proteins through post-processing and analysis of the data. The SERS detection method has the advantages of quickness, simplicity in operation, low cost and the like, and can be used for effectively detecting the surface enhanced Raman spectra of the proteins in different biological samples.
Owner:FUJIAN NORMAL UNIV
Method for preparing small-sized nano-hydroxyapatite by using carbon dots (CDs) as template
The invention belongs to the field of nano-biological materials, and discloses a method for preparing small-sized nano-hydroxyapatite by using carbon dots (CDs) as a template. The method comprises thefollowing steps: weighing solids H2N(CH2)10COOH and NaOH and dissolving in deionized water, then adding a citric acid solution and stirring for reacting, collecting white precipitate, drying, grinding, and then carrying out a thermal oxidization reaction at 300 DEG C to obtain the CDs; adjusting the pH of a Ca(NO3)2 solution to 10.5 with an alkaline solution, then dropwise adding the CDs to carryout a complexation precipitation reaction, dropwise adding an Na3PO4 solution, carrying out a hydrothermal reaction at 140 to 180 DEG C, and washing and drying a product to obtain the small-sized nano-hydroxyapatite. Hydroxyapatite nanoparticles prepared by the method are shaped like short rods, are smaller in size than particles without the CDs, can be reduced in particle size through the increase of the CD content, and have a potential application prospect in the field of nanomedicine.
Owner:SOUTH CHINA UNIV OF TECH
Fluorine-containing coating material for outdoor protection of 5G communication base station and preparation method thereof
ActiveCN111363423AExtended service lifeMany active sitesAnti-corrosive paintsPolyurea/polyurethane coatingsEpoxyFiber
The invention discloses a fluorine-containing coating material for outdoor protection of a 5G communication base station and a preparation method thereof. The fluorine-containing coating material comprises a substrate material layer, a functional material layer and a maintenance material layer, wherein the substrate material layer is formed by mixing a nano-fiber dispersion liquid consisting of electrostatic spinning fibers with epoxy resin; the functional material layer is mainly formed by wrapping wave-absorbing nano particles with a fluorine-containing polymer, and is further connected withthe substrate material layer in a crosslinking manner through a ring-opening catalyst, so that the connecting strength of the coating and a substrate is greatly improved while the excellent weather resistance and radiation resistance are improved. The maintenance material layer is mainly composed of a mixed solution of hydroxyapatite nano particles and polyvinyl butyral, has excellent corrosion resistance, softness and flexibility, can well protect the functional material layer, and prolongs the service life of the coating.
Owner:无锡市恒创嘉业纳米材料科技有限公司
CEA concentration detection probe, preparation method and applications thereof, and CEA concentration detection biosensor
InactiveCN106950270AGood choiceHigh sensitivityMaterial electrochemical variablesDNA/RNA fragmentationSodium molybdateElectrochemistry
The present invention discloses a CEA concentration detection probe, which comprises a CEA aptamer and hydroxyapatite nanoparticles, wherein the CEA aptamer and the hydroxyapatite nanoparticles are integrally compounded through a cross-linking agent, the CEA aptamer contains the nucleotide sequence 5'-ATACCAGCTTATTCAATT-3' and has the 5'-NH2 modified 5' terminal, and the surface of the hydroxyapatite nanoparticles is coated with a chitosan film. According to the present inventin, the hydroxyapatite and the aptamer contained in the CEA concentration detection probe can respectively react with sodium molybdate to produce electrochemical signals so as to achieve the double signal amplification and improve the detection sensitivity; and with the application f the CEA concentration detection probe in the preparation of the biosensor for CEA concentration detection, the advantages of high detection sensitivity, low detection limit and wide detection range are provided.
Owner:CENT SOUTH UNIV
Hydroxyapatite-based electrochemical probe construction method and method for determining activity and inhibition property of BACE1
InactiveCN106093160AEnables sensitive detection of activitySimple and fast operationBiological testingMaterial electrochemical variablesAntibodyAbnormal alkaline phosphatase
The invention discloses a hydroxyapatite-based electrochemical probe and a construction method thereof, and a method for determining the activity and the inhibition property of BACE1. According to the present invention, an A[beta] antibody and alkaline phosphatase are co-modified on a hydroxyapatite matrix to form the hydroxyapatite-based electrochemical probe; the preparation method comprises: sequentially placing hydroxyapatite nanoparticles in a polyethylenimine solution and carrying out a reaction, placing in a glutaraldehyde solution and carrying out a reaction, and placing in a solution containing an A[beta] antibody and alkaline phosphatase and carrying out a reaction so as to obtain the probe; and the method for determining the activity and the inhibition property of BACE1 by using the hydroxyapatite-based electrochemical probe has advantages of simpleness, rapidness, high sensitivity and wide detection range, and can be widely promoted and applied.
Owner:CENT SOUTH UNIV
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