The invention relates to the field of food, health care products and medicine, in particular to a composition containing ginseng and colla corii asini. The composition contains ginseng extract which is total ginseng prosapogenin medicine composition or purified ginseng prosapogenin monomer, the ginseng prosapogenin monomer is at least one selected from Rg1, Rg2, Rg3, Rg4, Rg5, Rk1, Rz1, Rh1, Rh2, Rb1, Rb2, Rb3, Re, Rc or Rd, the composition is further added with medlar or medlar extract, and cartialgenous or cartialgenous extract. The colla corii asini and the total ginseng prosapogenin in the composition are combined and can promote the synthesis of dermato-pontin the dermato-hydroxyproline level is improved, and the utilization rate of the colla corii asini collagen is improved; the enzymatic activity of Na<+>, K<+>-ATP is improved, the cell membrane matter translocation is promoted, the appearance and the elasticity of aged skin are improved or restored, and the composition has better skin aging prevention and beautifying functions.