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Preparation method of corn cervi pantotrichum extract, and related products

The technology of extract and water-soluble extract is applied in the field of preparation of deer antler extract, which can solve the problems of toxic and side effects, pay little attention to non-motor symptoms, cannot prevent the degeneration of dopaminergic neurons, etc., and achieve a good therapeutic effect.

Inactive Publication Date: 2017-01-18
EXPERIMENTAL RES CENT CHINA ACAD OF CHINESE MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The inventors found out how they discovered another substance called Deeferoxin (DEO) which was extracted from Antlers bulean beetle shellfishes during research into treatments against neurological disorders such as Parkinsonism or Alzheimer’ s disease. These results showed that DEFO could improve certain aspects of these diseases without causing any side effects like other medications used today.

Problems solved by technology

This patented technical problem addressed in this patents relating to drug discovery involves identifying specific proteins found within volatile oily extracts derived from velveteen or deferoxytolone hydrogel used alone or together with other ingredients such as calcium salt solution or carbopolymers like caffeine. These identified peaks may be associated with neurological disorders including PD, Alzheimer’ s disease, stroke, brain damage caused by trauma, spinaciitis, etc., while others also report their presence indicating potential medical benefits related to these compounds.

Method used

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  • Preparation method of corn cervi pantotrichum extract, and related products
  • Preparation method of corn cervi pantotrichum extract, and related products
  • Preparation method of corn cervi pantotrichum extract, and related products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0080] Embodiment 1, have the preparation of the velvet antler protein extract of preventing and / or treating Parkinson's disease

[0081] 1. Preparation of velvet antler protein extract

[0082] The velvet protein extract is prepared according to the following method, and the velvet protein extract is the velvet protein extract for preventing and / or treating Parkinson's disease. details as follows:

[0083] The fresh velvet antler is directly crushed for the first time with a pulverizer to obtain the first crushed velvet antler. Put the velvet antler crushed for the first time into liquid nitrogen quick-freezing, put it into a superfine pulverizer, add an appropriate amount of water for the second crushing until it is minced meat, and obtain the second crushed velvet antler, the molecular particle size of the second crushed velvet antler is 75 μm. Add a certain amount of water to the second crushed velvet antler (the mass ratio of the second crushed velvet to water is 1:5),...

Embodiment 2

[0161] Embodiment 2, the pharmacodynamic study of velvet antler protein extract

[0162] 1. Animal modeling

[0163] After intraperitoneal injection of 10% chloral hydrate according to the injection dose of 0.35mL / 100g body weight in rats was anesthetized, sensory loss was induced. Fix the head on the stereotaxic instrument, incise the scalp, remove the subcutaneous tissue and periosteum, and find the anterior and posterior fontanelles. It is determined that the right side of the substantia nigra compact part is 4.8mm posterior to the anterior bregma, 2.0mm to the right of the sagittal suture, and 8.0mm subperiosteum; the ventral tegmental area of ​​the midbrain is 4.8mm posterior to the anterior bregma, 1.2mm to the right of the midline, and 8.0mm subperiosteal mm. After determining the coordinates, inject 8 μL of the prepared 6-OHDA solution into the substantia nigra pars compacta and the ventral tegmental area of ​​the midbrain, and inject in divided doses, and keep the n...

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Abstract

The invention discloses a preparation method of corn cervi pantotrichum extract, and related products. The obtained corn cervi pantotrichum protein extract is capable of relieving Parkinson disease symptoms of model rats, and increasing the amount of neuronal cells in brain corpus striatum. After treatment of model rats with the corn cervi pantotrichum protein extract, DA, DOPAC, and HVA in rat cerebrospinal fluid, and DA and 5-HT in brain tissue are increased, the content of glutamic acid and gamma-aminobutyric acid in rat cerebrospinal fluid and the content of glutamic acid in brain tissue are reduced, and the ratio of HAV/DA, DOPAC/DA, 5-HIAA/5-HT, and glutamic acid/amma-aminobutyric acid in rat cerebrospinal fluid and brain tissue are reduced. It is confirmed by pharmacological experiments that the corn cervi pantotrichum protein extract possesses excellent therapeutical effects on Parkinson disease animal models, and experimental foundation is provided for research and development of novel drugs used for treating Parkinson disease.

Description

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Claims

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Application Information

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Owner EXPERIMENTAL RES CENT CHINA ACAD OF CHINESE MEDICAL SCI
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