144 results about "Cyclobutene" patented technology

The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.

A method of forming a pattern by directed self-assembly, comprising: (a) providing a semiconductor substrate comprising one or more layers to be patterned; (b) applying a crosslinkable underlayer composition over the one or more layers to be patterned to form a crosslinkable underlayer, wherein the crosslinkable underlayer composition comprises a crosslinkable polymer comprising a first unit of the following general formula (I-A) or (I-B):wherein: P is a polymerizable functional group; L is a single bond or an m+1-valent linking group; X1 is a monovalent electron donating group; X2 is a divalent electron donating group; Ar1 and Ar2 are trivalent and divalent aryl groups, respectively, and carbon atoms of the cyclobutene ring are bonded to adjacent carbon atoms on the same aromatic ring of Ar1 or Ar2; m and n are each an integer of 1 or more; and each R1 is independently a monovalent group; (c) heating the crosslinkable underlayer to form a crosslinked underlayer; (d) forming a self-assembling layer comprising a block copolymer over the crosslinked underlayer; and (e) annealing the self-assembling layer. The methods and compositions find particular applicability in the manufacture of semiconductor devices or data storage devices for the formation of high resolution patterns.

The invention relates to a manufacturing method for a soft magnetic core spiral micro-inductor, which is characterized by integrating a NiFe-AlOx soft magnetic core spiral micro-inductor and comprising the following steps: 1) preparing lower-layer metal of an inductor; 2) preparing a first benzo-cyclobutene BCB dielectric layer; 3) preparing a NiFe-AlOx film; 4) preparing a second benzo-cyclobutene BCB dielectric layer; 5) preparing a benzo-cyclobutene BCB dielectric through hole; and 6) preparing upper-layer metal of the inductor. The manufacturing method has the advantages that the soft magnetic core spiral micro-inductor for an RF / MMIC (Radio Frequency / Monolithic Microwave Integrated Circuit) is prepared by integrating a soft magnetic material with an MMIC micro-inductor. Compared with the micro-inductor free from the magnetic core, the soft magnetic core spiral micro-inductor has the advantages: (1) the inductance volume is greatly increased; (2) the quality factor is certainly increased; and (3) the whole technology is compatible with the manufacturing technology of a GaAs and GaN MMIC.

The invention discloses a hypochlorite ion fluorescence probe, and a synthetic method and an application thereof. The synthetic method comprises the following steps: 1, adding 3,4-dihydroxy-3-cyclobutene-1,2-dione (squaric acid) and 3-N,N-diethylamino phenol to a solvent which is a mixed solution comprising toluene and n-butanol, carrying out a heating reflux reaction for 8-12h, filtering, washing the obtained reaction precipitate with methanol, and drying to obtain an intermediate squaric acid dye, wherein the molar ratio of 3,4-dihydroxy-3-cyclobutene-1,2-dione (squaric acid) to 3-N,N-diethylamino phenol is 1:1.8-2.2; and 2, carrying out the heating reflux reaction of the squaric acid dye and a Lawesson reagent in a solvent toluene under the protection of nitrogen for 6-24h, carrying out reduced pressure distillation to remove the solvent, and carrying out silica gel column chromatography to obtain the fluorescence probe. The probe has a simple synthetic process, has a very high selectivity and a very high sensitivity to hypochlorite ions, and has a good application prospect.

An OLED device including a cathode, an anode, and having therebetween a light-emitting layer and further comprising a first layer between the light-emitting layer and the cathode containing a cyclobutene compound comprising a cyclobutene nucleus substituted in the 1-position with a five- or six-membered heteroaromatic ring group containing at least one trivalent nitrogen atom; substituted in the 2-position with an aromatic ring group; and substituted with a first methylene group in the 3-position and a second methylene group in the 4-position, provided said first and second methylene groups are further disubstituted in the 1′,1′-positions and the 1″,1″-positions with independently selected aromatic groups.

Disubstituted 3,4-diamino-3-cyclobutene-1,2-dione compounds are disclosed that are represented by general formula (I). Also disclosed, are pharmaceutical compositions including these compounds and methods of using these compounds and compositions for the treatment of chemokine-mediated pathologies.

The invention relates to a benzocyclobutene polysiloxane polymer monomer or resin and a preparation method thereof. The invention discloses a dimethyl-4-benzocyclobutene silicon-based ethylmethyl cyclotetrasome disclosed as Formula (III) and a preparation method thereof. The preparation method of the polysiloxane polymer monomer comprises the following steps:Sequentially adding a tetramethyl-tetravinyl-cyclosiloxane solution diluted by solvent methylbenzene and 4-(1-H-1,1-methyl)silicon benzocyclobutene into a reactor, adding a platinum catalyst after applying a nitrogen atmosphere, and reacting at 60-90 DEG C for 20-40 hours; and adding triphenylphosphine, heating under reflux for 3 hours, cooling, filtering, concentrating the filtrate by distillation, adding methanol, mixing, precipitating, filtering, repeatedly precipitating the solid with methanol, and drying the solid to obtain the polysiloxane polymer monomer product. The product has excellent thermal properties, mechanical properties, electric properties and film-forming properties, and has wide development and application prospects as a high-performance dielectric film material or packaging material in the fields of micro-electronics, aerospace, national defence and the like. (III).

Provided is a dielectric / barrier rib composition for a plasma display panel, comprising a compound 1 of the formula or at least one compound belonging to a polyhedral oligosilsesquioxane (compound 2) having R6SiO1.5 as a repeating unit, or comprising inorganic / organic hybrid materials having compounds 1 and 2 as a monomer, wherein X is an integer inclusive 0, R1, R2, R3, R4, R5 and R6 are independently a linear, branched or cyclic C1-C12 hydrocarbon group containing one or more alkyl, alkoxy, ketone, acryl, methacryl, allyl, aromatic, halogen, amino, mercapto, ether, ester, sulfone, nitro, hydroxyl, cyclobutene, carbonyl, carboxyl, alkyd, urethane, vinyl, nitrile, hydrogen, or epoxy functional group, and A is oxygen or NH. The inorganic / organic hybrid materials can be a material composed of an extended matrix, containing silicon and oxygen or nitrogen atoms, and having at least one silicon fraction directly bonded to a substituted or unsubstituted hydrocarbon atom.

Disubstituted 3,4-diamino-3-cyclobutene-1,2-dione compounds are described that correspond to general formula (I). Also described, are pharmaceutical compositions that include these compounds and methods of using these compounds and compositions for the treatment of chemokine-mediated diseases.

The present invention provides methods of making low energy polymerizable monomers and resins for use in making dielectric materials. The methods comprise deprotecting or deacylating an organic alkali cleavable protecting group containing addition polymerizable, amine containing aromatic monomer or oligoaromatic phenol resin containing an organic alkali cleavable protecting group, such as a C2 to C9 alkanoyl group, preferably, an acyl group, by hydrolyzing to remove the protecting group in organic alkali in a polar solvent containing an excess of alkali C1 to C7 alkoxide and form a hydroxyl functional monomer or resin, followed by; reacting via nucleophilic substitution the resulting hydroxyl functional monomer or resin with an alpha-halide (α-halide) or strong acid conjugate leaving group containing arylcyclobutene compound in a polar solvent, to yield a product an arylcyclobutene-containing addition polymerizable or amine containing aromatic monomer or oligoaromatic phenol resin having an ether linkage from the cyclobutene ring to an aromatic group of the addition polymerizable aromatic monomer, aromatic amine or oligoaromatic phenol.

The invention relates to a high molecular material and discloses an adamantyl benzocyclobutene monomer and a synthesizing method of a polymer of the adamantyl benzocyclobutene monomer. According to the adamantyl benzocyclobutene monomer and the synthesizing method of the polymer of the adamantyl benzocyclobutene monomer, the structural formula of the adamantyl benzocyclobutene monomer is shown as the specification, wherein a formula in the specification is adamantane; a formula in the specification is benzocyclobutene; O is oxygen and Si is silicon; m and n are the quantities of substituent groups on 1, 3, 5 and 7 sites of the adamantane; the sum of the m and the n is smaller than or equal to 4; the n is more than or equal to 1 and less than or equal to 4; R1 is a first fat substituent group or a first aromatic substituent group; R2 is a second fat substituent group or a second aromatic substituent group; R3 is a third fat substituent group or a third aromatic substituent group. The adamantyl benzocyclobutene monomer prepared by the invention is used for carrying out a polymerization reaction to obtain an adamantyl benzocyclobutene monomer polymer. According to the adamantyl benzocyclobutene monomer and the synthesizing method of the polymer of the adamantyl benzocyclobutene monomer, the adamantyl benzocyclobutene monomer and the polymer thereof have low dielectric constants and low dielectric losses; the dielectric properties are good; meanwhile, the adamantyl benzocyclobutene monomer and the polymer thereof have higher hydrophobic property and heat resistance.

The invention provides a manufacturing method of convective acceleration sensor chip based on a temperature sensitive resistor. The method comprises the following steps: firstly, forming an oxide layer and a low stress silicon nitride layer on the surface of a mono-crystalline silicon wafer; manufacturing the polycrystalline silicon temperature sensitive resistor and a polycrystalline silicon heating resistor on the low stress silicon nitride layer; manufacturing metal interconnection lines to form an acceleration sensor output circuit; corroding the mono-crystalline silicon wafer to form a concave cavity, releasing a cantilever; bonding a cover on the silicon wafer by a BCB (benzo cyclobutene) adhesive to form a sealed cavity, finally the acceleration sensor chip is obtained. The method of the invention uses the low stress silicon nitride layer deposited by LPCVD (low pressure chemical vapor deposition) as a supporting layer of the heating resistor and the temperature sensitive resistor, and manufactures the polycrystalline silicon heating resistor and the polycrystalline silicon temperature sensitive resistor by an LPCVD and doping technology; the manufactured convective acceleration sensor chip has the advantages of high detection precision, high reliability and good stability; and the manufacturing technology is compatible with IC (integrated circuit) technology. In this way, the method of the invention is helpful for realizing chip microminiaturization and low cost.

The invention relates to novel cycloalkyl- or cycloalkenyl-substituted pyrazolopyrimidinones of formula (I), wherein A is selected from the group A1 consisting of a C3-C8-cycloalkyl group or a C4-C8-cycloalkenyl group, whereby the members of C3-C8-cycloalkyl group being selected from the group of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptanyl and cyclooctanyl; and the members of the C4-C8-cycloalkenyl group, being selected from cyclobutenyl, cyclopentenyl, cyclohexenyl, cycloheptenyl, cyclooctenyl, cyclopentadienyl, cyclohexadienyl, cycloheptadienyl, cyclooctadienyl, cycloheptatrienyl, cyclooctathenyl, cyclooctatetraenyl. The new compounds shall be used for the manufacture of medicaments, in particular medicaments for improving perception, concentration, learning and / or memory in patients in need thereof. Chemically, the compounds are characterised as pyrazolopyrimidinones with a cycloalkyl-moiety directly bound to the 1 position of the pyrazolopyrimidinone and a second substituent in the 6 position which is bound via an optionally substituted methylene-bridge. Further aspects of the present invention refer to a process for the manufacture of the compounds and their use for producing medicaments.

This invention provides a method of treating pain in a mammal that includes administering to a mammal in need of such treatment a pain treating effective amount of a compound of the formula (I): where R1 is H, alkyl or phenylalkyl; R2 is H, alkyl, alkenyl or phenylalkyl; or R1 and R2 taken together as Z are -CH2C-H2-, -CH2C(R6)(R7)CH2- or -CH2C(R8)(R9)-C(R10)(R11)CH2-, where R6, R8 and R10 are, independently, H, alkyl or hydroxyl and R7, R9 and R11 are, independently, H or alkyl; A is alkylene or alkenylene; X is CO2R3, P(O)(OR4)(OR5), 3,5-dioxo-1,2,4-oxadiazolidin-2-yl or 5-tetrazolyl in which R3, R4 and R5 are, independently, H or alkyl, or a pharmaceutically acceptable salt thereof. The present invention also provides pharmaceutical compositions for treating pain containing a pain treating effective amount of the compound of formula (I).

The invention discloses a grinding polishing method for a wafer and belongs to the technical field of chip manufacture. According to the grinding polishing method for the wafer, benzocyclobutene is adopted for coating the surface of the wafer, the coated wafer is pasted on a clamp, the heating treatment is carried out so that the benzocyclobutene coating is vitrified, next, the wafer is placed into solvents capable of dissolving the benzocyclobutene to be soaked after the grinding polishing is carried out so that the benzocyclobutene coating can automatically slide off from the clamp, finally, the etching is carried out, meanwhile, the residue BCB (benzocyclobutene) is removed, and the clean back side polished wafer is obtained. The method provided by the invention avoids the problems of poor flatness and poor repeatability caused by artificial paraffin wax coating by people, meanwhile, the production process is nontoxic and harmless, the production time is shortened, and the finished product rate is improved.

Disubstituted 3,4-diamino-3-cyclobutene-1,2-dione compounds corresponding to general formula (I) are disclosed. Also disclosed, are pharmaceutical compositions including these compounds and methods of using these compounds and compositions for the treatment of chemokine-mediated diseases.

The invention belongs to the field of chemical analysis and testing and particularly relates to a preparation method and an application of a 1,3-position symmetric squarylium cyanine probe based on carboxamidoquinoline. Firstly, a mixture of 8-aminoquinoline and 2-chloroacetyl chloride is subjected to ice-bath stirring in a dichloromethane solvent, a product and p-phenylenediamine are subjected to reflux in a methanol solvent, then 3,4-diethoxy-3-cyclobutene-1,2-dione and a product are subjected to reflux reaction in toluene and n-butyl alcohol, and a final product is obtained through separation and purification. The obtained squarylium cyanine compound has excellent ionic selectivity and facilitates silver ion detection.

The invention discloses a method to make diene siloxane crosslink bibenzo cyclobutene monomer that includes the following steps: whisking alkali and water to dissolve, adding solvent, catalyst, reacting material, reacting for 18-30 hours at 90-150 degree centigrade in nitrogen air, extracting and post processing to gain the monomer. The feature is that it solvent is iron liquid or recycled iron liquid. The invention also discloses the manufacture method for performed polymer. It has no pollution to the environment, low cost, short production cycle, and no influence to yield, lower power consumption.

The invention relates to a method for synthesizing fluorochloro succinic acid, and belongs to the field of organic chemical synthesis. The method for synthesizing fluorochloro succinic acid is characterized in that hexachlorobutadiene (the molecular formula is as follow: CCl2 being equal to CCl-CCl being equal to CCl2) generates fluorochloro cyclobutene (the molecular formula is as follow: Cyclo-C2FxCly-CCl being equal to CCl-, wherein the sum of the x and y is 4) under the effect of cyclo-fluorinated catalysts; then, the fluorochloro succinic acid (the molecular formula is HOOC-C2FxCly-COOH)is generated under the effect of oxidizing agents. CCl2 is equal to CCl-CCl being equal to CCl2 arrow Cyclo-C2FxCly-CCl being equal to CCl- arrow HOOC-C2FxCly-COOH. The method has the advantages thatthe raw materials are cheap; the resources can be conveniently obtained; the product separation and purification are simple; the industrial production is easy; three industrial wastes (waste water, waste solid and waste water) are few.

The invention discloses a novel synthetic method of 1,2-dihydro cyclobutene [alpha] naphthalene, which comprises the following steps that (1) 2-methylnaphthalene, paraformaldehyde, glacial acetic acid and hydrochloric acid are directly fed; heating and reaction are performed at 60-70 DEG C; a 1-chloromethane-2-methylnaphthalene crude product is prepared; (2) the obtained 1-chloromethane-2-methylnaphthalene crude product is subjected to reduced pressure distillation; unconverted 2-methylnaphthalene is removed; high-purity 1-chloromethane-2-methylnaphthalene is obtained; (3) high-purity 1-chloromethane-2-methylnaphthalene is added to a pyrolyzer for pyrolysis; a 1,2-dihydro cyclobutene [alpha] naphthalene crude product is obtained; and (4) the 1,2-dihydro cyclobutene [alpha] naphthalene crude product is dried, distilled, subjected to column chromatography and condensed; and a target product is obtained. Compared with the prior art, the method takes 2-methylnaphthalene as a basic raw material to prepare 1,2-dihydro cyclobutene [alpha] naphthalene by chloromethylation and pyrolysis cyclization, and is mild in synthetic condition, high in yield, very high in production value and good in industrial prospect.

The characteristics is that this kind of monomer includes two new monomers. Benzo cyclobutane-4-boracic acid or the ester, or benzo cyclobutane-4-boracic acid or the ester and 4-bromo-benzo cyclobutane, or dihalogeno arene and benzo cyclobutane-4-boracic acid or the ester, or arylhypoboric acid or the ester and 4-bromobenzene cyclobutane are used as reaction material to be stirred with catalytic agent, inorganic alkali dissolvant more than 3 hours on room temp. in the air or nitrogen gas, then monomer I or / and monmer II is produced by a series of reprocessing.

An OLED device including a cathode, an anode, and having therebetween a light-emitting layer and further comprising a first layer between the light-emitting layer and the cathode containing a cyclobutene compound comprising a cyclobutene nucleus substituted in the 1-position with a five- or six-membered heteroaromatic ring group containing at least one trivalent nitrogen atom; substituted in the 2-position with an aromatic ring group; and substituted with a first methylene group in the 3-position and a second methylene group in the 4-position, provided said first and second methylene groups are further disubstituted in the 1′,1′-positions and the 1″,1″-positions with independently selected aromatic groups.

The present invention provides a polymer composition comprising, in copolymerized form, one or more addition polymerizable arylcyclobutene monomers A having an alkyl, aryl, alkoxy, aryloxy, thioalkyl or thioaryl cyclobutene ring substituent, one or more aromatic addition polymerizable second monomers and one or more addition polymerizable monomer chosen from one or more nitrogen heterocycle containing third monomers, one or more addition polymerizable fourth monomer, such as n-butyl acrylate, or one or more of both monomers. The polymer compositions find use in making thin films or coatings having improved flexibility. Methods for making the polymer compositions are also provided.

The invention discloses a Bola type surfactant with anion and cation reversal capability and a preparation method thereof, and the preparation method comprises the following steps: 1) adding 1,12-diaminododecane and cyclobutane-3-ene dicarboxylic anhydride into a three-neck flask, introducing nitrogen, and carrying out nucleophilic addition-elimination reaction to generate imide; and then reducingcarbonyl by using LiAlH4; and 2) diluting the product, adding potassium permanganate, heating, and carrying out oxidation reaction to generate carboxyl; and after the reaction is finished, adding sodium sulfite to remove excessive potassium permanganate, filtering by adopting diatomite and extracting impurities by adopting ethyl acetate, collecting a water phase, filtering and drying to constantweight to obtain a final product. The surfactant has excellent anion and cation inversion characteristics, and the type of the surfactant can be changed according to the external environment. The surfactant is an anionic surfactant under an alkaline condition in an external environment, and the surfactant is a cationic surfactant under an acidic condition in the external environment.

The invention relates to a preparation method of hexafluorobutadiene, which comprises the following steps: respectively dehydrating a 3, 4-dichlorohexafluoro-1-butene raw material and an organic solvent, adding the dehydrated 3, 4-dichlorohexafluoro-1-butene raw material and the dehydrated organic solvent into a dechlorination reaction kettle together with zinc powder, carrying out a dechlorination reaction to obtain a dechlorination product, and carrying out rectification and catalytic conversion on the dechlorination product to obtain a hexafluorobutadiene product. Compared with the prior art, the method has the advantages that the by-product is rearranged into hexafluorobutadiene by using a catalyst, and rectification purification is combined, so that the purity of the obtained hexafluorobutadiene product is high, the content of impurities such as hexafluoro-2-butyne and hexafluorocyclobutene in the hexafluorobutadiene product is remarkably reduced, the difficulty of downstream production of high-purity hexafluorobutadiene can be reduced, and the purity requirement on 3, 4-dichlorohexafluoro-1-butene raw material is reduced from 99.95% to 99%, the requirement on the purity of the 3, 4-dichlorohexafluoro-1-butene raw material is reduced, the pressure of upstream production and investment is greatly reduced, and the height of a rectifying tower for producing the 3, 4-dichlorohexafluoro-1-butene can be greatly reduced.

Disubstituted 3,4-diamino-3-cyclobutene-1,2-dione compounds are disclosed that are represented by general formula (I). Also disclosed, are pharmaceutical compositions including these compounds and methods of using these compounds and compositions for the treatment of chemokine-mediated pathologies.

The invention belongs to the technical field of polymer dielectric materials and in particular relates to benzocyclobutene monomers containing siloxane and imide structure and a synthesis method and application of the Benzocyclobutene monomers. Hydrosilylation reaction is allowed to take place between hydrogen-terminated polysiloxane / siloxane and 5-norbornylene-2,3-dianhydride in the presence of platinum catalysts to produce an intermediate compound, and imidization reaction is allowed to take place between the intermediate compound and 4-aminobenzocyclobutene to obtain the target monomers. The monomers have good solubility, and can be directly formed by thermal polymerization or dissolved in solvents to make films by spin-coating, followed by curing. The polymerization process is simple and free of byproducts. The cured resins have the characteristics of good heat resistance, low dielectric constant and low hydroscopicity; and the mechanical properties of the cured resins can be regulated by changing siloxane structure.

The invention discloses a method for synthesizing a 4-cyclobutyl biphenyl fluorine-containing compound. The method comprises the following steps: by taking chlorine benzene halide as an initial raw material, performing a Grignard reaction; performing a coupling reaction on the chlorine benzene halide with cyclobutanone so as to generate cyclobutanol chlorobenzene; performing a dehydration reactionso as to generate cyclobutene chlorobenzene; performing a one-pot method reaction to generate 4-cyclobutene phenylboronic acid; performing a coupling reaction with fluorine-containing benzene halideso as to generate a 4-cyclobutene biphenyl fluorine-containing compound; performing a hydrogenation reaction, thereby obtaining a 4-cyclobutyl biphenyl fluorine-containing compound IX. The method hasthe characteristics of being high in conversion rate, low in cost, safe and stable in process, short in reaction step, green and environmental-friendly in process route and small in pollutant emission.