33 results about "3-Aminophenol" patented technology

The invention relates to a preparation method of nitrogen and sulfur co-doping micropore-mesopore carbon microspheres, and belongs to the scientific and technical field of materials. The method comprises the steps that 3-aminophenol, a formaldehyde solution, an L-cysteine, a surface active agent, silica soil, ethyl alcohol and water are taken on the basis of the mass ratio being 1:(1.2-1.8):(0.5-1.5):(0.5-1.5):(1-3):(32-82):(40-100); the water and ethyl alcohol are mixed to be uniform under the temperature of 20-35 DEG C, and the other raw materials are added into the mixture in sequence, the reaction is performed for 24 h, hydrothermal treatment is performed under the temperature of 100 DEG C for 24 h, under the nitrogen atmosphere, the room temperature is increased to 600-900 DEG C at the heating rate of 2-10 DEG C / min for carbonization, NaOH is used for removing SiO2, and nitrogen and sulfur co-doping mesoporous carbon microspheres are obtained. The obtained carbon microspheres, KOH and water are taken on the basis of the mass ratio being 1:(1-4):(20-50) and mixed to be uniform, after drying, in the nitrogen atmosphere, the room temperature is increased to 600-900 DEG C at the heating speed of 2-10 DEG C / min for activation, and the nitrogen and sulfur co-doping micropore-mesopore carbon microspheres are obtained. The technology is simple, the obtained nitrogen and sulfur co-doping micropore-mesopore carbon microspheres are wide in application prospect on the aspect of adsorption and removal of heavy metal ions in wastewater.

The invention discloses a fluorescent probe for detecting hydrogen peroxide and a preparation method and application thereof. The structural formula of the fluorescent probe for detecting hydrogen peroxide is shown in the description, wherein any one or two of R1-R5 represents electron withdrawing groups. The fluorescent probe is novel in group response, good in selectivity and high in sensitivity; the excitation emission wavelength of the fluorescent probe is located in the range of near infrared waves, damage to tissue is small, the penetrating power is high, and the fluorescent probe can be used for living body imaging. The preparation method comprises the steps that 3-aminophenol and Cy.7.Cl are subjected to a substitution reaction, and Cy-Ph-NH2 is obtained; a retro-Knoevenagel reaction is conducted, and P-NH2 is obtained; P-NH2 and a derivative of phenylglyoxylic acid are subjected to the substitution reaction, and the product P-R is obtained, that is, the fluorescent probe for detecting hydrogen peroxide is obtained. The synthesizing method is simple and suitable for industrial production.

The invention discloses a method for preparing mono-dispersed N-doped ordered mesoporous carbon spheres with the particle size of 100-800 nm at high yield in a single-pass mode. According to the method, F127, 3-aminophenol and NH3.H2O serve as a template, a carbon and nitrogen source and a catalyst respectively, and the mono-dispersed N-doped ordered mesoporous carbon spheres with the particle size of 100-800 nm are produced at high yield in the single-pass mode on a large scale by regulating and controlling product morphology through ethyl alcohol. The preparing method is easy to implement, the concentration of the carbon and nitrogen source in the system is high, dosage of solvent is greatly reduced, several grams of N-doped ordered mesoporous carbon spheres can be obtained at high yield in the single-pass mode, the obtained N-doped ordered mesoporous carbon spheres are small in size distribution range, good in monodispersity and regular in pore structure and can be directly used as a catalyst, adsorbent and the like.

Provided is a dye composition comprising at least one of oxidation base, 2-chloro-6-methyl-3-aminophenol and 3-methyl-1-phenyl-5-pyrazolone. The composition is used for dyeing keratin fiber, specifically human keratin fiber. Also, provided is the use of 3-methyl-1-phenyl-5-pyrazolone as a stabilizer of 2-chloro-6-methyl-3-aminophenol.

The present invention relates to 8-hydroxyjulolidine, its analogous compounds and their preparation methods. The invented method comprises one single step of cyclization reactions of 3-aminophenol or 1,3-dihydroxyaniline with 1,3-dihalopropane or its analogs, to prepare the desired julolidines with improved yields. The products of this invention have the following structures: wherein R1 and R2 represent independently H, halogen, hydroxyl or alkyl. The method of this invention includes the following chemical reaction: wherein X and Y represent independently halogen, acyloxyl, sulfonyloxyl or phosphoryloxyl and R1 and R2 are as defined above. This invention also discloses method for the preparation of various coumarins by additionally reacting the produced 8-hydroxyjulolidine and its analogs with appropriate reagents such as malonate and acetoacetate. This invention also discloses the products and intermediates prepared therefrom.

The invention discloses a novel synthesis method for 7-Hydroxy-3,4-dihydroquinolone. The method is as follows: as shown in a formula (II), N-(3-chloropropionyl)-3-aminophenol undergoes intramolecular friedel-craft alkylation under the catalysis of solid acid catalyst at a temperature of between 132 and 200 DEG C, added with a solvent for elution after the reaction completes, filtered to reclaim the catalyst. The filtrate is cooled and crystallized to give the 7-Hydroxy-3,4-dihydroquinolone shown in a formula (I). The synthesis method for 7-Hydroxy-3,4-dihydroquinolone of the invention has the advantages of reasonable process, simple operation, high yield rate, low discharge of three waste gases, excellent application value.

The subject matter of the present invention relates to an agent for oxidatively dyeing keratinous fibers, comprising, in a cosmetic carrier, (A) 4,5-diamino-1-(2-hydroxyethyl)-1H-pyrazole and / or one of the physiologically acceptable salts thereof as a developer, (B) at least one p-diaminobenzene derivative from the group of p-toluylenediamine, 2-(2,5-diaminophenyl)ethanol, and / or one of the physiologically acceptable salts thereof as a developer, (C) at least one m-diaminobenzene derivative from the group of 2-(2,4-diaminophenoxy)ethanol, 1-methoxy-2-amino-4-(2′-hydroxyethylamino)benzene, 2,6-bis(2′-hydroxyethylamino)-1-methylbenzene, and / or one of the physiologically acceptable salts thereof as a coupler, and (D) at least one m-aminophenol derivative from the group 3-aminophenol, 5-amino-2-methylphenol, and / or one of the physiologically acceptable salts thereof as a coupler, wherein the molar ratio of all developers of group (A) included in the agent to all developers of group (B) included in the agent, i.e., the molar ratio (A) / (B), has a value of at least 1.2.

The invention discloses a fluorescent probe for detecting hydrogen peroxide and a preparation method and application thereof. The structural formula of the fluorescent probe for detecting hydrogen peroxide is shown in the description, wherein any one or two of R1-R5 represents electron withdrawing groups. The fluorescent probe is novel in group response, good in selectivity and high in sensitivity; the excitation emission wavelength of the fluorescent probe is located in the range of near infrared waves, damage to tissue is small, the penetrating power is high, and the fluorescent probe can be used for living body imaging. The preparation method comprises the steps that 3-aminophenol and Cy.7.Cl are subjected to a substitution reaction, and Cy-Ph-NH2 is obtained; a retro-Knoevenagel reaction is conducted, and P-NH2 is obtained; P-NH2 and a derivative of phenylglyoxylic acid are subjected to the substitution reaction, and the product P-R is obtained, that is, the fluorescent probe for detecting hydrogen peroxide is obtained. The synthesizing method is simple and suitable for industrial production.

The invention discloses a method for preparing 8-hydroxy julolidine and a derivative thereof. The method comprises the following steps of: (1) solving 3-aminophenol compound and X(CH2)3Y in an organic solvent S1, adding alkali B1, performing intramolecular reaction, reacting until the 3-aminophenol compound fully converts into an intermediate, and processing after finishing the reaction to obtain an intermediate; and (2) adding the intermediate obtained in the step (1) and alkali B2 into an organic solvent S2, performing intramolecular reaction, and processing until finishing the reaction to obtain the objective product. The method for preparing the 8-hydroxy julolidine and the derivative thereof is simple in steps; by strictly controlling the reaction stages, occurrence of disubstituted side reaction and oxidation side reaction is reduced, and productivity ratio of the objective product is improved; and high-poisonous and high-polluted substrate or reagent is avoided in the whole reaction process, which is suitable for industrialization.

An agent for oxidatively dyeing keratinous fibers includes in a cosmetic carrier: (A) 4,5-diamino-1-(2-hydroxyethyl)-1H-pyrazole and / or one of the physiologically acceptable salts thereof as developer; (B) at least one p-aminophenol derivative from the group comprising p-aminophenol, 4-amino-3-methylphenol, and / or the physiologically acceptable salts thereof as developer; (C) at least one m-diaminobenzene derivative from the group comprising 2-(2,4-diaminophenoxy)ethanol, 1-methoxy-2-amino-4-(2′-hydroxyethylamino)benzene, 2,6-bis(2′-hydroxyethylamino)-1-methylbenzene, and / or one of the physiologically compatible salts thereof as coupler; and (D) at least one m-aminophenol derivative from the group 3-aminophenol, 5-amino-2-methylphenol and / or one of the physiologically acceptable salts thereof as coupler, wherein the molar ratio of all the developers of group (A) included in the agent to all the developers of group (B) included in the agent, i.e., the molar ratio (A) / (B), has a value of at least 1.2.

This invention discloses a method for testing bacteria AmpC enzyme with paper containing 3-amino-phenol-boric acid. It prepares APB solution first and adds APB on the CAZ, CTX and FOX paper without APB to apply APB paper reinforcement method to carry out paper method drug hypersensitive test to test the AmpC enzyme generated by bacteria. APB can enlarge the microbiostatic ring of CAZ, CTX or FOX paper to the generated AmpC enzyme bacteria so as to judge the existence of AmpC enzyme by testing the change of the diameter of the ring to avoid missed test brought with using the single base material to increase the positive rate.

The invention discloses a method for preparing mono-dispersed N-doped ordered mesoporous carbon spheres with the particle size of 100-800 nm at high yield in a single-pass mode. According to the method, F127, 3-aminophenol and NH3.H2O serve as a template, a carbon and nitrogen source and a catalyst respectively, and the mono-dispersed N-doped ordered mesoporous carbon spheres with the particle size of 100-800 nm are produced at high yield in the single-pass mode on a large scale by regulating and controlling product morphology through ethyl alcohol. The preparing method is easy to implement, the concentration of the carbon and nitrogen source in the system is high, dosage of solvent is greatly reduced, several grams of N-doped ordered mesoporous carbon spheres can be obtained at high yield in the single-pass mode, the obtained N-doped ordered mesoporous carbon spheres are small in size distribution range, good in monodispersity and regular in pore structure and can be directly used as a catalyst, adsorbent and the like.

The invention relates to a preparation method of an epidermal growth factor receptor (EGFR) inhibitor neratinib. The method is characterized in that 6-[(E)-4-(dimethylamino)-2-butenylamido]-7-ethoxy-4-chloro-3-quinolylmethylnitrile (I) continuously reacts with 2-chloro-3-aminophenol (II) and dichloromethylpyridine hydrochloride (III) to temporarily obtain an intermediate (E)-N-{4-[3-chloro-4-hydroxyanilino]3-cyno-5-ethoxy-6-quinolyl}-4-dimethylamino-2-butenylamide (IV) in order to finally obtain neratinib. The preparation method adopts a continuous reaction process, and dichloromethylpyridine hydrochloride (III) is a catalyst in the first stage of the continuous reaction and is a reaction reagent in the second stage of the continuous reaction, so the method has the advantages of simple and easily available raw materials, high yield, mild reaction conditions, extremely small amount of a generated waste liquid, and high facilitation of industrial production of the above raw medicine.

The invention discloses an aromatic diamine compound containing aryl phosphine groups, a prepration method and an application thereof. The structural general formula of the compound is shown in a formula I. The compound takes 3,5-difluoro-bromobenzene and diphenylphosphinic chloride as raw materials, firstly prepares 3,5-difluorophenyl diphenyl phosphine oxide by Grignard reaction and then continuously reacts with 3-aminophenol for preparation. The compound has smaller steric effect and has great value for improving the heat resistance performance of atomic oxygen resistant polyimide thin film materials and improving the visible light transparency. In addition, polyimide phosphine-containing polymer materials prepared by utilizing the phosphine-containing aromatic diamine compound have good atomic oxygen resistance performance, higher glass transition temperature and better visible light transparency, thereby being capable of being applied in the manufacturing of satellites and other aircraft parts in the LEO environment.

An agent for oxidatively dyeing keratin fibers includes in a cosmetic carrier, (A) as developer, 4,5-diamino-1-(2-hydroxyethyl)-1H-pyrazole and / or one of the physiologically acceptable salts thereof, (B) as developer, at least one pyrimidine derivative selected from 2,4,5,6-tetraaminopyrimidine, 4-hydroxy-2,5,6-triaminopyrimidine, 2-hydroxy-4,5,6-triaminopyrimidine and / or one of the physiologically acceptable salts thereof, (C) as coupler, at least one m-diaminobenzene derivative selected from 2-(2,4 -diaminophenoxy)ethanol, 1-methoxy-2-amino-4-(2′-hydroxyethylamino)benzene, 2,6-bis(2′-hydroxyethylamino)-1-methylbenzene, and / or one of the physiologically acceptable salts thereof, and (D) as coupler, at least one m-aminophenol derivative selected from 3-aminophenol, 5-amino-2-methylphenol and / or one of the physiologically acceptable salts thereof.

The application relates to agents for dyeing keratin fibers. The agent can be present in a cosmetic carrier and includes at least one compound of formula (I) and / or a physiologically compatible salt of this compound,in which R1 is a C1-C4 alkyl group, R2 is a hydrogen atom, a C1-C8 alkyl group, a C2-C6 alkenyl group, a C1-C6 hydroxyalkyl group, a C2-C6 polyhydroxyalkyl group, a C1-C6 alkoxy group, a C1-C6 alkylamino group, a di-C1-C6 alkylamino group, a C1-C6 polyalkoxy group, a C1-C6 alkylamido-(C1-C6) alkyl group, wherein the amide function can be substituted by one or two groups X, or is an aryl group, Y is an NH2 or an OH group, at least one coupler component selected from 3-amino-2-methylamino-6-methoxypyridine, 3-amino-6-methylphenol, 3-amino-2-hydroxypyridine, 1,3-bis-(2,4-diaminophenoxy)propane, 2,7-dihydroxynaphthalene, 2-methylresorcinol, 2,5-dimethylresorcinol, 4-chlororesorcinol, 3-aminophenol, 2-amino-3-hydroxypyridine, 2-chloro-6-methyl-3-aminophenol, 2,6-dihydroxy-3,4-dimethylpyridine, 2-({3-[(2-hydroxyethyl)amino]-4-methoxy-5-methylphenyl}amino)ethanol, 2-({3-[(2-hydroxyethyl)amino]-2-methoxy-5-methylphenyl}amino)ethanol, 1-methoxy-2-amino-4-beta-hydroxy-ethylaminobenzene (Lehmann's blue), 2,4-diaminophenoxyethanol, 5-amino-4-chloro-o-cresol, 2,4-dichloro-m-aminophenol, 2,6-dihydroxy-3,4-dimethylpyridine and / or a physiologically compatible salt of these compounds.

An agent for oxidatively dyeing keratinous fibers includes in a cosmetic carrier: (A) 4,5-diamino-1-(2-hydroxyethyl)-1H-pyrazole and / or one of the physiologically acceptable salts thereof as developer; (B) at least one p-aminophenol derivative from the group comprising p-aminophenol, 4-amino-3-methylphenol, and / or the physiologically acceptable salts thereof as developer; (C) at least one m-diaminobenzene derivative from the group comprising 2-(2,4-diaminophenoxy)ethanol, 1-methoxy-2-amino-4-(2′-hydroxyethylamino)benzene, 2,6-bis(2′-hydroxyethylamino)-1-methylbenzene, and / or one of the physiologically compatible salts thereof as coupler; and (D) at least one m-aminophenol derivative from the group 3-aminophenol, 5-amino-2-methylphenol and / or one of the physiologically acceptable salts thereof as coupler, wherein the molar ratio of all the developers of group (A) included in the agent to all the developers of group (B) included in the agent, i.e., the molar ratio (A) / (B), has a value of at least 1.2.