The invention discloses a novel pharmaceutical composition for prevention and control of liberobacter asiaticum, wherein the pharmaceutical composition comprises the following raw materials: herba patriniae, pterocarya stenoptera leaves, mint, mangnolia officinalis, melia azedarach, celasturs angulatus maxim, ailanthus altissima, lettuce, sylvite, phosphorus salt, nitrogen salt, calcium salt, magnesium salt, iodised salt, boron salt, molybdenum salt, zinc salt, manganese salt, copper salt, iron salt, vitamins, amino acids, indolebutyric acid, gibberellin, 6-benzylaminopurine, naphthylacetic acid, agar, kinetin, polyvinylpyrrolidone, sodium methylene bis-naphthalene sulfonate, an American DuPont EEA2112AC compatibilizer, an ampullaria gigas powder, alkyl potassium sulfate, acrylate, glycidoxypropyltrimethoxysilane, xanthan gum, and ethanol. The pharmaceutical composition for prevention and control of liberobacter asiaticum can increase the yield and the sugar content; citrus reticulata blanco has the advantages of good taste, mellow and full appearance and color, and high quality; and the pharmaceutical composition has the use effect higher than that of a conventional pharmaceutical composition for prevention and control of liberobacter asiaticum.