38results about How to "One-step synthesis" patented technology

The invention provides a fluorine-modified titanium and aluminum phosphate molecular sieve F-TAPO-5 and a preparation method thereof. The preparation method comprises the steps that 1, a phosphorus source, an aluminum source, a fluorine-containing titanium source, a templating agent and deionized water are mixed to be uniform according to the molar ratio of 0.96:1.5:(0.04-0.3):0.8:50 under vigorous stirring, stirring is conducted for 20-40 min at the temperature of 25-35 DEG C, and molecular sieve precursor sol is obtained; the precursor sol is converted into a hydrothermal reactor with a PTFE lining, crystallization treatment is conducted for 18-30 h at the temperature of 160-185 DEG C, after crystallization is finished, solids are separated out through centrifugation, the solids are washed with distilled water and then dried by 10-15 h at the temperature of 90-110 DEG C, and fluorine-containing titanium and aluminum phosphate molecular sieve raw powder is obtained; 2, the molecular sieve raw powder obtained in the step 1 is put into a tubular furnace constant temperature area, calcination is conducted for 4-8 h at the temperature of 500-650 DEG C in an oxygen atmosphere to remove the templating agent, and the fluorine-modified titanium and aluminum phosphate molecular sieve F-TAPO-5 is obtained. The fluorine-modified titanium and aluminum phosphate molecular sieve F-TAPO-5 obtained through the method has high Lewis acid and surface hydrophobicity and can be applied in a catalytic cyclohexanone ammoximation reaction.

The invention discloses a lithium ion battery cathode active material and its preparation method. The material is pink terephthalic cobalt powder, and its molecular formula is Co2(OH)2(C8H4O4). The preparation method adopts a solvothermal technique for one-step synthesis, and has the advantages of simple process, convenient and feasible operation, and wide raw material sources. Compared with traditional carbon cathode materials, the material provided in the invention has higher specific capacity and good cycle performance.

The invention relates to a preparation method of bis-hydroxypropyl neopentyl glycol ether and belongs to the technical field of organic compound synthesis. According to the technical scheme of the preparation method of bis-hydroxypropyl neopentyl glycol ether, neopentyl glycol is adopted as a raw material, and a product of bis-hydroxypropyl neopentyl glycol ether is adopted as a solvent. A 3-(4-methoxyphenyl) phosphine catalyst is added. After that, propylene oxide is adopted as a chain extender for the synthesis of bis-hydroxypropyl neopentyl glycol ether. The method is applied to the synthesis of bis-hydroxypropyl neopentyl glycol ether and has the advantages of high product content, low neopentyl glycol content, low content of allyl alcohol as a by-product, stable quality and the like.

The invention discloses a sialic acid-carboxylic acid compound conjugate and a preparation method thereof. The sialic acid-carboxylic acid compound conjugate is obtained by subjecting a sialic acid glucocinolate donor and a carboxylic acid compound to direct glycosylation reaction and is a compound with carboxylate at an anomeric position of sialic acid. The preparation method includes: (1), sequentially adding the sialic acid glucocinolate donor, a newly-activated molecular sieve and the carboxylic acid compound into a reaction container, adding redistilled dichloromethane for dissolution, and stirring for 15min at 25 DEG C under argon shield; (2), sequentially adding an activation system, boron trifluoride diethyl ether and iodosuccinimide quickly, and stirring for reaction at 25 DEG C for 5-10min; (3), filtering a reaction system, using an organic solvent to dilute, using a saturated sodium thiosulfate solution to wash an organic phase once, using the organic solvent to extract an aqueous phase for three times, merging the organic phase, using anhydrous sodium sulfate to dry, filtering, spin-drying, and using a silica gel column for chromatography and elution to obtain the sialic acid-carboxylic acid compound conjugate. By the preparation method, the sialic acid-carboxylic acid compound conjugate which is efficient can be provided to benefit society.

The invention discloses a method for synthesizing 1,5-diaminonaphthalene by one step with naphthalene. The method is characterized in that in a mixed solvent of glacial acetic acid and water, naphthalene and hydroxylammonium salts carry out one-step reaction in the presence of catalysts, namely metavanadate and / or vanadium oxide, to generate 1,5-diaminonaphthalene. The method is low in cost, simple in process, short in flow and mild in reaction conditions, is environment-friendly and meets the industrial production requirements.

The invention discloses a Saccharomyces cerevisiae recombinant bacterium, which integrates in the genome RgTAL Gene, HpaB genes and HpaC Gene. The invention also discloses the construction method and application of Saccharomyces cerevisiae recombinant bacteria. Finally, the invention also discloses a production method of caffeic acid. The present invention integrates three exogenous genes required for caffeic acid synthesis into the chromosome of Saccharomyces cerevisiae, and through the knockout of competition pathway genes, the elimination of feedback inhibition steps, and the overexpression of rate-limiting enzymes, the transition from glucose to For the total synthesis of caffeic acid, the shake flask yield reached about 760 mg / L, which is the highest level of yeast yield reported so far, which provides a new method for the industrial production of caffeic acid.

The invention discloses an environment-friendly synthesis method of 1-naphthylamine. The method is characterized in that in a mixed solvent of glacial acetic acid and water, naphthalene and hydroxylammonium salts carry out one-step reaction to generate 1-naphthylamine. The method is low in cost, simple in process, short in flow and mild in reaction conditions, is environment-friendly and meets the industrial production requirements.

The invention discloses an amphiphilic core-shell porous polymer microsphere and a preparation method thereof. The preparation method of the amphiphilic core-shell porous polymer microspheres of the present invention comprises the following steps: a) adding the emulsion obtained after emulsifying an organic solvent, a surfactant and water into an aqueous solution of polystyrene microspheres, and stirring; b) adding hydrophobic monomers, hydrophilic monomers and initiators to surfactant aqueous solution and emulsifying; c) adding the emulsion obtained in step b) to the solution obtained in step a) and stirring; d) c) The obtained emulsion is passed through nitrogen to polymerize; e) Washed repeatedly with ethanol and deionized water, and freeze-dried to obtain the obtained emulsion. The porous polymer microspheres of the present invention use polystyrene microspheres as the basic construction unit, and the controllable synthesis of amphiphilic porous polymer microspheres can be realized by introducing hydrophilic / hydrophobic monomers, which can be used for drug release, tissue engineering, Biomolecular separation, adsorption, sensing and other fields.

The invention relates to a method for synthesizing a preservative and antistaling agent, and in particular relates to a method for synthesizing a sodium diacetate crystal in one step. The following raw materials are adopted in percent by weight: 70.4-72.4% of glacial acetic acid, 10.8-12.0% of ionic membrane method caustic soda flake and 16.5-18.6% of anhydrous sodium carbonate. The synthesis steps are as follows: (1) mixing the ionic membrane method caustic soda flake with the anhydrous sodium carbonate, slowly adding the glacial acetic acid and then naturally heating, controlling total reaction time to be 30-50 minutes, and controlling maximum reaction temperature to be 65-85 DEG C; and (2) cooling the temperature below 50-60 DEG C after the reaction is completed, and discharging. By applying the method provided by the invention, solid-liquid separation equipment, drying equipment and a reaction heating device are eliminated, a sodium diacetate crystal one-step synthesis method is realized, process is simple and safe, energy is saved, production cost can be greatly reduced, yield of the product reaches up to more than 97%, product quality is easy to control, and the standard of FAO / WHO (Food and Agriculture Organization / World Health Organization) is met.

The present invention relates to a kind of synthetic method of preparing 2-substituted indole derivatives, aromatic amine compound (I), ketone compound (II) and desiccant are mixed in organic solvent, after adding palladium catalyst, in aerobic Reaction under weakly acidic environment makes described indole compound (III), (I) is (II) is (III) is wherein R 1 selected from hydrogen, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkanoyl, C2-C6 alkenyl, C2-C6 alkynyl, halogen, hydroxyl, substituted or unsubstituted amino, substituted or unsubstituted phenyl, pyridyl and heterocyclic aryl; (1) also can be substituted or unsubstituted pyridinamine, pyrimidinamine, pyridazinamine or pyrazinamine; substituting group is selected from one or more C1-C6 alkyl, C1‑C6 alkoxy, C1‑C6 alkanoyl, C2‑C6 alkenyl, C2‑C6 alkynyl, halogen, hydroxyl, amino; R 2 Selected from C1-C6 alkyl group, formate group or C1-C6 alkanoyl amido group.

The invention relates to a method for synthesizing 6-ethylthio-3-heptene-2-ketone. The method comprises the following steps of: mixing a dilute alkali solution with a concentration of between 1 and 20 percent and acetone, and heating the mixture to 60 DEG C; slowly adding 3-ethylthio butyraldehyde into the mixture for 0.5 to 10 hours, with a mol ratio of a solute in the dilute alkali solution to the 3-ethylthio butyraldehyde being 0.3-1.5 to 1, a pH value being between 9 and 11, and the quality of the acetone being 0.44 to 8.8 times of that of the 3-ethylthio butyraldehyde; constantly maintaining a boiling state of the system during the process of dripping the 3-ethylthio butyraldehyde; and maintaining the system below 60 DEG C after dripping is completed, and stirring for 2 hours to obtain the 6-ethylthio-3-heptene-2-ketone. In the reaction, the acetone is substituted for sodium acetoacetate to directly react with the 3-ethylthio butyraldehyde under an alkali condition, and dehydration can be directly realized under the condition, thereby realizing one-step synthesis of a product. The method has the advantages of simplified steps, low cost, good atom economy, greenness and environmental friendliness.