32results about How to "Non-toxic method" patented technology

The invention discloses a polysubstituted oxazoline compound and a preparation method thereof. In the present invention, 0.15-0.45 mmol N-(1-substituted vinyl) substituted amide, 0.15 mmol α-carbonylthio ylide, 10 mol% silver salt catalyst and 0.15 mmol additive are sequentially added into Schlenk sealed tube under nitrogen atmosphere to mix, The mixture was heated to 60-120° C. and stirred for 12-24 h, then the reaction solution was cooled to room temperature, and the polysubstituted oxazoline compound was obtained by separation by silica gel column chromatography. The reaction conditions required by the preparation method of the invention are mild, the raw materials used include enamide and sulfur ylide are cheap and easy to obtain, and the substrate is suitable for a wide range. Compared with the traditional oxazoline synthesis route, the method is greener, non-toxic, and has more synthetic steps. The target product can be obtained simply and in high yield, and the obtained oxazoline compound has potential application prospects in the field of pharmaceutical synthesis.

The invention relates to a preparation method of porous boron nitride nanofibers. The preparation method mainly utilizes a three-step synthesis method, namely (1) synthesizing melamine diboronic acid precursor powder from boric acid and melamine in a hydrothermal manner; (2) rapidly freezing and cooling a hot water solution of a melamine diboronic acid precursor with liquid nitrogen by virtue of a freeze-drying method, then drying, and synthesizing melamine diboronic acid nanofibers; and (3) carrying out high-temperature thermal cracking on the melamine diboronic acid nanofibers in protective atmosphere, so as to obtain the porous boron nitride nanofibers. According to the preparation method, molecular crystals of melamine diboronic acid are rapidly separated and nucleated by virtue of a freeze drying technique, so that the growth of the crystals is avoided; the diameters of the prepared porous boron nitride nanofibers reach a nanometer scale, and the porous boron nitride nanofibers are high in purity, uniform in shape, high in slenderness ratio and large in specific surface area.

The invention relates to a preparation method of chitosan derivative nanoparticles for delivering siRNA, belonging to the technical field of gene biology. The present invention mixes positively charged chitosan hydrochloride solution with siRNA solution that can inhibit colon cancer cell proliferation and migration-related protein expression, and then adds negatively charged carboxymethyl chitosan solution, through intermolecular electrostatic interaction function and self-assemble into chitosan-derived nanoparticles (siRNA‑CDNPs) for delivery of siRNA. The chitosan derivative nanoparticles for delivering siRNA can effectively protect siRNA under the condition of pH value 1.2, and realize the controllable release of siRNA by responding to external stimuli (ultrasound) under the condition of pH value 5.5 in the environment of colon cancer cells ; siRNA‑CDNPs can effectively inhibit the expression of β‑catenin protein in colon cancer cells, and is expected to inhibit the proliferation and migration of cancer cells. The preparation method of the invention is simple to operate, environmentally friendly and low in cost.

The invention discloses a preparation method of a visible light absorption layer based on an Ag3PO4 film, and belongs to a preparation method of photocatalysis and photoelectric materials. The visible light absorption layer is prepared by using a four-step process including coprecipitation, spin coating, drying and sintering, and the method comprises the steps of 1) preparing Ag3PO4 nano-scale ultrafine powder of which the size scale is between 20 and 500 nm by using a coprecipitation method; 2) ultrasonically dispersing the Ag3PO4 powder into transparent organic solvents, and performing spin coating on the obtained sol shaped dispersion liquid on a substrate to obtain a prefabricated Ag3PO4 film layer; and 3) putting the prefabricated Ag3PO4 film layer into an oven at the temperature of 20-80 DEG C for drying, and putting into a muffle furnace for sintering and removing organic residues. The Ag3PO4 visible light absorption layer has a thickness of 0.2-10 microns, and is high in response characteristics and adhesive force of visible light; because the visible light absorption layer is used as a photocatalyst, the visible light absorption layer is easy to recover, can be used for a photo-anode of a photoelectrochemical cell, and has a large application potential on the fields of light degradation pollutants, photolysis of water, photovoltaic conversion and the like. The method is simple, free of toxicity, easy to operate and low in cost.

The invention relates to a preparation method of a foamed boron nitride block material. The preparation method comprises the following steps: (1) preparing a melamine-boric acid-water mixed solution; (2) carrying out ultrasonic treatment for 1h to 24h by an ultrasonic apparatus; separating out a white block body; (3) putting the white block body and a residual solution into a freezing dryer; freezing and pumping in vacuum to obtain a dried white solid precursor; (4) keeping the heat of the white solid precursor at 900 DEG C to 1500 DEG C for 2h to 6h under a protective atmosphere; cooling under the protective atmosphere to room temperature, so as to obtain a white block-shaped solid substance, namely a block-shaped boron nitride foam material. According to the preparation method of the foamed boron nitride block material, the energy consumption and cost of production are reduced; the method has no toxin and has high efficiency, and is applicable to large-scale and industrial synthesis of the foamed boron nitride block material; the prepared foamed boron nitride block material is composed of boron nitride micro-nano fibers with a high length-diameter ratio, and has the characteristics of good connectivity, large specific surface area, super hydrophobicity and the like.

The invention discloses a heterogeneous structure catalyst and a preparation method for decomposing water to produce hydrogen by using solar energy, and belongs to the preparation method of semiconductor photocatalytic materials. Steps: 1) SiO 2 Disperse the nanospheres in deionized water, add urea and nickel nitrate and mix evenly; 2) transfer the mixed solution to a hydrothermal reaction kettle, and react at 105°C for 12h; 3) after natural cooling, centrifuge and dry the product to obtain SiO 2 @nickel silicate powder; 4) SiO 2 Disperse @nickel silicate into deionized water, add sodium sulfide, and adjust the pH of the mixed solution with NaOH; 5) Transfer the mixed solution to a hydrothermal reaction kettle and react at 160°C for 12‑20h; 6) After natural cooling, centrifuge to collect the black Precipitation and vacuum drying to obtain NiS hollow nanosphere powder; 7) Dissolve NiS and glycerin in water, add zinc chloride, indium chloride and thioacetamide; 8) react the solution at 80°C for 2h under stirring; 9) After centrifugation, washing and drying, NiS@ZnIn was obtained 2 S 4 . Pros: NiS@ZnIn 2 S 4 Spherical heterostructures have large specific surface area, low density, good surface permeability and visible light response.

The invention relates to a preparation method of a TiO2 grading structure with visible light response, and belongs to a preparation method of a semiconductor photocatalysis and photoelectric chemical material. According to the method, firstly, villiaumite is dissolved in water; acetic acid is dropwise added into the villiaumite water solution; continuous stirring is performed; then, tetra-n-butyl titanate is dropwise added into an obtained mixed solution, and continuous stirring is performed; the mixed solution is put into a hydrothermal reaction kettle; the temperature is raised to 140 to 180 DEG C, enabling the reaction to be performed for 8 to 16h; after the reaction kettle is naturally cooled, precipitates are taken out; centrifugation or filtering, washing and drying are performed; the temperature is raised to 300 to 550 DEG C in air atmosphere; heat insulation sintering is performed for 0.5 to 3h. The prepared TiO2 grading nanometer structure has the advantages of large specific surface area, visible light response, single-crystal structure and the like, and is suitable for being applied to the fields of photocatalytic degradation of pollutant, photoelectrocatalysis water decomposition hydrogen production and the like. The preparation method has the advantages that the method is simple and nontoxic; the operation is easy; the cost is low; the preparation method is suitable for industrial production.

The invention discloses a method for preparing a silver phosphate thin film, which belongs to the method for preparing semiconductor photocatalysis and photoelectrochemical materials. Steps: 1) Use alcohol and acetone reagents to ultrasonically clean the glass or silicon wafer substrate in sequence; 2) Deposit a layer of Ag film on the substrate by sputtering and thermal evaporation; 3) Drop silver nitrate AgNO on the Ag film layer. 3 , spin coating, drying; then drop disodium hydrogen phosphate Na 2 HPO 4 Aqueous solution, spin coating and drying; 4) Place it in a muffle furnace, raise the temperature to 300-550°C, heat-preserve and sinter for 0.5-3 hours to obtain silver phosphate Ag 3 PO 4 film. The silver nitrate AgNO 3 The mass percentage concentration of aqueous solution is 0.017%-0.34%; Described disodium hydrogen phosphate Na 2 HPO 4 The mass percent concentration of the aqueous solution is 0.014%-0.28%; the silver phosphate Ag 3 PO 4 The film is a structure with a thickness of 0.3-10 μm. Advantages: 1. The method of the present invention is simple, non-toxic and easy to operate. 2. The method of the present invention does not need to be protected by an inert atmosphere, has low cost, and is suitable for industrial production. 3. The adhesion of the obtained film layer is good, and the thickness of the film layer is easy to control.

The invention belongs to the field of electrochemistry battery, and more specifically relates to a black phosphorus nanosheet-graphene composite film anode used for flexible lithium ion batteries, and a preparation method thereof. According to the preparation method, high purity and large scale black phosphorus blocks are synthesized via mineral substance assistant vapor transporting method with high efficiency; a large amount of clean and high quality black phosphorus sheets are prepared in water via ultrasound treatment; the clean and high quality black phosphorus sheets and high conductive graphene nanosheets prepared via intercalation stripping method are subjected to mixing ultrasonic dispersion; and flexible high-strength laminated composite film is prepared via vacuum filtration. The preparation process of the flexible high-strength laminated composite film is simple and controllable; large scale low cost preparation can be realized; black phosphorus nanosheets are high in capacity, graphene is high in electrical conductivity, and the black phosphorus nanosheets and graphene both possess two-dimensional structures high in flexibility and strength, so that problems the black phosphorus is poor in electrical conductivity and stability are solved, lithium ion battery capacity, cycling stability, and entire energy density are increased, and lithium ion battery electrode integrated flexible design is realized.

A preparation method of bio-based water-based UV curing environment-friendly nail polish, by weighing 30-50% of bio-based water-based UV curing environment-friendly nail polish resin, 5-10% of deionized water, 40-60% of pigment, moistening Wet dispersant 0.1-0.5%, leveling agent 0.1-0.5%, defoamer 0.2-0.5% and thickener 1.0-2.0%; add pigment, wetting and dispersing agent, leveling agent, defoamer to the ball mill Grind with deionized water to obtain color paste a; add bio-based water-based UV curing environmentally friendly nail polish resin to color paste a, add thickener after high-speed stirring, and filter through a 200-mesh filter to obtain bio-based water-based UV curing environmental protection nail polish. The nail polish prepared by the invention has the characteristics of fast curing speed, good transparency, storage stability, high gloss, good adhesion, etc. The method of the invention is green, environmentally friendly, non-toxic and tasteless, and reduces product cost.