The invention discloses an acetylisovaleryl
tylosin tartrate granular preparation and a preparation method thereof. The acetylisovaleryl
tylosin tartrate granular preparation comprises the following steps: (1) preparing, namely, respectively weighing acetylisovaleryl
tylosin tartrate and a carrier auxiliary material according to a formula ratio for later use; (2) mixing, namely, heating to melt the carrier auxiliary material, uniformly stirring, mixing acetylisovaleryl
tylosin tartrate with the molten carrier auxiliary material, shearing, uniformly stirring so as to obtain a uniform dispersed
system, and preparing mixed liquid; and (3) performing condensation spraying pelletization, namely, pumping the mixed liquid of step (2) to a condensation
spray granulation system, performing centrifugal spray pelletization so as to prepare acetylisovaleryl
tylosin tartrate granules, cooling, screening by using an oscillation
sieve being 20-120 meshes, and collecting, thereby obtaining a product. According to the acetylisovaleryl
tylosin tartrate granules prepared by the invention, the main
medicine is uniformly distributed, the granules are round and tidy, the flowability and the
dispersity of the granular preparation can be improved, and the acetylisovaleryl tylosin tartrate granular preparation can be easily mixed with feed; in addition, the acetylisovaleryl tylosin tartrate granular preparation adopts a simple production process, and is good in smell masking effect and good in slow-release effect.