The invention discloses a method for extracting high-purity
nobiletin from citrus peels. The method comprises the following steps: 1, carrying out
reflux extraction of crushed dry citrus peels for 2 to 4 times, combining the filtrate after
filtration, and concentrating under reduced pressure to obtain a concentrated solution; 2, adding water into the concentrated solution, then adding an acidic solution or an alkaline solution till the pH value of the
system ranges from 3 to 9, standing for removal of the supernatant to obtain a
sediment,
settling and washing the
sediment, centrifuging, and collecting
solid to acquire a polymethoxylated flavonoids crude product; 3, conducting ungrease treatment; 4, using an
organic solvent to achieve
reflux dissolution of the polymethoxylated flavonoids crude product which is subject to ungrease treatment, then adding
activated charcoal for
reflux decoloration, filtering, standing the concentrated filtrate for
crystallization, and filtering the crystallized filtrate to obtain a
nobiletin crude product; and 5, recrystallizing to obtain the high-purity
nobiletin of which the quality purity is not less than 98 percent. The method provided by the invention has the characteristics of simplicity, feasibility, short production period, no need of expensive production equipment, low cost and the like, and is easy for realizing industrial production of high-purity nobiletin.