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60results about How to "Has antiviral activity" patented technology
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Gallbladder wood leaf composition containing strictosamide as well as preparation and application thereof
InactiveCN102600269AHas antibacterial activityProtectiveOrganic active ingredientsNervous disorderDiseaseKaempferol-3-O-rutinoside
The invention relates to a gallbladder wood leaf composition containing strictosamide. The gallbladder wood leaf composition is characterized in that the gallbladder wood leaf composition is prepared by combining alkaloid and flavonoid extracted from gallbladder wood leaf; the alkaloid contains strictosamide,10-hydroxy-strictosamide and short snakeroot glucoside; the flavonoid contains kaempferol-3-O-rutinoside and rutin; and the total weight of the three alkaloid and flavonoid is 50-98% of that of the composition, and the ratio of the total weight of the three alkaloid and the total weight of the flavonoid is (10-0.7):(0.5-10). The invention also discloses a preparation of the composition. The composition provided by the invention can play the role of clearing away heat and toxic materials and relieving swelling and pain, and can treat diseases such as acute tonsillitis, acute pharyngitis, acute conjunctivitis, upper respiratory tract infection or chronic pelvic inflammatory disease and appendagitis; and can cure slight and medium pain.
Owner:江苏中康药物科技有限公司 +1
Antibody-peptide bispecific immunotherapeutic agent for Middle East respiratory syndrome coronaviruses
InactiveCN111378048AHas antiviral activitySsRNA viruses positive-senseAntibody mimetics/scaffoldsMiddle East respiratory syndromeImmunotherapeutic agent
The invention belongs to the technical field of biology, and relates to fused protein of an antibody and an antivirus peptide, in particular to a bispecific efficient immunotherapeutic agent, of a fully human neutralizing antibody and a high-activity MERS-CoV-inhibiting peptide, for Middle East respiratory syndrome coronaviruses (MERS-CoV), and application of the bispecific efficient immunotherapeutic agent, of the fully human neutralizing antibody and the high-activity MERS-CoV-inhibiting peptide, for the Middle East respiratory syndrome coronaviruses (MERS-CoV). The antibody-peptide bispecific immunotherapeutic agent is the fused protein of the antibody and the antivirus peptide, wherein the antibody is the high-activity fully human neutralizing antibody to the MERS-CoV, and the peptideis the high-activity MERS-CoV-inhibiting peptide. The bispecific immunotherapeutic agent has antivirus activity of the antibody and the antivirus activity of the peptide at the same time, can be usedfor further producing a potent antivirus medicine, and is especially suitable for treating disease caused by the Middle East respiratory syndrome coronaviruses (MERS-CoV).
Owner:FUDAN UNIV
Pyrone compounds and preparation method and application thereof
ActiveCN108148031AHas antiviral activityGood yieldOrganic active ingredientsOrganic chemistryMicroorganismSide effect
The invention provides alpha-pyrone compounds having antiviral activity and their application in resisting influenza viruses H1N1 and H3N2. The invention also discloses a preparation method of the alpha-pyrone compounds having antiviral activity, comprising: (1) acquiring a fermented material having rich pyrone compounds through microbial fermentation culture, wherein a recombinant vector used inthe microbial fermentation culture carries polyketide synthase having a nucleotide sequence of KU534995.1; (2) separating and purifying the fermented material of step (1) to obtain the alpha-pyrone compounds. Compared with existing drugs, the pyrone compounds have good anti-H2N1 and anti-H3N2 activity and are substantially nontoxic to normal cells; compared with existing drugs, the alpha-pyrone compounds have natural advantages, including good activity and toxic and side effects reduced as far as possible, and also have a promising application prospect and huge market.
Owner:OCEAN UNIV OF CHINA
Alga oligosaccharide fish feed additive
The invention discloses an alga oligosaccharide fish feed additive and relates to an alga oligosaccharide. Aiming at solving the problems of the prior art, the invention provides the alga oligosaccharide fish feed additive. The alga oligosaccharide fish feed additive improves a feed utilization rate, promotes growth, improves disease resistance, reduces a cost and improves fish quality. The alga oligosaccharide of the alga oligosaccharide fish feed additive is gracilaria lemaneiformis agar oligosaccharide and is a mixture which comprises tetrasccharide to octasaccharide and is obtained through co-culture of a Flammeovirga Pacifica H2 strain and gracilaria lemaneiformis so that gracilaria lemaneiformis is directly degraded through an enzyme produced through microorganism. The Flammeovirga Pacifica H2 has a preservation number of CCTCC NO: M2012229.
Owner:CENT LAB FUJIAN ACADEMY OF AGRI SCI +1
Preparation method of colorful crisp potato chips through osmotic dehydration and vacuum freeze-drying
InactiveCN105661413AGood shape and colorRetained anthocyaninsFood dryingFood ingredient functionsSaccharumFreeze-drying
The invention discloses a preparation method of colorful crisp potato chips through osmotic dehydration and vacuum freeze-drying. According to the preparation method, an osmotic dehydration technology and a vacuum freeze-drying technology are combined, a sucrose solution is firstly taken as an osmotic solution to remove part of moisture in the colorful potato chips, and then the colorful crisp potato chips are prepared with the vacuum freeze-drying technology. According to the scheme, the drying temperature is low, the drying time is shorter than that of single vacuum freeze-drying, the prepared colorful crisp potato chips have good color, luster and shape and taste crisp and slightly sweet, and nutrient substances of the prepared colorful crisp potato chips are almost not lost; besides, with the adoption of the method, anthocyanin in the colorful potato chips can be reserved to the greatest extent, so that the prepared colorful crisp potato chips have certain functions of resisting to oxidation, eliminating free radicals and delaying senescence; further, the colorful crisp potato chips have functions of protecting the liver and preventing cardiovascular diseases as well as certain anti-mutation effect, antitumor activity and antiviral activity.
Owner:贵州省生物技术研究所 +2
Natural film coating agent applied to food and healthcare products
ActiveCN103583932ADissolve fastGood film formingPharmaceutical non-active ingredientsFood shapingChemical synthesisDirect effects
The invention relates to a natural film coating agent applied to food and healthcare products. The natural film coating agent comprises the following raw materials in parts by weight: 40-67 parts of cellulose ether derivatives, 3-32 parts of seaweed polysaccharides, 1-10 parts of natural pigments, 2-25 parts of micromolecular sugar alcohol and 4-15 parts of lecithin. According to the coating agent, natural plant materials are adopted, pollution of heavy metal lead and arsenic is very low and cannot directly influence the coating agent, and the actually measured heavy metal lead and arsenic content also meets the regulations and standards of food additives; the coating agent does not contain chemical synthesized materials and is free from harmful compounds and monomer residues, so that the requirements of the food and the healthcare products on the safety are fully met; main ingredients in the natural coating agent can be dissolved in water, so that an organic solvent does not need to be used in a coating process and the production cost is greatly saved; a water solution is used for performing a coating process, so that coated drugs do not contain organic solvent residues and the safety of the drugs is improved.
Owner:TIANJIN BOKELIN MEDICINE PACKAGING TECH
Accelerant health protection additive of feedstuff using Chinese traditional medicine and its preparation method
InactiveCN1480058AImprove digestive functionPromote secretionAnimal feeding stuffAccessory food factorsHot peppersTraditional medicine
A health-care additive of feed for promoting growth and taking care of health is prepared from 8 Chinese-medicinal material including haw, hot pepper, garlic, motherwort, etc through extracting in water and vinegar.
Owner:NANFANG BAMBOO & WOOD PROD ZHEJIANG
Antiviral emulsion composition, coating and preparation method thereof
ActiveCN111333862AReduce surface viral activityAvoid uneven loadAntifouling/underwater paintsPaints with biocidesPhosphonium saltPolyvinyl alcohol
The invention provides an antiviral water-based matrix emulsion composition and an antiviral coating containing the same. The emulsion composition is composed of an inorganic metal nanocomposite dispersion liquid with photocatalytic antiviral activity, a water-based high-molecular polymer emulsion containing a high-content quaternary phosphonium salt unit, and an optional polyvinyl alcohol auxiliary agent. The water-based matrix emulsion or the coating thereof can be used for surface coating treatment of textile articles, plastic products, glass products, leather, wooden products and other objects, so that the virus activity on the surfaces of the objects is reduced or inactivated in a short time, and the effects of inhibiting viruses and blocking propagation are achieved.
Owner:LONGHAI ZHENGUYUAN ADHESIVE CO LTD
Preparation of carrageenan sulfated oligosaccharide with antivirus activity
InactiveCN101463372AHigh yieldUndamagedMicroorganism based processesAntiviralsCarrageenanEvaporation
The invention relates to a method for preparing carrageenin-sulfate oligosaccharide with antiviral activity, which is characterized in that culture medium for beta-glucanase production is prepared, marine cellulophaga is inoculated; kappa-carrageenin crude digestive enzyme liquid is fermented and extracted; additionally, the kappa-carrageenin is dissolved in distilled water and undergoes enzymatic hydrolysis reaction after the kappa-carrageenin crude digestive enzyme liquid is added; the enzymatic hydrolysis reaction liquid is converted into concentrated liquid after the rotary evaporation; enzymatic hydrolysis oligosaccharide fragment is collected by precipitating organic solvent; and then sulfate modification is carried out on the enzymatic hydrolysis oligosaccharide fragment and carrageenin-sulfate oligosaccharide is obtained. The invention has the advantage that the step combining enzymatic hydrolysis and the sulfate modification is applied, so that the preparation process is simple, the product yield is high, the product quality is stable and active groups during the preparation are not damaged, in addition, the product has the antiviral activity, in particular to the obvious antiviral activity against herpes simplex virus.
Owner:OCEAN UNIV OF CHINA
Recombinant strain of mink IFN-Gamma gene
InactiveCN101531986AHas antiviral activityBacteriaMicroorganism based processesEscherichia coliBiotechnology
The invention relates to a recombinant strain of a mink IFN-Gamma gene, which is characterized by being an IFN-Gamma gene sequence which is cloned from peripheral mink bloodlymph cells (PMBC) simulated by phytohemagglutinin (PHA) and being a recombinant plasmid vector containing a nucleotide sequence; i.e., using a plasmid vector pGM-T which is formed by the cutting of a cloning vector by taking an EcoR V enzyme as the cutting point and then adding a 'T' from the '3' end at both sides; and TA cloning is carried out on the nucleotide sequence of a coding Gamma-interferon which is amplified from the peripheral mink bloodlymph cells so as to construct the recombinant plasmid of the nucleotide sequence of the mink Gamma-interferon. In addition, Escherichia coli conversed from the plasmid vector is used as a host. The recombinant strain aims at laying down foundation for researching and developing genetically engineered mink recombinant interferons biological products with anti-viral activity and immunomodulatory activity.
Owner:INST OF SPECIAL ANIMAL & PLANT SCI OF CAAS
Thiourea compounds and preparation method and application thereof
InactiveCN109970675ACtiveHas antiviral activityOrganic active ingredientsOrganic chemistryThioureaMechanism of action
The invention discloses a group of thiourea compounds and a preparation method and application thereof. The oxazole phenylthiourea compound or a pharmaceutically acceptable salt thereof has a structure represented by the general formula (I). According to the present inventors, a class of compounds having both IMPDH inhibitory activity and broad-spectrum antiviral activity and pharmaceutical saltsthereof are screened and obtained by studying the structure-activity relationship and the action mechanism of active compounds, wherein the virus comprises influenza virus, hepatitis B virus, coxsackie virus and herpes simplex virus. The invention lays a foundation for the development and application of the compounds as antiviral and other related drugs and pharmaceutical compositions thereof, andprovides a new technical means for antiviral treatment.
Owner:MEDICINE & BIOENG INST OF CHINESE ACAD OF MEDICAL SCI
Compound of antitumor antibiotic of new carbon framework as well as preparation method and application
InactiveCN1626507ANovel structureNovel chemical structureAntibacterial agentsOrganic active ingredientsMicroorganismMelanoma
A kind of antineoplastic antibiotic compound, chinikornycin A and B, for suppressing the cells of lung cancer, breast cancer, melanoma, renal cancer and uterine cancer is prepared from Streptomyces sp. through fermenting and chromatography by silica gel column.
Owner:INST OF OCEANOLOGY - CHINESE ACAD OF SCI +2
Application of N-acetyl-L-cysteine in preparing drug for treating or preventing porcine virus infection
ActiveCN104398498AImprove securityEnhances antioxidant defensesOrganic active ingredientsAntiviralsSide effectPorcine circovirus
The invention discloses an application of N-acetyl-L-cysteine in preparing a drug for treating or preventing porcine virus infection. The application comprises the steps: A, preparing N-acetyl-L-cysteine, absolute ethyl alcohol, tween-80, lactose, soluble starch and bran into a granule, oral liquid or powder, B, adding the granule, the oral liquid or the powder into feed or drinking water, or C, independently administering N-acetyl-L-cysteine, D, continuously using N-acetyl-L-cysteine during a whole feeding period as preventive addition and long-term usage in the feed, E, feeding the powder and the granule directly for treatment, or F, mixing the powder and the granule with daily ration, adding into the feed in the morning, at noon and in the evening every day, and continuously using the powder and the granule. N-acetyl-L-cysteine has high safety, no toxic or side effects, and antiviral activity, and can effectively prevent and treat the porcine circovirus type 2 and porcine epidemic diarrhea virus infection, reduce a mortality rate of infected pigs, and effectively increase a survival rate and productivity of the pigs.
Owner:HUBEI HAOHUA BIOTECH
Method for synthesizing marine polyhydroxyl sterol (25R)-5alpha -cholest-3 beta, 5alpha, 6beta, 26-tetrol
The invention discloses a method for synthesizing marine polyhydroxyl sterol (25R)-5alpha-cholest-3beta, 5alpha, 6beta, 26-tetrol. Diosgenine is used as a raw material, and (25R)-5alpha-cholest-3beta, 5alpha, 6beta, and 26-tetrol are prepared by the steps of reduction ring-opening carried out by zinc amalgam, 3, 26-bit hydroxy protection carried out by tert-butyl dimethylchlorosilane, 16-bit hydroxyl esterification carried out by methylsufonyl chloride and sulfuryl, 16-bit methyl sulphonic acid ester reduction carried out by lithium aluminum hydride, 5-6-bit double linkage oxidation carried out by m-chloroperoxybenzoic acid, and ring opening and deprotection reaction under acid condition. The synthesizing method has the advantages of low-cost and easily obtained raw materials, moderate reaction condition, favorable selectivity and high yield, and the target compound has the potential antineoplastic and antiviral activity.
Owner:SUN YAT SEN UNIV +1
Traditional Chinese medicine composition for treating chronic prostatitis and preparation method thereof
InactiveCN108114266AImprove immunityRestore physical functionOrganic active ingredientsHydrolysed protein ingredientsChlorogenic acidSide effect
The invention relates to a traditional Chinese medicine composition for treating chronic prostatitis and a preparation method thereof. The traditional Chinese medicine composition is prepared from thefollowing raw materials in parts by weight: 8 to 12 parts of cortex eucommiae chlorogenic acid, 6 to 10 parts of cortex cinnamomi polyphenol, 13 to 17 parts of oyster peptide, 8 to 12 parts of maca,8 to 12 parts of cordyceps militaris, 13 to 17 parts of silk peptide, 2 to 6 parts of herba abelmoschi esculenti, 2 to 6 parts of cortex pausinystaliae macroceras, 2 to 6 parts of catuaba, 2 to 6 parts of herba epimedii, 2 to 6 parts of herba gynostemmatis, 2 to 6 parts of herba rhodiolae, 2 to 6 parts of radix salviae miltiorrhizae and 2 to 6 parts of semen persicae. The traditional Chinese medicine composition disclosed by the invention is simple in preparation and remarkable in curative effect, has no side effect, is safe and effective, is low in cost and is suitable for oral administration.
Owner:江苏优曦特斯生物制品有限公司
Method for preparing recombinant porcine alpha-interferon
ActiveCN102229944AHas antiviral activityStrong antiviral activityMicroorganism based processesVector-based foreign material introductionPichia pastorisYeast
The invention provides a method for preparing porcine alpha-interferon, which comprises: obtaining the coding region of a porcine alpha-interferon gene by the conventional polymerase chain reaction (PCR) process; cloning the coding region to a Pichia pastoris secretory expression vector pHBM905A; performing electric transformation of Pichia pastoris; and screening a high-resistance transformant to realize the secretory expression of the recombinant protein in the Pichia pastoris and obtaining the recombinant protein with antiviral activity. In the invention, by optimizing the expression system of the Pichia pastoris, the antiviral activity of the recombinant protein is improved.
Owner:HUNAN AGRI UNIV ANIMAL PHARMA
Application of exogenous ATG10S protein in preparation of antiviral drugs
PendingCN112794895AActivation of autophagic fluxAchieve antiviral effectCompound screeningOrganic active ingredientsAntiviral drugNucleotide
The invention relates to application of an exogenous ATG10S protein in preparation of an antiviral drug. The exogenous ATG10S is an rhATG10S protein, the coding nucleotide sequence of the exogenous ATG10S is shown as SEQ ID NO. 1 or SEQ ID NO. 2, and the amino acid sequence of the rhATG10S protein is shown as SEQ ID NO. 3. The invention also relates to application of the rhATG10S protein in preparation of drugs for inhibiting viruses. The invention further discloses a method for screening antiviral drugs by taking the ATG10S protein as a target spot.
Owner:MEDICINE & BIOENG INST OF CHINESE ACAD OF MEDICAL SCI
Porcine alpha interferon gene and synthetic method thereof
InactiveCN104878017AHas antiviral activityMicroorganism based processesFermentationNucleotide sequencingPichia
The invention discloses a porcine alpha interferon gene and a synthetic method thereof. The gene provided by the invention has the advantages that the high expression of the interferon in pichia pastoris is realized; porcine alpha interferon protein with antiviral activity is acquired; the anti-VSV activity of the porcine alpha interferon gene prepared from the synthetic method is (3.82*107) U / mg. The synthetic method designs the coding nucleotide sequence of the porcine alpha interferon on the basis that the amino acid sequence of the porcine alpha interferon is not changed; each codon in a reading frame is preferred by pichia pastoris; the coding nucleic acid is designed in the synthetic steps; a proper expression vector is inserted in the synthetic nucleic acid to build recombinant expression vector; finally the built recombinant expression vector converts proper pichia pastoris for inducible expression; the result shows the high expression of the porcine alpha interferon in the pichia pastoris, and the porcine alpha interferon protein with antiviral activity is acquired; the synthetic method is suitable for the synthesis of the porcine alpha interferon.
Owner:JIANGSU HFQ BIO TECH CO LTD
Preparation method for selenium-rich hair weed product
InactiveCN104839018AHarm reductionPromote absorptionHorticulture methodsPlant tissue cultureBiotechnologySodium selenate
The invention specifically relates to a preparation method for a selenium-rich hair weed product, which belongs to the technical field of food bio-concentration. According to the invention, hair weed cells transforms the inorganic selenium--sodium selenite in a nutrient solution into organic selenium in virtue of the own transformation effect of the cells, so harm to the human body is reduced, and absorption and utilization of selenium by human beings and animals are improved; and the growth rate of the hair weed cells in the process of culture is 30 times of the growth rate of cells of wild hair weed, so rapid growth and reproduction of hair weed are realized. The hair weed cells produced in the invention can be used as a natural biological raw material for selenium supplement and are extensively applied to a variety of health food, beverages and new resource food to meet demands of the human body for selenium. The nutrient solution deprived of the hair weed cells contains abundant hair weed exopolysaccharide which has antiviral activity and can replace hair weed as a raw material for production of functional food. A hair weed selenium enrichment culture method provided by the invention is simple and convenient to operate, poses no pollution to the environment, has low cost and is applicable to industrialized production.
Owner:HENAN UNIV OF SCI & TECH
Lipopeptide compounds Totopotensamides and preparation method and application thereof
ActiveCN111378008AHas inhibitory activityHas antiviral activityBacteriaTetrapeptide ingredientsChemical compoundCombinatorial chemistry
The invention discloses lipopeptide compounds Totopotensamides and a preparation method and application thereof. The invention discloses antibiotic compounds Totopotensamides (TPMs) R1-1 to R1-6(1-6),R2-1(7), P3-1(8), P3-2(9), P2-1 to P2-7(10-16), U5-1(17), U5-2(18), H1 to H8(19-26) and HM1 to HM3(27-29). The lipopeptide compounds Totopotensamides with antiviral activity are obtained through separation and purification from mutant strains, especially the lipopeptide compounds Totopotensamides have inhibitory activity on 3CL hydrolase of a novel coronavirus and are expected to be used for preparing anti-novel-coronavirus drugs.
Owner:SOUTH CHINA SEA INST OF OCEANOLOGY - CHINESE ACAD OF SCI
(2R,5R)-5-phosphoryl methoxy-2-(2-substituted adenine-9-yl)-2,5-dihydrofuran nucleoside analog as well as preparation method and application thereof
InactiveCN103788160AImprove stabilityExcellent resistance to nucleolytic enzyme decompositionOrganic active ingredientsSugar derivativesFuranPurine
The invention discloses a novel beta-furan phosphonate purine nucleoside analog, and in particular relates to a (2R,5R)-5-phosphoryl methoxy-2-(2-substituted adenine-9-yl)-2,5-dihydrofuran nucleoside analog as well as a preparation method and an application thereof, which belongs to the field of nucleoside chemicals and pharmaceutical chemistry. The analog has a structure as shown in the formula (1) in the specification, wherein R1 represents C1, NH2, OCH3, SCH3, NHCH3 or NHNH2; R2 represents NH2, OCH3 and NHCH3; R' represents H, Na or K. Chlorinated sugar with high activity is formed through chlorination of 3.5-di-O-p-methyl benzoyl-2-deoxidation-D-ribose glucoside, the chlorinated sugar is subsequently reacted with alkali, and a novel beta-D-dihydrofuran phosphonate adenine nucleoside analog is formed through selective oxidation, decarboxylation, addition, elimination, functional group conversion and ethyl removal. The analog has anti-virus activity and good development prospect.
Owner:ZHENGZHOU UNIV
Handmade calligraphy paper using crofton weed root powder as new filling material and preparation method thereof
InactiveCN104164804ASpecial textureGood ink absorptionSpecial paperVegetable material additionFilling materialsMedicine
The invention discloses a handmade calligraphy paper using crofton weed root powder as the new filling material and a preparation method thereof. The handmade calligraphy paper is made of edgeworthia gardneri bark and crofton weed root, and is prepared through the following steps: (1) preparing crofton weed root powder: preparing a proper amount of crofton weed root, soaking, steaming and boiling, drying in air, cutting, grinding, and finally sieving so as to obtain the crofton weed root powder; (2) preparing edgeworthia gardneri pulp: weighing edgeworthia gardneri according to a certain weight ratio, and making the weighed edgeworthia gardneri into pulp through a traditional handmade paper technology; (3) pulping and paper making: mixing the prepared crofton weed root powder and edgeworthia gardneri pulp, then pulping, and finally producing paper through a conventional handmade paper manufacturing method. The prepared handwork calligraphy paper has the advantages of special texture, good ink absorbing performance, and mothproof effect.
Owner:MINZU UNIVERSITY OF CHINA +2
Compound echinacea extract powder capable of improving animal disease resistance
InactiveCN109043136AHas antiviral activityHigh activityAnimal feeding stuffAccessory food factorsBiotechnologyBacillus subtilis
The invention relates to compound echinacea extract powder capable of improving animal disease resistance. The compound echinacea extract powder is prepared from the following components in parts by weight: 60-75 parts of echinacea extract, 5-15 parts of lipase, 5-15 parts of glucose oxidase and 5-15 parts of bacillus subtilis. The compound echinacea extract powder can resist virus, enhance animalimmunity, and greatly reduce the illness probability of animals, meanwhile, the components are simple, preparation is convenient, and the compound echinacea extract powder can be suitable for multiple kinds of animals, and has very wide applicability.
Owner:隆昌康诺生物科技有限公司
Preparation method of cordyceps militaris craft beer
PendingCN112812908AClear and bright colorRich foamWort preparationBeer fermentationMouthfeelBiotechnology
The invention discloses a preparation method of cordyceps militaris craft beer. The preparation method comprises the following steps: preparation of a cordyceps militaris extract, gelatinization, saccharification, filtration, clarification, tank washing, boiling, wort cooling, fermentation and wine filtration. The prepared beer is clear and transparent in color, rich in foam and pure and natural in taste, has the characteristic flavor of beer, also has a good human body health-care effect, and meets the double requirements of consumers on taste and health.
Owner:刁佳新
Use of rimantadine Schiff base
InactiveCN109223741AHas antibacterial activityHas antiviral activityAntibacterial agentsOrganic active ingredientsSynthesis methodsFormate
The invention discloses a use of rimantadine Schiff base. Rimantadine ethylamine Schiff base was prepared by chlorination of adamantane formic acid with thionyl chloride, alkylation in the presence oftrimethyl aluminum and cerium formate, oximation to ketoxime, reduction with palladium-carbon and aldehyde-amine condensation reaction with cinnamaldehyde to obtain adamantane ethylamine cinnamaldehyde Schiff base. The reaction route of the invention changes the route of synthesizing adamantane methyl ketone, and cerium formate is used for assisting the reaction of trimethyl aluminum, so that thereaction conditions are mild and the by-products are few. The synthesis method has the advantages of simple and feasible process, low catalyst consumption, environmental protection and high product yield. The adamantine Schiff base prepared by the invention has antibacterial activity, antiviral activity and antitumor activity, and can be used in the fields of medicine, daily chemistry, food and the like, and has the potential to be used as an antibacterial agent, an antiviral agent and an antineoplastic agent.
Owner:赵旭萌
Recombinant expression and application of reconstructed fenneropenaeus chinensiss antifungal protein gene ALFm
InactiveCN105255900AGood for recombinant expressionHas antibacterial activityAntibacterial agentsPeptide/protein ingredientsBase JAntifungal protein
The invention relates to a recombinant expression and application of a reconstructed fenneropenaeus chinensiss antifungal protein gene ALFm. Reconstruction is carried out with a fenneropenaeus chinensiss anti-lipopolysaccharide factor FcALF2 as an archetype, reconstructed antifungal protein is named ALFm, and has a base sequence shown in SEQ ID No.1 and an amino acid sequence shown by SEQ ID No.2. An expression vector pPIC9K and expression strain pichia pastoris GS115 are utilized for carrying out eukaryon recombinant expressions on ALFm, and recombinant protein with biological activity is obtained. The biological function of ALFm is verified in vitro, and it is proved that the recombinant protein can have effective inhibiting effects on various bacteria and WSSV.
Owner:INST OF OCEANOLOGY - CHINESE ACAD OF SCI
Anti-hsv agent for inhibiting replication of HSV-1 and HSV-2 and method of producing a substance having anti-HSV activity
InactiveCN1604786AIncrease productionHas antiviral activityAntiviralsUnknown materialsAnti hsv activityPotassium hydroxide
Owner:田中昭子 +2
A synergistic chemical and photodynamic antibacterial and antiviral coating and its preparation method
ActiveCN113018500BEfficient killingStop transmissionBiocideSurgeryPhthalocyanineAntibacterial activity
Owner:CHINA WEST NORMAL UNIVERSITY
Compound, and preparation method and application thereof
ActiveCN111269222AGood anticancer effectNo apparent toxicityOrganic active ingredientsOrganic chemistryAnticarcinogenic EffectAntiviral drug
The invention relates to a compound, and a preparation method and an application thereof. The compound is prepared by connecting sydnone with a PBTs compound. A pharmaceutical composition containing the compound and / or the pharmacologically acceptable salt thereof has the following advantages: the anticancer effect is obvious; compared with (-)-Antofine, the compounds have better anticancer effects, have no obvious toxicity to animals, also have antiviral activity, and can be used for preparing drugs for preventing and / or treating cancers and / or resisting viruses.
Owner:辽宁孚音生物科技有限公司
Pig samhd1 gene, protein, monoclonal antibody and application thereof
ActiveCN104164442BSuitable for developmentHas antiviral activityBacteriaPeptide/protein ingredientsBiotechnologySAMHD1 Protein
Owner:SHANGHAI VETERINARY RES INST CHINESE ACAD OF AGRI SCI
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