37 results about "Veratric acid" patented technology

The invention relates to a synthesis method of all-trans-retinoic acid. The method comprises: taking [3-methyl-5-(2, 6, 6-trimethylcyclohexen-1-yl)-2, 4-pentadiene]-triphenylphosphine salt and beta-formyl crotonic acid as raw materials, which undergo a WITTIG reaction under an alkali effect, then adding a palladium compound or a rhodium compound for a direct isomerization reaction, thus obtaining the needed all-trans configuration product. According to the method, a reaction intermediate product has no need for separation, and the WITTIG reaction and the isomerization reaction undergo continuously in one container. With the advantage of simple operation and production cost saving, the method is suitable for industrialized production.

The invention relates to a medicinal control release nanometer and method for making same, in particular a retinoic acid release control nanomicrosphere and its preparation method, the constituents of the composition are polylactic acid (PLA), vitamin A acid (RA) and gelatin aqueous solution.

A method for improving skin conditions containing applying a composition containing veratric acid or acceptable salt thereof as an active ingredient. The composition has an excellent effect of reducing skin wrinkles through molecular mechanisms including the promotion of collagen synthesis and inhibition of collagenase activity. Also, the composition has an excellent effect of reducing wrinkles by absorbing UVB to prevent UV rays from penetrating the skin, promotion of collagen synthesis and inhibition of collagenase activity. In addition, the composition has effect of promotion of hair growth and the prevention of hair loss through growth promotion of hair dermal papilla cells, stimulation of IGF-1 secretion, and inhibition of TGF-beta1 secretion. Also, because the composition is derived from plants such as natural materials, it is harmless to the human body and can be safely applied to cosmetic, pharmaceutical, and food compositions.

The invention discloses a composite of all-trans-retinoic acid and liposome and application thereof. The composite of all-trans-retinoic acid and liposome consists of the liposome and the all-trans-retinoic acid encapsulated in the liposome. The composite is prepared by a method comprising: 1) dissolving lipid materials and the all-trans-retinoic acid to prepare a mixture of a lipid membrane and the all-trans-retinoic acid; 2) hydrating the mixture of the liquid membrane and the all-trans-retinoic acid to prepare a hydration product; and 3) performing ultrasonic on the hydration product to prepare the composite of the all-trans-retinoic acid and the liposome. Experiments of the invention prove that the composite of the all-trans-retinoic acid and the liposome can be used for inhibiting the reproduction of tumor cells, and the combined application of the composite of the all-trans-retinoic acid and the liposome and Vinorelbine invisibile liposome produces the strongest inhibitory effect on the recrudesce of tumors.

The invention discloses a preparation process of veratronic acid, which mainly uses veratraldehyde as the main raw material, uses water as the solvent, forms a salt with alkali, oxidizes with hydrogen peroxide, and acidifies to obtain veratronic acid, and uses an organic solvent as the The solvent method greatly reduces the cost of raw materials and greatly improves the production efficiency, and the detection target content reaches more than 95%, and the liquid phase content reaches more than 99.5%.

The invention belongs to the field of natural organic chemistry, and particularly relates to a method for enriching and purifying veratric acid in globeflower by using macroporous adsorbent resin. By using macroporous adsorption technology to separate and purify veratric acid, the invention has the characteristics of good adsorption selectivity for veratric acid, high adsorption and desorption speed, high adsorption capacity, abundant material sources, low production cost, obvious separation effect and high extraction purity, can be used for extracting veratric acid conveniently and quickly, can be used to obtain a semi-finished product of which the content of veratric acid is higher than 30% and a final product of which the content of veratric acid is higher than 90%, and can overcome the defects of low extraction yield and low extraction purity in the conventional method. The macroporous adsorbent resin, which has the advantages of stable physicochemical properties, large surface area, high exchange speed, high mechanical strength, high antipollution capability and high thermal stability, is used for selectively adsorbing veratric acid from the solution in a physical adsorption mode; and the invention has the advantages of high adsorption and desorption speed, and high adsorption capacity.

The invention relates to non-spherical drug-loaded particles and a controlled release preparation of a lactyl polymer and preparation methods thereof. The non-spherical particles of polylactic-co-glycolic acid (PLGA) are prepared by using an emulsion-solvent volatilization method assisted by small molecule materials. The PLGA is used as raw material coated with at least one of the following hydrophobic drugs: all-trans retinoic acid, paclitaxel, epirubicin, camptothecin or roxithromycin, wherein the mass ratio of the hydrophobic drug to a lactyl polymer high polymer material is 1:4-40. The drug-loaded particles of the all-trans retinoic acid are prepared and subjected to in vitro drug release evaluation. The results show that the preparation method has the advantages of simple preparationprocess, good reproducibility, significantly increased drug loading amount and encapsulation efficiency relative to spherical particles, very good controlled-release effect, no hemolysis initiation and safety use. The novel carrier and preparation have a potential industrial production value in the field of long-circulating controlled release of the hydrophobic drugs.

The invention relates to a compound all-trans retinoic acid cream and its preparation method and application. The all-trans retinoic acid cream is composed of 10-50 parts of all-trans retinoic acid, 10-50 parts of beclomethasone dipropionate, 5000-20000 parts of urea, and 80000-95000 parts of matrix; the preparation method of the cream comprises: ( 1) Take 50-65g of urea, 150-180g of glycerin, 3-5g of sodium lauryl sulfate, 6-10g of triethanolamine and add distilled water to 400-450g as the water phase; (2) Take 20-40g of monoglyceride, hard Fatty acid 100-120g, white petrolatum 50-70g, liquid paraffin 190-200g and ethylparaben 1-3g are used as the oil phase; (3) The two phases are placed in containers separately, heated to melt or dissolve, and kept at 60-80 At about ℃, add the oil phase to the water phase, add 0.125-1g of all-trans retinoic acid and 0.125-1.5g of beclomethasone dipropionate, and stir well. The cream of the invention is directly externally applied to the skin of the scar, which can not only effectively inhibit the recurrence of the scar, reduce the pigmentation of the scar, but also promote the reversal of the skin of the scar to normal skin.

The invention discloses application of an oleanolic acid and retinoic acid pharmaceutical composition to medicament for treating insulin resistance and diabetes. Intraperitoneal injection of the oleanolic acid and retinoic acid pharmaceutical composition to diabetic animal can significantly lower the blood glucose level; and addition of the oleanolic acid and retinoic acid pharmaceutical composition in culture solution for culturing liver cells can significantly promote transmission of an insulin signal. Therefore, the oleanolic acid and retinoic acid pharmaceutical composition can be applied to medicaments for treating diabetes, insulin resistance and metabolic syndrome closely related to insulin resistance.

The invention relates to a method for preparing veratric acid from trollius chinensis bunge. The method comprises the following steps: adopting 15 times amount of ethyl acetate to carry out direct reflux extraction on the trollius chinensis bunge twice, 2h each time, concentrating the extracts to certain volume and uniformly mixing the concentrated extracts with powdered polyamide with weight doubling that of the drug, drying the mixture, carrying out suction filtration on the solid particle mixture with 20 times amount of 20% of ethanol and recrystallizing the concentrated suction filtrate with petroleum ether-acetone to obtain the veratric acid.

A process for the preparation of 13-cis-retinoic acid (I)from 3-methyl-5-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4-pentadienyl)-triphenylphosphonium chloride (IIa)and 5-hydroxy-4-methyl-2(5H)-furanone (III)is herein disclosed. Compounds (IIa) and (III) are reacted in ethanol as the solvent and KOH as the base at a temperature ranging from −5 to 0° C. to give a mixture of retinoic acids which is isomerized to (I) by treatment with a palladium complex.