Application of oleanolic acid and retinoic acid pharmaceutical composition in medicament for treating insulin resistance and diabetes

A technology for insulin resistance and oleanolic acid, which can be used in drug combinations, medical preparations containing active ingredients, metabolic diseases, etc., and can solve problems such as high liver and kidney toxicity

Inactive Publication Date: 2013-11-06
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, effective drugs for the treatment of insulin resistance and diabetes mainly include thiazolidinediones and metformin, etc. These drugs have relatively high liver and kidney toxicity

Method used

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  • Application of oleanolic acid and retinoic acid pharmaceutical composition in medicament for treating insulin resistance and diabetes
  • Application of oleanolic acid and retinoic acid pharmaceutical composition in medicament for treating insulin resistance and diabetes
  • Application of oleanolic acid and retinoic acid pharmaceutical composition in medicament for treating insulin resistance and diabetes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0018] 1. Experimental instrument

[0019] Blood glucose meter (Johnson & Johnson, USA), precision electronic balance, 1ml syringe, etc.

[0020] 2. Laboratory animals and materials

[0021] 2.1 Experimental animals

[0022] SD rat, clean grade, male, weighing 180±220g, provided by the Experimental Animal Center of the Fourth Military Medical University.

[0023] BRL-3A rat normal liver cell line, purchased from Wuhan Cell Collection Center.

[0024] 2.2 Experimental materials

[0025] Normal saline, picric acid, blood glucose test paper, insulin.

[0026] 3. Experimental method

[0027] Forty SD rats, clean grade, male, weighing 180±220g, were randomly divided into normal control group (8) and model group (32), and they were labeled separately. Animals in the model group were intraperitoneally injected with streptozotocin to construct an animal model of diabetes. After the blood sugar of the model group animals increased and reached the diagnostic criteria for diabetes, the model group a...

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Abstract

The invention discloses application of an oleanolic acid and retinoic acid pharmaceutical composition to medicament for treating insulin resistance and diabetes. Intraperitoneal injection of the oleanolic acid and retinoic acid pharmaceutical composition to diabetic animal can significantly lower the blood glucose level; and addition of the oleanolic acid and retinoic acid pharmaceutical composition in culture solution for culturing liver cells can significantly promote transmission of an insulin signal. Therefore, the oleanolic acid and retinoic acid pharmaceutical composition can be applied to medicaments for treating diabetes, insulin resistance and metabolic syndrome closely related to insulin resistance.

Description

Technical field [0001] The invention relates to the use of a drug combination of oleanolic acid and retinoic acid, and specifically refers to the application of a drug combination of oleanolic acid and retinoic acid in the treatment of insulin resistance and diabetes. Background technique [0002] In recent years, as people's lifestyle changes, the incidence of diabetes has increased year by year. The American Diabetes Association estimates that by 2030, 3.5 billion people worldwide will suffer from diabetes and its complications. A recent survey in my country showed that the number of diabetes patients in my country has reached 92 million, second only to India. Diabetes has exerted tremendous pressure on the economic development of the world, especially developing countries. According to statistics, the expenditure on diabetes in developing countries exceeds 10% of the health budget. More than 90% of diabetic patients are type 2 diabetes patients, and insulin resistance is the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/56A61K31/203A61P5/50A61P3/10A61P1/16
Inventor 王欣海春旭
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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