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Application of oleanolic acid and retinoic acid pharmaceutical composition to medicament for treating insulin resistance and diabetes

A technology for insulin resistance and oleanolic acid, which can be used in drug combinations, medical preparations containing active ingredients, metabolic diseases, etc., and can solve problems such as high liver and kidney toxicity

Inactive Publication Date: 2012-11-07
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, effective drugs for the treatment of insulin resistance and diabetes mainly include thiazolidinediones and metformin, etc. These drugs have relatively high liver and kidney toxicity

Method used

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  • Application of oleanolic acid and retinoic acid pharmaceutical composition to medicament for treating insulin resistance and diabetes
  • Application of oleanolic acid and retinoic acid pharmaceutical composition to medicament for treating insulin resistance and diabetes
  • Application of oleanolic acid and retinoic acid pharmaceutical composition to medicament for treating insulin resistance and diabetes

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Experimental program
Comparison scheme
Effect test

Embodiment

[0018] 1. Experimental equipment

[0019] Blood glucose meter (Johnson & Johnson), precision electronic balance, 1ml syringe, etc.

[0020] 2. Experimental animals and materials

[0021] 2.1 Experimental animals

[0022] SD rats, clean grade, male, weighing 180±220 g, were provided by the Experimental Animal Center of Fourth Military Medical University.

[0023] BRL-3A rat normal liver cell line was purchased from Wuhan Cell Collection Center.

[0024] 2.2 Experimental materials

[0025] Normal saline, picric acid, blood glucose test strips, insulin.

[0026] 3. Experimental method

[0027] Select 40 SD rats, clean grade, male, weighing 180±220g, randomly divide them into normal control group (8 rats) and model group (32 rats), and mark them respectively. Model group animals were intraperitoneally injected with streptozotocin to establish diabetic animal models. After the blood sugar of the animals in the model group increased and reached the diagnostic criteria for dia...

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PUM

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Abstract

The invention discloses application of an oleanolic acid and retinoic acid pharmaceutical composition to medicament for treating insulin resistance and diabetes. Intraperitoneal injection of the oleanolic acid and retinoic acid pharmaceutical composition to diabetic animal can significantly lower the blood glucose level; and addition of the oleanolic acid and retinoic acid pharmaceutical composition in culture solution for culturing liver cells can significantly promote transmission of an insulin signal. Therefore, the oleanolic acid and retinoic acid pharmaceutical composition can be applied to medicaments for treating diabetes, insulin resistance and metabolic syndrome closely related to insulin resistance.

Description

technical field [0001] The present invention relates to the use of oleanolic acid and retinoic acid medicine combination, specifically refers to the application of oleanolic acid and retinoic acid medicine combination in treating insulin resistance and diabetes medicine. Background technique [0002] In recent years, with the transformation of people's lifestyle, the incidence of diabetes has increased year by year. The American Diabetes Association predicts that by 2030, 3.5 billion people worldwide will suffer from diabetes and its complications. Recently, a survey in our country shows that the number of people with diabetes in our country has reached 92 million, second only to India. Diabetes has put enormous pressure on the economic development of the world, especially in developing countries. According to statistics, the expenditure on diabetes in developing countries exceeds 10% of the health budget. More than 90% of diabetic patients are type 2 diabetic patients, an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/56A61K31/203A61P5/50A61P3/10A61P1/16
Inventor 王欣海春旭
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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