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Trollius chinensis extract, preparation method thereof and preparation containing same

The technology of a trogon lotus extract and trogloline, which is applied in the field of troglodynia extract and its preparation, can solve the problems of high cost, many organic residues, and long production cycle, and achieve low organic residues, strong antibacterial activity, and preparation The effect of simple method

Active Publication Date: 2016-10-12
李宏 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method has the disadvantages of long production cycle, high cost, and many organic residues.

Method used

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  • Trollius chinensis extract, preparation method thereof and preparation containing same
  • Trollius chinensis extract, preparation method thereof and preparation containing same
  • Trollius chinensis extract, preparation method thereof and preparation containing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] A kind of Trollius extract, containing total flavonoids, trochlein and veratronic acid; wherein the weight ratio of total flavonoids, trophylline and veratronic acid in the Trollius extract is 182.2:1:2.2, and the content of total flavonoids It is 41.9% in terms of rutin.

[0063] The preparation method of this nasturtium extract comprises the following steps:

[0064] 1) Add 10 times the weight of nasturtium in water, soak for 1 hour, decoct twice for 1 hour each time, filter, and combine the filtrates to obtain the decoction of nasturtium; deep-layer filter the decoction of nasturtium, and The filtrate is concentrated under reduced pressure at 70°C to a relative density of 1.05 (measured at 60°C) to obtain a concentrated solution; wherein, the filter core of the deep layer filter is lignocellulose with a pore size of 0.1-0.5 μm; the pressure of the deep layer filter is 1.2-2.0 μm bar, the flow rate is 3-5L / min;

[0065] 2) Add 8% flocculation clarifier by weight of ...

Embodiment 2

[0069] A kind of Trollius extract, containing total flavonoids, trochlein and veratronic acid; wherein the weight ratio of total flavonoids, trophylline and veratronic acid in the Trollius extract is 160:1:2, and the content of total flavonoids Calculated as rutin, it is 60.8%.

[0070] The difference between the preparation method of this nasturtium extract and Example 1 is only that in step 2) the flocculation clarifying agent is composed of B component and chitosan in Type II ZTCl+1 natural clarifying agent, wherein B component and shell The weight ratio of glycans is 3:1.

experiment example 1

[0074] Add 10 times the weight of nasturtium in water, soak for 1 hour, decoct twice for 1 hour each time, filter, and combine the filtrates to obtain the decoction of nasturtium flower water; carry out clarification treatment according to different methods, and then the clarified obtained The medicinal solution was concentrated under reduced pressure at 70°C to a relative density of 1.20 (measured at 60°C), and dried under reduced pressure at 65°C to obtain the extract of Trollius chinensis. Detect the content of total flavonoids in the extract of nasturtium, and compare the effects of different methods. The specific clarification treatment methods and test results are shown in Table 1 below.

[0075] Table 1

[0076]

[0077] Note: the deep filtration method of comparative example 1 is the same as that of Example 1, but does not include the step of adding a flocculation clarifying agent for clarification; comparative example 2 does not include the step of deep filtration...

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Abstract

The invention relates to a trollius chinensis extract, a preparation method thereof and a preparation containing the same. The trollius chinensis extract contains total flavone, cytisine and veratric acid, and the preparation method of the trollius chinensis extract includes the steps that trollius chinensis liquid obtained through water decoction or alcohol water is subjected to deep filtration, and a flocculating and clarifying agent is adopted for clarification; the flocculating and clarifying agent is a type-II ZTCl + natural clarifying agent or is prepared from a component B in the type-II ZTCl + natural clarifying agent and chitosan. A deep filtration combined flocculation precipitation technology is adopted to remove impurities, macromolecular substances such as tannin are effectively removed, the flavone, the cytosine, the veratric acid and other active ingredients are also effectively retained, the active ingredient content of the extract is improved, and the antibacterial activity and in-vitro antiviral activity of the extract are strong. The preparation method is simple, capable of saving energy, environmentally friendly and low in organic residue content.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a nasturtium extract, a preparation method thereof and a preparation containing the same. Background technique [0002] Trollius chinensis Bunge is a commonly used traditional Chinese medicine, which is recorded in the 1977 edition of "Chinese Pharmacopoeia". It has the functions of treating aphtha, swollen throat, burning hot teeth, ear pain and eye pain, improving eyesight, and resolving miasma. Modern pharmacological studies have proved that nasturtium has antiviral, antibacterial and other effects. In recent years, it has been clinically used to treat acute suppurative tonsillitis, upper respiratory tract infection, pharyngitis, acute enteritis, acute bronchitis, etc. The chemical components of nasturtium are mainly flavonoids, alkaloids, organic acids and so on. The content of flavonoids in nasturtium is the highest, but its bioavailability is poor; the content of alkalo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61P11/04A61P27/16A61P27/02A61P31/04
CPCA61K36/71A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53
Inventor 阎红麻军法范玲玲田宏迪
Owner 李宏
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