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52 results about "Sodium taurocholate" patented technology
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Liposome injection of pharmaceutical composition of amoxicillin sodium and clavulanate potassium
InactiveCN101804051AImprove stabilityHigh encapsulation efficiencyAntibacterial agentsPharmaceutical non-active ingredientsFreeze-dryingAntioxidant
The invention provides a liposome injection of a pharmaceutical composition of amoxicillin sodium and clavulanate potassium, which consists of amoxicillin sodium, clavulanate potassium, a liposome carrier, a lyoprotectant and a freely optional antioxidant, wherein the liposome carrier is egg yolk phosphatidylinositol and sodium taurocholate. The liposome injection has good preparation stability, liposome can avoid the fracture due to dehydration, fusion, ice crystal generation and the like during the freeze-drying process, and the liposome can still keep the good encapsulation rate after hydration and redissolution.
Owner:HAINAN MEILAN SMITH KLINE PHARMA
Collagen skin firming lifting plumping glowing cream
InactiveCN107233282ALighten the dullnessEasy to synthesizeCosmetic preparationsToilet preparationsPullulanHydrolysis
The invention discloses a collagen skin firming lifting plumping glowing cream which comprises red ginseng snail secreta filter liquor, soluble collagen, hydrolysis collagen, atelocollagen, sodium hyaluronate, caesalpinia spinosa fruit extracts / Kappaphycus alvarezii extracts, nicotinamide, mica, hydrogenated phosphatidylcholine, lysoph-osphatidylcholine / sclerotium gum / xanthan gum / aureobasidium pullulans polysaccharide, mentha piperita extracts, hydroxyethyl acrylate / acryloyl dimethyl sodium taurocholate copolymers. Periocular skins are firmed, lifted and glowed from outside to inside by the aid of the cream. Ray refraction modes are adjusted by the aid of the mica, so that wrinkles are flatted, skins are brightened, melanin can be restrained by the nicotinamide, black eyes are faded, 'external regulation and internal nourishing' are achieved, the periocular skins are rapidly and effectively brightened and rapidly firmed and lifted, the hydrogenated phosphatidylcholine serves as emulsifying agents and thickening agents, mild and non-irritating effect is achieved, the mentha piperita extracts bring cool and refreshing skin feeling, fatigue is relieved, generation of fat granules is prevented, and the healthy state of the skins is kept.
Owner:NOX BELLCOW COSMETICS CO LTD
Tauroursodeoxycholic acid synthesis method
The present invention discloses a tauroursodeoxycholic acid synthesis method, which comprises that chenodeoxycholic acid is adopted as a raw material, the chenodeoxycholic acid and N-hydroxy succinimide or N-hydroxyphthalimide are subjected to condensation under effects of a condensation agent and a catalyst to obtain an active ester, the active ester reacts with sodium taurocholate to obtain taurochenodeoxycholic acid, and further an oxidation reaction and a reduction reaction are performed to synthesize the tauroursodeoxycholic acid. The synthesis method of the present invention adopts the chenodeoxycholic acid as the raw material, and has characteristics of low cost, simple and controllable purification process, high target product purity, and easy industrialization.
Owner:GUANGZHOU YINGYU PHARMA TECH CO LTD
Dual long-chain s-triazine amphoteric surfactants and synthesis method thereof
InactiveCN102029125AThe synthesis method is simpleMild conditionsOrganic chemistryTransportation and packagingFatty amineSolvent
The invention discloses a synthesis method of N-methyl-N-(4,6-aliphatic fatty diamine-1,3,5-s-triazine-2-group)-2-amino sodium taurine amphoteric surfactants which are prepared from cyanuric chloride, alicyclic amine and N-methyl sodium taurocholate as main raw materials. The synthesis method comprises the following steps of: dissolving the cyanuric chloride into acetone or ethanol, dropping alicyclic amine A at the temperature of 0-5DEG C and using an alkaline solution as an acid binding agent; dissolving the purified 2-fatty amine-4,6-dichlone-1,3,5-s-triazine into an acetone solution and reacting with a water solution of 40 percent N-methyl sodium taurocholate at the temperature of 30-50DEG C to generate N-methyl-N-(4-fatty amine-6-chloride-1,3,5-s-triazine-2-group)-2-amino sodium taurine amphoteric surfactants; condensing at reduced pressure, sucking filtering and vacuum drying; and dissolving the obtained N-methyl-N-(4-fatty amine-6-chloride-1,3,5-s-triazine-2-group)-2-amino sodium taurine amphoteric surfactants into a mixed solution of ethanol and water and reacting with licyclic amine B at the temperature of 80-100DEG C to obtain the N-methyl-N-(4,6-aliphatic fatty diamine-1,3,5-s-triazine-2-group)-2-amino sodium taurine amphoteric surfactants. The synthesis method is simple; the yield in each step of reaction is more than or equal to 80.00 percent; the solvents for reaction include petroleum ether, ethyl acetate, acetone, ethanol and water and have little hazard to human body; and the petroleum ether and the ethyl acetate can be recycled and are environment-friendly.
Owner:DALIAN UNIV OF TECH
Irbesartan-hydrochlorothiazide drug combination liposome solid preparation
InactiveCN101862336AGuaranteed stabilityChange the disadvantage of not easy to dissolveOrganic active ingredientsLiposomal deliveryDrugSodium taurocholate
The invention relates to an irbesartan-hydrochlorothiazide drug combination liposome solid preparation, which is prepared with irbesartan-hydrochlorothiazide drug combination liposome and other solid preparation auxiliary materials, and the irbesartan-hydrochlorothiazide drug combination liposome is prepared with irbesartan, hydrochlorothiazide, distearoyl phosphatidylcholine and sodium taurocholate. Compared with the conventional preparation, the stability and bioavailability of the preparation are greatly enhanced, release is stable, the side effect is minor, and the treatment effect is more remarkable.
Owner:HAINAN MEILAN SMITH KLINE PHARMA
Industrial wastewater treatment microbial inoculum and preparation method thereof
ActiveCN108017110AHigh hole densityLarge specific surface areaDispersed particle separationWater/sewage treatment by sorptionCross-linkBacillus licheniformis
The invention provides an industrial wastewater treatment microbial inoculum. The microbial inoculum comprises the following components of sea-foam stone powder, modified clays, polyacrylamide, kaolin, cross-linked rectorite, chitosan, shells, lotus seed hulls, hazelnut shells, ginkgo shells, macadamia shells and compound microorganisms; a preparation method of the compound microorganisms includesthe steps that compound bacteria are inoculated into a culture medium, filtration is conducted to obtain a compound bacteria solution, and the compound bacteria solution is concentrated and dried toobtain the compound microorganisms; the compound microorganisms include bacillus licheniformis, actinomycetes, bacillus radicicola, wood-destroying fungi and arthrobacterium mixtures; the culture medium includes the following components of water, yeast extracts, glucose, dipotassium phosphate and sodium taurocholate. The industrial wastewater treatment microbial inoculum contains the compound microorganisms which decompose organic pollutants in sewage into water and carbon dioxide or convert the organic pollutants into nutrients of sewage treatment microorganisms, and use the nutrients for reproduction, and the reproduction process can just degrade the pollutants.
Owner:湖北楚春归环保科技工程有限公司
Chinese medicinal composition for treating coronary disease, stenocardia, arrhythmia, hyperlipemia and preparation method thereof
ActiveCN101342207AAmphibian material medical ingredientsHydroxy compound active ingredientsDiseaseAntagonism
The invention provides a Chinese medicine composition used for curing coronary heart disease, angina, arrhythmia and high blood fat and a preparation method thereof. The Chinese medicine composition consists of components as follows: 5 to 20 weight percentage of musk, 12 to 50 weight percentage, 60 to 250 weight percentage of sodium taurocholate, 12 to 50 weight percentage of toad venom, 30 to 120 weight percentage of pearl, 40 to 160 weight percentage of borneol, 1500 to 15000 weight percentage of panax pseudo-ginseng wallich, 150 to 600 weight percentage of ginseng and 50 to 200 weight percentage of the dry extract of buffalo horn. The Chinese medicine composition of the invention can improve blood circulation, dilate coronary arteries, enhance myocardial ischemia, decrease crown arteries resistance, regulate cardiac rate, lower blood pressure, reduce myocardium metabolism, decrease consumed oxygen of myocardium and relieve or eliminate angina via the synergistic and beneficial antagonistic effect of the medicine. As a great amount of the sodium taurochlate is adopted, product cost is reduced while drug effect is ensured as much as possible, thus reducing the economic burden of a patient.
Owner:广东宏兴集团股份有限公司宏兴制药厂
Method for preparing insulin oral formulation
InactiveCN1593649AUndamagedAvoid destructionPeptide/protein ingredientsMetabolism disorderMicrosphereAcrylic resin
Disclosed is a method for preparing insulin oral formulation which comprises, (1) dissolving acrylic resin III in anhydrous alcohol solution, obtaining solution A, (2) charging insulin into the solution A to obtain solution B, (3) dissolving sodium taurocholate in liquid paraffin, charging into solution B to obtain solution C, (4) dissolving gelatin into distilled water, charging into solution C to obtain a first enveloped insulin microballoons, which is called solution D, (5) charging equal amount of fluid wax with solution C into solution D to obtain solution E, (6) dissolving acetylsalicylic acid into distilled water to form miscible liquid, charging equal amount of miscible liquid of gelatin and distilled water into another solution A, charging into solution E, finally obtaining a second enveloped insulin microballoon solution.
Owner:于晓玲
Biorelevant compositions
InactiveUS20150064794A1OptimizationReduce riskEducational modelsBiological testingSurface-active agentsSodium Taurodeoxycholate
This application relates to a homogeneous biorelevant composition for preparing fasted state biorelevant media having a surface tension between 25 mN / m and 50 mN / m for simulating fasted state gastric and fasted state upper small intestinal fluids of mammalian species, especially humans, dogs, etc. comprising at least one bile salt, eg. sodium taurocholate or sodium taurodeoxycholate; at least one phospholipid, especially 60-99 wt % phosphatidylcholine (PC), enzyme digested diacylphospholipids containing 50-90 wt % of monoacyl-PC; or mixtures thereof; and at least one fatty acid or monovalent salt of the fatty acid, such as sodium oleate. The application also relates to an aqueous biorelevant media composed of surfactants occurring in the gastrointestinal tract of mammals, in particular when prepared from above homogeneous biorelevant composition.
Owner:BIORELEVANT COM LTD
Dihydroartemisinin emulsion for injection, freeze-dried emulsion and preparation method thereof
InactiveCN101361711AImprove long-term stabilityAvoid layeringOrganic active ingredientsAntiparasitic agentsFreeze-dryingOil phase
The invention discloses an injection dihydroartemisinin emulsion, which is prepared by adjusting the pH value of the mixture consisting of the following raw materials with weight / volume percent based on the total volume of the emulsion: 0.05-0.3 percent of dihydroartemisinin, 5-30 percent of injection oil, 0.5-10 percent of emulsion, 0.1-3 percent of stabilizing agent, 0.5-5 percent of isoosmotic adjustment agent and the rest of injection water; the stabilizing agent consists of one or more of sodium taurocholate, sodium deoxycholate, oleic acid, sodium oleate and cholesterin and glycerol stearate. Freeze-dried emulsion can be made through freeze drying after adding freeze-dried protecting agent into the emulsion. The invention also discloses a method for preparing the emulsion as well as the freeze-dried emulsion. The injection dihydroartemisinin emulsion prepared by the method leads to the stable existence of dihydroartemisinin in the oil phase of the emulsion and has the advantages of good long term stability and curative effect, high bioavailability and accordance with the standards of intravenous injection; and the freeze-dried emulsion is convenient for carrying and storage and can further increase the stability of drugs.
Owner:ZHEJIANG UNIV
Application of gentiamarin in preparing medicine for preventing and treating acute pancreatitis
InactiveCN101940582AInhibition releaseSymptoms improvedOrganic active ingredientsDigestive systemInflammatory factorsWhite blood cell
The invention belongs to the field of traditional Chinese medicine preparation, relating to application of monomer gentiamarin extracted in the traditional Chinese medicine in preparing medicine for preventing and treating acute pancreatitis. In the invention, a model which is recognized by academic circles at home and abroad and is formed by continuously injecting caerulein to cause the acute pancreatitis of mice in enterocoelia and carrying out bezoar sodium taurocholate retrograde injection in cholangiopan so as to cause the acute pancreatitis of a rat, is adopted to study the action of the gentiamarin. The experiment result discloses that the gentiamarin has obvious function of resisting the acute pancreatitis caused by various reasons, and the action mechanism for resisting the acute pancreatitis is related to the releasing of the inflammatory factor, reduction of concentration of the tumor necrosis factor-alpha and interleukin-1beta in the serum or tissue, the increasing of the glutathione peroxidase activity in the serum or tissue, and the clearing of the radical and the expression of NF-kB P65.
Owner:SHANGHAI UNIV OF T C M
Oral insulin composition
InactiveCN106581646AGood hypoglycemic effectPowder deliveryPeptide/protein ingredientsCholesterolSodium taurocholate
The invention provides an oral insulin composition. The composition comprises the following components in parts by weight: 1 part of insulin, 0.01-0.05 part of sodium glycocholate, 10-50 parts of sodium taurocholate, 130-150 parts of lecithin, 0.5-5 parts of cholesterol, 1-1.5 parts of bilirubin, 0.01-0.1 part of chloroquine, 10-50 parts of microcrystalline cellulose, and 2-5 parts of gelatin. The invention also provides a preparation method of the oral insulin composition. The duration time of insulin reaches 3 days or above due to the oral insulin composition, and at the same time, compared with saled long-acting insulin, the composition has better hypoglycemic effects.
Owner:GUANGZHOU KAIYAO ASSET MANAGEMENT CO LTD
Repair nourishing creamy essential oil handmade soap
InactiveCN106434037ABalance water oilKeep dryOrganic detergent compounding agentsAmpholytes/electroneutral surface-active compoundsBiotechnologyBetaine
The invention discloses repair nourishing creamy essential oil handmade soap which comprises, by weight, 24-28 parts of methyl lauroyl sodium taurocholate, 10-15 parts of octadecyl sulfopropyl glycine betaine, 53-56 parts of vegetable oil, 2-3 parts of vegetable glycerin, 12-15 parts of hyaluronic acid, 4-8 parts of glutathione, 0.7-1 part of endothelial cell growth factors, 9-12 parts of goat milk, 4-6 parts of royal jelly, 1-2 parts of vitamin, 2.5-4 parts of 1, 2-propanediol, 1.5-2.5 parts of hydroxyethyl urea, 1-1.5 parts of sodium lactate, 1-2 parts of menthol, 2-3 parts of pachymaran, 5-8 parts of astragalus polysaccharide, 2-4 parts of salvia extract and 6-8 parts of plant essential oil. The repair nourishing creamy essential oil handmade soap is mild and clear and has the functions of delaying skin aging, decreasing melanogenesis, enabling skins to be fair, clear and delicate, achieving plentiful nourishing and efficient uptake, repairing injured cells, promoting cell metabolism, preserving moisture, whitening and enhancing external injury resistance of the skins.
Owner:跨越生物科技(滁州)有限公司
Liposome injection of pharmaceutical composition of amoxicillin sodium and clavulanate potassium
InactiveCN101804051BImprove stabilityHigh encapsulation efficiencyAntibacterial agentsPharmaceutical non-active ingredientsAntioxidantFreeze-drying
The invention provides a liposome injection of a pharmaceutical composition of amoxicillin sodium and clavulanate potassium, which consists of amoxicillin sodium, clavulanate potassium, a liposome carrier, a lyoprotectant and a freely optional antioxidant, wherein the liposome carrier is egg yolk phosphatidylinositol and sodium taurocholate. The liposome injection has good preparation stability, liposome can avoid the fracture due to dehydration, fusion, ice crystal generation and the like during the freeze-drying process, and the liposome can still keep the good encapsulation rate after hydration and redissolution.
Owner:HAINAN MEILAN SMITH KLINE PHARMA
Dihydroartemisinin emulsion for injection, freeze-dried emulsion and preparation method thereof
InactiveCN100579523CImprove long-term stabilityAvoid decomposition and inactivationOrganic active ingredientsAntiparasitic agentsFreeze-dryingOil phase
Owner:ZHEJIANG UNIV
Construction method of pancreatic duct epithelial cell and pancreatic acinar cell co-culture system for simulating in vivo microenvironment
ActiveCN110656081ASuitable for growthHigh simulationPancreatic cellsArtificial cell constructsExocytosisApoptosis
The invention discloses a construction method of a pancreatic duct epithelial cell and pancreatic acinar cell co-culture system for simulating in vivo microenvironment, and belongs to the technical field of cell biology. The method comprises the steps of inoculating an upper layer of a Transwell dual-layer culturing chamber with original generation pancreatic acinar cells, inoculating a lower layer of the Transwell dual-layer culturing chamber with human pancreatic duct epithelial cells, performing co-culturing, adding sodium taurocholate in the pancreatic duct epithelial cells at the lower layer of the Transwell dual-layer culturing chamber, and observing the vitality, the shape and the apoptosis of the upper layer pancreatic acinar cells. Damage of the pancreatic duct epithelial cells and the pancreatic acinar cells are combined, a non-contact type co-culture manner is adopted for building the pancreatic duct epithelial cell and pancreatic acinar cell co-culture system. In the co-culture system, the two cells can exchange exocytosis secretion substances through Transwell transmembrane. The system can well simulate the pancreatitis induced by cholestasis, and the invention provides an in vitro cell model which can really reflect pancreatitis induced by cholestasis.
Owner:云谱康(大连)生物科技有限公司
Application of matrimony vine and black fungus in preparing fatty liver resistant medicament
InactiveCN101269152AAnti-fatty liver effect is obviousLower cholesterol levelsDigestive systemGranular deliveryCholesterolLycium
The invention belongs to the foodstuff and health product field, in particular relates to an application of the traditional Chinese medicine of medlar and blackfungus to the preparation of a drug for curing fatty liver. The invention adopts a medlar and blackfungus compound granular formulation. The fat emulsion made of fat, cholesterin, sodium taurocholate and propylthiouracil is given to rats; a fatty liver animal model is made; the function for preventing fatty liver of medlar and blackfungus is studied. The experimental results show that the medlar and the blackfungus have evident functions for preventing fatty liver and can reduce the liver weight / body mass index, the contents of serum and hepatic tissue cholesterin are decreased and the number of liver cells of steatosis is reduced. The medlar and the blackfungus can be used for preparing the drug for curing fatty liver.
Owner:SHANGHAI UNIV OF T C M
Method for preparing blood lipid reducing ingredient in heracleum modlendouffii
InactiveCN108157964AIncrease profitHigh yieldFood shearingNatural extract food ingredientsAdditive ingredientMedicine
The invention provides a method for preparing the blood lipid reducing ingredient in heracleum modlendouffii. The method comprises the step of extracting, purifying and concentrating heracleum modlendouffii to obtain an extracting liquid of the blood lipid reducing ingredient in the heracleum modlendouffii. By adopting the method, the blood lipid reducing ingredient can be successfully extracted from the heracleum modlendouffii, and the deep processing degree of heracleum modlendouffii can be improved. Experimental results in the embodiment indicate that the extract of the blood lipid reducingingredient in the heracleum modlendouffii has relatively high content of flavones and polyphenols, wherein the content of flavones is 0.987mg / g, and the content of polyphenols is 2.238mg / g; and the blood lipid reducing ingredient has a relatively high binding rate with sodium cholate in vitro, has binding rates with sodium glycocholate and sodium taurocholate respectively being 50.27 percent and38.12 percent, and has a relatively good blood lipid reducing effect. The blood lipid reducing ingredient extract prepared by adopting the method can be directly applied to foods, so that the economicvalue of heracleum modlendouffii can be improved.
Owner:NORTHEAST FORESTRY UNIVERSITY
Refining method of sodium taurocholate
The invention discloses a refining method for sodium taurocholate. The method includes the following steps that a crude sodium taurocholate product is dissolved in alcoholic solvents, ester solvents are added while the alcoholic solvents are hot, after cooling, the temperature is reduced, and high-purity sodium taurocholate is obtained by vacuum drying. Compared with the prior art, the method hasthe advantages that the refining method is simple in operation, ester solvents with relatively higher boiling points are adopted to reduce solvent volatilization, thus use of acetone with irritating odor and the use of low-boiling-point ether are avoided, operation is safer, and industrial production is facilitated. The yield is high, the product purity is high and not less than 91%, the purity ofrefined sodium taurocholate is 100% through an area normalization method, the purity of HPLC is more than and equal to 99.00% through ELSD detection, the purity of HPLC can be up to 99.91%, the content of a single impurity A is smaller than 0.30%, the content of a single impurity B is smaller than 0.8%, the type of impurities is significantly reduced, and the refined final product are free of impurities C and D.
Owner:AMPHASTAR NANJING PHARMA +1
Moistening and whitening facial cleanser and preparation method thereof
InactiveCN106551840ALong lasting moisturizingIt has the function of antifreeze and crack preventionCosmetic preparationsToilet preparationsBetaineGlycol distearate
The invention relates to a moistening and whitening facial cleanser and a preparation method of the moistening and whitening facial cleanser. The moistening and whitening facial cleanser is prepared from, by weight, 3-5 parts of glycerinum, 5-6 parts of wheat-germ oil, 5-6 parts of pawpaw extract, 2-3 parts of sodium cocoyl glycinate, 0.5-1 part of glycol distearate, 2-3 parts of lauroamide propyl betaine, 1-2 parts of sodium taurocholate, 0.5-1 part of citric acid, 6-8 parts of polyquaternium-10, 1-2 parts of Carbomer, 3-5 parts of butanediol, 3-5 parts of nicotinamide, 0.5-1 part of PEG-40 hydrogenated castor oil, 0.5-0.8 part of methylparaben, 2-3 parts of propylene glycol, 0.2-0.3 part of ethylparaben and 30-40 parts of water. The moistening and whitening facial cleanser has the beneficial effects of being capable of effectively removing cosmetics, impurities and redundant sebum, meanwhile gently protecting the natural protective layer of skin, and bringing a moist, white, soft and comfortable feeling to facial skin.
Owner:WUXI WEITONG TRADEMARK AGENT SERVICE CO LTD
Nursing medicine for preventing liver injury postoperation complications and preparation method thereof
InactiveCN105641227AImprove immunityLittle side effectsAntibacterial agentsHydroxy compound active ingredientsSide effectNaringenin
The invention discloses a nursing medicine for preventing liver injury postoperation complications and a preparation method thereof. The nursing medicine for preventing liver injury postoperation complications is prepared from, by weight, raffinose, betulinic acid, naringenin, cryptotanshinone, nutritional nano powder, paulownia leaf extracts, extracts of herb of Wilson wassionflower, beautyberry leaf extracts, sodium taurocholate, alpinetin, riboflavin, vitamin A and amino acid. By means of reasonable matching of various components, the nursing medicine has the effects of promoting blood circulation to remove stasis, cooling the blood to stop bleeding, diminishing inflammation to relieve pain and being anti-microbial and anti-infectious, meanwhile, nutrients needed by a human body after an operation are supplemented, immunity is improved, side effects caused by Western medicine are reduced, the nursing medicine is used for nursing liver injury postoperation complications, and the curative effect is remarkable.
Owner:刘宗杰
Novel method for detecting taurocholic acid content and related substances
ActiveCN108254461AAccurate measurementReduce testing costsComponent separationCholic acidChenodeoxycholic acid
The invention discloses a novel method for detecting a taurocholic acid content and related substances. The method comprises the following steps: taking a taurocholic acid-TRC reference substance as aknown reference substance, dissolving the reference substance by a diluent to form a reference substance solution, and dissolving a taurocholic acid sample by a diluent to form a reference substancesample solution; injecting 20ul of each solution into a liquid chromatograph respectively, recording a peak area, and carrying out calculation according to an external standard method on the basis ofanhydrous taurocholic acid; taking cholic acid as a reference substance, dissolving the reference substance by a mobile phase to form a concentration impurity reference substance solution, and dissolving the taurocholic acid sample by a diluent to form a concentration sample solution; injecting 20ul of each solution into the liquid chromatograph respectively, recording the peak areas of sodium taurocholate and cholic acid in a chromatogram, and calculating the sizes of related substances in the taurocholic acid sample according to the external standard method. Effective separation and accuratequantitative detection of taurochenodeoxycholic acid and chenodeoxycholic acid which are two cholic acid substances with large difference in polarities are realized under the same liquid chromatography condition.
Owner:ZHONGSHAN BAILING BIOTECHNOLOGY CO LTD
Slow released antituberculotic preparation
InactiveCN1857714AIncrease concentrationReduce concentrationAntibacterial agentsOrganic active ingredientsMicrosphereWhole body
The slow released antituberculotic preparation contains the composition of ofloxacin, ciprofloxacin or sparxacin, capreomycin, sodium taurocholate and / or deoxysodium taurocholate. The slow released antituberculotic preparation is slow released injection or slow released implanting agent. The injection consists of slow released microsphere and solvent. The slow released microsphere contains slow releasing supplementary material and antituberculotic and the solvent is special solvent containing suspending agent carboxymethyl cellulose, etc. and with viscosity of 100-3000 cp at 20-30 deg.c. The slow releasing supplementary material is selected from EVAc, PLA, PLGA, etc. The slow released implanting agent is prepared through a certain process. The present invention has obvious unique treating effect on various kinds of intractable tuberulosis.
Owner:JINAN SHUAIHUA PHARMA TECH
Disinfecting skin-moisturizing hand sanitizer and preparation method thereof
The invention provides a disinfecting skin-moisturizing hand sanitizer. The disinfecting skin-moisturizing hand sanitizer is prepared from, by weight, 60-80 parts of disodium lauryl polyoxyethylene sulfosuccinate, 50-60 parts of decyl glucoside, 8-10 parts of vermiculite powder, 13-15 parts of rosewood essential oil, 80-100 parts of coconut oil acyl methyl sodium taurocholate, 6-8 parts of loquat leaf extract, 8-10 parts of evodia rutaecarpa extract, 1-1.5 parts of zinc gluconate, 0.4-0.6 part of potassium cinnamate, 0.5-0.7 part of nisin from streptococcus lactis, 0.8-1 part of citric acid and 900-1100 parts of deionized water. The disinfecting skin-moisturizing hand sanitizer is prepared by compounding a variety of soft decontamination ingredients and a variety of antibacterial and antiseptic ingredients, especially contains multiple plant essence ingredients, the ingredients produce a 'synergistic effect', and the disinfecting skin-moisturizing hand sanitizer has an outstanding disinfection and sterilization effect, meanwhile is nonirritant to the skin and has a skin-moisturizing effect and can make skin more smooth after being used for a long term of time.
Owner:张秀丽
Carbon black particle dispersing agent, preparation method and application thereof
ActiveCN103965664BImprove performanceImprove securityPigment treatment with non-polymer organic compoundsOrganic solventSodium taurocholate
The present invention provides a carbon black particle dispersing agent, a preparation method and an application thereof. The carbon black particle dispersing agent is formed by mixing sodium dodecylbenzene sulfonate and / or sodium taurocholate, ethylene glycol and an organic solvent. With the carbon black particle dispersing agent, the dispersion of the carbon black aggregate can achieve the small state, the number of the carbon black particles in each aggregate is less, and the guarantee can be provided for the quality of the polyethylene mixing material. The carbon black particle dispersing agent can be used for preparation of high performance polyethylene pipes.
Owner:CHINA PETROLEUM & CHEM CORP +1
Polysaccharide P4, separation and purification method thereof and application of polysaccharide P4 to blood-lipid lowering drug
ActiveCN109134678AIt has the effect of lowering blood fatLow costOrganic active ingredientsMetabolism disorderPositive controlChemistry
The invention discloses a myrtle polysaccharide P4, a separation and purification method thereof and an application of the polysaccharide P4 to preparation of a blood-lipid lowering drug. The polysaccharide comprises, in mole percent, 10.48% of monosaccharide: ribose, 4.05% of rhamnose, 65.50% of arabinose, 5.13% of xylose, 2.39% of mannose, 4.74% of glucose and 7.71% of galactose. Experimental results indicate that the myrtle polysaccharide P4 has a certain in-vitro cholate binding capacity, colestyramine serves as a positive control, and relative binding rates of the myrtle polysaccharide P4for sodium taurocholate, sodium glycocholate and sodium cholate are 31.54%, 47.61% and 52.76% by transformation according to the binding rate of 100% of the colestyramine for cholate.
Owner:SOUTH CHINA NORMAL UNIVERSITY
Chinese medicinal composition for treating coronary disease, stenocardia, arrhythmia, hyperlipemia and preparation method thereof
ActiveCN101342207BAmphibian material medical ingredientsHydroxy compound active ingredientsDiseaseAntagonism
The invention provides a Chinese medicine composition used for curing coronary heart disease, angina, arrhythmia and high blood fat and a preparation method thereof. The Chinese medicine composition consists of components as follows: 5 to 20 weight percentage of musk, 12 to 50 weight percentage, 60 to 250 weight percentage of sodium taurocholate, 12 to 50 weight percentage of toad venom, 30 to 120 weight percentage of pearl, 40 to 160 weight percentage of borneol, 1500 to 15000 weight percentage of panax pseudo-ginseng wallich, 150 to 600 weight percentage of ginseng and 50 to 200 weight percentage of the dry extract of buffalo horn. The Chinese medicine composition of the invention can improve blood circulation, dilate coronary arteries, enhance myocardial ischemia, decrease crown arteries resistance, regulate cardiac rate, lower blood pressure, reduce myocardium metabolism, decrease consumed oxygen of myocardium and relieve or eliminate angina via the synergistic and beneficial antagonistic effect of the medicine. As a great amount of the sodium taurochlate is adopted, product cost is reduced while drug effect is ensured as much as possible, thus reducing the economic burden of a patient.
Owner:广东宏兴集团股份有限公司宏兴制药厂
A myrtle polysaccharide p3, its separation method and its use in blood lipid-lowering drugs
ActiveCN109134679BLow costGood repeatabilityOrganic active ingredientsMetabolism disorderCholic acidPharmaceutical Substances
The invention discloses a myrtle polysaccharide P3, its separation and purification method and its use in the preparation of blood lipid-lowering drugs. The polysaccharide contains the following molar percentages of monosaccharides: 9.97% of ribose, 2.40% of rhamnose, and 64.51% of arabinose , xylose 6.14%, mannose 5.39%, glucose 1.74%, galactose 9.85%. The experimental results of the present invention show that myrtle polysaccharide P3 has a certain ability to bind bile salts in vitro. With cholestyramine as a positive control, the binding rate of cholestyramine to each bile salt is calculated as 100%. The relative binding rates of myrtle polysaccharide P3 to sodium taurocholate, sodium glycocholate, and sodium cholate were 29.65%, 45.84%, and 51.90%, respectively.
Owner:SOUTH CHINA NORMAL UNIVERSITY
Myrtle polysaccharide P3, separation method thereof and application of myrtle polysaccharide P3 in blood-lipid-lowering drugs
ActiveCN109134679AIt has the effect of lowering blood fatLow costOrganic active ingredientsMetabolism disorderPositive controlChemistry
The invention discloses myrtle polysaccharide P3, a separation method thereof and application of the myrtle polysaccharide P3 in blood-lipid-lowering drugs. The myrtle polysaccharide P3 comprises, bymole percentage, 9.97% of ribose, 2.40% of rhamnose, 64.51% of arabinose, 6.14% of xylose, 5.39% of mannose, 1.74% of glucose and 9.85% of galactose. Experiment results show that the myrtle polysaccharide P3 has certain in-vitro cholate binding ability; when colestyramine is used as the positive control and the cholate binding rate of the colestyramine is 100%, the sodium taurocholate relative binding rate of the myrtle polysaccharide P3 is 29.65%, the sodium glycocholate relative binding rate of the myrtle polysaccharide P3 is 45.84%, and the sodium cholate relative binding rate of the myrtlepolysaccharide P3 is 51.90%.
Owner:SOUTH CHINA NORMAL UNIVERSITY
Application of sodium taurocholate as synergist for antituberculosis antibiotic
InactiveCN1143676CReduce intensityImprove efficacyAntibacterial agentsOrganic active ingredientsKanamycinSide effect
The present invention relates to a synergist for antituberculotic antibiotic medicines, such as streptomycin, isoniazid, rifampin, kanamycin, capreomycin, ethambutol, PASA, thiacetazone or prothionamide, etc. It is characterized by that the described synergist is sodium taurocholate, possesses the action of solving cell membrane of mycobacterium tuberculosis, can reduce strength of cell membrane of mycobacteruim tuberculosis, and can make antibiotic medicine easily come into the cell of mycobacteruim tuberculosis to kill mycobacteruim tuberculosis, so that it can raise medicinal effect of antibiotic medicine, and can reduce its does to further reduce its toxic side effect.
Owner:黄林君
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