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Oral insulin composition

An insulin and composition technology, applied in the field of oral insulin composition, can solve the problems of unsolvable stability and low bioavailability of oral insulin, and achieve the effect of good hypoglycemic effect

Inactive Publication Date: 2017-04-26
GUANGZHOU KAIYAO ASSET MANAGEMENT CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The bioavailability of oral insulin in the prior art is low, less than 20% of the injection dose, and the problem of stability cannot be solved at the same time

Method used

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  • Oral insulin composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Embodiment 1: the preparation of insulin composition

[0050] 1) Dissolve 1 g of insulin in 10 ml of hydrochloric acid solution (pH 1-2), and adjust the pH to 4 with sodium hydroxide solution (10%-20%) after dissolving;

[0051] 2) Add 3g of gelatin to 150ml of distilled water to dissolve into a gelatin solution;

[0052] 3) adding the insulin solution into the gelatin solution under stirring, mixing evenly, adjusting the pH to 5-8 with 10% NaOH solution, the complex is precipitated, and an insulin-gelatin complex suspension is formed;

[0053] 4) 0.02g of glycocholic acid, 25g of sodium taurocholate, 145g of lecithin, 0.7g of cholesterol, 0.2g of bilirubin and 0.05g of chloroquine were dissolved in absolute ethanol to form a solution, and the ethanol was recovered under reduced pressure, and dried to prepare mixture;

[0054] 5) adding the above mixed solution to the insulin-gelatin complex suspension to form insulin complex liposomes;

[0055] 6) Add 25 g of microc...

Embodiment 2

[0057] Example 2: In vivo effect comparison between insulin composition and commercially available long-acting insulin

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PUM

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Abstract

The invention provides an oral insulin composition. The composition comprises the following components in parts by weight: 1 part of insulin, 0.01-0.05 part of sodium glycocholate, 10-50 parts of sodium taurocholate, 130-150 parts of lecithin, 0.5-5 parts of cholesterol, 1-1.5 parts of bilirubin, 0.01-0.1 part of chloroquine, 10-50 parts of microcrystalline cellulose, and 2-5 parts of gelatin. The invention also provides a preparation method of the oral insulin composition. The duration time of insulin reaches 3 days or above due to the oral insulin composition, and at the same time, compared with saled long-acting insulin, the composition has better hypoglycemic effects.

Description

technical field [0001] The present invention relates to the field of protein medicine, more specifically, to oral insulin composition. Background technique [0002] As a biochemical drug for lowering blood sugar, insulin has been used in the treatment of diabetes for 88 years, and it is still the drug of choice for patients with insulin-dependent diabetes mellitus (IDDM), and it is also the must-have for more and more patients with non-insulin-dependent diabetes mellitus (NIDDM). Indispensable drugs. The current clinical treatment is more inclined to use insulin as early as possible for patients with type II diabetes (2DM), so that the islet cells can be repaired and the complications caused by diabetes can be better reduced. However, since insulin is a polypeptide drug, it will be degraded by proteolytic enzymes in the gastrointestinal tract and not absorbed, so oral treatment is almost ineffective. For this reason, insulin injections are commonly used in clinical treatmen...

Claims

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Application Information

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IPC IPC(8): A61K38/28A61K9/19A61K47/42A61P3/10
CPCA61K38/28A61K9/0056A61K9/19A61K47/42
Inventor 何颖
Owner GUANGZHOU KAIYAO ASSET MANAGEMENT CO LTD
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