71 results about "Silyamandin" patented technology

The invention relates to an oral silymarin slow release preparation and process of making, wherein the preparation comprises silymarin solubilized composition 10%-80%, retarding agent 5%-80%, and balancing medicinal adjuvant. The silymarin can be prepared into solid dispersion and capsule. Compared with the existing common tablets, the preparation is characterized by the substantial curative effect for treating diseases including chronic hepatitis, persisting type hepatitis and alcohol liver.

The invention relates to the technical field of pharmaceutical preparations, in particular to a silymarin-phospholipid complex and a preparation method thereof and a silybin-phospholipid complex soft capsule prepared from the complex. According to the silymarin-phospholipid complex and the preparation process, a phospholipid complex is prepared from silymarin, so that the water solubility of the silymarin is greatly improved, the lipid solubility and water solubility of the obtained complex are balanced, and the bioavailability is greatly improved; moreover, the silymarin-phospholipid complex soft capsules prepared from the complex also have high bioavailability, and are convenient to take; the utilization of the silymarin is greatly promoted.

The invention relates to the medical technology field, and particularly relates to a solid self-microemulsion based on a spherical crystallization technique and a preparation method thereof. The solid self-microemulsion is characterized in that: with the use of the spherical crystallization technique, the solid self-microemulsifying micoparticles are prepared from poorly water soluble drugs in a liquid phase by one step. The solid self-microemulsion with the poorly water soluble drugs comprises the components, by weight: 0.1 to 1.5 g of the poorly water soluble drugs, 4.0 g of a polyoxyethylene hydrogenated castor oil, 2.0 g of capric caprylic triglyceride, 2.0 g of tpropylene glycol, 1.0 ml of ethanol, 4.0 ml of dichloromethane, 0.5 to 1.1 g of ethylcellulose (or Eudragit RS100, RL100), 0.05 g of PEG4000, and 0.5 g of colloidal silicon dioxide. The poorly water soluble drugs include cyclosporine A, fenofibrate, glimepiride, cilnidipine, isradipine, simvastatin, baicalein, neogambogic acid, puerarin, cyclovirobuxine D, silymarin and the like.

The present disclosure relates to compositions and methods for providing full spectrum photo protection to skin, which includes protection from infrared (IR) radiation and/or visible light in addition to protection from UV radiation. The compositions typically include: (a) silymarin; (b) one or more antioxidants selected from the group consisting of ferulic acid, Vitamin C, polydatin, and hespertin; (c) optionally, one or more solubilizers; and (d) a cosmetically acceptable carrier. The compositions are unique in that the combination of (a), (b), optional (c), and (d) alone, provide at least full spectrum protection from ultraviolet radiation (UV), visible light, and infrared radiation (IR). The composition can additionally, optionally, include one or more UV filters to further enhance protection from UV radiation.

The invention discloses a silymarin compound and a pharmaceutical composition containing an extract thereof. Polyethylene glycol 2,000-8,000 is adopted as an excipient, and thus the content of silymarin in combined medicines is increased by selecting a proper proportion; meanwhile, the polyethylene glycol 2,000-8,000 plays a key role in key technologies of preparation, dropping preparation and the like of the product, the preparation time is shortened, and the product yield is increased.

The invention relates to the field of application of plant products, particularly an optimized scheme for comprehensively utilizing silybum mariamum. The invention solves the problems of poor comprehensive utilization effect of silybum mariamum, complex technique, high organic solvent consumption, low production efficiency, great potential safety hazard and the like, breaks through the restriction of the existing technical field; and the scheme of oil pressing after drying seeds extracted by ethanol simplifies the technique, enhances the production efficiency, improves the product quality, and is suitable for popularization.

The invention belongs to the field of daily-use chemical industry, and in particular relates to a silymarin phospholipid compound, a mask prepared from the silymarin phospholipid compound and a preparation method of the silymarin phospholipid compound. The silymarin phospholipid compound is prepared by suspending silymarin in an organic solvent compatible with the silymarin, adding soybean phospholipid and heating for a period of time, reducing the pressure for recovering the organic solvent and drying. The silymarin phospholipid compound mask is prepared from silymarin phospholipid compound powder, polyvinyl alcohol-1788, sodium cellulose glycolate, vitamin E, humectant, zinc oxide, essence, preservative and deionized water. The silymarin phospholipid compound mask based on silymarin hasa stronger effect on eliminating free radicals and a stronger antioxidation effect, takes the silymarin phospholipid compound as the raw material for preparing a mask for delaying skin aging, and hasthe characteristics of good water solubility and high bioavailability compared with other silymarin cosmetics.

The invention relates to a preparation method for extracting high-purity silymarin from silybum marianum seed husk. The preparation method comprises the following steps: separating silybum marianum seeds from seed husk, radiating by ultraviolet, carrying out the enzymolysis, extracting by absolute ethyl alcohol, volatilizing a solvent in an extracting solution, and washing solids to obtain a silymarin crude product; dissolving in absolute ethyl alcohol, obtaining supernatant, treating by adopting the reversed phase partition chromatography, carrying out the gradient elution by using water-ethyl alcohol, collecting eluate of the absolute ethyl alcohol part, concentrating the eluate, and vacuum-drying by virtue of microwaves to obtain a product. The method is simple in process, high in production efficiency and simple to operate, the product purity can reach up to 93 percent or more, and basically no solvent remains.

The invention provides a preparation method of silymarin. The preparation method comprises the steps of: firstly preparing composite microorganism fermenting agent freeze-dried powder of Trichoderma reesei CICC 13052 and Trichoderma koningii CICC 40144, activating with 2% glucose solution, inoculating the activated composite microorganism fermenting agent freeze-dried powder to silybum mariamum deoiled seed cake powder with moisture content of 40-45% and sucrose content of 4.2-4.8%, carrying out heat-insulation fermentation at 25-28 DEG C for 60h, drying by hot air, extracting at 15-20 DEG C and vacuum degree of -0.1MPa for 10h to obtain yellow powdered substance, adding methanol for dissolving, filtering, and vacuum-drying insoluble substance to obtain silymarin.

The present invention discloses a feed additive with liver-protection functions and a preparation method thereof. The feed additive with the liver-protection functions prepared from a natural plant extract of silymarin as a main active ingredient is developed. The present invention aims to solve the technical problems that the silymarin is not stable in chemical properties, not resistant in storage and high in addition costs and how to improve application effects in animal feeds. The compound technology prepares the silymarin into a powdery coated micro-particle compound with a good fluidity,enables the silymarin content in the micro-particle compound to be kept stable for a long time and the product to be good in fluidity, effectively improves use effects, and is low in costs. Animal experiment results show that the feed additive with the liver-protection functions has very good animal liver-protecting effects and at the same time can improve growth performance of the bred animals.

The invention, which relates to the technical field of cosmetics, discloses silymarin nanometer anti-wrinkle eye cream comprising silymarin, superoxide dismutase, hydrolyzed collagen, egg yolk lecithin, glyceryl monostearate, sorbitan isostearate, wool fat, Polyglyceryl-10-stearate, stearic acid, tocopherol, squalane, polydimethylsiloxane, ethylparaben, tridecanoic acid triglyceride, glycerinum, phytic acid, honey, sodium hyaluronate and purified water. In addition, the invention further discloses a preparation method of the silymarin nano anti-wrinkle eye cream. With the nanometer form of thenatural anti-aging component silymarin, the disclosed eye cream is capable of delaying senescence of the skin around eyes and improving the e existing fine wrinkles around the eyes and has good moisturizing and anti-wrinkle effects; and the silymarin nanometer anti-wrinkle eye cream is used safely with good healthy and comfortable effects and has the great social and economic benefits.

The invention relates to a pharmaceutic preparation for livestock, comprising silymarin, or silymarin and antibiotics, wherein the antibiotics is selected from beta-lactams, quinolones, tetracyclines, sulfonamides, chloramphenicols or macrolide antibiotics. The test shows that the sensitivity of the antibiotics to the bacterium can be effectively improved, and the drug resistance of the antibiotics to the animal pathogeny can be reduced according to the invitro bacteriostasis test result and the animal invivo test result when the silymarin with a certain concentration is jointly used with the antibiotics, so that the animal bacterial disease can be effectively controlled, the usage amount of the antibiotics in the animal disease can be reduced, the breeding cost can be reduced, the breeding income can be increased, and the safety of the animal-derived food can be improved.

The invention discloses a natural product composition used for reducing blood fat and a preparation method thereof. The basic components of the composition are opuntia milpa alta, functional red infested rice and silymarin. The opuntia milpa alta is prepared into refined dry powder. The ratio of the opuntia milpa alta refined dry powder to the functional red infested rice to the silymarin is 300-600g:30-100g:30-80g. The opuntia milpa alta is prepared into an ethanolic extract. The ratio of the opuntia milpa alta ethanolic extract to the functional red infested rice to the silymarin is 300-100g:30-100g:30-80g. The composition can be used for preparing foods, medicaments and health-care products which have the functions of reducing blood fat and blood sugar, improving immunity, preventing cardiovascular and cerebrovascular diseases and removing fatty liver.

The invention discloses a preparation method of high-purity silybin. The method comprises the following steps: (1) superfinely grinding: superfinely grinding Silybum marianum to 70-120 meshes, and screening the ground Silybum marianum to obtain a ground material; (2) performing countercurrent extraction: adding the ground material into ethyl acetate, heating the obtained solution to 50-80 DEG C, carrying out circulating extracting for 1-3 h, and concentrating the obtained extract after extraction to obtain crude silymarin; (3) recrystallizing: adding the crude silymarin into acetone, dissolving the crude silymarin to obtain a silymarin dissolved acetone solution, adding the silymarin dissolved acetone solution into water, and filtering the obtained solution to obtain a wet silybin product;and (4) drying and crushing the wet silybin product. The method has the advantages of simplicity in operation, and short time, and the obtained silibinin has the advantages of high extraction rate, few solvent residues and high purity.

The invention discloses a method for extracting and preparing silymarin from polygonum capitatum herb, and belongs to the technical field of medicines.. The method comprises the following steps of: firstly extracting the polygonum capitatum herb with petroleum ether under refluxing by heating, and removing extracting solution; then soaking with high-concentration ethanol solution, percolating or extracting under refluxing by heating, and concentrating under reduced pressure to obtain fluid extract; adding water into the fluid extract for suspension, extracting with ethyl acetate, carrying out concentration and evaporation on the extracting solution under reduced pressure, then adopting silica gel column chromatography, firstly removing impurities by elution of eluent of petroleum ether and ethyl acetate at a ratio being 2:1, then eluting by using eluent of petroleum ether and ethyl acetate at a ratio being 1:1, and carrying out concentration and evaporation on the eluate under reduced pressure to obtain the light-green silymarin powder.. The method disclosed by the invention has the advantages of no toxicity, environment-friendly effect, no pollution to environment, simpleness in operation, low cost, higher yield and purity of the silymarin and easiness in popularization.

The invention discloses a preparation method of a composite carrier applied to drug solubilization, sweetgum, poloxamer and terpilenol are used as the composite carrier, the mass ratio of sweetgum to poloxamer is 1: (1-6), the mass ratio of sweetgum to terpilenol is 1: (1-6), and the mass ratio of insoluble drugs is 10%-40% of the total mass of the system. The solid dispersion is prepared by taking silymarin as a model drug, adopting a hot melting method and taking sweetgum, poloxamer and terpilenol as composite carriers, the accumulative dissolution rate of the solid dispersion in simulated gastric juice and intestinal juice reaches 91.8% within 40 minutes, and the saturation solubility of the solid dispersion is improved by 42 times.