75 results about "Silyamandin" patented technology

The invention relates to a novel process for the isolation of a hepatoprotective agent Silymarin from the seeds of the plant Silybum marianum comprising (i) Precooling the seeds to (-) 20° C. for 24 hours in a deep freezer / cold room. (ii) Powdering the cooled seeds in a hammer mill, fitted with about 40 mesh discharge screen. (iii) Defatting the seeds by extracting with hexane in a soxhlet type extractor to remove the total quantity of fatty oil without using a scrain. (iv) Extracting the defatted seeds with acetonitrile at 20-30° C. to extract silymarin fraction. (v) Concentration of the sensitive silymarin fraction under vacuum in a agitated wiped thin film evaporator (vi) stirring the silymarin such dry powder with cold dichloromethane at 5° C. followed by filtration and drying with a slow purge of nitrogen gas. (vii) Further purification of silymarin by suspending in 5 times its weight of acetonitrile and precipitating by 8-12 times its weight of water at 20° C. (viii) Filtering the precipitated silymarin in a closed vacuum filter and having 1-2 mum screen washing the cake three times with distilled water (ix) Drying of Silymarin cake in vacuum oven to obtain substantially pure silymarin.

The present invention features that silybin is included by cyclodextrin or its derivative so as to dissolve in water to prepare injection. The present invention solves the problem of water insoluble silybin for being suitable for intravenous injection.

A supplement composition for enhancement of methylation process is provided, which contains vitamin B6 (as pyridoxine HCl), folic acid, vitamin B12 (as cyanocobalamin), betaine HCl, and methylsulfonylmethane; and also contains S-adenosylmethionine. The supplement composition further includes silymarin (from milk thistle seed extract), N-acetyl L-cysteine, and cruciferious blend which includes broccoli (brassica oleracea var. talica), kale (brassica oleracea var. acephala), and radish (raphanus sativus). Further provided is a method of using the supplement composition for enhancement of methylation process.

The invention relates to an oral silymarin slow release preparation and process of making, wherein the preparation comprises silymarin solubilized composition 10%-80%, retarding agent 5%-80%, and balancing medicinal adjuvant. The silymarin can be prepared into solid dispersion and capsule. Compared with the existing common tablets, the preparation is characterized by the substantial curative effect for treating diseases including chronic hepatitis, persisting type hepatitis and alcohol liver.

The invention discloses a method for extracting silybin, wherein silymarin is adopted as original raw material by the method, and undergoes two cycles of circumfluence, two cycles of condensation and extraction, decoloring and refining to produce the silybin. The method has the advantages of simple and convenient operative technology, obviously improved yield rate, decreased cost, and improved quality of products.

The invention relates to the technical field of pharmaceutical preparations, in particular to a silymarin-phospholipid complex and a preparation method thereof and a silybin-phospholipid complex soft capsule prepared from the complex. According to the silymarin-phospholipid complex and the preparation process, a phospholipid complex is prepared from silymarin, so that the water solubility of the silymarin is greatly improved, the lipid solubility and water solubility of the obtained complex are balanced, and the bioavailability is greatly improved; moreover, the silymarin-phospholipid complex soft capsules prepared from the complex also have high bioavailability, and are convenient to take; the utilization of the silymarin is greatly promoted.

The invention relates to the medical technology field, and particularly relates to a solid self-microemulsion based on a spherical crystallization technique and a preparation method thereof. The solid self-microemulsion is characterized in that: with the use of the spherical crystallization technique, the solid self-microemulsifying micoparticles are prepared from poorly water soluble drugs in a liquid phase by one step. The solid self-microemulsion with the poorly water soluble drugs comprises the components, by weight: 0.1 to 1.5 g of the poorly water soluble drugs, 4.0 g of a polyoxyethylene hydrogenated castor oil, 2.0 g of capric caprylic triglyceride, 2.0 g of tpropylene glycol, 1.0 ml of ethanol, 4.0 ml of dichloromethane, 0.5 to 1.1 g of ethylcellulose (or Eudragit RS100, RL100), 0.05 g of PEG4000, and 0.5 g of colloidal silicon dioxide. The poorly water soluble drugs include cyclosporine A, fenofibrate, glimepiride, cilnidipine, isradipine, simvastatin, baicalein, neogambogic acid, puerarin, cyclovirobuxine D, silymarin and the like.

The invention relates to a Silybin / Silymarin (SLB / SM) micellar preparation using amphiphilic polymers as a carrier. By using the amphiphilic polymers as a solubilization carrier, the preparation can greatly increase the solubility of SLB / SM; the oral administration thereof can remarkably promote the absorption of SLB / SM in the gastrointestinal tract and improve the bioavailability of SLB / SM; and the injection administration thereof can achieve the liver-targeting effect of the drug, thereby improving the curative effect of the drug.

A Chinese medicine in the form of dropping pill for treating acute and chronic hepatitides is prepared from silymarinum, polyethylene glycol and tween-80 through mixing the fused silymarium with polyethylene glycol and dripping in condensing liquid. Its advantages are high dissolving speed and biologic utilization rate.

Dispersive silybum marianum with obviously raised bioavailability is prepared by combining sold dispersing technology and particle technology and adopting dispersive tablet as carrier. Compared with available technology, the present invention has fast disintegration, fast seepage, high bioavailability and effectively raised clinical treating effect. After mixing with water, the dispersive silybum marianum tablet can disintegrate into suspension, so that it is convenient in taking, especially for aged people and children in patients.

The present disclosure relates to compositions and methods for providing full spectrum photo protection to skin, which includes protection from infrared (IR) radiation and / or visible light in addition to protection from UV radiation. The compositions typically include: (a) silymarin; (b) one or more antioxidants selected from the group consisting of ferulic acid, Vitamin C, polydatin, and hespertin; (c) optionally, one or more solubilizers; and (d) a cosmetically acceptable carrier. The compositions are unique in that the combination of (a), (b), optional (c), and (d) alone, provide at least full spectrum protection from ultraviolet radiation (UV), visible light, and infrared radiation (IR). The composition can additionally, optionally, include one or more UV filters to further enhance protection from UV radiation.

The invention relates to the field of application of plant products, particularly an optimized scheme for comprehensively utilizing silybum mariamum. The invention solves the problems of poor comprehensive utilization effect of silybum mariamum, complex technique, high organic solvent consumption, low production efficiency, great potential safety hazard and the like, breaks through the restriction of the existing technical field; and the scheme of oil pressing after drying seeds extracted by ethanol simplifies the technique, enhances the production efficiency, improves the product quality, and is suitable for popularization.

The invention belongs to the field of daily-use chemical industry, and in particular relates to a silymarin phospholipid compound, a mask prepared from the silymarin phospholipid compound and a preparation method of the silymarin phospholipid compound. The silymarin phospholipid compound is prepared by suspending silymarin in an organic solvent compatible with the silymarin, adding soybean phospholipid and heating for a period of time, reducing the pressure for recovering the organic solvent and drying. The silymarin phospholipid compound mask is prepared from silymarin phospholipid compound powder, polyvinyl alcohol-1788, sodium cellulose glycolate, vitamin E, humectant, zinc oxide, essence, preservative and deionized water. The silymarin phospholipid compound mask based on silymarin hasa stronger effect on eliminating free radicals and a stronger antioxidation effect, takes the silymarin phospholipid compound as the raw material for preparing a mask for delaying skin aging, and hasthe characteristics of good water solubility and high bioavailability compared with other silymarin cosmetics.

The present invention provides gero-protective pharmaceutical compositions and methods, the compositions being adapted to enhance at least one of cell survival and cell metabolism in a mammalian subject, the pharmaceutical compositions include at least two of Withaferin a or its structural analogs, coumestrol, ginsenoside, quinidine, silymarin, licochalcone a, lipoic acid and apigenin, in a pharmaceutically effective amount.

The invention relates to a preparation method for extracting high-purity silymarin from silybum marianum seed husk. The preparation method comprises the following steps: separating silybum marianum seeds from seed husk, radiating by ultraviolet, carrying out the enzymolysis, extracting by absolute ethyl alcohol, volatilizing a solvent in an extracting solution, and washing solids to obtain a silymarin crude product; dissolving in absolute ethyl alcohol, obtaining supernatant, treating by adopting the reversed phase partition chromatography, carrying out the gradient elution by using water-ethyl alcohol, collecting eluate of the absolute ethyl alcohol part, concentrating the eluate, and vacuum-drying by virtue of microwaves to obtain a product. The method is simple in process, high in production efficiency and simple to operate, the product purity can reach up to 93 percent or more, and basically no solvent remains.

The invention provides a preparation method of silymarin. The preparation method comprises the steps of: firstly preparing composite microorganism fermenting agent freeze-dried powder of Trichoderma reesei CICC 13052 and Trichoderma koningii CICC 40144, activating with 2% glucose solution, inoculating the activated composite microorganism fermenting agent freeze-dried powder to silybum mariamum deoiled seed cake powder with moisture content of 40-45% and sucrose content of 4.2-4.8%, carrying out heat-insulation fermentation at 25-28 DEG C for 60h, drying by hot air, extracting at 15-20 DEG C and vacuum degree of -0.1MPa for 10h to obtain yellow powdered substance, adding methanol for dissolving, filtering, and vacuum-drying insoluble substance to obtain silymarin.

The present invention discloses a feed additive with liver-protection functions and a preparation method thereof. The feed additive with the liver-protection functions prepared from a natural plant extract of silymarin as a main active ingredient is developed. The present invention aims to solve the technical problems that the silymarin is not stable in chemical properties, not resistant in storage and high in addition costs and how to improve application effects in animal feeds. The compound technology prepares the silymarin into a powdery coated micro-particle compound with a good fluidity,enables the silymarin content in the micro-particle compound to be kept stable for a long time and the product to be good in fluidity, effectively improves use effects, and is low in costs. Animal experiment results show that the feed additive with the liver-protection functions has very good animal liver-protecting effects and at the same time can improve growth performance of the bred animals.

The invention, which relates to the technical field of cosmetics, discloses silymarin nanometer anti-wrinkle eye cream comprising silymarin, superoxide dismutase, hydrolyzed collagen, egg yolk lecithin, glyceryl monostearate, sorbitan isostearate, wool fat, Polyglyceryl-10-stearate, stearic acid, tocopherol, squalane, polydimethylsiloxane, ethylparaben, tridecanoic acid triglyceride, glycerinum, phytic acid, honey, sodium hyaluronate and purified water. In addition, the invention further discloses a preparation method of the silymarin nano anti-wrinkle eye cream. With the nanometer form of thenatural anti-aging component silymarin, the disclosed eye cream is capable of delaying senescence of the skin around eyes and improving the e existing fine wrinkles around the eyes and has good moisturizing and anti-wrinkle effects; and the silymarin nanometer anti-wrinkle eye cream is used safely with good healthy and comfortable effects and has the great social and economic benefits.

The present invention provides a pharmaceutical compound of phillygenin ibuprofen ester as represented by formula (I), preparation method thereof, and applications thereof in anti-virus, antipyresis, anti-inflammation, analgesia and the like:

The invention relates to a silymarin meglumine inclusion compound, which is prepared form hepadestal aminomethane and different materials through enclosing technology, the invention also discloses a Silymarin Methylglucamine clathrate compound preparation method.

The invention relates to a pharmaceutic preparation for livestock, comprising silymarin, or silymarin and antibiotics, wherein the antibiotics is selected from beta-lactams, quinolones, tetracyclines, sulfonamides, chloramphenicols or macrolide antibiotics. The test shows that the sensitivity of the antibiotics to the bacterium can be effectively improved, and the drug resistance of the antibiotics to the animal pathogeny can be reduced according to the invitro bacteriostasis test result and the animal invivo test result when the silymarin with a certain concentration is jointly used with the antibiotics, so that the animal bacterial disease can be effectively controlled, the usage amount of the antibiotics in the animal disease can be reduced, the breeding cost can be reduced, the breeding income can be increased, and the safety of the animal-derived food can be improved.

The invention discloses a new method for extracting silymarin from silybum mariamum, and particularly relates to a method for synergistically extracting the silymarin through enzyme-continuous counterflow ultrasonics. The method comprises the following steps of squeezing a dried silybum mariamum seed as a raw material to remove oil; drying at 60 DEG C; crushing; soaking by adopting ethanol, and adding a complex enzyme for enzymolysis; carrying out continuous counterflow ultrasonic extraction; filtering; purifying pretreated macroporous adsorption resin positioned above filter liquor; eluting by adopting a solvent; and concentrating to obtain the silymarin. The method disclosed by the invention enhances the dissolution rate of an effective component through the synergistic effect of biological enzyme wall-breaking and the continuous counterflow ultrasonic and has the advantages of no toxicity, moderate reaction condition, high extraction rate, short extraction time and low extraction cost, and is suitable for industrialized production.

The invention provides a liver aid troche, which is characterized by comprising the following components in weight ratio: in each 1000 troches: 60 g of silymarin, 55-65 g of calcium hydrophosphate, 70-80 g of calcium sulphate, 35-45 g of cane sugar, 6.0-6.2 g of starch added with 2.0-2.5 g of starch slurry which is 15%, 10-14 g of sodium starch glycolate, 1-2.0 g of magnesium stearate, and 7.5-8.5 g of Opadry. The liver aid troche disclosed by the invention is formed by adopting a novel preparation method and screening a more appropriate formula; therefore, the weight difference in the tabletting process meets the requirement, and mass production is smooth to carry out; simultaneously, the phenomena of being uneven in troche surface, pocked and broken after troches are coated can be solved; the rejection rate is reduced; the production efficiency is increased; and the method disclosed by the invention is simple, free from addition of new cost, easy for scale production and higher in application value.

The invention discloses a natural product composition used for reducing blood fat and a preparation method thereof. The basic components of the composition are opuntia milpa alta, functional red infested rice and silymarin. The opuntia milpa alta is prepared into refined dry powder. The ratio of the opuntia milpa alta refined dry powder to the functional red infested rice to the silymarin is 300-600g:30-100g:30-80g. The opuntia milpa alta is prepared into an ethanolic extract. The ratio of the opuntia milpa alta ethanolic extract to the functional red infested rice to the silymarin is 300-100g:30-100g:30-80g. The composition can be used for preparing foods, medicaments and health-care products which have the functions of reducing blood fat and blood sugar, improving immunity, preventing cardiovascular and cerebrovascular diseases and removing fatty liver.

The invention provides a traditional Chinese medicine granular preparation with silymarin and a preparation method thereof. Traditional Chinese medicine spheroidized particles are prepared by using a silymarin extract and a pharmaceutically acceptable carrier. The shapes of the traditional Chinese medicine spheroidized particles are spherical or similar to spheres, and the density of the traditional Chinese medicine spheroidized particles ranges from 0.6 g / ml to 1.3 g / ml. A single dose of the spheroidized particles is small, the medicine taking is convenient, and the granular preparation can be used as a semifinished product of capsules and can also be used for developing sustained and controlled release preparations of traditional Chinese medicine.

The invention discloses a medicinal preparation used for clearing heat, transforming dampness and soothing liver and gallbladder and used for acute / chronic cholecystitis, biliary tract infection, biliary calculus and the like and a preparation method thereof. The preparation method is characterized in that synthetic bovine bezoar, silymarin, berberine hydrochloride, corydalis root, rhubarb, dandelion, loosestrife and mint oil are used as raw materials, and the raw materials and pharmaceutically acceptable matrix or additive are prepared into dripping pills or soft capsules. The medicinal preparation improves the leaching performance of the medicament, increases the medicament stability, reduces adverse reaction of the medicament, is convenient to carry and take, and is suitable for industrialized production.

The invention provides a silymarin extraction method. The method comprises the following steps: 1, carrying out crude extraction: placing greaseless milk thistle seeds and an organic solvent in an extraction container, cutting and stirring the greaseless milk thistle seeds to break the greaseless milk thistle seeds and form a negative pressure in order to make a silymarin extract product rapidly ooze out of cells of the greaseless milk thistle seeds and be uniformly dispersed in the organic solvent, and filtering to obtain a silymarin crude extract filtrate; 2, concentrating the crude extract filtrate: concentrating the silymarin crude extract filtrate to obtain a silymarin total extract product; and 3, carrying out fine extraction: separating finished silymarin from the silymarin total extract product. The extraction method has the advantages of rapidness, high efficiency, normal temperature extraction, no destroy to effective components of silymarin, energy saving, consumption reduction and simplicity.

The invention discloses a composition containing ginsenoside Rg3 and silymarin and medicine, and mainly relates to the technical field of medicine. The composition comprises, by weight, 3-7 parts of the ginsenoside Rg3 and 3-7 parts of the silymarin. The composition containing the ginsenoside Rg3 and the silymarin and the medicine have the beneficial effects that the ginsenoside Rg3 and the silymarin are combined according to a certain proportion, the excellent synergistic medicine efficacy is achieved, tumor cells are effectively restrained, lymphopoiesis is stimulated, and the composition and the medicine have the medicine efficacy of efficient cancer fighting and immunity boosting, and also have a health-care effect.

The invention discloses a preparation method of high-purity silybin. The method comprises the following steps: (1) superfinely grinding: superfinely grinding Silybum marianum to 70-120 meshes, and screening the ground Silybum marianum to obtain a ground material; (2) performing countercurrent extraction: adding the ground material into ethyl acetate, heating the obtained solution to 50-80 DEG C, carrying out circulating extracting for 1-3 h, and concentrating the obtained extract after extraction to obtain crude silymarin; (3) recrystallizing: adding the crude silymarin into acetone, dissolving the crude silymarin to obtain a silymarin dissolved acetone solution, adding the silymarin dissolved acetone solution into water, and filtering the obtained solution to obtain a wet silybin product;and (4) drying and crushing the wet silybin product. The method has the advantages of simplicity in operation, and short time, and the obtained silibinin has the advantages of high extraction rate, few solvent residues and high purity.