Medicinal preparation used for liver and gallbladder diseases and preparation method thereof

A pharmaceutical preparation, a technology for soothing the liver and gallbladder, applied in the directions of pharmaceutical combinations, pharmaceutical formulations, and medical preparations containing active ingredients, etc., can solve the problems of slow disintegration, volatile peppermint oil, and complicated sugar-coated tablet process.

Inactive Publication Date: 2009-11-25
于晓 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Long-term clinical application has found that Danning Tablets have the advantages of clear curative effect, non-toxicity, and small side effects, but there are also obvious disadvantages: low bioavailability, slow onset of action, long-term storage of plain tablets, mint oil is volatile and oily, Sugar-coated tablets have cumbersome process, unstable quality and slow disintegration

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Prescription: artificial bezoar 30g silymarin 17.5g berberine hydrochloride 12.5g

[0022] Corydalis 125g Rhubarb 12.5g Dandelion 150g

[0023] Lysimachia 200g Peppermint Oil 2g

[0024] Preparation:

[0025] (1) Take the prescription amount of Corydalis and Rhubarb and pulverize properly, use 25 times the amount of 60% ethanol as a solvent, soak for 24 hours and then percolate according to the flow extract and the extract (refer to the appendix of the Chinese Pharmacopoeia 2005 edition), and collect the percolation Concentrate into a concentrated solution at a temperature below 70℃. Add 10 times the amount of water to dandelion and Lysimachia sylvestris to decoct 2 times for 1 hour each time until the taste is exhausted. After filtering, the filtrate is concentrated and merged into the above concentrated solution. Paste-like, dry, mixed with artificial bezoar, silymarin, and berberine hydrochloride, pulverized and mixed to obtain a clear powder.

[0026] (2) Take...

Embodiment 2

[0030] Prescription: artificial bezoar 30g silymarin 17.5g berberine hydrochloride 12.5g

[0031] Corydalis 125g Rhubarb 12.5g Dandelion 150g

[0032] Lysimachia 200g Peppermint Oil 2g

[0033] Preparation:

[0034] (1) Take the prescription amount of Corydalis and Rhubarb properly crushed, use 20 times the amount of 60% ethanol as a solvent, soak for 24 hours, and then percolate according to the flow extract and extract (refer to the appendix of the Chinese Pharmacopoeia 2005 edition), and collect the percolation Concentrate into a concentrated solution at a temperature below 70℃. Add 8 times the amount of water to dandelion and Lysimachia and decoct 3 times for 1 hour each time until the taste is exhausted. After filtering, the filtrate is concentrated and combined into the above concentrated solution and concentrated to a thick Paste-like, dry, mixed with artificial bezoar, silymarin, and berberine hydrochloride, pulverized and mixed to obtain a clear powder.

[0035]...

Embodiment 3

[0039] Prescription: artificial bezoar 30g silymarin 17.5g berberine hydrochloride 12.5g

[0040] Corydalis 125g Rhubarb 12.5g Dandelion 150g

[0041] Lysimachia 200g Peppermint Oil 2g

[0042] Preparation:

[0043] (1) Take the prescription amount of Corydalis and Rhubarb properly crushed, use 20 times the amount of 60% alcohol as a solvent, soak for 24 hours and then percolate according to the flow extract and the extract (refer to the appendix of the Chinese Pharmacopoeia 2005 edition), and collect the percolation Concentrate into a concentrated solution at a temperature below 70℃. Add 8 times the amount of water to dandelion and Lysimachia and decoct 3 times for 1 hour each time until the taste is exhausted. After filtering, the filtrate is concentrated and combined into the above concentrated solution and concentrated to a thick Paste-like, dry, mixed with artificial bezoar, silymarin, and berberine hydrochloride, pulverized and mixed to obtain a clear powder.

[00...

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PUM

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Abstract

The invention discloses a medicinal preparation used for clearing heat, transforming dampness and soothing liver and gallbladder and used for acute / chronic cholecystitis, biliary tract infection, biliary calculus and the like and a preparation method thereof. The preparation method is characterized in that synthetic bovine bezoar, silymarin, berberine hydrochloride, corydalis root, rhubarb, dandelion, loosestrife and mint oil are used as raw materials, and the raw materials and pharmaceutically acceptable matrix or additive are prepared into dripping pills or soft capsules. The medicinal preparation improves the leaching performance of the medicament, increases the medicament stability, reduces adverse reaction of the medicament, is convenient to carry and take, and is suitable for industrialized production.

Description

Technical field [0001] The present invention relates to the field of traditional Chinese medicine, in particular to a pharmaceutical preparation for clearing away heat and removing dampness, soothing the liver and promoting bile, which can be used for acute and chronic cholecystitis, biliary tract infections, gallstones, etc., and a preparation method thereof. Background technique [0002] Cholecystitis, biliary tract infection, and gallstones are common clinical digestive diseases. Gallstones are coagulum formed in the bile duct tree (including the gallbladder). The clinical manifestations mainly include episodic abdominal pain and acute inflammation. Cholecystitis is divided into acute cholecystitis and chronic inflammation. Acute cholecystitis is generally caused by small stones blocking the gallbladder duct Chronic cholecystitis refers to the chronic inflammation of the gallbladder, the most common cause of chronic inflammation is stones in the gallbladder. Chronic cholecysti...

Claims

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Application Information

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IPC IPC(8): A61K36/708A61K9/48A61K9/20A61K9/28A61P1/16A61K35/413A61K31/357A61K31/4375
Inventor 于晓李松涛张芳张永清周凤琴
Owner 于晓
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