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Soft capsule with peppermint oil as raw material medicine for treating gallbladder disease

A technology of peppermint oil and gallbladder disease, applied in capsule delivery, plant raw materials, drug combination, etc., can solve the problems of unstable quality in preparation process and dosage form selection, achieve stable quality, low cost, and improve stability

Active Publication Date: 2008-05-14
CHONGQING PHARSCIN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Danshu Hard Capsules has its unique curative effect in treating the above diseases, but the fly in the ointment is that there are certain quality instability factors in the preparation process and dosage form selection

Method used

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  • Soft capsule with peppermint oil as raw material medicine for treating gallbladder disease

Examples

Experimental program
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Effect test

experiment example 1

[0021] In order to prove that Danshu Soft Capsule is indeed more stable than Danshu Hard Capsule, we compared Danshu Hard Capsule The accelerated stability test of Shuruan Capsules was carried out under the same conditions of temperature of 60°C and relative humidity of 75%. The results are shown in Table 1.

[0022] Table 1 Hard Capsule and Soft Capsule Accelerated Stability Test

[0023]

[0024] It can be seen from Table 1 that at the same temperature and humidity, the loss rate of menthol in the soft capsule is 11.31 percentage points less than that in the hard capsule. Therefore, it is proved that the quality of the soft capsule is more stable than that of the hard capsule.

experiment example 2

[0026] In order to understand whether the drug effect will be affected after the hard capsule is changed into a soft capsule, the results of pharmacological comparison experiments are as follows:

[0027] (1) After acute jaundice was induced by a-naphthalene isocyanate in rats with CCL4-induced liver injury, serum T-bil, D-bil, ALT and AST of the rats all increased significantly (P0.05), but had no significant effect on ALT and AST (P>0.05).

[0028] (2) 0.2g / kg soft capsules can significantly promote the secretion of bile in guinea pigs 30 minutes after administration (P<0.05). The soft capsule mainly inhibits the excretion of cholesterol in bile significantly (P<0.001), increases the excretion of bile acid (P<0.001), and has little effect on the excretion of calcium and bilirubin in bile.

[0029] (3) In the experiment, 0.2-0.05g / kg soft capsule can significantly reduce the tension of Oddi's sphincter of guinea pig bile duct (P<0.05).

[0030] (4) Analgesic tests showed tha...

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Abstract

This invention discloses a soft capsule for treating gallbladder disease. The peppermint oil dementholized is used as raw material added with fat soluble medical adjuvant to a scale and prepared by modern technology. The said capsule has improved stability exception for the keeping effect of original medicine.

Description

technical field [0001] The invention relates to a soft capsule prepared by using peppermint oil as a crude drug for treating gallbladder disease. Specifically, it is a Chinese patent medicine made into soft cavity capsules by using peppermint oil as a raw material and formulating with pharmaceutical auxiliary materials in a certain proportion, which belongs to the field of preparations. Background technique [0002] The incidence of cholecystitis in my country is increasing year by year. However, most cholecystitis is closely related to gallstones, and they are like a pair of twin sisters, often coexisting at the same time. From the 1950s to the 1960s, China launched a census of the incidence of gallstones in major hospitals across the country. The survey results showed that the incidence of gallstones accounted for less than 50%, and bile duct stones accounted for more than 50%. And after the 1980s to the 1990s, the incidence of gallbladder stones accounted for more than ...

Claims

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Application Information

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IPC IPC(8): A61K36/534A61K9/48A61P1/16A61K127/00A61K135/00
Inventor 唐贤俊
Owner CHONGQING PHARSCIN PHARM CO LTD
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