An optimized scheme for the comprehensive utilization of milk thistle

An optimization scheme and technology of silymarin, which is applied to the protein composition, application, and digestive system of vegetable seeds, can solve the problems of large amount of organic solvent, poor quality of silymarin, and long extraction cycle, so as to simplify production steps and reduce equipment, the effect of reducing security risks

Inactive Publication Date: 2011-12-28
北京京卫燕康药物研究所有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] An object of the present invention is to solve the above-mentioned process of extracting silymarin in the prior art when pressing oil, because part of the pigment in the seed shell is brought in, and the oil There are many pigments in the medium; the cake after oil extraction is usually degreased with petroleum ether or gasoline, which takes a long time and uses a large amount of organic solvents, which is flammable and explosive; ethyl acetate, acetone an...

Method used

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  • An optimized scheme for the comprehensive utilization of milk thistle
  • An optimized scheme for the comprehensive utilization of milk thistle
  • An optimized scheme for the comprehensive utilization of milk thistle

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Add 250Kg of milk thistle seeds, add 2000L of 75% edible ethanol, extract by heating and reflux for 2hr., and filter. Add 2000L and 1300L to the filter residue, and then reflux and extract twice, each time for 1.5hr. Combine the ethanol extracts. After the residue is de-alcoholized and dried, the oil is pressed, and the cake is used for preparing protein or processing feed.

[0041] The ethanol extract is decompressed to recover an appropriate amount of solvent, and flows through 300Kg polar adsorption resin HPD-600 at a speed of 1.5-2BV / hr. After washing with deionized water to remove impurities, then press 1-1.5BV with 5-6BV70% ethanol The target substance is eluted at a speed of / hr. The eluate is concentrated under reduced pressure until it has no alcohol smell, centrifugally filtered, and the centrifuge is dried and crushed under reduced pressure at 60°C to obtain 4.25Kg of silymarin, which is detected by HPLC. and B) 33%.

Embodiment 2

[0043] Add 300Kg of milk thistle seeds, add 2400L of 75% edible ethanol, extract by heating and reflux for 2hr., and filter. Add 1800L and 1800L to the filter residue, and then reflux and extract twice, each time for 1.5hr. Combine the ethanol extracts. After the residue is de-alcoholized and dried, the oil is pressed, and the cake is used for preparing protein or processing feed.

[0044] The ethanol extract was decompressed to recover the solvent to an appropriate amount, and flowed through 300Kg polar adsorption resin ADS-7 at a speed of 1.5-2BV / hr. The target substance was eluted at a speed of BV / hr. The eluate was concentrated under reduced pressure until it had no alcohol smell, and was centrifugally filtered. The centrifuge was dried and crushed under reduced pressure at 60°C to obtain 5.75Kg of silymarin, which was detected by HPLC ( A and B) 31%.

Embodiment 3

[0046] Add 250Kg of milk thistle seeds, add 2000L of 80% edible ethanol, extract by heating and reflux for 2hr., and filter. Add 1500L and 1500L to the filter residue, and then reflux and extract twice, each time for 1.5hr. Combine the ethanol extracts. After the residue is de-alcoholized and dried, the oil is pressed, and the cake is used for preparing protein or processing feed.

[0047] The ethanol extract is decompressed to recover the solvent to an appropriate amount, and flows through 250Kg polar adsorption resin LSA-7 at a speed of 1.5-2BV / hr. The target substance was eluted at a speed of BV / hr. The eluate was concentrated under reduced pressure until it had no alcohol smell, and was centrifugally filtered. The centrifuge was dried and crushed under reduced pressure at 60°C to obtain 4.31Kg of silymarin, which was detected by HPLC ( A and B) 31.6%.

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Abstract

The invention relates to the field of application of plant products, particularly an optimized scheme for comprehensively utilizing silybum mariamum. The invention solves the problems of poor comprehensive utilization effect of silybum mariamum, complex technique, high organic solvent consumption, low production efficiency, great potential safety hazard and the like, breaks through the restriction of the existing technical field; and the scheme of oil pressing after drying seeds extracted by ethanol simplifies the technique, enhances the production efficiency, improves the product quality, and is suitable for popularization.

Description

technical field [0001] The invention relates to the application field of plant products, and is an optimized scheme for comprehensive utilization of milk thistle. Background technique [0002] Milk thistle is Silybum marianum (L.) Gaertner, a plant of the genus Silybum in the family Asteraceae. This plant is native to southern Europe and North Africa. Its seed extract "silymarin" was first developed in Germany as a drug for treating hepatitis (trade name: Legalon, liver benefit Long). The plant was introduced into my country in 1972 and promoted as a hepatoprotective medicinal plant. [0003] Silymarin (silymarin) is the total flavonoid component extracted from milk thistle seeds. It is composed of several dihydroflavonoid compounds. The main detection index components (the components with the highest content and the strongest activity) are silybin (silybin A and ), and silydianin, silychristin, silybonol, etc. Silymarin not only has anti-hepatotoxicity, protects liver ce...

Claims

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Application Information

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IPC IPC(8): A61K36/28C11B1/06A23J1/14A23K1/14A61P1/16A61K131/00A23K10/37
CPCY02P60/87
Inventor 宋耕福
Owner 北京京卫燕康药物研究所有限公司
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