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Medication for treating acute hepatitis and chronic hepatitis and preparation technique

A technology for chronic hepatitis and preparation process, which is applied to pure traditional Chinese medicine preparations for chronic hepatitis, in the field of acute treatment, and can solve the problems of slow dissolution, poor bioavailability and low dissolution rate of Yiganling tablets.

Inactive Publication Date: 2004-10-27
YANTAI DAYANG PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This result shows that the dissolution of Yiganling Tablets is slow and the dissolution rate is low, so the bioavailability is poor.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0091] 1. Example

[0092] Take 10.5g of silymarin, crush it into fine powder, put it in a container and mix it evenly with 31.5g of polyethylene glycol 4000, put it on a boiling water bath and heat until the matrix melts, then stir at high speed and keep it warm for 20 minutes, so that it becomes a brown-yellow melt with uniform color and luster. liquid; transfer the above molten liquid to the liquid storage tank of the dripping pill machine, close it, make it in a suitable vacuum state, keep it at 70°C for 30 minutes, and stir at a speed of 15 rpm at the same time; add dimethyl to the cooling column Silicone oil, the temperature of the condensate is 1 / 3 downward from the top, and the 1 / 2 gradient drops to 40°C, 28°C, and 10°C respectively; the inner diameter of the dripper is 3mm, and the outer diameter is 4mm. The dropping speed is 25 drops / min, and the molten liquid is dripped into the condensed liquid from top to bottom, and the dropping pills are collected, and the conde...

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Abstract

A Chinese medicine in the form of dropping pill for treating acute and chronic hepatitides is prepared from silymarinum, polyethylene glycol and tween-80 through mixing the fused silymarium with polyethylene glycol and dripping in condensing liquid. Its advantages are high dissolving speed and biologic utilization rate.

Description

(1) Technical field [0001] The invention belongs to the technical field of medicines for treating acute and chronic hepatitis, in particular to a pure traditional Chinese medicine preparation for treating acute and chronic hepatitis and a production method thereof. (2) Background technology [0002] Yiganling Tablets is a variety recorded in the eighth volume of Chinese medicine standard preparations of the Ministry of Health of my country. It is a single preparation of silymarin. Because it can improve liver function and protect liver cell membranes, it has been used as a liver-protecting drug for emergency treatment for many years. Chronic hepatitis and persistent hepatitis. According to investigations, the sales volume of the drug is currently low. One is that new drugs for the treatment of hepatitis continue to come out, and the old drugs are impacted. The main reason is that silymarin itself is an insoluble flavonoid compound, but it is made into tablets. dosage form. ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/357A61P1/16A61P31/12
Inventor 张贞丽
Owner YANTAI DAYANG PHARMA GRP
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