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Pharmaceutic preparation for livestock and application thereof

A pharmaceutical preparation and pharmaceutical technology, applied in the field of veterinary pharmaceutical preparations containing silymarin, can solve the problems of not finding silymarin, etc.

Active Publication Date: 2012-12-05
HENAN XINZHENGHAO BIO ENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, silymarin is called "natural liver-protecting drug", and is currently used in human medicine for the treatment of liver poisoning, liver dysfunction, anti-radiation and hypolipidemic effects. The prior art has not found silymarin as an antibacterial synergist. use

Method used

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  • Pharmaceutic preparation for livestock and application thereof
  • Pharmaceutic preparation for livestock and application thereof

Examples

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Embodiment 1

[0021] A pharmaceutical preparation for veterinary use, comprising 1 g of silymarin, 10.0 g of doxycycline hydrochloride, 25 g of magnesium chloride hexahydrate, 60 g of propylene glycol and 30 g of water for injection.

[0022] Preparation method: Stir and dissolve magnesium chloride hexahydrate with water for injection, then add propylene glycol, doxycycline hydrochloride and silymarin, stir at 40°C for 30 minutes until completely dissolved.

Embodiment 2

[0024] A pharmaceutical preparation for veterinary use, comprising 2 g of silymarin, 10.0 g of florfenicol, 30 g of sucrose and 58 g of starch.

[0025] Preparation method: Take silymarin, florfenicol, sucrose and starch and stir evenly.

[0026] Application test 1: In vitro antibacterial test of silymarin (taking Staphylococcus aureus as an example)

[0027] The minimum inhibitory concentration (MIC) of several antibacterial drugs after adding silymarin was determined according to the method of the National Committee for Clinical Laboratory Standardization (NCCLS).

[0028] Medium: MH broth medium, purchased from Qingdao Haibo Biotechnology Co., Ltd. Weigh 21g of medium, heat and dissolve in 1000ml of distilled water, autoclave at 121°C for 15 minutes, and set aside.

[0029] Bacterial solution: Staphylococcus aureus was purchased from the China Veterinary Drug Administration, No. CVCC2086, diluted to a concentration of 1.0×10 6 CFU / ml.

[0030] Antibacterial drugs...

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PUM

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Abstract

The invention relates to a pharmaceutic preparation for livestock, comprising silymarin, or silymarin and antibiotics, wherein the antibiotics is selected from beta-lactams, quinolones, tetracyclines, sulfonamides, chloramphenicols or macrolide antibiotics. The test shows that the sensitivity of the antibiotics to the bacterium can be effectively improved, and the drug resistance of the antibiotics to the animal pathogeny can be reduced according to the invitro bacteriostasis test result and the animal invivo test result when the silymarin with a certain concentration is jointly used with the antibiotics, so that the animal bacterial disease can be effectively controlled, the usage amount of the antibiotics in the animal disease can be reduced, the breeding cost can be reduced, the breeding income can be increased, and the safety of the animal-derived food can be improved.

Description

technical field [0001] The invention belongs to the technical field of veterinary drugs, in particular to a veterinary drug preparation containing silymarin and its application. Background technique [0002] Due to the continuous and extensive application and even abuse of antimicrobial drugs in animal breeding practices, coupled with the objective existence of cross-resistance to antimicrobial drugs shared by humans and animals, the drug resistance of pathogenic bacteria is increasing, and the efficacy of many drugs is rapidly declining. Under the selection pressure of antibacterial drugs, bacteria are resistant to almost all clinically used antibacterial drugs. At present, the use concentration of fluoroquinolones has increased to several times or even dozens of times the previous amount. Since the 1970s, it has become more and more difficult to find new antibacterial drugs, and how to deal with drug-resistant strains of infection has become a serious problem. [0003] S...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K31/357A61P31/04
Inventor 王祝义焦黎赵晓峰李家诚
Owner HENAN XINZHENGHAO BIO ENG
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