86 results about "Metallofullerene" patented technology

The present invention provides a layered metal / fullerene anode structure for efficient hole injection. The layered anode structure includes one or more layers of electrical conductors and a second layer containing fullerenes. The thickness of the second layer is selected so that the layered structure facilitate hole transfer from the layer to second layer under electrical bias. The present invention also provides a light-emitting device which includes a layered metal / fullerene anode. The device includes an hole transport layer, and a second electrically conductive layer defining a cathode electrode layer. The device includes a layer of light-emissive material between the hole transport layer and the cathode electrode. The device may also include a hole injection layer interposed between the layered metal / fullerene anode and the hole transport layer. The device may also include a dielectric layer attached to the metal layer of the layered metal / fullerene anode.

The invention discloses an application of metal fullerene monocrystal nanoparticles in preparation of a tumor vascular disrupting agent. The monocrystal nanoparticles are water-soluble metal fullerene nanoparticles with the surface charged with negative electricity, and have the particle size range of 50-250 nm; the nanomaterial can absorb and convert outside world radiation energy into heat energy, and the volume is expanded sharply when a temperature reaches a phase transition point. During treatment, a tumor-carried living organism is injected and given with the metal fullerene monocrystal nanoparticles; the metal fullerene monocrystal nanoparticles reach a tumor part through blood circulation, and are stranded at tumor pores and defective parts; under the action of the outside world radiation energy, the metal fullerene monocrystal nanoparticles accumulate heat, the temperature rises, and the volume is expanded sharply when the temperature exceeds the phase transformation critical point, so that morphological structures or functions of tumor vascular endothelial cells are changed, and tumor vessels are interdicted so as to make the tumor cells starved to death.

The invention provides a novel application of a fullerene and / or metallic fullerene micro-nano material. The novel application is that of the fullerene and / or metallic fullerene micro-nano material in the preparation of drugs or drug carriers having at least one property as in 1) to 5): 1), preventing and / or treating bone marrow suppression; 2), clearing free radicals; 3), enriching bone marrow; 4), preventing and / or treating at least one of leukocyte decrease, platelet decrease, hemoglobin decrease and monocyte decrease caused by bone marrow suppression; 5), protecting bone marrow cells and / or hematopoietic cells. The fullerene and / or metallic fullerene micro-nano material is simple and quick to prepare, is good in biocompatibility and highly rich in bone marrow area, has certain residence time, can also be finally discharged out of the body by metabolism, has no evident cytotoxicity on bone marrow cells and normal cells and is safe and nontoxic. The fullerene and / or metallic fullerene micro-nano material has a promising application prospect as a protectant for bone marrow suppression caused by chemotherapy.

The invention discloses an extraction method of an internally-embedded metal fullerene, which comprises the steps of: processing an internally-embedded metal fullerene and fullerene-containing soot by reacting and the extracting the internally-embedded metal fullerene, and converting the internally-embedded metal fullerene into a derivant which can be dissolved in dissolvent; converting the fullerene into a material which is hard to dissolve in the dissolvent, and precipitating the material; and recovering the derivant of the internally-embedded metal fullerene to be an un-derived status, andperforming the chromatograph to the derivant to obtain the internally-embedded metal fullerene. The method is simple, is easy to amplify, can effectively improve the chromatograph efficiency, and canbe used for extracting the internally-embedded metal fullerene on a large scale.

The invention discloses a fullerene micro-nano material with effects of prevention and / or treatment on myelosuppression and a use thereof. The novel use of the fullerene micro-nano material comprises use of the fullerene and / or metallofullerene micro-nano material in a drug or a drug carrier with at least one of properties such as 1, prevention and / or treatment on myelosuppression, 2, prevention and / or treatment on at least one of myelosuppression-caused leucopenia, platelet decreasing, hemoglobin decreasing and monocyte decreasing, and 3, protection of liver tissue, spleen tissue and kidney tissue. The myelosuppression is caused through tumor radiation therapy or rays producing myelosuppression side effects. The fullerene and / or metallofullerene micro-nano material can prevent and treat myelosuppression and prevent liver, spleen and kidney damage.

The present invention relates to a reverse osmosis membrane and a preparation method thereof, and belongs to the technical field of membrane separation. The reverse osmosis membrane comprises metal fullerene dispersed in the reverse osmosis membrane, wherein the metal fullerene is preferably Gd@C82, ie., metal gadolinium embedding C82. The present invention further provides a preparation method of the reverse osmosis membrane, wherein the method comprises: preparing a water phase solution with m-phenylenediamine dissolved inside and an oil phase solution with trimesoyl chloride dissolved inside, dissolving fullerene in the oil phase solution or dissolving hydroxylated fullerene in the water phase solution, and carrying out interfacial polymerization to obtain the reverse osmosis membrane. According to the present invention, the a unique cage-like structure, the nanometer pore structure and the good water molecule mass transfer channel effect of the metal fullerene are utilized to introduce the metal fullerene into the polyamide separation layer, such that the water flux and the salt rejection rate of the reverse osmosis membrane can be effectively improved, and the reverse osmosis membrane has good antibacterial property.

An optical apparatus (100), an optical system (200) and a method (300) of light amplification by stimulated emission employ an endohedral metallofullerene (120, 220) as an active material coupled to an optical waveguide (110, 210). The endohedral metallofullerene (120, 220) is optically coupled to an optical field of the optical waveguide (110, 210). The coupled optical field produces a stimulated emission in the endohedral metallofullerene (120, 220). The optical system (200) further includes an optical source (230) that generates optical power (232) to pump a stimulated emission. The method (300) further includes optically pumping (330) the coupled endohedral metallofullerene by introducing an optical pump into the optical waveguide.

The invention discloses a novel bimodal (magnetic / fluorescent) integrated molecular image probe and a preparation method. The preparation method for the molecular image probe comprises the following steps of: adding a carbon nanometer material into mixed solution of hydrogen peroxide and ammonia water, and reacting to obtain solution containing the magnetic / fluorescent bimodal molecular image probe; centrifuging to remove insoluble substances and concentrating; and adding ethanol into concentrated solution, oscillating to generate a large number of precipitates, collecting the precipitates, washing by using the ethanol, and drying to obtain the magnetic / fluorescent bimodal molecular image probe, wherein the carbon nanometer material may be one of metal-embedded fullerene, hollow fullereneand oxidized graphene. In the method, the intervention of an organic solvent is saved, intermediate products are not needed to be separated, conditions of water, oxygen and the like are saved, and the preparation method has the advantages of simplicity, economy, environment friendliness and the like.

This invention provides improved methods for the derivatization and solubilization of fullerenes, which are particularly useful for those fullerenes that are normally insoluble and which are specifically applied, among others, to endohedral fullerenes, including endohedral metallofullerenes; empty fullerenes, including small-bandgap fullerenes and other insoluble fullerenes and to very high molecular weight fullerenic materials generated in fullerenic soot, including giant fullerenes, fullerenic polymers, carbon nanotubes and metal-carbon nanoencapsulates. More specifically the invention relates to improved methods for cyclopropanation of fullerenes. Specific reaction conditions are provided which allow for cyclopropanation reactions to be successfully performed for the first time on insoluble classes of fullerenes. Also provided is a method for purification of one or more fullerenes from a fullerenic material containing the one or more fullerenes in addition to non-fullerenic carbonaceous material, particularly amorphous carbonaceous material, by derivatizing one or more fullerenes using the methods of the invention and separating soluble derivatizes fullerenes from insoluble materials.

The magnetic resonance imaging contrast medium based on metal fullerene has the molecular expression of Gd@C82OHx(NH2CH2CH2COOH)y.Gd@C82OHx(HNCH2CH2SO3H)y, where x=16-22 and yú¢6-8. The preparation process is the neucleophilic addition reaction between metal fullerene material Gd@C82 and the alkali solution of beta-alanine or amino ethyl sulfuric acid to form the water- soluble metal fullerene derivative with decorating carboxyl radical or sulfo radical. The preparation process is simple and mild, and may be used in industrial production. The water- soluble derivative of the present invention has magnetic resonance imaging efficiency obviously higher than available Gd-divinyl triamino penta acetic acid chelate.

The embodiment of the invention relates to a carboxylated metal fullerene modified titanium dioxide compound material, a preparation method and application thereof. The compound material is prepared from raw materials including carboxylated metal fullerene derivatives and a TiO2 carrying hydroxyl on the surface, wherein the carboxylated metal fullerene derivatives and the TiO2 carrying hydroxyl onthe surface are linked through an ester bond; and the ester bond is formed by-COOH in the carboxylated metal fullerene derivatives and-OH on the surface of the titanium dioxide. The carboxylated metal fullerene derivatives have a stable structure, can be characteristically absorbed in a visible region, has a wide light response range and a level structure having a high matching rate with TiO2, can be used for simply, conveniently and efficiently realizing separation of photo-induced electron-electron hole pairs by modifying the surface of titanium dioxide with the carboxylated metal fullerenederivatives, and has strong operability.

The invention relates to a metallic fullerene compound as well as a preparation method and applications of the metallic fullerene compound. The metallic fullerene compound is micro-nano particles obtained by compounding metallic fullerene or a derivative of metallic fullerene with a medical carrier through covalent bonds or non-covalent bonds. The preparation method of the metallic fullerene compound comprises the following step: bonding metallic fullerene to the medical carrier through the non-covalent effect or bonding the derivative of metallic fullerene with the medical carrier through the covalent effect. As the medicine for realizing the targeted diagnosis and / or treatment on tumor, the metallic fullerene compound is safe and non-toxic, has the aggregating size being 1-500 nm in an aqueous solution, can be effectively gathered to the tumor location through blood circulation by utilizing the EPP effect, has no toxic or side effect for the normal biological tissue, and has extremely high biosecurity, the targeted diagnosis and / or treatment on malignant tumor is realized, the use dosage of the antitumor drugs is reduced, and meanwhile, the metallic fullerene compound has high tumor targeting property, and has a broad prospect in the diagnosis and treatment integrated application of tumor.

The invention discloses application of amino-acid-modified metallofullerene water-soluble nanoparticles in the preparation of tumor vascular disrupting agents; the amino-acid-modified metallofullerene water-soluble nanoparticles have a structural general formula: metallofullerene-(OH)x(amino acid)y, wherein metallofullerene is metallic fullerene, with 0< / =x< / =50 and 0< / =y< / =50, and amino acid is a water-soluble amino acid. The tumor vascular disrupting agents prepared by applying the amino-acid-modified metallofullerene water-soluble nanoparticles to their preparation have higher biosafety, have zero toxic and side effects for normal biological tissues, are low in dosage and are good in treatment effect.

The invention discloses a fullerene nano-material for preventing and / or treating aplastic anemia and a use thereof. The use of the fullerene nano-material comprises 1, improving a leukocyte generation amount, 2, improving an erythrocyte generation amount, 3, improving a hemoglobin generation amount, 4, improving a platelet generation amount, 5, improving a hematocrit value, 6, improving a mean corpuscular volume, 7, improving mean corpuscular hemoglobin content or 8, improving a mean corpuscular hemoglobin concentration. The fullerene and / or metallofullerene nanometer material can be prepared through a simple and fast method, has good biocompatibility, has no toxic or side effects on organisms and can be used for related hemopoietic tissue through blood circulation. The fullerene and / or metallofullerene nanometer material has a certain protection and / or restoration effect on anaemia and related diseases and has obvious anaemia-related index recovery effects. The fullerene and / or metallofullerene nanometer material has stable properties and can protect and / or repair cells, blood and marrow.

The invention discloses amino acid modified metallofullerene water-soluble nanoparticles as well as a preparation method and an application thereof. The general structural formula of the amino acid modified metal fullerene water-soluble nanoparticles is metallofullerene@C2n(OH)x(Amino Acid)y, wherein x is larger than or equal to 0 and smaller than 50, y is larger than or equal to 0 and smaller than 20, and Amino Acid is water-soluble amino acid. The preparation method comprises steps as follows: an alkaline solution of water-soluble amino acid and metallofullerene are mixed and subjected to a nucleophilic addition reaction, and thus the amino acid modified metallofullerene water-soluble nanoparticles are obtained. The nanoparticles can be dissolved in water, and the preparation method is simple and environment-friendly.

The invention provides a metal-organic framework compound-metal fullerene compound and a preparation method thereof. The method is characterized in that a metal-organic framework compound material is immersed into a metal fullerene organic solution to obtain a mixing system of the metal-organic framework compound-metal fullerene compound. The metal-organic framework compound material takes organic carboxylic acid as an organic ligand and takes transition metal as a node for constitution; the metal fullerene is selected from at least one of the followings: M@C2n, M2@C2n, M3N@C2n, M3CN@C2n, M2C2@C2n, M3C2@C2n,and M2@C79N, wherein M is Sc, Y and lanthanide metals, and n is 30-50. The metal-organic framework compound is used for absorbing metal fullerene, and a metal fullerene structure with monodispersity under a solid state.

The invention provides an oxidized graphene-metallic fullerene compound. The oxidized graphene-metallic fullerene compound comprises oxidized graphene and metallic fullerene. The metallic fullerene is loaded to the surface of the oxidized graphene under pi-pi interaction. The invention further provides a method for preparing the oxidized graphene-metallic fullerene compound and application of the oxidized graphene-metallic fullerene compound as a magnetic resonance imaging contrast agent. The oxidized graphene-metallic fullerene compound, the method and the application have the advantages that the metallic fullerene is loaded on the surface of the oxidized graphene in a pi-pi interaction mode, the method is simple, complicated surface modification effects can be omitted, and the oxidized graphene-metallic fullerene compound is excellent in water solubility, stability, biocompatibility and relaxation property and is quite suitable to be used as the MRI (magnetic resonance imaging) contrast agent.

The invention discloses a device for producing fullerene efficiently with an arc process. The device comprises a vacuum furnace, wherein more than one independent electric arc sources is mounted in the vacuum furnace; each electric arc source comprises an anode, a cathode and a cathode trigger, and the anode, the cathode and the cathode trigger form a zigzag diversion loop; and an anode and a cathode trigger of each electric arc source can produce electric arcs simultaneously, so that a mixture containing the fullerene is produced. According to the device, the problem that during production of the fullerene with an existing arc process, scientific researches in laboratories are converted to industrial batch production is solved, and the fullerene and metal fullerene can be produced automatically, continuously and efficiently.

The invention discloses a micro-nano material for preventing and / or treating myelosuppression and application thereof. A fullerene and / or metal fullerene micro-nano material can be applied to preparing medicine with at least one of the following properties of preventing and / or treating myelosuppression, removing free radicals, preventing and / or treating at least one of leukocyte reduction, platelet reduction, hemoglobin reduction and monocyte reduction caused by myelosuppression, preventing bone marrow cells and / or hematopoietic cells, improving the function of antioxidant systems of organisms and protecting liver tissue, spleen tissue and kidney tissue. The fullerene and / or metal fullerene micro-nano material can be metabolized out of organisms, is enriched in visceral organs and marrow through blood circulation after intragastric administration or intraperitoneal injection, has an excellent function of preventing myelosuppression induced by chemotherapy in bodies, can effectively reduce toxic and side effects of chemotherapy on marrow and other organs, and is still obvious in protection effect after multiple treatment courses.

The invention discloses a water-soluble fullerene structure for preparing a medicine for treating fatty liver, and discloses a pharmaceutical composition and a method for treating fatty liver. Activeingredients for treating fatty liver are water-soluble fullerene, water-soluble inlaid metal fullerene, composition of the water-soluble fullerene and the water-soluble inlaid metal fullerene, and pharmaceuitical ester of above three and pharmaceutical salt of the three. The active ingredient water-soluble fullerene structure can reduce fatty vesicles in the liver, lower blood lipids, and obviously improve liver function, so that the content of alanine aminotransferase and aspartate aminotransferase tends to be normal, and the effect of treating fatty liver is highly effective. The active ingredient water-soluble fullerene structure can also regulate the level of redox in the liver.

Trimetallic nitride endohedral metallofullerene derivatives and their preparation are described. The trimetallic nitride endohedral metallofullerene derivatives have the general formula A3-nXn@Cm(R) where n ranges from 0 to 3, A and X may be trivalent metals and may be either rare earth metal or group IIIB metals, m is between about 60 and about 200, and R is preferably an organic group. Derivatives where the R group forms cyclized derivatives with the fullerene cage are also described.

The invention discloses applications of a fullerene structure in preparation of drugs used for treating leukemia. The fullerene structure is taken as an active ingredient, and comprises at least one ingredient selected from an oil soluble fullerene, an oil soluble metal embedded fullerene, a composition of the oil soluble fullerene and the oil soluble metal embedded fullerene, a water soluble fullerene, a water soluble metal embedded fullerene, a composition of the water soluble fullerene and the water soluble metal embedded fullerene, and a pharmaceutical ester or a pharmaceutical salt of theabove six ingredients. The active ingredient is capable of accumulating in bone marrow at a high efficiency; effects are achieved quickly; excellent biocompatibility is achieved; the fullerene structure can be used for preventing and treating leukemia before leukemia model maturation; after leukemia onset, the active ingredient possesses bone marrow part targeted enrichment characteristics, and can be used for rapid prevention, treatment, and repairing of bone marrow haematopoietic function damages by leukemia and other organic damages.

The invention discloses a method for extracting endohedral metallofullerene in the technical field of fullerene extraction. The method for extracting the endohedral metallofullerene comprises the specific steps: S1, filling a pre-treated mixture of various rare-earth oxides and graphite powder in a deep hole; S2, enabling the rare-earth oxides to be changed into rare-earth carbides; S3, discharging to generate soot; S4, carrying out reverse discharging, so that a carbon deposition rod is consumed into soot; S5, extracting coarse ashes; S6, drying the extracted coarse ashes in a vacuum manner; S7, collecting and extracting the soot; S8, removing and drying the rest soot; S9, putting the ashes into a high pressure kettle to be extracted; S10, pumping, filtering and drying an extracting solution. According to the method for extracting the endohedral metallofullerene, the ashes generated in the discharging process are further extracted, so that the ashes can be sufficiently utilized and the content of high fullerenes in the product is obviously increased to develop a shortcut for further enrichment, separation and purification of the endohedral fullerene; therefore, the method for extracting the endohedral metallofullerene is especially suitable for larger-scale extraction.

The invention discloses the application of a water-soluble fullerene structure in the preparation of medicine for treating pulmonary fibrosis. The water-soluble fullerene structure comprises a water-soluble fullerene, a water-soluble intercalated metal fullerene, a composition of the water-soluble fullerene and the water-soluble intercalated metal fullerene, a pharmaceutically acceptable ester ofthe above three or a pharmaceutically acceptable salt of the above three. The water-soluble fullerene structure of the invention can treat pulmonary fibrosis, including treating congestion, edema or hyperplasia of the lung, and treating pulmonary collagen fiber hyperplasia and accumulation. Moreover, the active ingredient can be excreted out of the body through metabolism of the organism, has no toxic and side effects, and has good biocompatibility.

A method for recovering an endohedral metallofullerene comprises a complexation step of adding a Lewis acid comprising titanium halide or tin halide to a reaction solution formed by dissolving crude fullerenes in a solvent, thereby forming a complex of the endohedral metallofullerene and the Lewis acid, a filtering step of filtering the reaction solution to separate the complex, and a washing step of removing the Lewis acid from the complex to obtain the endohedral metallofullerene. The obtained endohedral metallofullerene is soluble in a solvent. This method provides a high recovery yield of the endohedral metallofullerene.

The invention discloses a method for rapidly separating endohedral metallofullerenes and belongs to the field of fullerene separation. The method comprises the following steps: completely dissolving afullerene mixture containing the endohedral metallofullerenes in an organic solvent to obtain a to-be-separated solution; mixing Lewis acid and the to-be-separated solution in a volume ratio being 1:100-1:2000 to obtain a precipitate; washing the precipitate with water to obtain the endohedral metallofullerenes. At least half a month is required for separating the endohedral metallofullerenes from 1 g of the fullerene mixture containing the endohedral metallofullerenes only with the conventional HPLC (high performance liquid chromatography) separation, manual operation is needed all the time,and much time and labor are consumed; while the Lewis acid based separation method is not limited by quantity, a large quantity of the fullerene mixture containing the endohedral metallofullerenes can be subjected to separation within one day, and an endohedral metallofullerene enriched product is obtained.

The invention discloses a high effective magnetic resonance image-forming contrast agent with bone tissue target taxis teat base on metallic enriched ocimene and preparing method, which is characterized by the following: setting molecule formula at Gd@C82Ox(OH)y(C(PO3Et2)2)10 or GdaM3-aN@C80Ox(OH)y(C(PO3Et2)2)10 or Gd2@C80Ox(OH)y(C(PO3Et2)2)10; setting a at 1, 2 or 3; setting M as Sc or Er; setting x as 2-8; setting y as 12-16; setting Et as ethyl group; choosing metallic enriched ocimene with Gd as raw material; proceeding Bingel addition reaction with tetraethyl methano diphosphate under existence of NaH; proceeding nucleophilic additive reaction with OH-; synthesizing water-soluble metallic enriched ocimene derivant with outer cage modification phosphatide group with big scale. This invention possesses the advantages of convenient operation and big scale production.

The invention relates to a method for increasing the performance of a metallofullerene single-molecular magnet. The method includes: dispersing the metallofullerene single-molecular magnet into the ducts of an organic porous material, wherein the organic porous material is a metal organic framework compound material or a covalent organic frame compound material. Magnetism test results show that the metallofullerene single-molecular magnet dispersed in the organic frame compound is high in blocking temperature and magnetization intensity. By the method, the performance of the metallofullerene single-molecular magnet can be increased effectively.

Metallofullerene derivatives, a preparing method thereof and an energy storage and conversion method of the derivatives are disclosed. The derivatives are obtained by modifying the surface of metallofullerene with derivatives of a nitroxide free radical micromolecule that is 2,2,6,6-tetramethylpiperidinooxy through an addition reaction. The metallofullerene derivatives are radiated by adopting ultraviolet light, and then participate catalytic oxidation reactions, the energy storage rate and energy conversion rate are high, storage of ultraviolet light energy and conversion from the light energy to chemical energy are achieved, and the energy storage and conversion method and process are simple. An electron transfer process of the metallofullerene derivatives radiated by the ultraviolet light can be analyzed by a conventional test instrument, the electron transfer situation can be reflected by changes of electron paramagnetic signals, and sensitivity is high. The time scale in the electron transfer process can be detected as an expansion.

The present invention is directed to a family of trimetallic nitride endohedral metalloheterofullerenes having the formula Ax X3-x N@Cn N, (x=0, 1, 2 or 3) (n=number of carbon atoms in the cage, typically between 59 and 199), wherein A and X are metal atoms encased within the cage, C is carbon and N is nitrogen. A and X are preferably selected from rare earth elements or group IIIB elements. A or X metal atoms are scandium, yttrium, lanthanum, gadolinium, lutetium, holmium, erbium, thulium, dysprosium, neodymium, cerium, praseodymium and ytterbium. Representative embodiments include Sc3N@C79N, Y3N@C79N, La3N@C79N, Tb3N@C79N, Ho3N@C79N, LaSc2N@C79N, PrSc2N@C79N, GdSc2N@C79N, La2ScN@C79N, and Gd2ScN@C79N. The present invention is also directed to a method of making the inventive endohedral metalloheterofullerenes having the formula AxX3-xN@CnN. These methods involve use of oxidizing gases (e.g. O2 and NOx) coupled with combustion as a means for making trimetallic nitride clusters encapsulated in heteroatom CnN cages made of both carbon and nitrogen.