194 results about "Bone marrow suppression" patented technology

The invention relates to methods for treating and preventing radiation and / or chemotherapy related injury and / or afflictions, such as myelosuppression and decreased macrophage activity, by administering a prophylactically or therapeutically effective amount of particulate, bioavailable β(1,3; 1,6) glucan. The invention also relates to methods in which β(1,3; 1,6) glucan is provided in the form of whole glucan particles, microparticulate β-glucan particles or a combination thereof.

The present invention relates to novel myeloid suppressor cells (MSCs) and to methods of isolating these MSCs are also included. The MSCs of the present invention can be used to treat or prevent autoimmune diseases or alloimmune responses. The MSCs of the present invention may also be used to reduce a T cell response, induce T regulatory cells, and produce T cell tolerance.

The invention discloses a phospholipid complex albumin nanoparticle containing epipodophyllotoxins medicine. The nanoparticle contains a complex formed by epipodophyllotoxins medicine and phospholipid and albumin. The nanoparticle comprises the following raw materials in parts by weight: 1 part of epipodophyllotoxins medicine, 1-50 parts of phospholipid and 2-100 parts of albumin. The phospholipid complex albumin nanoparticle can be used for remarkably reducing the toxicity of the epipodophyllotoxins medicine, especially bone marrow suppression; meanwhile, the phospholipid complex albumin nanoparticle has liver-lung targeting property.

The present invention relates to a method of use involving the administration of the herbal composition, comprising geranium oil and extracts from roots of the plants of the genus Sophora, to mammalian animals undergoing cancer treatments that would induce the bone marrow suppression side effect, such as chemotherapy and radiation therapy. The composition can take on the form of an oil capsule, tablets, pills, and pastes etc. to be administered orally at specific dosages. The composition can also take on the form of an injection to be administered intravenously and intraperitoneally at specific dosages. The administration can be made before and or after the cancer treatment.

The invention discloses a medicine for promoting leukopoiesis, which can be prepared into any one of conventional solid oral preparations by using milk vetch, deerhorn glue, American ginseng, epimedium, angelica, sealwort, eclipta, medlar, fructus psoraleae and spatholobus stem as raw medicines and using conventional methods of traditional Chinese medicine preparations. The medicine disclosed by the invention has the functions of strengthening the spleen and nourishing the kidney, nourishing qi and blood and tonifying yin and yang, can be used for regulating the bone marrow haematopoietic function after radiotherapy and chemotherapy and promoting the leukopoiesis, and is suitable for preventing and treating bone marrow suppression leukopenia after radiotherapy and chemotherapy. The clinical test research shows that the total effective rate of the leukopoiesis is 88.46%.

The present invention relates to a method of suppressing bone marrow (BM) and treating conditions that arise in or near bone such as cancer, myeloproliferative diseases, autoimmune diseases, infectious diseases, metabolic diseases or genetic diseases, with compositions having as their active ingredient a radionuclide complexed with a chelating agent such as macrocyclic aminophosphonic acid.

The invention provides a protopanoxadiol submicroemulsion preparation and a preparation method thereof. The protopanoxadiol submicroemulsion preparation comprises protopanoxadiol, oil, an emulsifier and a co-emulsifier, average particle size of the protopanoxadiol submicroemulsion preparation is 110-130nm, and Zeta potential ranges from -40mV to -20mV. The invention also provides an application of the protopanoxadiol submicroemulsion preparation in preparation of a medicine with the effects of promoting hematopoietic cell proliferation and alleviating bone marrow inhibiting effect caused by tumour treatment.

The invention provides application of a polyphenol compound, such as resveratrol, which is wide in sources, safe and effective, and economic and applicable, in preparing medicines for preventing and treating radiation-induced bone marrow suppression. Results show that the resveratrol has remarkable protection effects on radiation-induced bone marrow cell injuries, such as peripheral blood leukocyte reduction, hypoplastic bone marrow, aplastic anemia and function reduction, and the resveratrol can be used in large dose and has no remarkable toxic and side effects.

The invention discloses a Chinese medicinal composition for raising leucocytes, which is mainly prepared from the following raw material medicaments of Radix Astragali and polygonatum rhizome according to weight ratio being 1:1-2:1. The invention discloses a traditional Chinese medicine for raising leucocytes, the active components are a Radix Astragali extract product and a polygonatum rhizome extract product, wherein the Radix Astragali extract product is at least a Radix Astragali polysaccharide extract product, and the polygonatum rhizome extract product is at least a polygonatum rhizome polysaccharide extract product; and the weight ratio of the Radix Astragali polysaccharide extract product to the polygonatum rhizome polysaccharide extract product is 1:1-3:1. The invention also discloses a preparation method and an application of the Chinese medicinal composition for raising leucocytes. The Chinese medicinal composition for raising leucocytes promote the differentiation propagation of the leucocytes and bone marrow cells, raising the leucocytes of the chemicotherapy patients, preventing and controlling marrow suppression of chemoradiotherapy, and improving Chinese medicinal symptoms and living quality of patients with cancer; for the patients with qi deficiency, through supplementing qi and nourishing Yin, the immunity is enhanced for improving the recovery of the patients with qi deficiency, and no toxic and side effects can be generated.

The invention relates to methods for treating and preventing radiation and / or chemotherapy related injury and / or afflictions, such as myelosuppression and decreased macrophage activity, by administering a prophylactically or therapeutically effective amount of particulate, bioavailable β(1,3; 1,6) glucan. The invention also relates to methods in which β(1,3; 1,6) glucan is provided in the form of whole glucan particles, microparticulate β-glucan particles or a combination thereof.

The invention relates to application of arctigenin in preparation of medicines for preventing and treating bone marrow suppression. The arctigenin has unexpected activities for enhancing immunity, promoting hemopoiesis and many other aspects. The animal in-vivo test proves that the arctigenin can obviously increase the quantity of leucocytes after chemotherapy, especially the quantity of neutrophilic granulocytes. Thus, the arctigenin is an active component capable of resisting side reactions of chemotherapy and enhancing the chemotherapeutic effect of tumors, and has very important meanings for prolonging the life time of cancer patients and improving the life quality of cancer patients.

The invention relates to a traditional Chinese medicine preparation for preventing and treating bone marrow suppression after radiotherapy and chemotherapy. The traditional Chinese medicine preparation is prepared from, by weight, 10-20 parts of codonopsis pilosula, 15-60 parts of astragali radix, 15-20 parts of fructus ligustri lucidi, 10-20 parts of eclipta alba, 15-30 parts of caulis spatholobi, 10-30 parts of peanut coat, 10-20 parts of rhizoma polygonati, 6-10 parts of ginger and 10-15 parts of radix bupleuri. The traditional Chinese medicine preparation has the advantages of good curative effect and low cost, has the curative effect similar to GM-CsF on the aspect of leukopenia (including severe bone marrow suppression) after radiotherapy and chemotherapy, can improve the clinical symptoms, has no obvious side effect, and meanwhile can effectively improve blood platelet and hemoglobin values and effectively prevent adverse consequences, such as serious infection and fever caused by leukocyte decrease.