38 results about "Leukocyte reduction" patented technology

This invention provides a method for controlling a fluid separation system, preferably a blood apheresis system having a leukocyte reduction chamber. The method utilizes a three-level alarm system. A first-level alarm condition is triggered in response to a pressure drop in the system to less than or equal to a specified system pressure and pauses fluid flow in at least a portion of the system. A second-level alarm condition is triggered in response to a specified number of said pressure drops within a specified period and reduces the flow rate of the fluid in the system. The alarm conditions may also trigger a visible and / or audible alarm. These alarm levels permit flow through the leukocyte reduction chamber to continue when the pressure drop is caused by a non-serious, self-resolving or easily-correctable condition such as misalignment of system components.

This invention provides a method for controlling a fluid separation system, preferably a blood apheresis system having a leukocyte reduction chamber. The method utilizes a three-level alarm system. A first-level alarm condition is triggered in response to a pressure drop in the system to less than or equal to a specified system pressure and pauses fluid flow in at least a portion of the system. A second-level alarm condition is triggered in response to a specified number of said pressure drops within a specified period and reduces the flow rate of the fluid in the system. The alarm conditions may also trigger a visible and / or audible alarm. These alarm levels permit flow through the leukocyte reduction chamber to continue when the pressure drop is caused by a non-serious, self-resolving or easily-correctable condition such as misalignment of system components.

The invention discloses a Chinese medicinal composition for treating malignant tumor, belonging to the field of Chinese medicines. The Chinese medicinal composition is a medicament preparation formed from herba oldenlandiae, astragalus root, tuckahoe, prepared pinellia tuber, herba scutellariae barbatae, teloon, scorpion, scolopendra and the like by adopting advanced processes including extraction with water, extraction with ethanol, enzymolysis of trypsinase and the like according to a certain compatible requirement, and the medicament preparation is preferably prepared into capsules and tablets. The Chinese medicinal composition has a certain function for relieving symptoms for lung cancer, liver cancer, gastric cancer, intestinal cancer, breast cancer, encephaloma, lymph cancer and other malignant tumors, reducing tumor bodies, inhibiting the growth of the tumors and the like; and according to the Chinese medicinal composition, the human immune capability can be improved, the lives of patients suffered from tumors can be prolonged and the adverse reactions of leukocytopenia, dizzy, weakness and fatigue, skinniness, poor appetite, nausea and vomiting and the like due to radiotherapy chemotherapy for cancers can be effectively relieved.

This invention provides a method for controlling a fluid separation system, preferably a blood apheresis system having a leukocyte reduction chamber. The method utilizes a return-flow alarm system. A return-flow alarm-triggering pressure is specified, and when pressure of the return flow in the system is higher than or equal to the specified pressure, a return-flow alarm is triggered.

The invention relates to a preparation method of a traditional Chinese medicine lotion for curing acute conjunctivitis, which pertains to the technical field of traditional Chinese medicine preparation methods. At present, acute conjunctivitis is cured by adopting a sulfa drug which is easy to cause gastrointestinal tract reaction or crystalluria, hematuria or tetter, antipyretic, leukocyte reduction, etc. The technical proposal of the invention is that: chrysanthemum, mint, cicada slough, mulberry leaf, fructus viticis, taraxacum mongolicum, viola yedoensis makino, herba patriniae, blackberrylily, ampelopsis japonica mak, cyrtomium fortunei, smilax glabra, bistortae, polygonum bistatum, herba lobeliae radicantis, potentilla discolor bunge, barberry root, cayratia japonica, tupan root, prunella vulgaris, clearson, seed of feather cockscomb, pale butter-fly bush bud, pipewort, equisetum hyemale, bat dung, princesplume ladysthumb fruit, and unripe licorice are taken as raw materials, the raw materials are soaked by using 1600ml water for 30mintues and boiled by small fire, residues are filtered by using gauze, thus preparing 1000ml of traditional Chinese medicine liquid which is the traditional Chinese medicine lotion for curing acute conjunctivitis. The lotion of the invention has the advantages of simple preparation method, low toxicity, fewer side effects of the prepared traditional Chinese medicine lotion and being able to directly achieve to the focus.

The invention belongs to the field of traditional Chinese medicine and relates to a traditional Chinese medicine compound preparation for treating ovarian cancer and a preparation method of the traditional Chinese medicine compound preparation. According to the traditional Chinese medicine compound preparation, extracts of bulk medicine such as astragalus mongholicus, codonopsis pilosula, rehmannia root, sculellaria barbata, asparagus cochinchinensis, medlar, cornu cervi, fiveleaf akebia fruit, elecampane and radix paeoniae alba are prepared into solid and liquid preparations. Animal experiment results show that the weight loss and the white cell reduction can be relieved, the T lymphocyte function is improved, the bax expression is increased, the cancer cell apoptosis is promoted, the anti-tumor angiogenesis effect is realized, the oxygen deficiency microenvironment of tumor cells is improved, and the sensitivity of ovarian cancer cells on chemotherapeutics is enhanced. Clinical test results show that the clinical symptoms of later-stage ovarian cancer patients can be relieved, and the survival quality of patients is improved; the chemotherapy toxic and side effect is lightened, and the chemotherapy tolerance and the compliance of the patients are improved; and the uncontrolled and recurrence rate of later-stage ovarian cancer can be reduced, and the five-year survival rate is improved; and no obvious adverse reaction exists, and good safety is realized. The traditional Chinese medicine compound preparation is applicable to the treatment on ovarian cancer and ovarian cancer postoperative chemotherapy patients.

Methods, systems and apparatus for photo-processing of fluids, particularly complex fluids, such as blood products, pharmaceuticals, injectables and vaccines, are provided. The disclosed methods and systems employ non-laser light source(s) to generate monochromatic light energy, preferably in the range of 260 nm to 310 nm, for fluid treatment. Advantageous processing regimens and / or adjunct additives and / or agents may also be used to achieve desired and / or enhanced results, e.g., inactivation of pathogens, bacteria and / or viruses, modulation of immune response, and / or leukoreduction. Particularly preferred embodiments include specific wavelengths, novel temperature control systems and geometric / structural arrangements that provide enhanced processing results and / or efficiencies. The disclosed methods, systems and apparatus achieve desirable results in a broad range of diagnostic, therapeutic and treatment applications, and generally provide enhanced operating efficiencies and / or processing results in application modalities that employ a broad range of photo-activated and / or photo-responsive materials and / or compounds.

A fermentation Chinese Caterpillar Fungus hypha micro-powder, its production and use are disclosed. It is cheap and has less medicine use account. It can be used to prevent or treat chronic bronchitis, cough, leukocyte reduction and nephropathy.

This invention provides a method for controlling a fluid separation system, preferably a blood apheresis system having a leukocyte reduction chamber. The method utilizes a return-flow alarm system. A return-flow alarm-triggering pressure is specified, and when pressure of the return flow in the system is higher than or equal to the specified pressure, a return-flow alarm is triggered.

The invention provides application of a polyphenol compound, such as resveratrol, which is wide in sources, safe and effective, and economic and applicable, in preparing medicines for preventing and treating radiation-induced bone marrow suppression. Results show that the resveratrol has remarkable protection effects on radiation-induced bone marrow cell injuries, such as peripheral blood leukocyte reduction, hypoplastic bone marrow, aplastic anemia and function reduction, and the resveratrol can be used in large dose and has no remarkable toxic and side effects.

The invention discloses a micro-nano material for preventing and / or treating myelosuppression and application thereof. A fullerene and / or metal fullerene micro-nano material can be applied to preparing medicine with at least one of the following properties of preventing and / or treating myelosuppression, removing free radicals, preventing and / or treating at least one of leukocyte reduction, platelet reduction, hemoglobin reduction and monocyte reduction caused by myelosuppression, preventing bone marrow cells and / or hematopoietic cells, improving the function of antioxidant systems of organisms and protecting liver tissue, spleen tissue and kidney tissue. The fullerene and / or metal fullerene micro-nano material can be metabolized out of organisms, is enriched in visceral organs and marrow through blood circulation after intragastric administration or intraperitoneal injection, has an excellent function of preventing myelosuppression induced by chemotherapy in bodies, can effectively reduce toxic and side effects of chemotherapy on marrow and other organs, and is still obvious in protection effect after multiple treatment courses.

The invention discloses a Chinese medicine effective part composition with an antitumor effect and a preparation method thereof, in particular to a Chinese medicine effective part composition extracted from oldenlandia diffusa, astragalus mongholicus and centipede and a preparation method thereof, belonging to the field of traditional Chinese medicines. In the Chinese medicine composition, effective parts are extracted from the oldenlandia diffusa, the astragalus mongholicus and the centipede as main ingredients, then corresponding auxiliary materials are added so as to prepare pills, tablets, granules, hard capsules, mixtures, pill drops, soft capsules, effervescent tablets, injections or powder-injections used for inhabiting tumor growth, reducing a tumor body, adjusting immunologic function, improving immunity of a human body, prolonging the life of a patient with the tumor, effectively relieving adverse reactions such as leucopenia, dizziness, tireness, weakness, magersucht, poor appetite, nausea and vomiting and the like caused by operation, radiotherapy or chemotherapy of the patient with the tumor; and the Chinese medicine effective part composition has the advantages of definite effective ingredients, obvious drug effect, less dosage and diversified formulation, is convenient to use, conforms to the modern requirements on the traditional Chinese medicine and has betterdevelopment prospect.

The invention relates to a medicine composition for tumor therapy and the preparation method, comprising ginseng, radix polygoni multiflori preparata, angelica sinensis, prepared radix rehmanniae, astragalus, lanceolata, rhizoma fagopyricymosi wild buckwheat rhizome, Lightyellow Sophora Root, Largehead Atractylodes Rhizome, hedyotis diffusa willd, bergamot and crab apple. The medicine composition has the functions of heat-clearing and detoxifying, qi and blood invigorating as well as spleen and stomach reinforcing, can be used for curing symptoms such as leucopenia, dizziness, insomnia, few eating, anorexia, weirdness and tiredness and vertigo caused by tumor, and can improve the immunity of the body. The medicine composition has the advantages of stable technology, controllable quality, safe taking and side effects eliminating.

The invention discloses a medicament for treating malignant tumors, and relates to the technical field of traditional Chinese medicines. The medicament is prepared by processing oldenlandia diffusa, sculellaria barbata, poria cocos, fructus arctii, achyranthes and atorvastatin calcium as raw materials according to the requirements of compatibility, and the medicament is preferably prepared into capsules and tablets. The pharmaceutical composition has certain symptom relieving, tumor shrinkage and tumor growth inhibition effects and the like on various malignant tumors such as lung cancers, liver cancers, gastric cancers, colorectal cancers, breast cancers, brain tumors and lymph cancers, can enhance the human immunity and prolong the lives of patients with tumors, and can effectively relieve adverse reactions such as leukopenia, dizziness, tireness, power leakage, emaciation, poor stomach intake and nausea and vomiting caused by the radiotherapy and chemotherapy of tumors.

The invention discloses a preparation method of inosine and a composition injection thereof. The injection is composed of raw materials of inosine and sodium chloride, and accessories of glycine and water for injection. 100ml of the composition contains 0.6 wt% of inosine, 0.9 wt% of sodium chloride and 0.15-0.25wt% of glycine. The injection is a large volume injection prepared from inosine and pharmaceutically acceptable accessories and has stable quality; and the injection is used for auxiliary treatment of leukopenia, thrombocytopenia, heart failure, angina pectoris and hepatitis caused by various reasons, and can also be used for auxiliary treatment of optic atrophy and central retinitis. The invention also involves preparation of a composition injection containing polygeline and inosine; the composition injection is a large volume injection prepared from polygeline, inosine and pharmaceutically acceptable excipients and has stable quality; and the composition injection is used for acute normovolemic hemodilution, improves microcirculation and prevents the occurrence of ischemic and hypoxic injury of tissues.

The invention discloses application of spleen aminopeptide in preparation of a drug for treating leucopenia. The leucopenia is caused by chemotherapy drugs such as epirubicin hydrochloride; and the spleen aminopeptide is a spleen aminopeptide solution or spleen aminopeptide freeze-dried powder, can significantly improve myelosuppression condition of mice, and has the effect of treating the leucopenia caused by the chemotherapy drugs. By constructing an ICR mouse chemotherapy model, the spleen aminopeptide is verified to be capable of remarkably improving the myelosuppression condition of the mice, effectively relieving the leucopenia symptom of the mice after chemotherapy, and remarkably improving the survival condition of the mice, so that a new way and method are provided for treating the leucopenia.

The invention discloses herbal cuisine for relieving the bone marrow inhibition effect caused by chemotherapy. The herbal cuisine is prepared by the following main raw materials, by weight, 9-15 parts of astragalus membranaceus, 12-20 parts of polygonatum kingianum, 9-15 parts of angelica sinensis, 5-10 parts of edible palm, 15-20 parts of goat tripe, 9-12 parts of salvia chinensis, 8-12 parts of apocynum venetum, 6-10 parts of oldenlandia diffusa, 10-15 parts of liquorice, 20-35 parts of dog kidneys, 10-16 parts of puerarin, 8-16 parts of semen cuscutae, 6-10 parts of morinda officinalis and 40-60 parts of ricefield eels. The herbal cuisine has the functions of benefiting qi and nourishing blood, strengthening the spleen and stomach and nourishing kidney essence, the immunity of the organism can be improved, the toxic action of radiotherapy and chemotherapy to the human body can be reduced, and the reactions of appetite lowering, vomiting and nausea, leucopenia and the like caused by chemotherapy can be reduced.

Methods for treating blood. The methods comprise obtaining whole blood from a donor, mixing the whole blood with a red blood cell enhancement composition, and incubating the mixture of whole blood and red blood cell enhancement composition. The method can be performed at a time proximate to the time of obtaining blood from the donor, or after the blood has been stored for a period of time. The method rejuvenates red blood cells. Incubation may be performed for a period of time sufficient to increase the level of a metabolically-significant compound in the RBCs in the leukoreduced blood to a level essentially equal to levels found in fresh blood, the level being greater than the level of the compound in non-leukoreduced blood mixed with the RBC enhancement composition and incubated for the period of time.

The invention discloses application of a composition of donkey-hide gelatin and novel donkey-hide gelatin to the preparation of a drug for preventing or treating diseases related to low leucocyte amount. A large number of experiments find that the composition of the donkey-hide gelatin and the novel donkey-hide gelatin has a reversing effect on chloramphenicol or vinorelbine-induced low leucocyteamount of zebrafish, and the effect of reversing the low leucocyte amount by the composition of the donkey-hide gelatin and the novel donkey-hide gelatin at a certain ratio and action concentration isfar greater than the effect of using only donkey-hide gelatin or only applying the novel donkey-hide gelatin. The experiment probes that the composition of the donkey-hide gelatin and the novel donkey-hide gelatin can be used for preparation of the drug for preventing or treating the diseases related to the low leucocyte amount, particularly for preparation of a drug for clinically related diseases caused by low leucocyte amount in a body, including leukopenia caused by radiotherapy and chemotherapy.

The invention provides a composite preparation for treating leucopenia caused by radiotherapy and chemotherapy. The composite preparation is prepared from leucogen tablet powder and traditional Chinese medicine effective extract ingredient powder. The traditional Chinese medicine preparation is combined with western medicine leucogen tablets to act on leucopenia caused after radiotherapy and chemotherapy, and has the advantage of syndrome differentiation and treatment; the defect that traditional western medicine cannot achieve distinguishing therapies for syndromes is overcome; by using the traditional Chinese medicine ingredients, the healthy energy is supported, immunity is enhanced, and body recovery and tumor restraining effect are promoted; comprehensive analysis is adopted, the traditional Chinese medicine and western medicine combined treatment method is adopted, and the better treatment effect and degree of satisfaction are obtained.

The invention discloses a three-ingredient placenta cream capable of replenishing qi, enriching blood and improving immunity and a preparation method thereof. The three-ingredient placenta cream capable of replenishing qi, enriching blood and improving immunity is prepared from the following components in parts by weight: 34 to 36 parts of sheep placenta, 1.8 to 2.2 parts of rhizoma polygonati and 1.8 to 2.2 parts of radix astragali. The preparation method comprises the following steps: (1) preparing raw materials; (2) pretreating the sheep placenta; (3) preparing sheep placenta enzymatic hydrolysate; (4) decocting to obtain liquid medicine; (5) mixing; and (6) obtaining a finished product of the three-ingredient placenta cream. The three-ingredient placenta cream provided by the invention has good effects of supporting healthy energy, reinforcing qi, nourishing blood and improving immunity, and is suitable for weak constitution, aeipathia, chronic kidney diseases, postoperative and postpartum deficiency of qi and blood, pale or sallow complexion, short breath, laziness to speak, weakness and aching pain of limbs, insomnia, amnesia, leucopenia after radiotherapy and chemotherapy, immune dysfunction and the like; and the preparation method of the three-ingredient placenta cream provided by the invention is simple in process and convenient for batch production.

A Chinese medicine in the form of particles for treating the leukocytopenia, dizziness, vomitting, etc. which are caused by radiotherapy and chemicotherapy is prepared from 11 Chinese-medicinal materials including ginseng, astragalus root, Chinese angelica root, wolfberry fruit, etc.

The invention discloses a Chinese medicinal preparation for preventing the chemotherapeutic reaction, which respectively selects the following drug substances in weight: 20 to 30 g of rhizoma pinelliae, 10 to 20 g of fructus aurantii immaturus, 10 to 20 g of red ginseng, 10 to 20 g of poppy shell, 10 to 20 g of fructus amomi, 10 to 20 g of bighead atractylodes rhizome, 10 to 20 g of coptis chinensis, 10 to 20 g of pseudobulbus cremastrae seu pleiones, 10 to 20 g of the root of bidentate achyranthes, 8 to 15 g of dandelion, 8 to 12 g of polygonum cuspidatum, 8 to 12 g of seaweed, 8 to 12 g of charred triplet, 8 to 12 g of honeysuckle and 8 to 12 g of radix curcumae. All the raw material medicines are excellent in compatibility and take effects of strengthening the spleen and stomach, nourishing yin and kidney, relieving liver for smoothening qi, producing blood and protecting marrow and building body when being combined for use; and the Chinese medicinal preparation can effectively prevent adverse reactions, which are caused by chemotherapy, such as nausea, emesis and leukocyte reduction, reduces chemotherapeutic toxicity, improves living quality of a patient and is valuable to clinically popularize.

The invention provides a Chinese caterpillar fungus oral preparation and a preparation method thereof. The oral preparation is prepared from Chinese caterpillar fungus and mannatide; the prepared medicine has the effects of enhancing immunity of organisms, increasing the content of white blood cells in blood and improving hypoxia resistance of the organisms, and has an exact curative effect on diseases of impaired immunity, leucopenia and the like.

The invention relates to a traditional Chinese medicine composition for warming kidneys, strengthening marrow, tonifying qi, nourishing yin, promoting generation of blood and stopping bleeding and a preparation method thereof. The composition is prepared from six traditional Chinese medicinal materials, including melanterite, American ginseng, hippocampus, cinnamon, Chinese dates and walnut kernels. The composition has the effects of warming kidneys, strengthening marrow, tonifying qi, nourishing yin, promoting generation of blood and stopping bleeding, and is mainly used for treating deficient kidney-yang and deficient qi-blood patients due to aplastic anemia, leukopenia, thrombopenia, myelodysplastic syndrome, and bone marrow injury and leukopenia caused by radiotherapy and chemotherapy. The traditional Chinese medicine composition has remarkable clinical pharmacodynamic test effect, high bioavailability and no toxic or side effect.

The invention discloses a traditional Chinese medicine composition for treating myelosuppressive leukopenia after chemotherapy, which comprises sunburned epimedium, pilose antler, raw sun-dried ginseng, dried ginger, bran-fried Atractylodes macrocephala, astragalus, magnet, amomum, wine cornus, Polygonum multiflorum, donkey-hide gelatin, wine rhubarb and roasted licorice. The invention is used for patients with bone marrow suppression and leukopenia after malignant tumor chemotherapy, which belongs to deficiency of spleen and kidney yang. All the medicines work together to nourish the fire and warm the soil, to nourish the soil to subdue the fire, and to help the spleen and kidneys, and to have the effects of invigorating the spleen, tonifying the kidneys, warming yang and replenishing qi.

The invention belongs to the technical field of traditional Chinese medicine and relates to a traditional Chinese medicine composition for treating leucopenia caused by radiotherapy. The medicine composition is prepared from ginseng, radix codonopsis, turtle shells, radix paeoniae alba, ginger, pawpaw fruits, poria cocos, rhizoma sparganii and acanthopanax roots. The traditional Chinese medicine composition is prepared from the nine kinds of medicine materials according to a certain compatibility relation, and the nine kinds of medicine materials can jointly tonify qi and strength the foundation, strengthen the spleen and tonify the kidneys, nourish the blood and promote the blood circulation, tonify kidney-yin and nourish the bone marrow, and strength the body resistance to eliminate evil; the traditional Chinese medicine composition can balance organism functions, enhance the habitus of a patient and improve the immunity, the patient can maintain continuity of radiotherapy, and the treatment effect and the living quality of the patient can be improved.

The invention relates to the effect of radix bupleuri and ramulus cinnamomi soup and tigecycline on treating or preventing pneumonia, in particular to the effect on treating leukopenia baumanii pneumonia. A leukopenia baumanii pneumonia rat model is adopted to provide reference for clinical treatment of baumanii infection.