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Micro-nano material for preventing and/or treating myelosuppression and application thereof

A technology of bone marrow suppression and bulk materials, applied in the field of biomedicine, can solve the problems of low gastrointestinal tract absorption rate, gastrointestinal adverse reactions, and cannot be widely used, and achieve obvious protective effects, rapid prevention and repair of bone marrow suppression, Efficient scavenging effect of free radicals

Inactive Publication Date: 2016-11-16
BEIJING FUNAKANG BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prevention and treatment of myelosuppression, although many traditional Chinese and western medicines have certain curative effects, their application is limited due to their low absorption rate in the human gastrointestinal tract and easy to cause adverse reactions in the gastrointestinal tract; An effective treatment method is the use of recombinant human granulocyte colony-stimulating factor, but due to its high price and its own defects, it cannot be widely used at present

Method used

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  • Micro-nano material for preventing and/or treating myelosuppression and application thereof
  • Micro-nano material for preventing and/or treating myelosuppression and application thereof
  • Micro-nano material for preventing and/or treating myelosuppression and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Embodiment 1, olive oil coating hollow fullerene (hereinafter referred to as Olive-C 60 ) the first course of myelosuppressive protection at the in vivo level

[0051] Animal model: ICR mice of 4-5 weeks were selected and randomly divided into 5 groups, 6 mice in each group, corresponding to blank control group, cyclophosphamide (CTX)+Olive-C 60 Oral administration experimental group, CTX+Olive-C 60 The intraperitoneal administration experimental group, the CTX+Olive intragastric administration experimental group and the CTX experimental group.

[0052] Blank control group: the drugs injected in the experimental group were replaced by the same volume of normal saline, and the same volume of normal saline was injected into the stomach and abdominal cavity.

[0053] Cyclophosphamide (CTX)+Olive-C 60 Oral administration experimental group: rats were intraperitoneally injected with CTX solution, the drug dosage was 60mg / kg mouse body weight, and Olive-C was administered ...

Embodiment 2

[0060] Embodiment 2, olive oil coating hollow fullerene (hereinafter referred to as Olive-C 60 ) in the second course of myelosuppressive protection at the living level

[0061] Animal model: ICR mice of 4-5 weeks were selected and randomly divided into 5 groups, 6 mice in each group, corresponding to blank control group, cyclophosphamide (CTX)+Olive-C 60 Oral administration experimental group, CTX+Olive-C 60 The intraperitoneal administration experimental group, the CTX+Olive intragastric administration experimental group and the CTX experimental group.

[0062] Blank control group: the drugs injected in the experimental group were replaced by the same volume of normal saline, and the same volume of normal saline was injected into the stomach and abdominal cavity.

[0063] Cyclophosphamide (CTX)+Olive-C 60 Oral administration experimental group: rats were intraperitoneally injected with CTX solution, the drug dosage was 60mg / kg mouse body weight, and Olive-C was administer...

Embodiment 3

[0070] Embodiment 3, olive oil coating hollow fullerene (hereinafter referred to as Olive-C 60 ) monitoring of the relevant enzyme activity during the first course of treatment at the living level

[0071] Animal model: ICR mice of 4-5 weeks were selected and randomly divided into 5 groups, 6 mice in each group, corresponding to blank control group, cyclophosphamide (CTX)+Olive-C 60 Oral administration experimental group, CTX+Olive-C 60 The intraperitoneal administration experimental group, the CTX+Olive intragastric administration experimental group and the CTX experimental group.

[0072] Blank control group: the drugs injected in the experimental group were replaced by the same volume of normal saline, and the same volume of normal saline was injected into the stomach and abdominal cavity.

[0073] Cyclophosphamide (CTX)+Olive-C 60 Oral administration experimental group: rats were intraperitoneally injected with CTX solution, the drug dosage was 60mg / kg mouse body weight...

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Abstract

The invention discloses a micro-nano material for preventing and / or treating myelosuppression and application thereof. A fullerene and / or metal fullerene micro-nano material can be applied to preparing medicine with at least one of the following properties of preventing and / or treating myelosuppression, removing free radicals, preventing and / or treating at least one of leukocyte reduction, platelet reduction, hemoglobin reduction and monocyte reduction caused by myelosuppression, preventing bone marrow cells and / or hematopoietic cells, improving the function of antioxidant systems of organisms and protecting liver tissue, spleen tissue and kidney tissue. The fullerene and / or metal fullerene micro-nano material can be metabolized out of organisms, is enriched in visceral organs and marrow through blood circulation after intragastric administration or intraperitoneal injection, has an excellent function of preventing myelosuppression induced by chemotherapy in bodies, can effectively reduce toxic and side effects of chemotherapy on marrow and other organs, and is still obvious in protection effect after multiple treatment courses.

Description

technical field [0001] The invention relates to a micro-nano material for preventing and / or treating myelosuppression and its application, belonging to the field of biomedicine. Background technique [0002] In recent years, the incidence of tumors has been increasing, and malignant tumors seriously endanger people's health. Although with the advancement of science and technology, a variety of methods for treating cancer have emerged, but radiotherapy and chemotherapy are still one of the commonly used clinical treatments for malignant tumors. However, while most chemotherapy drugs and radiotherapy rays kill cancer cells, they also damage actively proliferating normal cells in the human body, which has great side effects, especially for bone marrow cells, hematopoietic stem cells, etc., which will cause secondary damage to the patient. Injuries and even leukemia and other diseases seriously affect the quality of life and prognosis of patients, limiting its clinical applicat...

Claims

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Application Information

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IPC IPC(8): A61K33/44A61K47/46A61K47/48A61P39/06A61P7/00A61P7/02A61P43/00A61P1/16A61P1/00A61P13/12
Inventor 王春儒张莹甄明明
Owner BEIJING FUNAKANG BIOTECH CO LTD
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